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Aktuelle Probleme der Masernvirusinfektion

  • U. G. Liebert
Conference paper
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Part of the Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics book series (KINDERHEILK. NF, volume 58)

Zusammenfassung

Masern sind eine weltweit verbreitete hochkontagiöse Infektionskrankheit im Kindes- und jungen Erwachsenenalter mit normierter Inkubationszeit und charakteristischem Exanthem. Den natürlichen Wirt stellt nur der Mensch dar. Das Masernvirus tritt endemisch in Bevölkerungsgruppen auf. Da nach einer Infektion eine lebenslange Immunität gegen Reinfektionen entsteht, sind vor allem die nicht geimpften Klein- und Schulkinder, bei denen kein Schutz durch maternale Antikörper mehr besteht, für die Virusinfektion empfänglich. Virologische und immunologische Untersuchungen haben gezeigt, daß die Antigenität des Masernvirus äußerst stabil ist. Subtypen sind nicht bekannt, und alle bisher untersuchten Masernvirusstämme sind bezüglich ihrer hauptantigenen Determinanten einheitlich. Durch aktive Immunisierung mit attenuierter Lebendvakzine können die akuten Masern verhindert werden. In den Ländern der dritten Welt, insbesondere in Südamerika und Afrika, sind Masern jedoch aufgrund fehlender Impfungen auch heutzutage noch eine lebensbedrohliche Erkrankung, deren Mortalität und Komplikationsrate hoch ist. Etwa 1 Million Kinder sterben jährlich in diesen Ländern an Masern.

Key words

Masern Masernvirus-Infektionen akut persistierend akute postinfektiöse Enzephalomyelitis subakute sklerosierende Panenzephalitis virusinduzierte Autoimmunität 

Literatur

  1. Agnarsdottir G (1977) Subacute sclerosing panencephalitis. In: Waterson AP (eds) Recent advances in clinical virology. Churchill Livingstone, Edinburgh, pp 21–49Google Scholar
  2. Alkhatib G, Briedis DJ (1986) The predicted primary structure of the measles virus hemagglutinin. Virology 150: 479–490PubMedCrossRefGoogle Scholar
  3. Appel MJG, Gibbs EPJ, Martin SJ, ter Meulen V, Rima BK, Stephenson JR, Taylor WP (1981) Morbillivirus diseases of animals and man. In: Kurstak E, Kurstak C (eds) Comparative diagnoses of viral diseases. Academic Press, London, pp 235–297Google Scholar
  4. Arneborn P, Biberfeld G (1983) T-lymphocyte subpopulations in relation to immunosuppression in measles and varicella. Infect Immun 39: 29–37PubMedGoogle Scholar
  5. Baczko K, Billeter M, ter Meulen V (1983) Purification and molecular weight determination of measles virus genomic RNA. J Gen Virol 64: 1409–1413PubMedCrossRefGoogle Scholar
  6. Baczko K, Billeter M, ter Meulen V (1984) Expression of measles virus RNA in brain tissue. In: Bishop DHL, Compans RW (eds) Nonsegmented negative strand viruses. Academic Press, New York, pp 233–238Google Scholar
  7. Baczko K, Liebert UG, Billeter M, Cattaneo R, Budka H, ter Meulen V (1986) Expression of defective measles virus genes in brain tissues of patients with subacute sclerosing panencephalitis. J Virol 59: 472–478PubMedGoogle Scholar
  8. Banerjee AK (1987) Transcription and replication of rhabdoviruses. Microbiol Rev 51: 66–87PubMedGoogle Scholar
  9. Barrett PN, Koschel K (1983) Effect of antibody induced modulation of measles ( SSPE) virus membrane proteins on ß-adrenergic receptor-mediated adenylate cyclase activity. Virology 127: 299–308PubMedCrossRefGoogle Scholar
  10. Barrett PN, Koschel K, Carter M, ter Meulen V (1985) Effect of measles virus antibodies on a measless SSPE virus persistently infected C6 rat glioma cell line. J Gen Virol 66: 1411–1421PubMedCrossRefGoogle Scholar
  11. Bellini WJ, Englund G, Rozenblatt S, Arnheiter H, Richardson CD (1985) Measles virus P gene codes for two proteins. J Virol 53: 908–919PubMedGoogle Scholar
  12. Bellini WJ, Englund G, Richardson CD, Rozenblatt S, Lazzarini RA (1986) The matrix genes of measles virus and canine distemper virus: cloning, nucleotide sequence and deduced amino acid sequences. J Virol 58: 408–416PubMedGoogle Scholar
  13. Billeter MA, Baczko K, Schmid A, ter Meulen V (1984) Cloning of DNA corresponding to four different measles virus genomic regions. Virology 132: 147–159PubMedCrossRefGoogle Scholar
  14. Bohn W, Rutter G, Hohenberg H, Mannweiler K, Nobis P (1986) Involvement of actin filaments in budding of measles virus: studies on cytoskeletons of infected cells, Virology 149: 91–106PubMedCrossRefGoogle Scholar
  15. Borgono JM (1983) Current impact of measles in Latin America. Rev Infect Dis 5: 417–421PubMedCrossRefGoogle Scholar
  16. Buckland R, Gerald RC, Barker R, Wild TF (1987) Fusion glycoprotein of measles virus: nucleotide sequence of the gene and comparison with other paramyxoviruses. J Gen Virol 68: 1695–1703PubMedCrossRefGoogle Scholar
  17. Carter MJ, ter Meulen V (1987) Measles. In: Zuckerman AJ, Banatvala JE, Pattison JR (eds) Principles and practice of clinical virology. John Wiley & Sons, Chichester New York Brisbane Toronto Singapore, pp 291–314Google Scholar
  18. Carter MJ, Barrett PN, Koschel K, ter Meulen V (1984) Immune response to virus-specific proteins in CNS infections. In: Behan P, Spreafico F (eds) Neuroimmunology. Raven, New York, pp 207–217Google Scholar
  19. Casali P, Rice GPA, Oldstone MBA (1984) Viruses disrupt functions of human lymphocytes. Effects of measles virus and influenza virus on lymphocytemediated killing and antibody production. J Exp Med 159: 1322–1337PubMedCrossRefGoogle Scholar
  20. Cattaneo R, Schmid A, Rebmann G, Baczko K, ter Meulen V, Bellini WJ, Rozenblatt S, Billeter MA (1986) Accumulated measles virus mutations in a case of subacute sclerosing panencephalitis: interrupted matrix protein reading frame and transcription alteration. Virology 154: 97107CrossRefGoogle Scholar
  21. Cattaneo R, Rebmann G, Schmid A, Baczko K, ter Meulen V, Billeter MA (1987) Altered transcription of a defective measles virus genome derived from a human brain. EMBO J 6: 681–688PubMedGoogle Scholar
  22. Cherry JD (1981) Measles. In: Feigin RD, Cherry JD (eds) Textbook of pediatric infectious diseases. Saunders, Philadelphia, pp 1210–1231Google Scholar
  23. Dave KH (1983) Measles in India. Rev Infect Dis 5: 406–410PubMedCrossRefGoogle Scholar
  24. Dörries R, ter Meulen V (1984) Detection and identification of virus-specific, oligoclonal IgG in unconcentrated cerebrospinal fluid by immunoblot technique. J Neuroimmunol 7: 77–89PubMedCrossRefGoogle Scholar
  25. Dowling PC, Blumberg BM, Menonna J, Adamus JE, Cook P, Crowley JC, Kolakofsky D, Cook SD (1986) Transcriptional map of the measles virus genome. J Gen Virol 67: 1987–1992PubMedCrossRefGoogle Scholar
  26. Dubois-Dalcq M (1979) Pathology of measles virus infection of the nervous system: comparison with MS. Int Rev Exp Pathol 19: 101–135PubMedGoogle Scholar
  27. Fontana A, Fierz W, Wekerle H (1984) Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature 307: 273–276PubMedCrossRefGoogle Scholar
  28. Fournier JG, Tardieu M, Lebon P, Robain O, Ponsot G, Rozenblatt S, Bouteille M (1985) Detection of measles virus RNA in lymphocytes from peripheral blood and brain perivascular infiltrates of patients with subacute sclerosing panencephalitis. N Engl J Med 313: 910PubMedCrossRefGoogle Scholar
  29. Fujinami RS, Oldstone MBA (1984) Antibody initiates virus persistence: immune modulation and measles virus infection. In: Notkins AL, Oldstone MBA (eds) Concepts in viral pathogenesis. Springer, Berlin Heidelberg New York, pp 188–193Google Scholar
  30. Fujinami RS, Oldstone MBA (1985) Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 230: 1043–1045PubMedCrossRefGoogle Scholar
  31. Fujinami RS, Oldstone MBA, Wroblewska Z, Frankel ME, Koprowski H (1983) Molecular mimicry in virus infection: cross-reaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments. Proc Natl Acad Sci (USA) 80: 2346–2350CrossRefGoogle Scholar
  32. Gendelman HE, Wolinsky JS, Johnson RT, Pressman NJ, Pezeshkpour GH, Boisset GF (1984) Measles encephalomyelitis: lack of evidence of viral invasion of the central nervous system and quantitative study of the nature of demyelination. Ann Neurol 15: 353–360PubMedCrossRefGoogle Scholar
  33. Giraudon P, Wild TF (1985) Correlation between epitopes on hemagglutinin of measles virus and biological activities: passive protection by monoclonal antibodies is related to their hemmagglutination inhibiting activity. Virology 144: 46–58PubMedCrossRefGoogle Scholar
  34. Giuffre RM, Tovell DR, Kay CM, Tyrell DLJ (1982) Evidence for an interaction between the membrane protein of a paramyxovirus and actin. J Virol 42: 963–968PubMedGoogle Scholar
  35. Good RA, Zak SJ (1959) Disturbances in gamma-globulin synthesis as experiments of nature. Pediatrics 18: 109–149Google Scholar
  36. Greenstein JI, McFarland HF (1983) Response of human lymphocytes to measles virus after natural infection. Infect Immun 40: 198–204PubMedGoogle Scholar
  37. Haase AT, Ventura P, Gibbs CJ, Tourtellotte WW (1980) Measles virus nucleotide sequences: detection by hybridization in situ. Science 212: 672–675CrossRefGoogle Scholar
  38. Haase AT, Swoveland P, Stowring L, Ventura P, Johnson KP, Norrby E, Gibbs CJ (1981) Measles virus genome in infections of the central nervous system. J Infect Dis 144: 154–160PubMedCrossRefGoogle Scholar
  39. Haase AT, Gantz D, Blum H, Stowring L, Ventura P, Geballe A, Moyer B, Brahic M (1985) Combined macroscopic and microscopic detection of viral genes in tissues. Virology 140: 201–206PubMedCrossRefGoogle Scholar
  40. Hall WW, ter Meulen V (1976) RNA homology between subacute sclerosing panencephalitis and measles virus. Nature 246: 474–477CrossRefGoogle Scholar
  41. Hall WW, Lamb RA, Choppin PW (1979) Measles and subacute sclerosing panencephalitis virus proteins: lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis. Proc Natl Acad Sci (USA) 76: 2047–2051CrossRefGoogle Scholar
  42. Hirsch MS, Proffitt MR (1975) Autoimmunity in viral infection. In: Notkins AL (ed) Viral immunology and immunopathology. Academic Press, New York, pp 419–427Google Scholar
  43. Hirsch RL, Griffin DE, Johnson RT, Cooper SJ, de Soriano IL, Roedenbeck S, Vaisberg A (1984) Cellular immune responses during complicated and uncomplicated measles virus infections of man. Clin Immunol Immunopathol 31: 1–10PubMedCrossRefGoogle Scholar
  44. Horta-Barbosa L, Hamilton R, Wittig B, Fuccillo DA, Sever JI, Vernon ML (1971) Subacute sclerosing panencephalitis: isolation of suppressed measles virus from lymph node biopsy. Science 173: 840–841PubMedCrossRefGoogle Scholar
  45. Hyypiä T, Korkiamäki P, Vainionpää R (1985) Replication of measles virus in human lymphocytes. J Exp Med 161: 1261–1271PubMedCrossRefGoogle Scholar
  46. Iverson LE, Rose JK (1981) Localized attenuation and discontinuous synthesis during vesicular stomatitis virus transcription. Cell 23: 477–484PubMedCrossRefGoogle Scholar
  47. Jacobson S, Richert JR, Biddison WE, Satinsky A, Hartzman RJ, McFarland HF (1984) Measles virus-specific T4+ human cytotoxic T cell clones are restricted by class II HLA antigens. J Immunol 133: 754–757PubMedGoogle Scholar
  48. Jahnke U, Fischer EH, Alvord EC Jr (1985) Sequence homology between certain viral proteins and proteins related to encephalomyelitis and neuritis. Science 229: 282–284PubMedCrossRefGoogle Scholar
  49. Johnson KP, Carrigan DR (1982) Neurologic diseases caused by measles virus. In: Katsuki S, Tsubaki T, Toyokura Y (eds) Neurology. Excerpta Medica, Amsterdam Oxford Princeton, pp 404–415Google Scholar
  50. Johnson RT, Griffin DE, Hirsch RL, Wolinsky JS, Roedenbeck S, DeSoriano IL (1984) Measles encephalomyelitis: clinical and immunological studies. N Engl J Med 310: 137–141PubMedCrossRefGoogle Scholar
  51. Joseph BS, Lampert BV, Oldstone MBA (1975) Replication and persistence of measles virus in defined subpopulations of human leukocytes. J Virol 16: 1638–1649PubMedGoogle Scholar
  52. Kingsbury DW, Bratt MA, Choppin PW, Hanson RP, Hosaka Y, ter Meulen V, Norrby E, Plowright W, Rott R, Wunner HW (1978) Paramyxoviridae. Intervirol 10: 137–152CrossRefGoogle Scholar
  53. Kreth HW, Käckell MY, ter Meulen V (1975) Demonstration of in vitro lymphocyte-mediated cytotoxicity against measles virus in SSPE. J Immunol 144: 1042–1046Google Scholar
  54. Liebert UG, ter Meulen V (1987) Virological aspects of measles virus induced encephalomyelitis in Lewis and BN rats. J Gen Virol 68: 1715–1722PubMedCrossRefGoogle Scholar
  55. Liebert UG, Baczko K, Budka H, ter Meulen V (1986) Restricted expression of measles virus proteins in brains from cases of subacute sclerosing panencephalitis. J Gen Virol 67: 2435–2444PubMedCrossRefGoogle Scholar
  56. Liebert UG, Linington C, ter Meulen V (1988) Induction of autoimmune reactions to myelin basic protein in measles virus encephalitis in Lewis rats. J Neuroimmunol 17: 103–118PubMedCrossRefGoogle Scholar
  57. Londei H, Lamb JR, Bottazzo GF, Feldmann M (1984) Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned T cells. Nature 312: 639–641PubMedCrossRefGoogle Scholar
  58. Lucas CJ, Biddison WE, Nelson DL, Shaw S (1981) Measles virus-specific cellular cytotoxicity. J Immunol 133: 754–757Google Scholar
  59. Massa PT, Dörries R, ter Meulen V (1986) Viral particles induce la antigen expression on astrocytes. Nature 320: 543–546PubMedCrossRefGoogle Scholar
  60. Massa PT, ter Meulen V, Fontana A (1987) Hyperinducibility of la antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci (USA) 84: 4219–4223CrossRefGoogle Scholar
  61. McChesney MB, Kehrl JH, Valsamakis A, Fauci AS, Oldstone MBA (1987) Measles virus infection of B lymphocytes permits cellular activation but blocks progression through the cell cycle. J Virol 61: 3441–3447PubMedGoogle Scholar
  62. Mehta PD, Kane A, Thormar H (1977) Quantitation of measles virus-specific immunoglobulins in serum, CSF, and brain extract from patients with subacute sclerosing panencephalitis. J Immunol 118: 2254–2261PubMedGoogle Scholar
  63. Merz DC, Scheid A, Choppin PW (1980) Importance of antibodies to the fusion glycoprotein of paramyxoviruses in the prevention of spread of infection. J Exp Med 151: 275–288PubMedCrossRefGoogle Scholar
  64. Meulen ter V, Carter MJ (1982) Morbillivirus persistent infections in animals and man. In: Mahy BWJ, Minson AC, Darby GK (eds) Virus persistence. Cambridge University Press, Cambridge, pp 97–132Google Scholar
  65. Meulen ter V, Carter MJ (1984) Measles virus persistency and disease. Progr Med Virol 30: 44–61Google Scholar
  66. Meulen ter V, Hall WW (1978) Slow virus infections of the nervous system: virological, immunological and pathogenetic considerations. J Gen Virol 41: 1–25PubMedCrossRefGoogle Scholar
  67. Meulen ter V, Stephenson JR (1983) The possible role of viral infections in multiple sclerosis and other related demyelinating diseases. In: Hallpike J, Adams C, Tourtellotte W (eds) Multiple sclerosis. Chapman and Hall, London, pp 241–274Google Scholar
  68. Meulen ter V, Käckell Y, Müller D et al. (1972) Isolation of infectious measles virus in measles encephalitis. Lancet 2: 1172–1175PubMedCrossRefGoogle Scholar
  69. Meulen ter V, Löffler S, Carter MJ, Stephenson JR (1981) Antigenic characterization of measles and SSPE virus haemagglutinin by monoclonal antibodies. J Gen Virol 57: 357–364PubMedCrossRefGoogle Scholar
  70. Meulen ter V, Stephenson JR, Kreth HW (1983) Subacute sclerosing panencephalitis. In: Fraenkel-Conrat H, Wagner RR (eds) Comprehensive virology. Plenum, New York, pp 105–159Google Scholar
  71. Mitchell CD, Balfour HF Jr (1985) Measles control: so near and yet so far. Progr Med Virol 31: 1–42Google Scholar
  72. Morgan EM, Rapp R (1977) Measles virus and its associated diseases. Bacteriol Rev 41: 636–666PubMedGoogle Scholar
  73. Nahamias AJ, Griffith D, Salisbury C, Yoshida K (1967) Thymic aplasia with lymphopenia, plasma cells, and normal immunoglobulins. JAMA 201: 729–734CrossRefGoogle Scholar
  74. Norrby E (1978) Viral antibodies in multiple sclerosis. Progr Med Virol 24: 1–30Google Scholar
  75. Norrby E (1985) Measles virus. In: Fields BN (ed) Virology. Raven, New York, pp 1305–1322Google Scholar
  76. Norrby E, Gollmar Y (1975) Identification of measles virus-specific hemolysis-inhibiting antibodies separate from hem agglutination inhibiting antibodies. Infect Immun 11: 231–239PubMedGoogle Scholar
  77. Norrby E, Kristensson K, Brzosko WJ, Kapsenberg JG (1985) Measles virus matrix protein detected by immune fluorescence with monoclonal antibodies in the brain of patients with subacute sclerosing panencephalitis. J Virol 56: 337–340PubMedGoogle Scholar
  78. Notkins AL, Onodera T, Prabhakar EL (1984) In: Notkins AL, Oldstone MBA (eds) Concepts in viral pathogenesis. Springer, Berlin Heidelberg New York Tokio, pp 210–215CrossRefGoogle Scholar
  79. O’Donovan C (1971) Measles in Kenyan children. East Afr Med J 48: 526–532PubMedGoogle Scholar
  80. Panum PL (1847) Iagttageiser anstillede under measlinge-apidemien yaa faeröerne i aaret 1846. Bibliothek for Laeger 1: 270–344Google Scholar
  81. Paterson RG, Lamb RA (1987) Ability of the hydrophobic fusion related external domain of a paramyxovirus F protein to act as a membrane anchor. Cell 48: 441–454PubMedCrossRefGoogle Scholar
  82. Richardson CD, Scheid A, Choppin PW (1980) Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with amino acid sequences similar to those at the N-termini of the F1 and HA2 viral polypeptides. Virology 105: 205–222PubMedCrossRefGoogle Scholar
  83. Richardson CD, Berkovich A, Rozenblatt S, Bellini WJ (1985) Use of antibodies directed against specific peptides for identifying cDNA clones, establishing reading frames and deducing the gene order of measles virus. J Virol 54: 186–193PubMedGoogle Scholar
  84. Rima BK (1983) The proteins of morbilliviruses. J Gen Virol 64: 1205–1219PubMedCrossRefGoogle Scholar
  85. Rima BK, Baczko K, Clarke DK, Curran MD, Martin SJ, Billeter MA, ter Meulen V (1986) Characterization of clones for the sixth ( L) gene and a transcriptional map for morbilliviruses. J Gen Virol 67: 1971–1978PubMedCrossRefGoogle Scholar
  86. Rose JW, Bellini WJ, McFarlin DE, McFarland HF (1984) Human cellular immune response to measles virus polypeptides. J Virol 49: 988–991PubMedGoogle Scholar
  87. Rosen A, Gergely P, Jondal M, Klein G, Britton S (1977) Polyclonal Ig production after Epstein-Barr virus detection of human lymphocytes in vitro. Nature 267: 52–54PubMedCrossRefGoogle Scholar
  88. Rozenblatt S, Koch T, Pinhasi O, Bratasin S (1979) Infective substructures of measles virus from acutely and persistently infected cells. J Virol 32: 329–333PubMedGoogle Scholar
  89. Rozenblatt S, Eizenberg O, Ben-Levy R, Lavie V, Bellini WJ (1985) Sequence homology within the morbilliviruses. J Virol 53: 684–690PubMedGoogle Scholar
  90. Sabin AB, Arechiga AF, de Castro JF, Albrecht P, Sever JL, Shekarchi I (1984) Successful immunization of infants with and without maternal antibody by aerosolized measles vaccine. II. Vaccine comparisons and evidence for multiple antibody response. JAMA 251: 2363–2371PubMedCrossRefGoogle Scholar
  91. Shapshak P, Tourtellotte WW, Wolman M et al. (1986) Search for virus nucleic acid sequences in postmortem human brain tissue using in situ hybridization technology with cloned probes: some solutions and results on progressive multifocai leukoencephalopathy and subacute sclerosing panencephalitis tissue. J Neurosci Res 16: 281–301PubMedCrossRefGoogle Scholar
  92. Sheshberadaran H, Norrby E (1984) Three monoclonal antibodies against measles virus F protein cross-react with cellular stress proteins. J Virol 52: 995–999PubMedGoogle Scholar
  93. Sissons JGP, Colby SD, Harrison WO, Oldstone MBA (1985) Cytotoxic lymphocytes generated in vivo with acute measles virus infection. Clin Immunol Immunopathoi 34: 60–68CrossRefGoogle Scholar
  94. Stallcup KC, Wechsler SL, Fields BN (1979) Purification of measles virus and characterisation of subviral components. J Virol 30: 166–176PubMedGoogle Scholar
  95. Stephenson JR, ter Meulen V (1979) Subacute sclerosing panencephalitis: characterization of the etiological agent and its relationship to the morbilliviruses. In: Tyrrell DAJ (ed) Aspects of slow and persistent virus infection. 2. New perspectives in clinical microbiology. Martinus Nijhoff, Hague, pp 61–75Google Scholar
  96. Sullivan JL, Barry DW, Lucas SJ, Albrecht P (1975) Measles infection of human mononuclear cells. I. Acute infection of peripheral blood lymphocytes and monocytes. J Exp Med 142: 773–784PubMedCrossRefGoogle Scholar
  97. Sun D, Wekerle H (1986) Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes. Nature 320: 70–72PubMedCrossRefGoogle Scholar
  98. Vandvik B, Norrby E (1973) Oligoclonal IgA antibody response in the central nervous system to different measles virus antigens in subacute sclerosing panencephalitis. Proc Natl Acad Sci (USA) 70: 1060–1063CrossRefGoogle Scholar
  99. Vandvik B, Norrby E, Nordal HJ, Degré M (1976) Oligoclonal measles virus-specific IgG antibodies isolated from cerebrospinal fluids, brain extracts, and sera from patients with subacute sclerosing panencephalitis and multiple sclerosis. Scand J Immunol 5: 979–1001PubMedCrossRefGoogle Scholar
  100. Varsanyi TM, Jörnvall H, Norrby E (1985) Isolation and characterization of the measles virus F, polypeptide: comparison with other paramyxovirus fusion proteins. Virology 147: 110–117PubMedCrossRefGoogle Scholar
  101. Walsh JA (1983) Selective primary health care: strategies for control of disease in the developing world. Measles. Rev Infect Dis 5: 330–340CrossRefGoogle Scholar
  102. Watanabe R, Wege H, ter Meulen V (1983) Adoptive transfer of EAE-like lesions from rats with coronavirusinduced demyelinating encephalomyelitis. Nature 305: 150–153PubMedCrossRefGoogle Scholar
  103. Wekerle H, Linington C, Lassmann H, Meyermann R (1986) Cellular immune reactivity within the CNS. Trends Neurosci 9: 271–277CrossRefGoogle Scholar
  104. Wong TC, Hirano A (1987) Structure and function of bicistronic RNA encoding the phosphor-protein and matrix protein of measles virus. J Virol 61: 584–589PubMedGoogle Scholar
  105. Wong TC, Wipf G, Hirano A (1987) The measles virus matrix gene and gene product defined by in vitro and in vivo expression. Virology 157: 497–508PubMedCrossRefGoogle Scholar
  106. Yoshida T, Nagai Y, Yoshii S, Maeno K, Matsumoto T (1976) Membrane protein of HVJ (Sendai virus): its role in virus assembly. Virology 71: 143–161PubMedCrossRefGoogle Scholar
  107. Yoshikawa Y, Yamanouchi K (1984) Effect of papaverine treatment on replication of measles virus in human neural and nonneural cells. J Virol 50: 489–496PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • U. G. Liebert
    • 1
  1. 1.Institut für Virologie und ImmunbiologieWürzburgGermany

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