The Immunopathogenesis of Chronic HBV Induced Liver Disease

  • Gary A. Levy
  • Francis V. Chisari


The pathogenesis of hepatitis B virus induced liver disease is not well understood. Because a suitable animal model and methods for in vitro propagation of hepatitis B virus (HBV) have not been available, most current information is derived from clinical studies. Although considerable circumstantial evidence suggests the involvement of immunologic mechanisms [61] it is difficult to determine if the reported immunologic events are primary pathogenetic determinants or merely secondary to the disease.


Chronic Active Hepatitis Hepatocellular Injury Chronic Active Liver Disease Suppressor Cell Activity Cytotoxic Effector Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • Gary A. Levy
    • 1
  • Francis V. Chisari
    • 1
  1. 1.Department of Molecular Immunology and Clinical ResearchResearch Institute of Scripps ClinicLa JollaUSA

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