A Possible Coronavirus Isolation from Multiple Sclerosis Autopsy Material
While epidemiologic and serologic evidence suggests a viral etiology of multiple sclerosis (MS), virus isolations have yet to be confirmed. Our laboratory has possibly isolated a coronavirus from two MS patients. Virus was isolated from two of nine MS patients’ brains at autopsy. This paper reports the isolation methods, the attempts to identify the virus as a coronavirus, and a preliminary serologic survey investigating the presence of antibody to this virus in MS and control populations.
KeywordsMultiple Sclerosis Mouse Hepatitis Virus Brain Material Weanling Mouse Isolation Attempt
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