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Determinants of Fluid and Solute Removal Rates During Hemofiltration

  • N. J. Ofsthun
  • C. K. Colton
  • M. J. Lysaght
Chapter

Abstract

The rates at which fluid and solutes are removed from blood during hemofiltration depend on device dimensions and operating conditions. The purpose of this chapter is to describe these factors qualitatively and quantitatively in order to give the reader both an understanding of the physical phenomena involved and a grounding in the mathematical models available to quantify such phenomena.

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References

  1. 1.
    Shaldon S, Beau MC, Deschodt G, Ramperez P, Mion C (1980) Vascular stability during hemofiltration. Trans Am Soc Artif Intern Organs 26: 391–393PubMedGoogle Scholar
  2. 2.
    Gotch FA (1983) Sodium-volume modelling of hemodialysis and hemofiltration therapy. Proc Clin Dial Transplant Forum 10 (6): 27Google Scholar
  3. 3.
    Shaldon S, Deschodt G, Branger B, Oules R, Granolleras C, Baldamus CA, Koch KM, Lysaght M J, Dinarello CA (1985) Hemodialysis hypotension: the interleukin hypothesis restated. Proc Eur Dial Transplant Assoc 22: 229–243Google Scholar
  4. 4.
    Lysaght MJ, Ford CA, Colton CK, Stone RA, Henderson LW (1978) Mass Transfer in clinical blood ultrafiltration devices. In: Frost TH (ed) Technical aspects of renal dialysis. Pitman Medical, Kent, pp 81–95Google Scholar
  5. 5.
    Lysaght MJ, Schmidt B, Gurland HJ (1983) Filtration rates and pressure driving force in AV hemofiltration. Blood Purif 1: 178–183CrossRefGoogle Scholar
  6. 6.
    Brenner BM, Rector FC Jr (1976) The kidney. Saunders, PhiladelphiaGoogle Scholar
  7. 7.
    Feldhof P, Turnham T, Klein E (1984) Effect of plasma proteins on the sieving spectra of hemofllters. Artif Organs 8 (2): 186–192CrossRefGoogle Scholar
  8. 8.
    Matthiasson E (1983) The role of macromolecular adsorption in fouling of ultrafiltration membranes. J Membr Sci 16: 23–26CrossRefGoogle Scholar
  9. 9.
    Reihanian H, Robertson CR, Michaels AS (1983) Mechanisms of polarization and fouling of ultrafiltration membranes by proteins. J Membr Sci 16: 237–258CrossRefGoogle Scholar
  10. 10.
    Zeman LJ (1983) Adsorption effects in rejection of macromolecules by ultrafiltration mem-branes. J Membr Sci 15: 213–230CrossRefGoogle Scholar
  11. 11.
    Horbett TA (1982) Protein adsorption on biomaterials. Adv Chem Ser 199: 233–244CrossRefGoogle Scholar
  12. 12.
    Dorson WJ Jr, Pizziconi VB, Allen JM (1971) Transfer of chemical species through a protein gel. Trans Am Soc Artif Intern Organs 17: 287–292PubMedGoogle Scholar
  13. 13.
    Colton CK, Friedman S, Wilson DE, Lees RE (1972) Ultrafiltration of lipoproteins through a synthetic membrane. J Lab Clin Med 51: 2472–2481Google Scholar
  14. 14.
    Streicher E (1982) Transport properties in filtration and dialysis membranes. Contrib Nephrol 32: 31–39PubMedGoogle Scholar
  15. 15.
    Nakao S-I, Yumoto S, Kimura S (1982) Analysis of rejection characteristics of macromolecular gel layer for low molecular weight solutes in ultrafiltration. Jpn J Chem Eng 15 (6): 463–468CrossRefGoogle Scholar
  16. 16.
    Henderson LW, Leypoldt JK, Frigon RP, Uyeji SN, Alford M (1984) Slow flow hemofiltration improves solute transport. Blood Purif 2: 9Google Scholar
  17. 17.
    Haas T, Dongradi G, Villeboeuf F, de Viel E, Fournier JF, Duruy D (1983) Plasma kinetics of small molecules during and after hemofiltration: decrease in hemofiltration efficiency related to increase in ultrafiltration rate. Clin Nephrol 19 (4): 193–200PubMedGoogle Scholar
  18. 18.
    Henderson LW, Colton CK, Ford CA (1975) Kinetics of hemodiafiltration. II Clinical characterization of a new blood modality. J Lab Clin Med 85 (3): 372–391PubMedGoogle Scholar
  19. 19.
    Guyton AC (1978) Textbook of medical physiology. Saunders, PhiladelphiaGoogle Scholar
  20. 20.
    Lauer A, Saccaggi A, Ronco C, Belledonne M, Glabman S, Bosch JP (1983) Continuous arteriovenous hemofiltration in the critically ill patient: clinical use and operational characteristics. Ann Intern Med 99 (4): 455–460PubMedCrossRefGoogle Scholar
  21. 21.
    Colton CK, Henderson LW, Ford CA, Lysaght MJ (1975) Kinetics of hemodiafiltration. I In vitro transport characteristics of a hollow-fiber blood ultrafilter. J Lab Clin Med 85 (3): 355–371PubMedGoogle Scholar
  22. 22.
    Blatt WF, Dravid A, Michaels AS, Nelson L (1970) Solute polarization and cake formation in membrane ultrafiltration: causes consequences and control techniques. In: Flinn JE (ed) Membrane science and technology. Plenum, New York, pp 47–97CrossRefGoogle Scholar
  23. 23.
    Probstein RF, Leung W-F, Alliance Y (1979) Determination of diffusivity and gel concentration in macromolecular solutions by ultrafiltration. J Phys Chem 83 (9): 1228–1232CrossRefGoogle Scholar
  24. 24.
    Kozinski AA, Lightfoot EN (1972) Protein ultrafiltration: a general example of boundary layer filtration. AI Ch E Journal 18 (5): 1030–1040CrossRefGoogle Scholar
  25. 25.
    Vilker VL, Colton CK, Smith KA, Green DL (1984) The osmotic pressure of concentrated protein and lipoprotein solutions and its significance to ultrafiltration. J Membr Sci 20: 63–77CrossRefGoogle Scholar
  26. 26.
    Wijmans JG, Nakao S, Smolders CA (1984) Flux limitation in ultrafiltration: osmotic pressure model and gel layer model. J Membr Sci 20: 115–124CrossRefGoogle Scholar
  27. 27.
    Leveque MA (1928) Les lois de la transmission de chaleur par convection. Ann Mines 13: 201Google Scholar
  28. 28.
    Okazaki M, Yoshida F (1976) Ultrafiltration of blood: effect of hematocrit on ultrafiltration rate. Ann Biomed Eng 4: 138–150PubMedCrossRefGoogle Scholar
  29. 29.
    Kochinke F, Baeyer HV, Kiener St, Schnabel R, Marx M, Mohnhaupt R, Kessel M (1982) Formation of a hybrid membrane in porous glass capillaries during hemofiltration ( HF ). Trans Am Soc Artif Intern Organs 28: 488–493PubMedGoogle Scholar
  30. 30.
    Porter MC (1972) Concentration polarization with membrane ultrafiltration. Ind Eng Chem Prod Res Devel 11 (3): 234–248CrossRefGoogle Scholar
  31. 31.
    Shen JJS, Probstein RF (1977) On the prediction of limiting flux in laminar ultrafiltration of macromolecular solutions. Ind Eng Chem Fundam 16 (4): 459–465CrossRefGoogle Scholar
  32. 32.
    Jaffrin MY, Butruille Y, Granger A, Vantard G (1978) Factors governing hemofiltration ( HF) in a parallel plate exchanger with highly permeable membranes. Trans Am Soc Artif Intern Organs 24: 448–453Google Scholar
  33. 33.
    Isaacson K, Duenas P, Ford C, Lysaght M (1980) Determination of graetz solution constants in the in vitro hemofiltration of albumin, plasma and blood. In: Cooper AR (ed) Ultrafiltration membranes and applications. Plenum, New York, pp 507–521CrossRefGoogle Scholar
  34. 34.
    Keller KH, Canales ER, Yum SI (1971) Tracer and mutual diffusion coefficients of proteins. J Phys Chem 75 (3): 379–387PubMedCrossRefGoogle Scholar
  35. 35.
    Schumaker VN (1973) Hydrodynamic analysis of human low density lipoproteins. Accts Chem Res 6 (12): 398–403CrossRefGoogle Scholar
  36. 36.
    Zydney AL, Colton CK (1982) Cross-flow membrane plasmapheresis: theoretical models for flux and hemolysis prediction. Trans Am Soc Artif Intern Organs 28: 404–412Google Scholar
  37. 37.
    Eckstein EC, Bailey DG, Shapiro AH (1977) Self-diffusion of particles in shear flow of a suspension. J Fluid Mech 79: 191–208CrossRefGoogle Scholar
  38. 38.
    Bixler HJ, Nelson LM, Besarab A (1968) The diaphron hemodiafilter: an alternative to dialysis for extracorporeal blood purification. Chem Eng Prog Symp Series 84 (64): 90–103Google Scholar
  39. 39.
    Zydney AL (1985) Cross-flow membrane plasmapheresis: an analysis of flux and hemolysis. Ph D Thesis, MIT, Cambridge, MassGoogle Scholar
  40. 40.
    Lysaght MJ, von Albertini B, Bosch JP, Ford CA, Geronomus R (1978) Relationship between surface area and ultrafiltration rate in capillary hemofilters. Proc Eur Soc Artif Organs 5: 178–182Google Scholar
  41. 41.
    Lysaght MJ, Ford CA, Isaacson KA (1981) Selection of optimal capillary internal diameter in blood ultrafilters. Proc Eur Soc Artif Organs 8: 130–134Google Scholar
  42. 42.
    Nakao S-I, Nomura T, Kimura S (1979) Characteristics of macromolecular gel layer formed on ultrafiltration tubular membrane. AI Ch E Journal 25 (4): 615–622CrossRefGoogle Scholar
  43. 43.
    Vilker VL, Colton CK, Smith KA (1981) Concentration polarization in protein ultrafiltration. Part II: theoretical and experimental study of albumin ultrafiltered in an unstirred cell. AI Ch E Journal 27 (4): 637–645CrossRefGoogle Scholar
  44. 44.
    Iorio G, Drioli E, Memoli B, Andreucci V, Salvatore M, Alfano B (1984) Ultrafiltration processes in blood treatment. J Membr Sci 18: 297–311CrossRefGoogle Scholar
  45. 45.
    Spiegler KS, Kedem O (1966) Thermodynamics of hyperfiltration (reverse osmosis): criteria for efficient membranes. Desalination 1: 311–326CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • N. J. Ofsthun
  • C. K. Colton
  • M. J. Lysaght

There are no affiliations available

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