Predilution hemofiltration (HF) was initiated as a test strategy to evaluate the pathophysiologic significance of “middle molecules” for the uremic patient [1, 2]. As such, the system was devised for use in the patient with stable end stage renal failure (ESRF). As originally applied, it was recognized to be at a disadvantage in the removal of low molecular weight solutes (<350 daltons) when compared with hemodialysis (HD). Since then many changes have occurred in how convective mass transport is applied. Postdilution vs predilution  as a means of economizing on diluting fluid, hemodiafiltration (HDF)[4,5,6] which combines the best of both diffusion and convection, and continuous low efficiency HF for the treatment of acute renal failure (ARF) are some of the creative applications to which this ultrafiltration methodology has been put. In placing this spectrum of techniques into the special perspective of “the future of hemofiltration” I wish to take a brief backward look in order to have you join me in extrapolating this line of development into the future.
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- 1.Henderson LW (1977) Development of a convective blood cleansing technique. Proceedings of the 10th Annual Contractors Conference, Bethesda, Maryland, p 130Google Scholar
- 2.Henderson LW (1981) The beginning of hemofiltration. In: Beryne GM, Giovannetti S, Thomas S (eds) Contributions to nephrology series, vol 32. Shaefer K, Koch KM, Quellhorst E, von Herrath D (eds) Symposium on hemofiltration volume. Karger, Basel, p 1Google Scholar
- 6.von Albertini B, Miller JH, Gardner PW, Norris KC, Roberts CE, Shinaberger JH (1984) High flux hemodiaflltration. Abstract, American Society for Nephrology, 17th annual meeting, p 76Google Scholar
- 7.Kramer P (ed) (1982) Arterio-venous hemofiltration, Vandenhoeck and Ruprecht, GottingenGoogle Scholar
- 9.McBride PT (1979) Genesis of the artificial kidney, chap 3. Travenol Labs, Deerfield, Illinois, USA, p9Google Scholar
- 11.Henderson LW, Besarab A, Michaels A, Bluemle LW Jr (1967) Blood purification by ultrafiltration and fluid replacement (diafiltration). Trans Am Soc Artif Intern Organs 12: 216Google Scholar
- 13.Paganini EP, Nakamoto S (1980) Continuous slow flow ultrafiltration in oliguric acute renal failure. Trans Am Soc Artif Intern Organs 26: 203Google Scholar
- 14.Leypoldt JK, Frigon RP, Henderson LW (1985) Characterization of solutes transport in membrane ultrafiltration. J Membrane Sci (in review)Google Scholar
- 15.Maeda K, Shinzato T, Sezaki R, Yamada K, Saito A, Ohta K (1984) Decrease sieving coefficient for middle molecule during hemofiltration and infusion free hemodiaflltration. Blood Purif 2: 54 (Abstract)Google Scholar
- 16.Icardi A, Lamperi B, Cappelli G, Lamperi S (1984) Hemofiltration and biofiltration: a comparative study on the short term effects. Blood Purif 2: 52 (Abstract)Google Scholar
- 19.Baldamus CA (1983) Clinical value and technical feasibility of long term hemofiltration. Assaio J 6: 192Google Scholar
- 20.Bosch JP, von Albertini B, Geronemus R, Glabman S, Goldstein MH, Kahn T, Kupfer S (1979) Comparison of hemofiltration and ultrafiltration plus hemodialysis to conventional hemodialysis. Annual Progress report to the Artificial Kidney Chronic Uremia Program, National Institute of Arthritis, Metabolic and Digestive Diseases, 15 March 1979Google Scholar
- 22.Quellhorst EA, Schuenemann B, Hildebrand U (1983) Morbidity and mortality in long term hemofiltration. Asaio J 6: 185Google Scholar
- 27.Wright JC (1982) Electrochemical dialysate regeneration: the electrooxidation of urea at the ruthenium titanium oxide electrode. Ph D Dissertation, Stanford UniversityGoogle Scholar