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Strategic Reserves

  • L. G. Lajtha
Conference paper

Abstract

New methodologies—particularly the combination of flow cytometry and the use of monoclonal antibodies — as adjuncts to existing techniques for the analysis of the various subpopulations of haemopoietic cells are becoming availabe. These enable a significant advance in understanding and monitoring haemopoietic mechanisms, both in normal and in abnormal states. With this help, a functional measurement of the proliferation and differentiating capacity of haemopoietic tissues is becoming possible.

Key Words

Stem cells Committed precursors Proliferative capacity Receptors Monoclonal antibodies. 

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References

  1. 1.
    DEXTER, T. M., ALLEN, T. D., LAJTHA, L. G.: Conditions controlling the proliferation of haemopoietic stem cell in vitro. J. Cell. Physiol. 91, 335–344, 1977 PubMedCrossRefGoogle Scholar
  2. 2.
    FRINDEL, E., CROIZAT, H., VASSORT, F.: Stimulating factors liberated by treated bone marrow. Exp. Hematol. 4, 56, 1976 PubMedGoogle Scholar
  3. 3.
    FRINDEL, E., GUIGON, M.: Inhibition of CFU entry into cycle by a bone marrow extract. Exp. Hematol. 5, 74, 1977 PubMedGoogle Scholar
  4. 4.
    GOLUB, E. S.: Brain associated stem cell antigens. J. Exp. Med. 142, 1200, 1972 Google Scholar
  5. 5.
    HOLTZER, H.: Cell lineages, stem cells and the quantal cell cycle concept. In: A. LORD, A. POTTEN, A. COLE, eds., Stem Cell and Tissue Homeostasis. Cambridge University Press, 1977, p. 1Google Scholar
  6. 6.
    ISCOVE, N.: Erythropoietin independent stimulation of early erythropoiesis. IN: GOLD, D. W., CLINE, M. J., METCALF, D., FOX, G. F., eds., Haemopoietic Cell Differentiation. Academic Press, 1978 Google Scholar
  7. 7.
    KIVILAASKO, E., RYTÖMAA, T.: Erythrocyte chalone, a tissue specific inhibitor of cell proliferation in the erythron. Cell Tissue Kinet. 4, 1, 1971 Google Scholar
  8. 8.
    LAJTHA, L. G.: Stem cell concepts. Differentiation, (in press) 1979 Google Scholar
  9. 9.
    LORD, B. I., MORI, K. J., WRIGHT, E. G.: A stimulator of stem cell proliferation in regenerating bone marrow. Biomedicine 27, 223, 1977 PubMedGoogle Scholar
  10. 10.
    LORD, B. I., MORI, K. J., WRIGHT, E. G., LAJTHA, L. G.: An inhibitor of stem cell proliferation in normal bone marrow. Br. J. Haematol. 34, 441, 1976 PubMedCrossRefGoogle Scholar
  11. 11.
    LORD, B. I., MORI, K. J., WRIGHT, E. G., LAJTHA, L. G.: Proliferation regulators in haemopoietic cell populations. Blood Cells 3, 451–159, 1977 Google Scholar
  12. 12.
    METCALF, D.: Haemopoietic Colonies. Springer, 1977 CrossRefGoogle Scholar
  13. 13.
    RYTÖMAA, T., KIVIMIEMI, K.: Control of granulocyte production. I. Chalone and antichalone, two specific humoral regulators. Cell Tissue Kinet. 1, 329, 1968 Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • L. G. Lajtha
    • 1
  1. 1.Paterson LaboratoriesChristie Hospital and Holt Radium InstituteManchesterUK

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