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Perspectives of the Use of Magnetically Labeled Antibodies in NMR Imaging

  • M. A. Macri
  • F. De Luca
  • G. Garreffa
  • B. Maraviglia
Conference paper

Abstract

Monoclonal antibodies tagged with radioactive isotopes have been used for several years for specific tissue recognition by y camera scanning. Tentatives of appling monoclonal antibodies to NMR imaging as specific contrast agents were recently made 1,2). Generally the objective of the research consisted in binding polimeric or other ion chelate molecules, capable of binding paramagnetic ions like Gd+3, to the antibody or to a monoclonal antibody fragment. Up to now anyway our results and the results of other laboratories showed a serious limitation in the effects that these paramagnetic impurities induce both “in vitro” and “in vivo”. The importance of having specific contrast agents is however so relevant that it is worth considering other possible means by which this objective could be reached. Therefore, besides considering the existing limitations of this research we will report and analysis of some recent new possibilities which arised in this field.

References

  1. 1).
    P. Shreve and A.M. Aisen, Magn. Res. in Med. 3, 336 (1986)CrossRefGoogle Scholar
  2. 2).
    M.A. Macri, F. De Luca, B. Maraviglia, F. Polizio, G. Garreffa, S. Cavallo and P.G. Natali, Magn. Res. in Med. 11, 283 (1989)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • M. A. Macri
    • 1
  • F. De Luca
    • 2
  • G. Garreffa
    • 2
  • B. Maraviglia
    • 2
  1. 1.Dipartimento di FisicaUniversità di Roma “La Sapienza”RomaItaly
  2. 2.Istituto Fisica MedicaUniversità di ChietiChietiItaly

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