Arenavirus Gene Structure and Organization

  • D. H. L. Bishop
  • D. D. Auperin
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 133)


For rhabdoviruses, paramyxoviruses, orthomyxoviruses, and some members of the Bunyaviridae, all the proteins are translated from the viral-complementary RNA sequence. This is in contrast to the genetic strategy of picornaviruses, caliciviruses, coronaviruses, togaviruses, flaviviruses, and retroviruses, whose proteins are all translated from the viral RNA sequence (i. e., viral RNA, or sequences corresponding to viral RNA sequences, functions as an mRNA species). The former group of single-stranded RNA viruses are described as negative- stranded RNA viruses, the latter as positive-stranded RNA viruses. The negative-stranded RNA viruses have a virion RNA polymerase that is responsible for the synthesis of the viral-complementary mRNA species. Although the purified viral RNA of most of the positive-stranded viruses is infectious per se, this is not the case for retroviruses since they have a virion reverse transcriptase that forms an obligatory DNA intermediate during the initial stages of the viral infection process.


Translation Initiation Codon Lassa Fever Lymphocytic Choriomeningitis Virus Terminal Nucleotide Sequence Lassa Fever Virus 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1987

Authors and Affiliations

  • D. H. L. Bishop
    • 1
  • D. D. Auperin
    • 2
  1. 1.NERC Institute of VirologyOxfordUK
  2. 2.Centers for Disease ControlAtlantaUSA

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