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Theoretical Aspects of Structure and Assembly of Viral Envelopes

  • Herbert A. Blough
  • John M. Tiffany
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 70)

Abstract

Viruses which can be seen in the electron microscope to have a coherent envelope structure are all found to contain lipid, and this has in the past been used as a means of classifying viruses, secondary to the type of nucleic acid they contain (Cooper, 1961). Another common feature which these viruses have more recently been found to possess is carbohydrate (other than that in their nucleic acid), and in all cases so far studied their distribution has been found to be asymmetric—the glycoproteins being found only in the exterior of the viral coat. The envelope may therefore be defined as a protective lipoprotein container for the genetic material, bearing, embedded in its surface, glycoproteins and glycolipids responsible for cell surface recognition of the virus and for the preliminary stages of infection (attachment and penetration). The virus is generally sensitive to agents such as detergents or lipid solvents, which disrupt the lipid region of the envelope. Virus assembly generally occurs at a specific cell membrane, where virally-specified materials are incorporated into the membrane to begin forming the envelope, followed by formation of a bud which eventually surrounds the viral core material.

Keywords

Influenza Virus Newcastle Disease Virus Rabies Virus Viral Envelope Vesicular Stomatitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag, Berlin · Heidelberg 1975

Authors and Affiliations

  • Herbert A. Blough
  • John M. Tiffany
    • 1
  1. 1.Division of Biochemical Virology and Membrane Research, Scheie Eye InstituteUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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