Summary and Concluding Remarks
- 22 Downloads
At the Locarno symposium on the pathogenesis and etiology of demyelinating diseases in 1967, Seitelberger stressed that on neuropathologic grounds human MS is a process and has features of its own which simply cannot be compared to the changes found in experimental models. This statement is still valid today. Meanwhile, however, at least one of the animal models of experimental demyelination, chronic relapsing EAE, has come closer to MS in the human. The undeniable value of experimental models, even though they clearly represent a pathologic process different from MS, is the possibility of focusing on phenomena that are, or may be, key reactions in the chain of pathogenetic events leading to demyelination and its recurrence in the human disease.