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Ektacytometric Analysis of Factors Regulating Red Cell Deformability

  • Narla Mohandas
  • Margaret R. Clark
  • Mark S. Jacobs
  • Warren Groner
  • Stephen B. Shohet
Conference paper

Abstract

Photometric analysis of laser diffraction patterns has been used to obtain quantitative measurements of deformability of specifically modified normal red cells. Variation of deformability with suspending medium osmolality and with applied shear stress was used to distinguish between changes in internal viscosity, surface area-to-volume ratio, and viscoelastic properties of the membrane in their influence on whole cell deformability.

Key Words

Red cell deformability Laser diffractometry Internal viscosity Membrane material properties. 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • Narla Mohandas
    • 1
    • 2
  • Margaret R. Clark
    • 1
  • Mark S. Jacobs
    • 1
  • Warren Groner
    • 3
  • Stephen B. Shohet
    • 1
  1. 1.Cancer Research InstituteUniversity of CaliforniaSan FranciscoUSA
  2. 2.Institut de Pathologie Cellulaire, Hôpital de BicêtreLe Kremlin-BicêtreFrance
  3. 3.Technicon Instruments Corp.TarrytownUSA

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