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Commentary of papers

  • M. Bessis
  • N. Mohandas
  • C. Feo
  • N. Mohandas
  • M. R. Clark
  • M. S. Jacobs
  • W. Groner
  • S. B. Shohet
  • Brian S. Bull
Conference paper

Abstract

Use of diffractometric methods for clinical analysis of red cell number, shape and hemoglobin content has been proposed repeatedly through the years. Reality has invariably fallen far short of the apparent promise for at least two reasons. First, locating the diffraction bands has proven to be difficult to do by eye, and secondly, the clarity of the diffraction image tends to decrease in direct proportion to the extent of disease in a red cell population. For a method to have clinical utility, the analysis should be rapidly, easily, and reproducibly accomplished on abnormal as well as normal red cell populations.

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References

  1. 1.
    BRAILSFORD, J.D., KORPMAN, R.A., BULL, B.S.: The red cell shape from discocyte to hypotonic spherocyte—A mathematical delineation based on a uniform shell hypothesis. J. Theor. Biol. 60, 131–145, 1976 PubMedCrossRefGoogle Scholar
  2. 2.
    SUTERA, S.P., MEHERJADA, M.A.: Deformation and fragmentation of human red blood cells in turbulent shear flow. Biophys. J. 15, 1–10, 1975 PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Sutera, S.P., Meherjardi, M.H., Mohandas, N.: Deformation of erythrocytes under shear. Blood Cells 1, 369–374, 1975 Google Scholar
  4. 4.
    ZARDA, P.R.: Large deformations of an elastic shell in a viscous fluid. Ph. D. Thesis, University Microfilms, 1975 Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • M. Bessis
    • 1
  • N. Mohandas
    • 1
  • C. Feo
    • 1
  • N. Mohandas
    • 1
  • M. R. Clark
    • 1
  • M. S. Jacobs
    • 1
  • W. Groner
    • 1
  • S. B. Shohet
    • 1
  • Brian S. Bull
    • 1
  1. 1.Clinical LaboratoryLoma Linda University Medical CenterLoma LindaUSA

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