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A Possible Coronavirus Isolation from Multiple Sclerosis Autopsy Material

  • J. S. Burks
  • B. De Vald
  • L. Jankovsky
  • J. Gerdes
Conference paper
  • 29 Downloads

Abstract

While epidemiologic and serologic evidence suggests a viral etiology of multiple sclerosis (MS), virus isolations have yet to be confirmed. Our laboratory has possibly isolated a coronavirus from two MS patients. Virus was isolated from two of nine MS patients’ brains at autopsy. This paper reports the isolation methods, the attempts to identify the virus as a coronavirus, and a preliminary serologic survey investigating the presence of antibody to this virus in MS and control populations.

Keywords

Multiple Sclerosis Mouse Hepatitis Virus Brain Material Weanling Mouse Isolation Attempt 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Tanaka R, Iwasaki Y, Koprowski, HJ (1976) Intracisternal virus-like particles in brain of a multiple sclerosis patient. J Neurol Sci 28:121PubMedCrossRefGoogle Scholar
  2. 2.
    Weiner LP (1973) Pathogenesis of demyelination induced by a mouse hepatitis virus (JHM virus). Arch Virol 28:298Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • J. S. Burks
    • 1
  • B. De Vald
    • 1
  • L. Jankovsky
    • 2
  • J. Gerdes
    • 2
  1. 1.Veterans Administration HospitalDenverUSA
  2. 2.University of Colorado Medical CenterDenverUSA

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