Hemofiltration pp 129-145 | Cite as

Quantitation and Prescription of Therapy

  • L. W. Henderson
  • J. K. Leypoldt


Since the inception of artificial kidney treatment, the renal clinician/researcher has been faced with the need to determine an adequate amount of therapy for the patient. As the artificial kidney attempts to replace the excretory function of the native kidney, determination of solute removal rates by the artificial kidney provides an important element necessary for quantitation of therapy. The classic work of Wolf et al. [1], who introduced the term dialysance to describe solute transport by hemodialyzers in analogy to renal clearance as defined by Van Slyke[2], was a major contribution and facilitated comparison of solute removal by the artificial kidney with that of the native kidney. Additional studies [3–5] provided the functional dependence of solute removal by the artificial kidney on clinical operating conditions, such as blood flow rate, dialyzer flow rate, membrane area, and membranes with different permeability spectra. While such studies contributed materially toward greater understanding of the impact of these variables on solute removal by the artificial kidney, they helped little, in the absence of good quality clinical correlations, to decide what an adequate amount of therapy should be for a given patient.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • L. W. Henderson
  • J. K. Leypoldt

There are no affiliations available

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