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Guidelines for the Use and Care of Small Laboratory Animals in Transplantation Research

  • W. Geise
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Abstract

In many cases biomedical research requires the use of experimental animals. Investigators must deal with animal welfare issues which have not only scientific but also ethical, legal, and social implications. Although the availability and development of viable alternatives, for example, mathematical models, computer simulation, and in vitro biological systems, are increasing, in many cases live animal research in biosciences currently has no acceptable alternative. This is the case particularly in transplantation research because of the complex interactions involved in whole animal systems.

References

  1. 1.
    Krebs A (1993) Haben wir moralische Pflichten gegenüber Tieren? Das pathozentrische Argument in der Naturethik. Dtsch Z Philos 41:995–1008Google Scholar
  2. 2.
    Morton DB, Griffiths PHM (1985) Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment. Vet Rec 116:431–436PubMedCrossRefGoogle Scholar
  3. 3.
    de Cock Buning T, Theune E (1994) A comparison of three models for ethical evaluation of proposed animal experiments. Anim Welfare 3:107–128Google Scholar
  4. 4.
    Porter DG (1992) Ethical scores for animal experiments. Nature 356:101–102PubMedCrossRefGoogle Scholar
  5. 5.
    Institute of Laboratory Animal Resources (1996) Guide for the care and use of laboratory animals. Commission on Life Sciences, National Research Council. National Academy, WashingtonGoogle Scholar
  6. 6.
    Working Committee for the biological characterization of laboratory animals/GV-SOLAS (1985) Guidelines for specification of animals and husbandry methods when reporting the results of animal experiments. Lab Anim 19:106–108CrossRefGoogle Scholar
  7. 7.
    van Zutphen LFM, Baumans V, Beynen AC (1993) Principles of laboratory animal science. Elsevier, AmsterdamGoogle Scholar
  8. 8.
    Fox JG, Cohen BJ, Loew FM (1984) Laboratory animal medicine. Academic, San DiegoGoogle Scholar
  9. 9.
    First Report of the BVA/FRAME/RSPCA/UFAW Joint Working Group on Refinement (1993) Removal of blood from laboratory mammals and birds. Lab Anim 27:1–22CrossRefGoogle Scholar
  10. 10.
    Loeb WFL, Quimby FW (1989) The clinical chemistry of laboratory animals. Pergamon, New YorkGoogle Scholar
  11. 11.
    Gärtner K, Stoll L (1972) Zur Akklimatisation von Laboratoriumsratten nach Ortswechsel unter besonderer Berücksichtigung der b- und g-Globuline und der adrenalen Corticoste-ronkonzentrationen. Res Exp Med 158:180–193CrossRefGoogle Scholar
  12. 12.
    Tuli JS, Smith JA, Morton DB (1995) Stress measurements in mice after transportation. Lab Anim 29:132–138PubMedCrossRefGoogle Scholar
  13. 13.
    Gesellschaft für Versuchstierkunde (GV-SOLAS) (1988) Planung und Struktur von Versuchstierbereichen tierexperimentell tätiger Institutionen.Google Scholar
  14. 14.
    Hessler JR, Moreland AF (1984) Design and management of animal facilities. In: Fox JG, Cohen BJ, Loew FM (eds) Laboratory animal medicine. Academic, San Diego, pp 505–526Google Scholar
  15. 15.
    Ruys T (1991) Handbook of facilities planning, vol 2. Laboratory animal facilities. Van Nostrand Reinhold, New YorkGoogle Scholar
  16. 16.
    Kraft V (1985) Virusinfektionen bei kleinen Versuchstieren: Einflüsse auf die biomedizinische Forschung. Dtsch Tierärztl Wochenschr 92:484–489PubMedGoogle Scholar
  17. 17.
    Hsu C-K, New AE, Mayo JG (1980) Quality assurance of rodent models. In: Spiegel A, Erichsen S, Solleveld HA (eds) Animal quality and models in biomedical research. 7th ICLAS Symposim, Utrecht 1979. Fischer, Stuttgart, pp 17–28Google Scholar
  18. 18.
    Bryant DH, Boscato LM, Mboloi PN, Stuart MC (1995) Allergy to laboratory animals among animal handlers. Med J Aust 163:415–418PubMedGoogle Scholar
  19. 19.
    Hunskaar S, Fosse RT (1993) Allergy to laboratory mice and rats: a review of its prevention, management, and treatment. Lab Anim 27:206–221PubMedCrossRefGoogle Scholar
  20. 20.
    Kahrs RF (1995) General disinfection guidelines. Rev Sci Tech Off Int Epiz 14:105–122Google Scholar
  21. 21.
    Deutsche Veterinärmedizinische Gesellschaft (1993) 8. Desinfektionsmittelliste für die Tierhaltung. Deutsches TierärzteblattGoogle Scholar
  22. 22.
    Rehbinder C, Baneux P, Forbes D, van Herck H, Nicklas W, Rugaya Z, Winkler G (1996) FELAS A recommendations for the health monitoring of mouse, rat, hamster, gerbil, guin-eapig and rabbit experimental units. Report of the Federation of European Laboratory Animal Science Associations (FELASA) Working Group on Animal Health accepted by the FELASA Board of Management, November 1995. Lab Anim 30(3):193–208PubMedCrossRefGoogle Scholar
  23. 23.
    Lindsey JR (1986) Prevalence of viral and mycoplasmal infections in laboratory rodents. In: Bhatt PN, Jacoby RO, Morse HC III, New AE (eds) Viral and mycoplasmal infections of laboratory rodents. Effects on biomedical research. Academic, Orlando, pp 801–808Google Scholar
  24. 24.
    Wyss-Spillmann SK, Hornberger FR (1995) Vorgehen bei der Hygiene-Überwachung in einer Zuchtanlage für spezifiziert pathogen freie Mäuse und Ratten. Schweiz Arch Tier-heilk 137:505–514Google Scholar
  25. 25.
    Flecknell PA (1994) Refinement of animal use — assessment and alleviation of pain and distress. Lab Anim 28:222–231PubMedCrossRefGoogle Scholar
  26. 26.
    Gärtner K, Militzer K (1993) Zur Bewertung von Schmerzen, Leiden und Schäden bei Versuchstieren. Parey, BerlinGoogle Scholar
  27. 27.
    FELASA Working Group on Pain and Distress (1994) Pain and distress in laboratory rodents and lagomorphs. Lab Anim 28:97–112CrossRefGoogle Scholar
  28. 28.
    Committee on Pain and Distress in Laboratory Animals of the Institute of Laboratory Animal Resources (1992) Recognition and alleviation of pain and distress in laboratory animals. National Academy, WashingtonGoogle Scholar
  29. 29.
    Paddleford RR, Erhardt W (1992) Anästhesie bei Kleintieren. Schattauer, StuttgartGoogle Scholar
  30. 30.
    Jenkins WL (1987) Pharmacologic aspects of analgesic drugs in animals: an overview. J Am Vet Med Assoc 191:1231–1240PubMedGoogle Scholar
  31. 31.
    Flecknell PA (1987) Laboratory animal anaesthesia. Academic, LondonGoogle Scholar
  32. 32.
    Whelan G, Flecknell PA (1992) The assessment of depth of anaesthesia in animals and man. Lab Anim 26:153–162PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1998

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  • W. Geise

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