The History of Hemofiltration

  • M. J. Lysaght


Writers in scientific and medical journals are fond of such sentences as “Polyvorpal Trans-jabberition, first introduced by Smith in 1958195–203” or “Polyvorpal Trans-jabberitation was developed by Smith 204–221 and Jones 222–250 in the late 50s.” Such statements are rarely false, but are often oversimplified, inaccurate, and misleading. Scientific developments do not typically enjoy a discreet birthing, but instead emerge and take form rather like a major river gathering mass and momentum from disperse watersheds and from the confluence of many minor tributaries. Moreover, qualities such as perseverance, practicality, endurance, and exactitude are at least as important indices of a contributor’s merit as is simple primacy. Accordingly, the purpose of this chapter is not to assign priority for the development of hemofiltration (HF), but rather to review the fascinating history of how and why this therapy came to be.


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  1. 1.
    Ferry JD (1936) Ultrafilter membranes and ultrafiltration. Chem Rev 18: 373–455CrossRefGoogle Scholar
  2. 2.
    Brull L (1928) Realisation de l’ultrafiltration in vivo. Biol C R 99: 105–107Google Scholar
  3. 3.
    Geiger A (1931) A method of ultra-filtration in vivo. J Physiol 71: 111–120PubMedGoogle Scholar
  4. 4.
    Malinow MR, Korzon W (1947) An experimental method for obtaining an ultrafiltrate of the blood. J Lab Clin Med 32: 461–471PubMedGoogle Scholar
  5. 5.
    Alwall N (1963) Therapeutic and diagnostic problems in severe renal failure. Scandinavian University books ( Munksgaard ), CopenhagenGoogle Scholar
  6. 6.
    Skeggs LT, Leonards JR, Kahn JR (1952) Removal of the fluid from normal and edematous dogs by continuous ultrafiltration of blood. Lab Invest 1: 488–494PubMedGoogle Scholar
  7. 7.
    Kolff WJ, Leonards JR (1954) Reduction of otherwise intractable edema by dialysis or filtration. Cleveland Clin Quat 21: 61–71CrossRefGoogle Scholar
  8. 8.
    Nakamoto S (1961) Removal of edema fluid by ultrafiltration with the disposable twin coil artificial kidney. Clev Clin Q 28: 10–15CrossRefGoogle Scholar
  9. 9.
    Bluemle LW (1966) Evaluation of new membranes for hemodialysis. Interim report on NIH contract PH-43-66-45Google Scholar
  10. 10.
    Henderson L, Besarb A, Michaels A, Bluemle LW (1967) Blood purification by ultrafiltration and fluid replacement (diafiltration). Trans Am Soc Artif Intern Organs 16: 216–222Google Scholar
  11. 11.
    Bixler HJ, Nelsen LM, Bluemle LW (1968) The development of a blood purification system for blood purification. Trans Am Soc Artif Intern Organs 14: 99–107PubMedGoogle Scholar
  12. 12.
    Henderson LW, Ford CA, Colton CK, Bluemle LW, Bixler HJ (1970) Uremic blood cleansing by diafiltration using a hollow fiber ultrafilter. Trans Am Soc Artif Intern Organs 16: 107–114PubMedGoogle Scholar
  13. 13.
    Hamilton R, Ford C, Colton C, Cross R, Steinmuller S, Henderson LW (1971) Blood cleansing by diafiltration in uremic dog and man. Trans Am Soc Artif Intern Organs 17: 259–265PubMedGoogle Scholar
  14. 14.
    Henderson LW, Livoti LG, Ford CA, Kelly AB, Lysaght MJ (1973) Clinical experience with intermittent hemofiltration. Trans Am Soc Artif Intern Organs 19: 119–123PubMedCrossRefGoogle Scholar
  15. 15.
    Silverstein ME, Ford CA, Lysaght MJ, Henderson LW (1974) Response to rapid removal of intermediate molecular weight solutes in uremic man. Trans Am Soc Artif Intern Organs 20: 614–621PubMedGoogle Scholar
  16. 16.
    Quellhorst E, Plashues E (1971) Ultrafiltration: Elimination harnpflichtiger Substanzen mit Hilfe neuartiger Membranen. In: Ditrich P, Skabal F (eds) Aktuelle Probleme der Dialysever-fahren und der Niereninsuffizienz. Bindernagel, Friedberg, pp 216–226Google Scholar
  17. 17.
    Quellhorst E, Fernandez F, Scheler F (1972) Treatment of uremia using an ultrafiltration-filtration system. Proc Eur Dial Transplant Assoc 9: 584–587PubMedGoogle Scholar
  18. 18.
    Reiger J, Quellhorst E, Lowitz HD, Kong RG, Scheler F (1974) Ultrafiltration for middle molecules in uremia. Proc Eur Dial Transplant Assoc 11: 158–164Google Scholar
  19. 19.
    Quellhorst E, Rieger J, Doht B, Beckmann H, Jacob I, Kraft B, Mietzsch G, Scheler F (1976) Treatment of chronic uremia by an ultrafiltration kidney: first clinical experience. Proc Eur Dial Transplant Assoc 13: 314–321Google Scholar
  20. 20.
    Markovitz M (1968) An artificial glomerulus. Ariz Med 25: 35–37Google Scholar
  21. 21.
    Dorson W, Markovitz M (1968) A pulsating artificial kidney. Chem Eng Prog Symp Ser 84: 85–89Google Scholar
  22. 22.
    Dorson WJ, Markovitz M, Pizziconi VB, Walter JA (1970) Molecular separation as an artificial kidney technique. Trans Amer Soc Artif Intern Organs 16: 127–133Google Scholar
  23. 23.
    Dorson WJ, Pizziconi VB, Vorhees ME, Calkins R, Christianson HB, Cotter DJ, Fargotstein R, Markovitz M, Monty DE, Tomisaka DM (1973) Initial trials of a molecular separation artificial kidney. Trans Am Soc Artif Intern Organs 19: 109–118PubMedCrossRefGoogle Scholar
  24. 24.
    Henderson LW (1982) The beginning of hemofiltration. Contrib Nephrol 32: 1–19PubMedGoogle Scholar
  25. 25.
    Dorson WJ, Pizziconi VB (1979) Present status of the hemofiltration molecular separation artificial kidney. Artif Organs 3 (1): 6–7PubMedCrossRefGoogle Scholar
  26. 26.
    Lysaght MJ, Ford CA (1974) Biomedical applications of anisotropic membranes. In: Hopfenberg HB (ed) Permeability of plastic films and coating to gases, vapors, and liquids. Plenum, New York, pp 459–468CrossRefGoogle Scholar
  27. 27.
    Colton CK, Henderson LW, Ford CA, Lysaght MJ (1975) Kinetics of hemodiafiltration: in vitro transport characteristics of a hollow fiber blood ultrafilter. J Lab Clin Med 85 (3): 355–371PubMedGoogle Scholar
  28. 28.
    Henderson LW, Colton CK, Ford CA (1975) Kinetics of hemodiafiltration II: clinical characterization of a new blood cleansing modality. J Lab Clin Med 85 (3): 372–391PubMedGoogle Scholar
  29. 29.
    Quellhorst E, Schuenemann B, Doht B (1978) Hemofiltration — a new method for the treatment of chronic renal insufficiency. In: Frost TH (ed) Technical aspects of renal dialysis. Pitman Medical, Kent, pp 96–106Google Scholar
  30. 30.
    Funk-Brentano JL, Man NK, Sausse A, Zingraff J, Boudet J, Becker A, Cueille GF (1976) Characterization of a 1100–1300 MW uremic neurotoxin. Trans Am Soc Artif Intern Organs 22: 163–167Google Scholar
  31. 31.
    Bergstrom J, Asaba H, Fürst P, Oules R (1976) Dialysis, ultrafiltration and blood pressure. Proc Eur Dial Transplant Assoc 13: 293–305Google Scholar
  32. 32.
    Quellhorst E, Scheler F (1976) Arbeitstagung über Hämofiltration Braunlage/Harz 25. September 1976. Wissenschaftliche Information Aktuelle Nephrologie (Fresenius Stiftung) 4: 85–103Google Scholar
  33. 33.
    Journal of Dialysis 1 (6): 529–649Google Scholar
  34. 34.
    Mackey BB (ed) (1977) Proceedings tenth annual contractors conference of the artificial kidney program of the National Institute of Arthritis, Metabolism, and Digestive diseases. DHEW publication 77–1422: 130–157, 166–191Google Scholar
  35. 35.
    Lysaght MJ, Ford CA, Colton CK, Stone RA, Henderson LW (1978) Mass transfer in clinical blood ultrafiltration devices — a review. In: Frost TH (ed) Technical aspects of renal dialysis. Pitman Medical, Kent, pp 81–95Google Scholar
  36. 36.
    Quellhorst E, Schuenemann B, Doht B (1977) Hemofiltration — A new method for treatment of chronic renal insufficiency. Trans Am Soc Artif Intern Organs 23: 681–682PubMedCrossRefGoogle Scholar
  37. 37.
    Henderson LW, San Felippo ML, Stone RA (1981) Comparison of hemodialysis and hemofiltration. Proc 12th Annu Contract Conf, Dept HEW Publ No. NIH 81-1979: 169Google Scholar
  38. 38.
    Bosch JP, Albertini B, Geronomos A, Glabman S (1981) Comparison of hemofiltration and ultrafiltration + hemodialysis to conventional hemodialysis. NIH Report AK-1-2228-FGoogle Scholar
  39. 39.
    Quellhorst E, Schuenemann B (1981) Controlled study to compare hemodialysis and hemofiltration treatment in patients with chronic renal insufficiency. NIH Report AK-1-8-2229-FGoogle Scholar
  40. 40.
    Koch K, Baldamus C (1981) Hemodialysis/hemofiltration: a comparison of medical, technical, and cost factors. NIH Report AK-1227-FGoogle Scholar
  41. 41.
    Scheler F, Von Henning H (1977) Hamofiltration. Dustri, MunichGoogle Scholar
  42. 42.
    Hemofiltration Bibliography (1978) Amicon Corporation, Lexington MA USA Publication #1430Google Scholar
  43. 43.
    Henderson LW, Beans E (1978) Successful production of sterile pyrogen-free electrolyte solution by ultrafiltration. Kidney Int 14: 522–525PubMedCrossRefGoogle Scholar
  44. 44.
    Bosch J, Geronomos R, Glabman S, Lysaght MJ, Kahn T, Von Albertini B (1978) High flux hemofiltration. Artif Organs 2 (4): 339–342PubMedCrossRefGoogle Scholar
  45. 45.
    Shaldon S, Beau MC, Claret G, Deschodt G, Ramperez P, Mion C (1978) Haemofiltration with sorbent regeneration of ultrafiltrate: First clinical experience in end stage renal disease. Proc Eur Dial Transplant Assoc 15: 220–227PubMedGoogle Scholar
  46. 46.
    Kramer P, Wigger W, Rieger J, Matthaei D, Scheler F (1977) Arterovenous haemofiltration: a new simple method for treatment of overhydrated patients resistant to diuretics. Klin Wochenschr 55: 1121, 1122Google Scholar
  47. 47.
    Kramer P (1982) Arterio-venoese Haemofiltration — Nieren-(Ersatz)-Therapie im Intensivpfle-gebereich. Vandenhoeck and Ruprecht, GöttingenGoogle Scholar
  48. 48.
    Kramer P (1985) Arteriovenous hemofiltration: A kidney replacement therapy for the intensive care unit. Springer, New York Berl in HeidelbergGoogle Scholar
  49. 49.
    Mion C (1982) Symposium sur l’hemofiltration. Opuscula Medico-technica lundensia X XIV. Rahms, LundGoogle Scholar
  50. 50.
    Schaeffer K, Koch K-M, Quellhorst E, Von Herrath D (1982) Hemofiltration. Contrib Nephrol 32Google Scholar
  51. 51.
    Intern J Artif Organs (1983) 6:1Google Scholar
  52. 52.
    Luehman D, Hirsch D, Ebben J, Collins A, Shapiro F, Keshaviah P (1984) Central on-site preparation of substitution for hemofiltration. Trans Am Soc Artif Intern Organs 30: 195–198Google Scholar
  53. 53.
    Ramperez P, Beau MC, Deschodt G, Flavier JL, Nilsson L, Mion C, Shaldon S (1981) Economic preparation of sterile pyrogen free infusate for hemofiltration. Proc Eur Dial Transplant Assoc 18: 293–296PubMedGoogle Scholar
  54. 54.
    Rameoofsky JA, Prestidge H, Ford C, Sanfelippo ML, Henderson LW (1981) Novel applications for hemofiltration membranes. Trans Am Soc Artif Intern Organs 27: 613–617Google Scholar
  55. 55.
    Shaldon S, Beau MC, Deschodt G, Mion C (1981) Mixed hemofiltration: 18 months experience with ultrashort treatment time. Trans Am Soc Artif Intern Organs 27: 610–612PubMedGoogle Scholar
  56. 56.
    Shinaberger JH, Miller JH, Rubini ME, Gardner PW, Martin FE (1969) Initial clinical evaluation of “Diafiltration.” Trans Am Soc Artif Intern Organs 15: 97–102Google Scholar
  57. 57.
    Silverstein ME, Ford CA, Lysaght MJ, Henderson LW (1974) The treatment of intractable fluid overload. N Engl J Med 291: 747–751PubMedCrossRefGoogle Scholar
  58. 58.
    Cheung AC, Kato Y, Leypoldt JK, Henderson LW (1982) Hemodiafiltration using a hybrid membrane system for self-generation of diluting fluid. Trans Am Soc Artif Intern Organs 28: 61–65PubMedGoogle Scholar
  59. 59.
    von Albertini B, Miller J, Gardner P, Shinaberger J (1984) High flux hemofiltration: under 6 hrs/week treatment. Trans Am Soc Artif Intern Organs 30: 227–231Google Scholar
  60. 60.
    Leber HW, Wizeman V, Goubeaud G, Rawer P, Schuetterle G (1978) Simultaneous hemofiltration/hemodialysis: an effective alternative to hemofiltration and conventional hemodialysis in the treatment of uremic patients. Clin Nephrol 9: 115–121PubMedGoogle Scholar
  61. 61.
    Streicher E, Schneider H (1985) The next generation of dialysis membranes: barriers or pathways. Contr Nephrol 44: 125–136Google Scholar
  62. 62.
    Romagnoli A, Hacker J, Keats A, Milam J (1976) External hemoconcentration after deliberate hemodilution. ( Abstr ). Ann Meet Am Soc AnesthesiolGoogle Scholar
  63. 63.
    Shapiro WB, Faubert PF, Fein PA, Tzeng T, Porush JG (1978) Hemofiltration with sorbent re-cycling of ultrafiltrate in uremic dogs. Trans Am Soc Artif Intern Organs 24: 185–191PubMedGoogle Scholar
  64. 64.
    Shettigar UR, Kablitz C, Stephen R, Kolff WJ (1983) A portable hemodialysis/hemofiltration system independent of dialysate and infusion fluid. Artif Organs 7 (2): 254–256PubMedGoogle Scholar
  65. 65.
    Schueneman B, Nebendahl K, Schunk O, Quellhorst E, Mund K, Richter G (1982) Regeneration of hemofiltrate using an absorption and electrochemical oxidation scheme. Contrib Nephrol 32: 192–199Google Scholar
  66. 66.
    Lysaght MJ (1985) Contemporary ESRD therapy: quagmire or eschaton? Contrib Nephrol 44: 255–284Google Scholar
  67. 67.
    Kramer P, Wigger W, Matthaei D, Langenscheid C, Reiger J, Fuchs C, Rumpf KW, Scheler F (1978) Clinical experience with continuously monitored fluid balance in automatic hemofiltration. Artif Organs 2: 147–149PubMedCrossRefGoogle Scholar
  68. 68.
    Neff MS, Sadjadi S, Slifkin R (1979) A wearable artificial glomerulus. Trans Am Soc Artif Intern Organs 25: 71–73PubMedCrossRefGoogle Scholar
  69. 69.
    Shaldon S, Beau MC, Deshodt G, Lysaght MJ, Ramperez P, Beau MC (1980) Continuous ambulatory hemofiltration. Trans Am Soc Artif Intern Organs 26: 210–211PubMedGoogle Scholar
  70. 70.
    Trautmann M, Groene HJ, Heuer E, Kramer P (1982) Intestinale substit ution bei arterio-venoeser haemofiltration. In: Kramer P (ed) Arterio-venoese Haemofiltration–Nieren-(Er- satz)-therapie im Intensivpflegebereich. Vandenhoeck and Ruprecht, Gottingen, pp 259–268Google Scholar
  71. 71.
    Blackshear PL (1978) Two new concepts that might lead to a wearable artificial kidney. Kidney Int [suppl] 13: S-133–137Google Scholar

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© Springer-Verlag Berlin Heidelberg 1986

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  • M. J. Lysaght

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