Advertisement

Magen pp 57-134 | Cite as

Physiologie

  • L. Demling
Chapter
Part of the Handbuch der inneren Medizin book series (INNEREN, volume 3 / 2)

Zusammenfassung

Das Magensekret ist eine wäßrige Flüssigkeit. Der Mensch produziert täglich 1,5 bis 3 1. Wenn nicht besondere Maßnahmen angewendet werden, ist das Magensekret meist vermischt mit Speichel und Duodenalinhalt. Beigemengte Speisereste noch 12 Std nach der letzten Nahrungsaufnahme sprechen für eine Entleerungsstörung. Das Magensekret hat in der Regel die gleiche Osmolarität wie das Serum (289 mosm/kg H2O) (Documenta Geigy, Wiss. Tabellen, 1968), jedoch sind vorübergehende Abweichungen nach oben und unten möglich. Der Magensaft besteht aus Wasser, Elektrolyten und Makromolekülen. Letztere befinden sich teils in Lösung, teils in einer mehr oder weniger stabilen Suspension. Große Moleküle des Magensekretes sind Enzyme, Schleimsubstanzen, Serumproteine, Peptide, Produkte des enzymatischen Abbaues von Proteinen und Mucoproteinen, Blutgruppensubstanzen und anderes biologisch aktives Material, wie der Intrinsic factor, weitere Vitamin B12-Binder und die sog. Gastrone. Daneben können Antigene und Antikörper nachgewiesen werden (Glass, 1968).

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

Sekretion des Magens

  1. Aagaard, P.: A comparison between the effect of peptavlon and histamine on gastric acid secretion in man after surgical vagotomy. Scand. J. Gastroent. 3, 476–480 (1968)PubMedGoogle Scholar
  2. Agunod, M., Yamaguchi, N., Lopez, R., Luhby, A. L., Glass, G. B. J.: Correlative study of hydrochloric acid, pepsin and intrinsic factor secretion in newborns and infants. Amer. J. dig. Dis. 14, 400–414 (1969)PubMedGoogle Scholar
  3. Alonso, D., Park, O. H., Harris, J. B.: Adenosine monophosphates and glycogenolysis in frog gastric mucosa. Amer. J. Physiol. 215, 1305–1309 (1968)PubMedGoogle Scholar
  4. Altamiro, M.: Alkaline secretion produced by intraarterial acetylcholine. J. Physiol. (Lond.) 168, 787–803 (1963)Google Scholar
  5. Anastasi, A., Erspamer, V., Endean, R.: Isolation and structure of caerulein, an active decapeptide from the skins of Hyla caerulea. Experientia (Basel) 23, 699 (1969)Google Scholar
  6. Andersson, S.: Inhibitory effects of hydrocloric acid in antrum and duodenum on gastric secretory responses to test meal in Pavlov and Heidenhain pouch dogs. Acta physiol. scand. 49, 231–241 (1960)PubMedGoogle Scholar
  7. Andersson, S.: Inhibitory effects of hydrochloric acid in the duodenum on gastrin-stimulated gastric secretion in Heidenhain pouch dogs. Acta physiol. scand. 50, 105–112 (1960)PubMedGoogle Scholar
  8. Andersson, S.: Inhibitory effects of hydrochloric acid in antrum and duodenum on histaminestimulated gastric secretion in Pavlov and Heidenhain pouch dogs. Acta physiol. scand. 50, 186–196 (1960)PubMedGoogle Scholar
  9. Andersson, S.: Inhibition of gastric secretion by duodenal acidification before and after sympathetic denervation of Heidenhain pouches. Gastroenterology 45, 752 (1963)PubMedGoogle Scholar
  10. Andersson, S.: Gastric and duodenal mechanisms inhibitory gastric secretion of acid. In: Code, C. F.: Handbook of physiology, Sect. 6, Vol. II: Secretion, Chapt. 48. Baltimore: Williams and Wilkins 1967Google Scholar
  11. Andersson, S.: Inhibitory mechanisms in duodenal control of gastric acid secretion. Gastroenterology 61, 778–780 (1971)PubMedGoogle Scholar
  12. Andersson, S., Grossman, M. I.: Profile of pH, pressure and potential difference at gastro-duodenal junction in man. Gastroenterology 49, 364 (1965)PubMedGoogle Scholar
  13. Andersson, S., Nilsson, G., Sjodin, L.: Mechanism of duodenal inhibition of gastric acid secretion. Nobel Symposium, XVI. Frontiers in Gastrointestinal Hormone Research (Andersson, S., Ed.). Stockholm: Almquist and Wiksell (1973)Google Scholar
  14. Andersson, S., Nilsson, G., Uvnäs, B.: Inhibition of gastric secretion by acid in proximal and distal duodenal pouches. Acta physiol. scand. 65, 191–192 (1965)Google Scholar
  15. Andersson, S., Nilsson, G., Uvnäs, B.: Effect of acid in proximal and distal duodenal pouches on gastric secretory responses to gastrin and histamine. Acta physiol. scand. 71, 368–378 (1967)PubMedGoogle Scholar
  16. Andersson, S., Uvnäs, B.: Inhibition of postprandial gastric secretion in Pavlov pouches by instillation of hydrochloric acid into the duodenal bulb. Gastroenterology 41, 486–490 (1961)PubMedGoogle Scholar
  17. Antia, F., Rosiere, C. E., Robertson, C., Grossman, M. I.: Effect of vagotomy on gastric secretion and emptying time in dogs. Amer. J. Physiol. 166, 470–479 (1951)PubMedGoogle Scholar
  18. Ardeman, S., Chanarin, I., Doyle, J. C.: Studies on secretion of gastric intrinsic factor in man. Brit. med. J. 1964 II, 600–603Google Scholar
  19. Aubry, D. A., Forrest, A. P. M.: Effects of histamine acid phosphate and pentagastrin on gastric secretion in normal human subjects. Gut 11, 395–404 (1970)Google Scholar
  20. Babkin, B. P.: Secretory mechanism of the digestive glands, 2nd. ed. New York: Paul B. Hoeber, Inc. 1950Google Scholar
  21. Bachrach, W. H.: Action of insulin hypoglycemia on motor secretory functions of the digestive tract. Physiol. Rev. 33, 566–592 (1953)PubMedGoogle Scholar
  22. Baddeley, R. M., Evans, J., Griffin, J. A.: Influence of hyperaldosteronism upon gastric secretion. Gut 10, 143–145 (1969)PubMedCentralPubMedGoogle Scholar
  23. Barreras, R. F.: Calcium and gastric secretion. Gastroenterology 64, 1168–1184 (1973)PubMedGoogle Scholar
  24. Barreras, R. F., Donaldson, R. M.: Effects of induced hypercalcemia on human gastric secretion. Gastroenterology 52, 670–675 (1967)PubMedGoogle Scholar
  25. Barrowman, J. A., Darnton, S. J.: The lipase of rat gastric mucosa. A histochemical demonstration of the enzymatic activity against a medium chain triglyceride. Gastroenterology 59, 13–21 (1970)PubMedGoogle Scholar
  26. Bedi, B. S., Debas, H. T., Gillespie, G., Gillespie, I. E.: Effect of bile salts on antral gastrin release. Gastroenterology 60, 256–262 (1971)PubMedGoogle Scholar
  27. Bernardi, L. Bosisio, G., de Castiglione, R., Goffredo, O.: Synthesis of Caerulein. Experientia 23, 700–704 (1967)PubMedGoogle Scholar
  28. Berson, S. A., Yalow, R. S.: Nature of immunoreactive gastrin extractet from tissues of gastrointestinal tract. Gastroenterology 60, 215–222 (1971)PubMedGoogle Scholar
  29. Bertaccini, G., Endean, R., Erspamer, V., Impicciatore, M.: The actions of caerulein on gastric secretion of the dog and the rat. Brit. J. Pharmacol. 34, 311–329 (1968)Google Scholar
  30. Bieck, P. R.: Role of cyclic AMP in the regulation of gastric secretion in dogs and humans. Advanc. Cyclic Nucl. Res. 1, (1972) (in press)Google Scholar
  31. Black, R. B., Hole, D., Rhodes, J.: Bile damage to the gastric mucosal barrier: The influence of pH and bile acid concentration. Gastroenterology 61, 178–184 (1971)PubMedGoogle Scholar
  32. Blix, G.: Mucopolysaccharides and glycoproteins. Scand. J. clin. Lab. Invest. 10, 128–134 (1957)Google Scholar
  33. Bodanszky, M., Klausner, Y. S., Said, S. J.: Biblogical activities of synthetic peptide corresponding to fragments of and to the entive sequence of the vagoactive intestinal peptide. Proc. nat. Acad. Sci. (Wash.) 70, 382–384 (1973)Google Scholar
  34. Bodanszky, M., Ondetti, M. A., Levine, S. D.: Synthesis of a heptacosapeptide amide with the hormonal activity of secretin. Chem. Industr. 42, 1757–1758 (1966)Google Scholar
  35. Beackney, E. L., Thal, A. P., Wangensteen, O. H.: Role of duodenum in the control of gastric secretion. Proc. Soc. exp. Biol. (N. Y.) 88, 302–306 (1955)Google Scholar
  36. Beooks, A. M., Geossman, M. I.: Postprandial pH and neutralizing capacity of the proximal duodenum in dogs. Gastroenterology 59, 85–89 (1970)Google Scholar
  37. Beooks, A. M., Geossman, M. I.: Effect of secretin on fasting and postprandial pH of the duodenal bulb in dogs. Gastroenterology 59, 90–94 (1970)Google Scholar
  38. Beooks, A. M., Geossman, M. I.: Effect of secretin and cholecystokinin on pentagastrin-stimulated gastric secretion in man. Gastroenterology 59, 114–119 (1970)Google Scholar
  39. Beooks, A. M., Johnson, L. R., Geossman, M. I.: Effect of combinations of histamine and pentagastrin on gastric secretion in man and dog. Gastroenterology 58, 470–475 (1970)Google Scholar
  40. Beooks, A. M., Isenbeeg, J., Geossman, M. I.: The effect of secretin, glucagon and duodenal acidification on pepsin secretion in man. Gastroenterology 57, 159–162 (1969)Google Scholar
  41. Beooks, F. A.: Central neural control of acid secretion. In: Code, C. F.: Handbook of physiology, Sect. 6, Vol. II, Secretion, Chapt. 45. Baltimore: Williams and Wilkins 1967Google Scholar
  42. Beown, J. C., Mutt, V., Pedeeson, R. A.: Further purification of a polypeptide demonstrating enterogastrone activity. J. Physiol. (Lond.) 209, 57–64 (1970)Google Scholar
  43. Beown, J. C., Pedeeson, R. A., Joepes, E.: Preparation of highly active enterogastrone. Canad. J. Physiol. Pharmacol. 47, 113–114 (1969)Google Scholar
  44. Beunschwig, A., Van Peohaska, J., Claeke, T. H., Kandel, E. V.: A secretory depressant in gastric juice of patients with pernicious anemia. J. clin. Invest. 18, 415–422 (1939)Google Scholar
  45. Butlee, D. B., Hands, A. P., Ivy, A. C.: Potency of liver extract in stimulating gastric secretion by intravenous injection and by direct lavage. Amer. J. Physiol. 139, 325–328 (1943)Google Scholar
  46. Card, W. I., Maeks, I. N.: The relationship between acid output of the stomach following “maximal” histamine stimulation and the parietal cell mass. Clin. Sci. 19, 147–163 (1960)PubMedGoogle Scholar
  47. Chung, R. S. K., Feomm, D., Teencis, L., Silen, W.: Gastric and pancreatic responses to jejunal distention. Gastroenterology 59, 387–395 (1970)PubMedGoogle Scholar
  48. Claeke, S. D., Neill, D. W., Welbourn, R. B.: The effects of corticotrophin and corticoids on secretion from denervated gastric pouches in dogs. Gut 1, 36–43 (1960)Google Scholar
  49. Classen, M., Koch, H., Deyhle, P., Weidenhillee, S., Demling, L.: Wirkung von Prostaglandin E1 auf die basale Magensekretion des Menschen. Klin. Wschr. 48, 876–878 (1970)PubMedGoogle Scholar
  50. Classen, M., Koch, H., Takebe, T., Beeg, G., Demling, L.: Steigerung der Magensekretion durch intravenös verabfolgte Aminosäuren. Med. u. Ernähr. 11, 153–155 (1970)Google Scholar
  51. Code, C. F.: Discussion. Gastroenterology 34, 216 (1958)Google Scholar
  52. Code, C. F., Watkinson, G.: Importance of vagal innervation in the regulatory effect of acid in the duodenum on gastric secretion of acid. J. Physiol. (Lond.) 130, 233–252 (1955)Google Scholar
  53. Coder, D. M., McIleath, D. C.: Composition of parietal and nonparietal components of canine gastric secretion. Amer. J. dig. Dis. N. S. 14, 324–331 (1969)Google Scholar
  54. Cooke, A. R.: Potentiation of acid output in man by a distention stimulus. Gastroenterology 58, 633–637 (1970)PubMedGoogle Scholar
  55. Cooke, A. R., Geossman, M. I.: Electrolytes in gastric juice after adrenalectomy and glucocorticoid administration. Physiologist 8, 139 (1965)Google Scholar
  56. Cooke, A. R., Nahewold, D. L., Geossman, M. I.: Effect of bilateral adrenalectomy on gastric acid and pepsin secretion from gastric fistulas and Heidenhain pouches in dogs. Gastroenterology 52, 488–493 (1967)PubMedGoogle Scholar
  57. Cooke, A. R., Peeshaw, R. M., Geossman, M. I.: Effect of adrenalectomy and glucocorticoids on the secretion and absorption of hydrogen ion. Gastroenterology 50, 761–767 (1966)PubMedGoogle Scholar
  58. Copeland, E. M., Millee, L. D., Smith, G. P.: The complex nature of small bowel control of gastric secretion. Ann. Surg. 168, 36–46 (1968)PubMedCentralPubMedGoogle Scholar
  59. Ceeamee, B., Shoetee, R. G., Bamfoeth, J.: The turnover and shedding of epithelial cells. Gut 2,110–116 (1961)Google Scholar
  60. Ceoft, D. N., Ingelfingee, F. J.: Isolated gastric parietal cells: oxygen consumption, electrolyte content and intracellular pH. Clin. Sci. 37, 491–501 (1969)Google Scholar
  61. Davenpoet, H. W.: Physiology of the digestive tract. Chicago: Year Book Medical Publ., Inc. 1961Google Scholar
  62. Debas, H. T., Bedi, B. S., Gillespie, G., Gillespie, I. E.: Mechanism by which fat in the upper small intestine inhibits gastric acid. Gastroenterology 56, 483–487 (1969)PubMedGoogle Scholar
  63. Demand, H. A., Geoss, H. U., Beeg, G.: Effects of continuous insulin infusions on unstimulated human gastric secretion. II. Quantitative changes of the gastric juice pattern. Gastroenterology 54, 1043–1049 (1968)Google Scholar
  64. Demling, L.: Diskussion. In: Heinkel, K., Schön, H., Hrsg.: Pathogenese, Diagnostik, Klinik und Therapie des exokrinen Pankreas. Europäisches Pankreassymposium 1963. Stuttgart: Schattauer 1964Google Scholar
  65. Demling, L.: Der kranke Magen. München-Berlin-Wien: Urban u. Schwarzenberg 1970Google Scholar
  66. Demling, L.: Gastrointestinal hormones. International Symposium at Erlangen, 1971. Stuttgart: Thieme 1972Google Scholar
  67. Demling, L., Classen, M.: Biotelemetrische Messungen von pH und Druckwerten im menschlichen Magen-Darm-Trakt. Dtsch. Z. Verdau-, u. Stoffwechselkr. 30, 135 (1970)Google Scholar
  68. Demling, L., Classen, M., Thebis, J.: Telemetrie der gastralen H-Ionen-Konzentration mit der Glaselektrode. In: Biotelemetrie-Symposium, Erlangen 1968. Stuttgart: Thieme 1970Google Scholar
  69. Demling, L., Ottenjann, R.: Non-insulin-producing tumors of the pancreas. International Symposium at Erlangen 1968. Stuttgart: Thieme 1969Google Scholar
  70. Demling, L., Ottenjann, R., Gebhardt, H.: Pankreas und peptisches Geschwür. Gastroenterologia (Basel) 102, 129 (1964)Google Scholar
  71. Demling, L., Schmidt, H. J.: pH-Messungen im menschlichen Dünndarm mit der Glaselektrode. Verh. dtsch. Ges. inn. Med. 1960. München: Bergmann 1961Google Scholar
  72. Deyhle, P., Miederer, S. E., Ottenjann, R.: Der Einfluß akuter Hypercalcämie auf die durch Hypermagnesiämie gehemmte Magensekretion. Klin. Wschr. 48, 384–385 (1970)PubMedGoogle Scholar
  73. Documenta Geigy, Wiss. Tabellen, 7. Aufl. Basel: J. G. Geigy AG Pharma 1968Google Scholar
  74. Domschke, W., Domschke, S., Classen, M., Demling, L.: Cyclisches Adenosin-3′,5′-monophosphat und die Magensekretion. Naturwissenschaften 58, 628 (1971)PubMedGoogle Scholar
  75. Domschke, W., Classen, M., Demling, L.: Circadian rhythmicity of gastric secretion and cyclic 3′,5′-adenosine monophosphate contents of gastric mucosa in rats. Scand. J. Gastroent. 7, 39–41 (1972)Google Scholar
  76. Domschke, W., Domschke, S., Classen, M., Demling, L.: Some properties of mucus in patients with gastric ulcer: Effect of treatment with carbenoxolone sodium. Scand. J. Gastroent. 7, 647–651 (1972).PubMedGoogle Scholar
  77. Domschke, W., Domschke, S., Classen, M., Demling, L.: Cyclic AMP and the stimulation of gastric secretion by histamine in rats. Gastroenterology 62, 744 (1972)Google Scholar
  78. Domschke, W., Domschke, S., Classen, M., Demling, L.: Histamine and cyclic 3′,5′-AMP in gastric acid secretion. Nature (Lond.) 241, 454–455 (1972)Google Scholar
  79. Domschke, W., Domschke, S., Rösch, W., Classen, M., Demling, L.: Failure of pentagastrin to stimulate cyclic AMP accumulation in human gastric mucosa. Scand. J. Gastroent. 9, 467–471 (1974)PubMedGoogle Scholar
  80. Domschke, W., Domschke, S., Classen, M., Demling, L.: Glucocorticoids and gastric secretion: the role of cyclic adenosine-3′,5′-monophosphate. Gastroenterology 63, 252–256 (1972)PubMedGoogle Scholar
  81. Domschke, W., Domschke, S., Classen, M., Demling, L.: N-Acetylneuraminic acid in gastric mucus: a possible mediator of carbenoxolone action in gastric ulcer patients. Acta hepato-gastroent. 19, 204–205 (1972)Google Scholar
  82. Domschke, W., Domschke, S., Classen, M., Demling, L.: Cyclic 3′,5′-AMP and gastric secretion in the rat: Effect of adrenalectomy and glucocorticoids. Horm. Metab. Res. 4, 226–227 (1972)PubMedGoogle Scholar
  83. Domschke, W., Domschke, S., Classen, M., Demling, L.: Histamine and glucocorticoids in gastric secretion: The role of cyclic 3′,5′-AMP. Proceedings of the 5th International Congress on Pharmacology, San Francisco (USA), 59 (1972)Google Scholar
  84. Dotevall, G., Kock, M. G., Walan, A.: Inhibition of pentagastrin-induced gastric acid secretion in man by glucagon given intravenously. Scand. J. Gastroent. 4, 713–716 (1969)PubMedGoogle Scholar
  85. Dragstedt, L. R., Kohatzu, S., Gwaltney, J., Nagano, K., Greenlee, H. B.: Further studies on the question of an inhibitory hormone from the gastric antrum. Arch. Surg. 79, 10–21 (1959)Google Scholar
  86. Dragstedt, L. R., Woodward, E. R., Oberhelman, H. A., Jr., Storer, E. H., Smith, C. A.: Effect of transplantation of antrum of stomach on gastric secretion in experimental animals. Amer. J. Physiol. 165, 386–398 (1951)PubMedGoogle Scholar
  87. Dritsas, K. G., Kowalewski, K.: The mechanism of pepsin secretion in the isolated perfused canine stomach. Canad. J. Surg. 11, 85–92 (1968)PubMedGoogle Scholar
  88. Duke, W. W., Hirschowitz, B. I., Sachs, G.: Vagal stimulation of gastric secretion in man by 2-deoxy-D-glucose. In: Code, C. F.: Handbook of physiology, Sect. 6, Vol. II: Secretion, Chapt. 50. Baltimore: Williams and Wilkins 1967Google Scholar
  89. Elwin, C. E., Uvnäs, B.: Distribution and local release of gastrin: In: Gastrin: Proceedings of a Conference. (Grossman, M. I., Ed.). Los Angeles: Univ. Calif. Press 1966Google Scholar
  90. Engstrom, J. F., Rybak, J. J., Duber, M., Greenberger, N. J.: Evidence for a lipase system in canine gastric juice. Amer. J. med. Sci. 256, 346–351 (1968)PubMedGoogle Scholar
  91. Enterogastrone (s): Anonyme Übersicht in Lancet 12, 1224–1225 (1971)Google Scholar
  92. Etherington, D. J., Taylor, W. H.: The pepsin of normal human gastric juice. Biochem. J. 113, 663–668 (1969)PubMedCentralPubMedGoogle Scholar
  93. Ewald, C. A., Boas, J.: Beiträge zur Physiologie und Pathologie der Verdauung. Virchows Arch. path. Anat. 104, 271–305 (1886)Google Scholar
  94. Farell, J. I., Ivy, A. C.: Studies on the motility of the transplanted gastric pouch. Amer. J. Physiol. 76, 227–228 (1926)Google Scholar
  95. Feng, T. P., Hou, H. C., Lim, R. K. S.: On the mechanism of the inhibition of gastric secretion by fat. Chin. J. Physiol. 3, 371–378 (1929)Google Scholar
  96. Ferguson, A. N.: A cytological study of the regeneration of gastric glands following the experimental removal of large areas of mucosa. Amer. J. Anat. 42, 403–435 (1928)Google Scholar
  97. Ferlito, S., Romano, F.: The effect of aldosterone on human gastric secretion. Riv. Gastroent. 20, 86–96 (1968)Google Scholar
  98. Fischermann, K., Andersen, J., Petersen, P. H., Rødbro, P.: Gastric function tests correlated to ABH blood group substances in gastric juice. Scand. J. clin. Lab. Invest. 20, 202–206 (1967)Google Scholar
  99. Forte, J. G.: Three components of Cl flux across isolated bullfrog gastric mucosa. Amer. J. Physiol. 216, 167–174 (1969)PubMedGoogle Scholar
  100. Frederick, P. L., Sizer, J. S., Odborne, M. P.: Relation of massive bowel resection to gastric secretion. New Engl. J. Med. 272, 509–514 (1965)PubMedGoogle Scholar
  101. Giles, G. R., Clark, C. G., Buchan, R.: Effect of esophageal perfusion with acid on basal gastric secretion. Gut 9, 52–56 (1968)PubMedCentralPubMedGoogle Scholar
  102. Gillespie, I. E., Clark, D. H., Kay, A. W., Tankel, H. J.: Effect of antrectomy, vagotomy with gastro-jejunostomy and antrectomy with vagotomy on the spontaneous and maximal gastric acid output in man. Gastroenterology 38, 361 (1960)PubMedGoogle Scholar
  103. Gillespie, I. E., Grossman, M. I.: Effect of acid in pyloric pouch on response of fundic pouch to injected gastrin. Amer. J. Physiol. 203, 557–559 (1962)PubMedGoogle Scholar
  104. Gillespie, I. E., Grossman, M. I.: Inhibitory effect of secretion and cholecystokinin on Heidenhain pouch responses to gastrin extract and histamine. Gut 5, 342–345 (1964)PubMedCentralPubMedGoogle Scholar
  105. Glass, G. B. J.: Proteins in gastric secretion. In: The physiology of gastric secretion (Semb, L. S., Myren, J., Eds.). Oslo: Universitetsforlaget 1968Google Scholar
  106. Götz, H., Scheiffarth, F., Dubeler, I.: Vergleichende elektrophoretische und immunoelektrophoretische Studien an Organextrakten des menschlichen Magens. Gastroenterologia (Basel) 98, 30–47 (1962)Google Scholar
  107. Gräsbeck, R., Simons, K., Sinkkonen, I.: Purification of intrinsic factor and Vitamin B12 binders from human gastric juice. Ann. Med. exp. Fenn. 40, 1024 (1962)Google Scholar
  108. Greenlee, H. B., Longhi, E. H., Guerrero, J. D., Nelsen, T. S., El-Berdi, A. L., Dragstedt, L. R.: Inhibitory effect of pancreatic secretin on gastric secretion. Amer. J. Physiol. 190, 396–402 (1957)PubMedGoogle Scholar
  109. Gregory, R. A.: Secretory mechanisms of the gastro-intestinal tract. London: Edward Arnold Ltd.1962Google Scholar
  110. Gregory, R. A., Tracy, H. J.: The constitution and properties of two gastrins extracted from hog antral mucosa. Gut 5, 103–117 (1964)PubMedCentralPubMedGoogle Scholar
  111. Grossman, M. I.: Secretion of acid and pepsin in response to distention of vagally innervated fundic gland area in dogs. Gastroenterology 42, 718 (1962)PubMedGoogle Scholar
  112. Grossman, M. I.: Neural and humoral stimulation of gastric secretion of acid. In: Code, C. F.: Handbook of physiology, Sect. 6, Vol. II, Secretion, Chapt. 47. Baltimore: Williams and Wilkins 1967Google Scholar
  113. Grossman, M. I.: Gastrin. Los Angeles: Univ. Calif. Press 1968Google Scholar
  114. Grossman, M. I., Robertson, C. R., Ivy, A. C.: The proof of a hormonal mechanism for gastric secretion – the humoral transmission of the distention stimulus. Amer. J. Physiol. 153, 1–9 (1948)PubMedGoogle Scholar
  115. Harper, A. A., Kidd, C., Schratcherdt, T.: Vago-vasai reflex effects on gastric and pancreatic secretion and gastrointestinal motility. J. Physiol. (Lond.) 148, 417–436 (1959)Google Scholar
  116. Harris, J. B., Alonso, D.: Stimulation of the gastric mucosa by adenosine-3′,5′-monophosphate. Fed. Proc. 24, 1368–1376 (1965)PubMedGoogle Scholar
  117. Harris, J. B., Nigon, K., Alonso, D.: Adenosine-3′,5′-monophosphate: Intracellular mediator for methyl xanthine stimulation of gastric secretion. Gastroenterology 57, 377–384 (1969)PubMedGoogle Scholar
  118. Harrison, R. C., Lakey, W. H., Hyde, H. A.: The production of an acid inhibitor by the gastric antrum. Ann. Surg. 144, 441–447 (1956)PubMedCentralPubMedGoogle Scholar
  119. Hart, W., Welsch, K. H., Klempa, J., Schützler, W.: Demonstration of the vagal-antral inhibition of the gastrin mechanism in animal experiments. Z. Gastroent. 6, 257–265 (1968)Google Scholar
  120. Heinz, E., Öbrink, K. J.: Acid formation and acidity control in the stomach. Physiol. Rev. 34, 643–673 (1954)PubMedGoogle Scholar
  121. Helander, H. F., Olivecrona, T.: Lipolysis and lipid absorption in the stomach of the suckling rat. Gastroenterology 59, 22–35 (1970)PubMedGoogle Scholar
  122. Henning, N., Kinzlmeier, H., Demling, L.: Über die elektrophoretisch darstellbaren Proteine normaler und pathologischer Magensäfte. Münch. med. Wschr. 95, 423–426 (1953)PubMedGoogle Scholar
  123. Henning, N., Kinzlmeier, H., Kimbel, H.: Die H-Ionenkonzentration im Magen während der Verdauung. Gastroenterologia (Basel) 81, 284–292 (1954)Google Scholar
  124. Herriott, R. M.: Isolation, crystallization and properties of swine pepsinogen. J. gen. Physiol. 21, 501–540 (1938)PubMedCentralPubMedGoogle Scholar
  125. Hirschowitz, B. I.: Pepsinogen: its origins, secretion and excretion. Physiol. Rev. 37, 475–511 (1957)PubMedGoogle Scholar
  126. Hirschowitz, B. I.: Gastric osmolar clearance and ionic barrier. Two mechanisms of electrolyte secretions by the human stomach. J. appl. Physiol. 15, 933–938 (1960)PubMedGoogle Scholar
  127. Hirschowitz, B. I.: The physiology of pepsinogen. In: Pathophysiology of peptic ulcer (Skoryna, S., Ed.). Montreal: McGill Univ. Press 1964Google Scholar
  128. Hirschowitz, B. I.: Secretion of pepsinogen. In: Code, C. F.: Handbook of physiology, Sect. 6, Vol. II, Secretion, Chapt. 50. Baltimore: Williams and Wilkins 1967Google Scholar
  129. Hirschowitz, B. I., Sachs, G.: Vagal gastric secretory stimulation by deoxy-D-glucose. Amer. J. Physiol. 209, 452–460 (1965)PubMedGoogle Scholar
  130. Hirschowitz, B. I., Sachs, G.: Atropine inhibition of insulin-, histamine- and pentagastrin-stimulated gastric electrolyte and pepsin secretion in the dog. Gastroenterology 56, 693–702 (1969)PubMedGoogle Scholar
  131. Hirschowitz, B. I., Schenker, S., Boyett, D. D.: A highly active gastric secretagogue extracted from a metastasis of a Zollinger-Ellison tumor. Amer. J. dig. Dis. N. S. 8, 499–508 (1963)Google Scholar
  132. Hoedemaker, P. J.: Investigations on the site of production of Castle’s gastric intrinsic factor (Doctoral dissertation) Groningen, the Netherlands: Univ. of Groningen 1965Google Scholar
  133. Hollander, F.: Studies in gastric secretion. Variations in chloride content of gastric juice and their significance. J. biol. Chem. 97, 585–604 (1932)Google Scholar
  134. Hollander, F.: Gastric secretion of electrolytes. Fed. Proc. 11, 706–714 (1952)PubMedGoogle Scholar
  135. Hollander, F.: The electrolyte patterns of gastric mucinous secretions: its implication for gastric fibiosis. Ann. N. Y. Acad. Sci. 106, 757–766 (1963)PubMedGoogle Scholar
  136. Hubel, K. A.: Progress in gastroenterology. Secretin: a long progress note. Gastroenterology 62, 318–341 (1972)PubMedGoogle Scholar
  137. Hunt, J. N., Wan, B.: Electrolytes of mammalian gastric juice. In: Code, C. F.: Handbook of physiology, Sect. 6, Vol. II: Secretion. Baltimore: Williams and Wilkins 1967Google Scholar
  138. Iggo, A.: Gastric mucosal chemoreceptors with vagal afferent fibres in the cat. Quart. J. exp. Physiol. 42, 398–409 (1957)PubMedGoogle Scholar
  139. Ihre, B. J.: Human gastric secretion. Acta med. scand. Suppl. 95, 1–226 (1938)Google Scholar
  140. Irvine, W. J.: Effect of gastrin I and II on secretion of intrinsic factor. Lancet 1965 I, 736–737Google Scholar
  141. Isakeanov, G. I.: The effect of resecting the small intestine at diffrrents levels on the secretory function of the stomach. Fiziol. Zh. (Mosk.) 54, 1094–1101 (1968)Google Scholar
  142. Jeffries, G. H.: Gastric secretion of intrinsic factor. In: Code, C. F.: Handbook of physiology, Sect. 6, Vol. II: Secretion, Chapt. 51. Baltimore: Williams and Wilkins 1967Google Scholar
  143. Jeffries, G. H., Sleisenger, M. H.: The pharmacology of intrinsic factor secretion in man. Gastroenterology 48, 444 (1965)PubMedGoogle Scholar
  144. Jepson, K., Johnston, D.: Effect of vagotomy on human gastric acid secretion stimulated by gastrin pentapeptide and by histalog. Gastroenterology 55, 665–669 (1968)PubMedGoogle Scholar
  145. Johnson, L. R.: Control of gastric secretion: no room for histamine? Gastroenterology 61, 106–118 (1971)PubMedGoogle Scholar
  146. Johnson, L. R., Grossman, M. I.: Secretin: The enterogastrone released by acid in the duodenum. Amer. J. Physiol. 215, 885–888 (1968)PubMedGoogle Scholar
  147. Johnson, L. R., Grossman, M. I.: (1) Effects of fat, secretin and cholecystokinin on histamine stimulated gastric secretion. Amer. J. Physiol. 216, 1176–1179 (1969)PubMedGoogle Scholar
  148. Johnson, L. R., Grossman, M. I.: (2) Characteristic of inhibition of gastric secretion by secretin. Amer. J. Physiol. 217, 1401–1404 (1969)PubMedGoogle Scholar
  149. Johnson, L. R., Grossman, M. I.: Progress in gastroenterology. Intestinal hormones as inhibitors of gastric secretion. Gastroenterology 60, 120–144 (1971)PubMedGoogle Scholar
  150. Johnston, D., Duthie, H. L.: Effect of acid in the duodenum on histamine stimulated gastric secretion in man. Gut 5, 573–580 (1964)PubMedCentralPubMedGoogle Scholar
  151. Johnston, D., Dtjthie, H. L.: Inhibition of gastrin secretion in the human stomach. Effect of acid in the duodenum. Lancet 1965 II, 1032–1035Google Scholar
  152. Jones, T. W., Harkins, H. N.: The mechanism of inhibition of gastric acid secretion by the duodenum. Gastroenterology 37, 81–86 (1959)PubMedGoogle Scholar
  153. Jordan, P. H., Jr., Sand, B. F.: A study of the gastric antrum as an inhibitor of gastric juice production. Surgery 42, 40–49 (1957)PubMedGoogle Scholar
  154. Jorpes, J. E.: The isolation and chemistry of secretin and cholecystokinin. Gastroenterology 55, 157–164 (1968)PubMedGoogle Scholar
  155. Jorpes, J. E., Mutt, V., Toczko, K.: Further purification of cholecystokinin and pancreozymin. Acta chem. scand. 18, 2408–2410 (1964)Google Scholar
  156. Jorpes, J. E., Mutt, V.: Cholecystokinin and pankreozymin one single hormone? Acta physiol. scand. 66, 196–202 (1966)PubMedGoogle Scholar
  157. Jost, J.-P., Rickenberg, H. V.: Cyclic AMP. Ann. Rev. Biochem. 40, 741–774 (1971)Google Scholar
  158. Klopper, P. J.: Les variations du pH de l’estomac pendant la phase cephalique de la sécrétion du suc gastrique chez le chien. J. Physiol. (Paris) 47, 621–631 (1955)Google Scholar
  159. Koch, H., Ohnhaus, E. E., Deyhle, P., Classen, M., Demling, L.: Der Einfluß von Heparin auf pentagastrininduzierte Ulcera duodeni bei der Katze. Therapiewoche 35, 1774–1777 (1970)Google Scholar
  160. Konturek, S. J.: The role of the intestines in the regulation of gastric secretion. Pol. Tyg. lek. 24, 267–270 (1969)PubMedGoogle Scholar
  161. Konturek, S. J.: Effect of secretin and jejunal acidification on gastric and pancreatic secretion in man. Gut 11, 158–162 (1970)PubMedCentralPubMedGoogle Scholar
  162. Konturek, S. J., Grossman, M. I.: Effect of perfusion of intestinal loops with acid, fat or dextrose on gastric secretion. Gastroenterology 49, 481 (1965)PubMedGoogle Scholar
  163. Konturek, S. J., Johnson, L. R.: Evidence for an enterogastric reflex for the inhibition of acid secretion. Gastroenterology 61, 667–674 (1971)PubMedGoogle Scholar
  164. Konturek, S. J., Moczurad, K.: The effect of gastrin analogs on HCl secretion from vagally innervated and denervated portions of the stomach. Acta physiol. pol. 19, 635–643 (1968)PubMedGoogle Scholar
  165. Konturek, S. J., Oleksy, J.: The effect of cholinergic and adrenergic blockage on basal and pentagastrin-induced acid secretion. Scand. J. Gastroent. 4, 13–16 (1969)PubMedGoogle Scholar
  166. Kosaka, T., Lim, R. K. S.: Demonstration of the humoral agent in fat inhibition of gastric secretion. Proc. Soc. exp. Biol. (N. Y.) 27, 890–891 (1930)Google Scholar
  167. Köster, K. H., Rune, S. J.: Antral control of gastric acid secretion. Lancet 1963 II, 1183 to 1187Google Scholar
  168. Kotrba, C., Code, C. F.: Gastric acid secretory responses to some purified foods and to additions of sucrose or olive oil. Amer. J. dig. Dis. 14, 1–8 (1969)PubMedGoogle Scholar
  169. Kowalewski, K., Schier, J. F.: Experimental peptic ulcer in dogs following the induced deficiency of gastric “mucus barrier”. Biochemical and histopathological study. In: 4th world congress of gastroenterology, Kopenhagen 12.–18. July, 1970. Advance abstracts (Riis, P., Anthonisen, P., Baden, H., Eds.) 1970Google Scholar
  170. Lai, K. S.: Studies on gastrin. Part I. A method of biological assay of gastrin. Part II. Quantitative study of the distribution of gastrin-like activity along the gut. Part III. Gastrin-like activity in stomachs of patients with peptic ulceration and gastric carcinoma. Gut 5, 327–341 (1964)PubMedCentralPubMedGoogle Scholar
  171. Leblond, C. P., Walker, B. E.: Renewal of cell populations. Physiol. Rev. 36, 255–276 (1956)PubMedGoogle Scholar
  172. Levey, G. S.: Solubilization of myocardial adenyl cyclase: Loss of hormone responsiveness and activation by phospholipide. Ann. N. Y. Acad. Sci. 185, 449–457 (1971)PubMedGoogle Scholar
  173. Levine, R. A., Cafferata, E. P., McNally, E. F.: Inhibitory effect of adenosine-3′,5′-monophosphate on gastric secretion and intestinal motility in man. Clin. Res. 14, 301 (1966)Google Scholar
  174. Ley, R., Bremen, J., Verbeustel, S., Woussen-Colle, M. C., De Graef, J.: Physiology of the secretion of acid, pepsin, sulfated polysaccharides. Digestion 2, 113–123 (1969)PubMedGoogle Scholar
  175. Lick, R. F., Hart, W., Hildenbrand, G., Balser, D., Riffelmacher, F.: Partielle Neutralisation von Salzsäurelösung in Heidenhaintaschen. Z. Gastroent. 6, 271–278 (1968)Google Scholar
  176. Lin, T. M., Spray, G. F.: Effect of glucagon on gastric HCl-secretion. Gastroenterology 54, 1254 (1968)Google Scholar
  177. Lin, T. M., Warrick, M. W.: Effect of glucagon on pentagastrin-induced acid secretion and mucosal blood flow in the dog. Gastroenterology 61, 328–331 (1971)PubMedGoogle Scholar
  178. Linde, S.: Studies on the stimulation mechanism of gastric secretion. Acta physiol. scand. Suppl. 74, 3–92 (1950)Google Scholar
  179. Lipkin, P., Sherlock, P., Bell, B.: Cell population kinetics in the gastrointestinal tract of man. 2. Cell renewal in stomach, ileum and rectum. Gastroenterology 45, 721 (1963)PubMedGoogle Scholar
  180. Long, J. F., Brooks, F. P.: Relation between inhibition of gastric secretion and absorption of fatty acids. Amer. J. Physiol. 209, 447–451 (1965)PubMedGoogle Scholar
  181. Longhi, E. H., Greenlee, H. B., Bravo, J. L., Guerrero, J. D., Dragstedt, L. R.: Question of an inhibitory hormone from the gastric antrum. Amer. J. Physiol. 191, 64–70 (1957)PubMedGoogle Scholar
  182. Lucas, K., Magee, D. F., Nakajima, S., Veith, M.: Pancreozymin/cholecystokinin, a physiological mediator of gastric secretory inhibition of duodenal origin. Experientia (Basel) 24, 570–571 (1968)Google Scholar
  183. Lucien, H. W., Itoh, Z., Schally, A. V.: Inhibitory effects of a purified enterogastrone, secretion and cholecystokinin on histamine – stimulated gastric acid secretion. Gastroenterology 59, 707–711 (1970)PubMedGoogle Scholar
  184. Makhlouf, G. M.: The action of gastrin II on gastric secretion. Edinburgh, Scotland: Edinburgh University 1965Google Scholar
  185. Makhlouf, G. M.: Models for the secretion of pepsin in man. Gastroenterology 58, 123 (1970)PubMedGoogle Scholar
  186. Makhlouf, G. M., McManus, J. P. A., Card, W. I.: A quantitative statement of the two-component hypothesis of gastric secretion. Gastroenterology 51, 149 (1966)PubMedGoogle Scholar
  187. Makhlouf, G. M., McManus, J. P. A., Knill, J. R.: Quantitative aspects of synergism and inhibition of gastric acid secretion. Gastroenterology 54, 532–537 (1968)PubMedGoogle Scholar
  188. Makhlouf, G. M., Moore, E. W., Blum, A. L.: Models for the “Secretion” of pepsin and other proteins by the human stomach. Gastroenterology 55, 457–464 (1968)PubMedGoogle Scholar
  189. Mao, C. C., Shanbour, L. L., Hodgins, D. S., Jacobson, E. D.: Cyclic AMP and gastric secretion. J. Lab. clin. Med. 78, 830 (1971)PubMedGoogle Scholar
  190. Mao, C. C., Shanbour, L. L., Jacobson, E. D.: Effects of secretagogues upon canine gastric mucosal adenyl cyclase (AC) and phosphodiesterase (PDase). Gastroenterology 62, 781 (1972)Google Scholar
  191. Master, S. P., Bedi, B. S., De Sousa, A. P., Gillespie, I. E.: Sustained inhibition of gastric secretion by repeated rapid intravenous injections of gastrin. Gastroenterology 56, 875–881 (1969)PubMedGoogle Scholar
  192. McGuigan, J. E.: Gastric mucosal intracellular localization of gastrin by immunofluorescence. Gastroenterology 55, 315–327 (1968)PubMedGoogle Scholar
  193. McGuigan, J. E.: Binding of caerulein by antibodies to human gastrin, I. Gastroenterology 56, 858–861 (1969)PubMedGoogle Scholar
  194. McGuigan, J. E., Greider, M. H.: Correlative immunochemical and light microscope studies of the gastrin cell of the antral mucosa. Gastroenterology 60, 223–236 (1971)PubMedGoogle Scholar
  195. McIlrath, D. C., Hallenbeck, G. A.: Comparison of gastric inhibitory properties of two secretin preparation. Amer. J. Physiol. 206, 1077–1080 (1964)PubMedGoogle Scholar
  196. McIntyre, O. R., Sullivan, L. W., Jeffries, G. H., Silver, R.: Pernicious anemia in childhood. New Engl. J. Med. 272, 981–986 (1965)PubMedGoogle Scholar
  197. Menguy, R.: Studies on the role of pancreatic and biliary secretions on the mechanism of gastric inhibition by fat. Surgery 48, 195–200 (1960)Google Scholar
  198. Mertz, D. P., Mann, K., Jahr, R.: Wirkung von Adenosin-3′,5′-cyclischem Monophosphat auf die basale Säuresekretion des menschlichen Magens. Klin. Wschr. 49, 936–939 (1971)PubMedGoogle Scholar
  199. Mertz, D. P., Poppe, W., Poser, G.: The maximal osmotic concentration of the gastric juice: A contribution to the problem of the mechanism of gastric secretion. Klin. Wschr. 46, 85–93 (1968)Google Scholar
  200. Meyer, J. H., Grossman, M. I.: Release of secretin and cholecystokinin in: Gastrointestinal Hormones (Demling, L., Ed.). Stuttgart: Thieme 1972Google Scholar
  201. Michal, G., Woschee, M., Wunderwald, P.: Cyclophosphates. IV. Penetration studies with A-3′,5′-MP in the rat liver. Life Sci. 10, II, 841–853 (1971)Google Scholar
  202. Miederer, S. E., Deyhle, P., Bodien, K., Ottenjann, R.: Akute Hypersiderinämie und Magensekretion. Klin. Wschr. 47, 1288–1289 (1969)PubMedGoogle Scholar
  203. Miederer, S. E., Deyhle, P., Ottenjann, R.: Glucagon und Magensekretion. Dtsch. med. Wschr. 95, 1497–1498 (1970)PubMedGoogle Scholar
  204. Miederer, S. E., Deyhle, P., Ottenjann, R.: Der gegenseitige Einfluß intestinaler Hormone auf die Magensekretion. Med. Klin. 1970Google Scholar
  205. Moore, E. W., Makhlouf, G. M.: Calcium in normal human gastric juice: a four-component model with speculation on the relation of calcium to pepsin secretion. Gastroenterology 55, 465–480 (1968)PubMedGoogle Scholar
  206. Mutt, V., Jorpes, J. E.: Secretin: isolation and determination of structure (Abstr.). Proceedings of the Fourth International Symposium on the Chemistry of Natural Products, Stockholm 1966Google Scholar
  207. Nakajima, S., Hirschowitz, B. I., Sachs, G.: Studies on adenyl cyclase in nectures gastric mucosa. Arch. Biochem. Biophys. 143, 123–126 (1971)PubMedGoogle Scholar
  208. Nakajima, S., Nakamura, M., Magee, D. F.: Effect of secretin on gastric acid and pepsin secretion in response to various stimuli. Amer. J. Physiol. 216, 87–91 (1969)PubMedGoogle Scholar
  209. Nakajima, S., Shoemaker, R. L., Hirschowitz, B. I.: Comparison of actions of aminophylline and pentagastrin on necturus gastric mucosa. Amer. J. Physiol. 219, 1259–1262 (1970)Google Scholar
  210. Nakamura, M., Nakajima, S., Magee, D. F.: Action of pancreozymin preparations on gastric acid secretion. Gut 9, 405–410 (1968)PubMedCentralPubMedGoogle Scholar
  211. Nigon, K., Harris, J. B.: Adenosine monophosphates and Phosphorylase in frog stomachs. Amer. J. Physiol. 215, 1299–1304 (1968)PubMedGoogle Scholar
  212. Northop, J. H., Kunitz, M., Herriott, R. M.: Crystalline enzymes, 2nd Ed. New York: Columbia 1948Google Scholar
  213. Oberhelman, H. A., Jr., Woodward, E. R., Zubiran, J. M., Dragstedt, L. R.: Physiology of the gastric antrum. Amer. J. Physiol. 169, 738–748 (1952)PubMedGoogle Scholar
  214. Olbe, L., Jacobsen, B.: Intraluminal pressure waves of the stomach in dogs studied by endoradiosondes. Gastroenterology 44, 787 (1963)PubMedGoogle Scholar
  215. Olbe, L., Ridley, P. T., Uvnäs, B.: Effects of gastrin and histamine an vagally induced acid and pepsin secretion in antrectomized dogs. Acta physiol. scand. 72, 492–497 (1968)PubMedGoogle Scholar
  216. Ondetti, M. A., Rubin, B., Engel, S. L., Pluscec, J., Sheehan, J. T.: Cholecystokinin-Pancreozymin: Recent developments. Amer. J. dig. Dis. 15, 149–156 (1973)Google Scholar
  217. Ottenjann, R., Demand, H., Link, E.: Studies on the two-component theory of gastric secretion. Digestion 1, 81–84 (1968)PubMedGoogle Scholar
  218. Ottenjann, R., Deyhle, P., Schaller, K. H., Stadelmann, O.: Über den Einfluß acuter Hypermagnesiämie auf die durch Hypercalcämie stimulierte Magensekretion. Klin. Wschr. 47, 1204–1206 (1969)PubMedGoogle Scholar
  219. Ottenjann, R., Deyhle, P., Paul, F.: Über den Einfluß von Glukagon auf die gastrale Sekretion bei synchroner Calcium-Infusion. Klin. Wschr. 47, 724–725 (1969)PubMedGoogle Scholar
  220. Ottenjann, R., Nitzsche, R., Miederer, S. E., Deyhle, P.: Über den Einfluß von exogenem Glukagon auf die Magensekretion bei akuter Hypercalcämie. Klin. Wschr. 48, 1005–1006 (1970)PubMedGoogle Scholar
  221. Pavlov, I. P.: The work of the digestive glands, 2nd Ed., translated by W. H. Thompson. London: Charles Griffin 1910Google Scholar
  222. Payne, R. A., Cox, A. G., Spencer, J., Cheng, F. C. Y.: Effect of vagotomy on gastric acid secretion stimulated by pentagastrin and histamine. Brit. med. J. 4, 456–457 (1967)PubMedCentralPubMedGoogle Scholar
  223. Pederson, R. A., Brown, J. C.: Inhibition of histamine-, pentagastrin- and insulin-stimulated canine gastric secretion by pure “gastric inhibitory polypeptide”. Gastroenterology 62, 393–400 (1972)PubMedGoogle Scholar
  224. Perrier, C. V., Laster, L.: Adenyl cyclase activity of guinea-pig gastric mucosa. Clin. Res. 17, 596 (1969)Google Scholar
  225. Petersen, H.: The relationship between the gastric and pancreatic secretion in man. Scand. J. Gastroent. 4, 345–351 (1969)PubMedGoogle Scholar
  226. Pe Thein, M., Schofield, B.: Release of gastrin from the pyloric antrum following vagal stimulation by sham feeding in dogs. J. Physiol. (Lond.) 148, 291–305 (1959)Google Scholar
  227. Pevsner, L., Grossman, M. I.: The mechanism of vagal stimulation of gastric acid secretion. Gastroenterology 28, 493 (1955)PubMedGoogle Scholar
  228. Pincus, I. J., Friedman, M. H. F., Thomas, J. E., Rehfuss, M. E.: A quantitative study of the inhibitory effect of acid in the intestine on gastric secretion. Amer. J. dig. Dis. 11, 205–208 (1944)Google Scholar
  229. Piper, P. J., Said, S. I., Vane, J. R.: Effects on smooth muscle preparations of unidentified vasoactive peptides from intestine and lung. Nature (Lond.) 225, 1444 (1970)Google Scholar
  230. Preshaw, R. M.: Latency of the gastric secretory response to sham feeding in the dog. Canad. J. Physiol. Pharmacol. 45, 633–641 (1967)Google Scholar
  231. Rall, T. W., Sutherland, E. W., Berthet, J.: The relationship of epinephrine and glucagon to liver Phosphorylase. IV. Effect of epinephrine and glucagon on the reactivation of Phosphorylase in liver homogenates. J. biol. Chem. 224, 463–475 (1957)PubMedGoogle Scholar
  232. Rasmussen, H.: Cell communication, calcium ion, and cyclic adenosine monophosphate. Science 170, 404–412 (1970)PubMedGoogle Scholar
  233. Redford, M., Schofield, B.: The effect of local anesthesia of the pyloric antral mucosa on acid inhibition of gastrinmediated acid secretion. J. Physiol. (Lond.) 180, 304–320 (1965)PubMedCentralGoogle Scholar
  234. Reid, N. C., Hackett, R. M., Welbourn, R. B.: The influence of cortisone on the parietal cell population of the stomach in the dog. Gut 2, 119–122 (1961)PubMedCentralPubMedGoogle Scholar
  235. Robert, A., Nezamis, J. E., Phillips, J. P.: Inhibition of gastric secretion by prostaglandins. Amer. J. dig. Dis. N. S. 12, 1073–1076 (1967)Google Scholar
  236. Robert, A., Nezamis, J. E., Phillips, J. P.: Effect of prostaglandin E1 on gastric secretion and ulcer formation in the rat. Gastroenterology 55, 481–487 (1968)PubMedGoogle Scholar
  237. Robertson, C. R., Rosiere, C. E., Blickenstaff, D., Grossman, M. I.: Potentiating action of certain xanthine derivatives on gastric acid secretory responses in dog. J. Pharmacol. exp. Ther. 99, 362–365 (1950)PubMedGoogle Scholar
  238. Rosemann, R.: Contribution to the physiology of digestion. The properties and composition of the dogs gastric juice, obtained by sham feeding. Arch. ges. Physiol. 118, 467–524 (1907)Google Scholar
  239. Roth, J. A., Ivy, A. C.: Synergistic effect of Coffeine upon histamine in relation to gastric secretion. Amer. J. Physiol. 142, 107–113 (1944)Google Scholar
  240. Rovelstad, R. A., Maher, F. T.: Problems associated with assessment of the effects of diet, antacids and anticholinergic agents on gastric and duodenal acidity, as measured by the glass electrode in situ. Gastroenterology 42, 588–594 (1962)Google Scholar
  241. Rowlands, C., Temperley, J. H., Wyllie, J. H.: Pentagastrin-infusion test after atropine or vagotomy. Lancet 1969 II, 348–349Google Scholar
  242. Ruch, Th. C., Patton, H. D.: Physiology and biophysics. Philadelphia and London: W. B. Saunders Comp. 1965Google Scholar
  243. Rune, S. J.: Gastric acid secretion after ingestion of solid food. A comparative study of gastric acid secretory capacity in response to solid food and histamine. Scand. J. Gastroent. 3, Suppl. 1 (1968)Google Scholar
  244. Said, S. J., Mutt, V.: Polypeptide with broad biological activity: isolation from small intestine. Science 169, 1217 (1970)PubMedGoogle Scholar
  245. Said, S. J., Mutt, V.: Potent peripheral and splanchnic vasodilator peptide from normal gut. Nature (Lond.) 225, 863 (1970)Google Scholar
  246. Samloff, I. M.: Progress in gastroenterology. Pepsinogens, pepsins and pepsin inhibitors. Gastroenterology 60, 586–604 (1971)PubMedGoogle Scholar
  247. Samloff, I. M.: Slow moving protease and the seven pepsinogens. Electrophoretic demonstration of the existence of eight proteolytic fractions in human gastric mucosa. Gastroenterology 57, 659–669 (1969)PubMedGoogle Scholar
  248. Schäfer, E. A.: Textbook of physiology, Vol. I. Edinburgh, London: Pentland 1898Google Scholar
  249. Schapiro, H., Storer, E. H., Britt, L. G.: Action of antidiuretic hormone on food stimulated gastric section. Amer. Surg. 34, 315–316 (1968)Google Scholar
  250. Schmidt, H. A.: Die Bestimmung der maximalen Magensekretion im sogenannten Stufentest nach Infusion von Histamin, Pentagastrin und Gastrin. Dtsch. med. Wschr. 96, 5–8 (1971)PubMedGoogle Scholar
  251. Schofield, B.: Inhibition by acid of gastrin release. In: Gastrin (Grossman, M. I., Ed.). UCLA Forum Med. Sci. No. 5, Los Angeles: Univ. Calif. Press 1966Google Scholar
  252. Schrager, J.: The isolation of the principle gastric glycoprotein and its physiological function. In: 4th world congress of gastroenterology, Kopenhagen, 12.–18. July, 1970. Advance Abstracts (Riis, P., Anthonisen, P., Baden, H., Eds.) 1971Google Scholar
  253. Schwann, T. L.: Über das Wesen des Verdauungsprozesses. Poggendorf Ann. Phys. Chem. 38, 358–364 (1836)Google Scholar
  254. Seelig, H. P.: Gastrin. Inaktivierung und Abbau. Stuttgart: Thieme 1972Google Scholar
  255. Seijffers, M. J., Segal, H. L., Miller, L. L.: Separation of pepsin I, pepsin II A, pepsin II B and pepsin III from human gastric mucosa. Amer. J. Physiol. 205, 1106–1112 (1963)PubMedGoogle Scholar
  256. Shay, H.: Emotional stress and parietal cell mass. Amer. J. dig. Dis. N. S. 4, 846–870 (1959)Google Scholar
  257. Shay, H., Gershon-Cohen, J., Fels, S. S.: The role of upper small intestine in the control of gastric secretion; the effect of neutral fat, fatty acid and soaps; the phase of gastric secretion influenced and the relative importance of the psychic and chemical phases. Ann. intern. Med. 13, 294–307 (1939)Google Scholar
  258. Shay, H., Gershon-Cohen, J., Fels, S. S.: A self regulatory duodenal mechanism for gastric acid control and an explanation for the pathologic gastric physiology in uncomplicated duodenal ulcer. Amer. J. dig. Dis. 9, 124–128 (1942)Google Scholar
  259. Sircus, W.: The intestinal phase of gastric secretion. Quart. J. exp. Physiol. 38, 91–100 (1953)PubMedGoogle Scholar
  260. Sircus, W.: Studies on the mechanisms in the duodenum inhibiting gastric secretion. Quart. J. exp. Physiol. 43, 114–133 (1958)PubMedGoogle Scholar
  261. Smallwood, R. A.: Effect of intravenous calcium administration on gastric secretion of acid and pepsin in man. Gut 8, 592–598 (1967)PubMedCentralPubMedGoogle Scholar
  262. Sokolov, A. P.: Thesis St. Petersburg 1904. Quoted by Babkin, B. P.: Secretory mechanisms of the digestive glands. New York: Paul B. Hoeber, Harper and Row, 1950Google Scholar
  263. Stavraky, G. W.: Some aspects of gastric secretion induced by mecholyl. Rev. canad. Biol. 2, 59–71 (1943)Google Scholar
  264. Stening, G. F., Johnson, L. R., Grossman, M. I.: Effect of secretin on acid and pepsin secretion in cat and dog. Gastroenterology 56, 468 (1969)PubMedGoogle Scholar
  265. Stening, G. F., Johnson, L. R., Grossman, M. I.: Effect of cholecystokinin and caerulein on gastrin and histamine — evoked gastric secretion. Gastroenterology 57, 44–50 (1969)PubMedGoogle Scholar
  266. Storozhuk, P. G.: The effect of protein products on gastric secretion in dogs. Vop. Pitan. 27, 50–55 (1968)PubMedGoogle Scholar
  267. Strickland, R. G., Fisher, J. M., Taylor, K. B.: Effect of prednisolone on gastric function and structure in man. Gastroenterology 56, 675–686 (1969)PubMedGoogle Scholar
  268. Sun, D. C. H.: Effect of corticotropin on gastric acid, pepsin and mucus secretion in dogs with fistulas. Amer. J. dig. Dis. 14, 107–112 (1969)PubMedGoogle Scholar
  269. Sutherland, E. W., Øye, J., Butcher, R. W.: The action of epinephrine and the role of the adenyl cyclase system in hormone action. Recent Progr. Hormone Res. 21, 623–642 (1965)PubMedGoogle Scholar
  270. Sutherland, E. W., Rall, T. W.: The properties of an adenine ribonucleotide produced with cellular particles, ATP, Mg++, and epinephrine or glucagon. J. Amer. chem. Soc. 79, 3608 (1957)Google Scholar
  271. Svensson, S. O., Emås, S.: Effect of cholecystokinin on histamine — and pentagastrin — stimulated acid secretion in conscious cats. Scand. J. Gastroent. 6, 371–376 (1971)PubMedGoogle Scholar
  272. Szafran, H., Popiela, T.: Correspondence: Identity and properties of gastric lipase. Gastroenterology 64, 140–141 (1973)PubMedGoogle Scholar
  273. Tamarit-Torres, J., Hunt, J. N., Bock, D., Kirsner, J. B.: Estudio sobre la composición del jugo gastrico basai en normales. Arch. Med. Exp. (Madr.) 23, 137–150 (1960)Google Scholar
  274. Tamarit-Torres, J., Hunt, J. N., Bock, D., Kirsner, J. B.: Estudio sobre la composición del jugo gástrico basaö en ulcerosos gastricos y duodenales. An. Inst. Farmacol. esp. 8, 229–240 (1961)Google Scholar
  275. Tang, J., Mills, J., Chiang, L.: Comparative studies on the structure and specifity of human gástricsin pepsin and zymogen. Ann. N. Y. Acad. Sci. 140, 688–696 (1967)PubMedGoogle Scholar
  276. Tenorova, M., Stuchlikova, E., Korinek, J.: Proteins of gastric juice; electrophoresis on agar and immunoelectrophoresis. Sborn. Lék. 63, 211–218 (1961)PubMedGoogle Scholar
  277. Teorell, T.: On the permeability of the stomach mucosa for acids and some other substances. J. gen. Physiol. 23, 263–274 (1939)PubMedCentralPubMedGoogle Scholar
  278. Teorell, T.: Electrolyte diffusion in relation to the acidity regulation of the gastric juice. Gastroenterology 9, 425 (1947)PubMedGoogle Scholar
  279. Tomenius, J., Williams, G.: Continuously recorded pH of gastric and duodenal contents in situ with evaluation of the efficiancy of some antacids in vivo. Acta med. scand. 166, 25–34 (1960)PubMedGoogle Scholar
  280. Uvnäs, B.: The effect of atropine, acetylcholine, eserine and Di-isopropyl fluorophosphate on gastric secretion in cat. Acta physiol. scand. 15, 427 –437 (1948)PubMedGoogle Scholar
  281. Vagne, M., Cille, Y., Martin, F., Lambert, R.: L’ammonium dans le suc gastrique humain. C. R. Soc. Biol. (Paris) 159, 380–383 (1965)Google Scholar
  282. Voukydis, P. C.: The effect of blood sugar level on the histamine-stimulated gastric secretion in shay-rats. Arch. int. Pharmacodyn. 179, 364–371 (1969)Google Scholar
  283. Wang, C. C., Grossman, M. I.: Physiological determination of the release of secretin and pancreozymin from intestine of dogs with transplanted pancreas. Amer. J. Physiol. 165, 527–545(1951)Google Scholar
  284. Wangel, A. G., Callender, S. T.: Effect of gastrin I and II on the secretion of intrinsic factor. Brit. med. J. 1965 I,1409–1411Google Scholar
  285. Wilhelmj, C. M., McCarthy, H. H., Hill, F. C.: Acid inhibition of the intestinal and intragastric chemical phases of gastric secretion. Amer. J. Physiol. 118, 766–774 (1937)Google Scholar
  286. Wilhelmj, C. M., McCarthy, H. H., Hill, F. C.: Acid inhibition and the sephalic (psychic) phase of gastric secretion. Amer. J. Physiol. 120, 619–623 (1937)Google Scholar
  287. Wilhelmj, C. M., Neigus, I., Hill, F. C.: Studies on the regulation of gastric acidity. Amer. J. Physiol. 106, 381–397 (1933)Google Scholar
  288. Wilhelmj, C. M., O’Brien, F. T., Hill, F. C.: The inhibitory influence of the acidity of the gastric contents on the secretion of acid by the stomach. Amer. J. Physiol. 115, 429–440 (1936)Google Scholar
  289. Williams, C. B., Forrest, A. P. M., Campell, H.: Buffering capacity of food in relation to stimulation of gastric secretion. Gastroenterology 55, 567–574 (1968)PubMedGoogle Scholar
  290. Wilson, D. E., Levine, R. A.: Decreased canine gastric mucosal blood flow induced by Prostaglandine E1: A mechanism for its inhibitory effect on gastric secretion. Gastroenterology 56, 1268 (1969)Google Scholar
  291. Windsor, C. W. O., Cockel, R., Lee, M. J. R.: Inhibition of gastric secretion in man by intestinal fat infusion. Gut 10, 135–142 (1969)PubMedCentralPubMedGoogle Scholar
  292. Woodward, E. R., Trumbull, W. E., Schapiro, H., Towne, I.: Does the gastric antrum elaborate an antisecretory hormone? Amer. J. dig. Dis. N. S. 3, 204–213 (1958)Google Scholar
  293. Wormsley, K. G.: The response to duodenal acidification in man. Gut 10, 1050 (1959)Google Scholar
  294. Wormsley, K. G.: Response to duodenal acidification in man. I. Electrolyte changes in the duodenal aspirate. Scand. J. Gastroent. 4, 717–726 (1969)PubMedGoogle Scholar
  295. Wormsley, K. G.: Reactions to acid in the intestine in health and disease. Gut 12, 67–84 (1971)PubMedCentralPubMedGoogle Scholar
  296. Wormsley, K. G.: Inhibition of gastric acid secretion. Gastroenterology 62, 156 (1972)PubMedGoogle Scholar
  297. Wormsley, K. G., Grossman, M. I.: Inhibition of gastric secretion by secretin and by endogenous acid in the duodenum. Gastroenterology 47, 72 (1964)PubMedGoogle Scholar
  298. Wünsch, E., Jaeger, E., Scharf, R.: Reindarstellung des synthetischen Glucagons. Chem. Ber. 101, 3664–3670 (1968)PubMedGoogle Scholar
  299. Wyllie, J. H., Limbosch, J. M., Nyhus, L. M.: The effect of atropine on gastric secretion in dog. Scand. J. Gastroent. 3, 18–22 (1968)PubMedGoogle Scholar
  300. Wyllie, J. H., Wendy, D. P., Ealding, Hesselbo, T., Plack, J. W.: Inhibition of gastric secretion in man by metiamide: a new, orally active histamine H2-receptor antagonist. Gut 14, 424 (1973)PubMedGoogle Scholar
  301. Yalow, R. S., Berson, S. A.: Further studies on the nature of immunoreactive gastrin in human plasma. Gastroenterology 60, 203–214 (1971)PubMedGoogle Scholar

Motorik

  1. Anderson, S., Grossman, M. I.: Profile of pH pressure and potential difference in gastro-duodenal junction in man. Gastroenterology 49, 364–371 (1965)Google Scholar
  2. Andersson, J. J., Bolt, R. J., Ullman, B. M., Bass, P.: Differential response to various stimulants in the body and antrum of the canine stomach. Amer. J. dig. Dis. N. S. 13, 147–157 (1968)Google Scholar
  3. Annegers, J. H., Ivy, A. C.: The effect of dietary fat upon gastric evacuation in normal subjects. Amer. J. Physiol. 150, 461–465 (1947)PubMedGoogle Scholar
  4. Aune, S.: Intragastric pressure after vagotomy in man. Scand. J. Gastroent. 4, 447–452 (1969)PubMedGoogle Scholar
  5. Beck, I., Szivek, J., Fox, J. E.: Computerized analysis of motility and transmural potential difference changes at the level of the gastroesophageal junction, body of the esophagus and upper sphincter in health and disease. In: Demling, L., Ottenjann, R.: Gastrointestinal motility. Stuttgart: Thieme 1971Google Scholar
  6. Bennett, M. R., Burnstock, G., Holman, M. E.: Transmission from intramural inhibitory nerves to the stomach muscle of the guinea pig taenia-coli. J. Physiol. (Lond.) 182, 541–558 (1966)Google Scholar
  7. Bennett, A., Fleshler, B.: Progress in gastroenterology: Prostaglandins and the gastrointestinal tract. Gastroenterology 59, 790–800 (1970)PubMedGoogle Scholar
  8. Bortoff, A., Weg, N.: Transmission of electrical activity through the gastroduodenal junction. Amer. J. Physiol. 208, 531–536 (1965)PubMedGoogle Scholar
  9. Brecht, K.: Muskelphysiologie. In: Keidel, W. D.: Lehrbuch der Physiologie. Stuttgart: Thieme 1970Google Scholar
  10. Brink, B. M., Schlegel, J. F., Code, C. F.: The pressure profile of the gastroduodenal junctional zone in dogs. Gut 6, 163–171 (1965)PubMedCentralPubMedGoogle Scholar
  11. Brown, J. C., Johnson, L. P., Magee, D. F.: Effect of duodenal alkalinization on gastric motility. Gastroenterology 50, 333–339 (1966)PubMedGoogle Scholar
  12. Brown, J. C., Cook, M. A., Dryburgh, J. R.: Motilin, a gastric motor activity-stimulating polypeptide: Final purification, amino acid composition and C-terminal residues. Gastroenterology 62, 401–404 (1972)PubMedGoogle Scholar
  13. Brown, J. C., Cook, M. A., Drybtjrgh, J. R.: Motilin, a gastric motor activity stimulating polypeptide: the complete amino acid sequence. Canad. J. Biochem. 51, 533–537 (1973)Google Scholar
  14. Byvsuk, N. S.: Vergleichsuntersuchungen des Einflusses von Adrenalin und Noradrenalin auf die motorische und Entleerungsfunktion des Magens. Farmakol. i. Toksikol. 26, 678–684 (1963)Google Scholar
  15. Cameron, A. J., Phillips, S. F., Summerskill, W. H.: Comparison of effects of gastrin, cholecystokinin-pankreozymin, secretin and glucagon on human stomach muscle in vitro. Gastroenterology 59, 539–545 (1970)PubMedGoogle Scholar
  16. Cannon, W. B.: The mechanical factors of digestion. London: Arnold 1911Google Scholar
  17. Cannon, W. B.: A law of denervation. Amer. J. med. Sci. 198, 737–750 (1939)Google Scholar
  18. Cannon, W. B., Lieb, C. W.: The receptive relaxation of the stomach. Amer. J. Physiol. 29, 267–273 (1911)Google Scholar
  19. Carlson, A. J.: The control of hunger in health and disease. Chicago: Univ. of Chicago Press 1916Google Scholar
  20. Carlson, A. J., Boyd, T. E., Pearcy, J. F.: Studies on the visceral sensory nervous system. XIII. The innervation of the cardia and the lower end of the esophagus in mammals. Amer. J. Physiol. 61, 14–41 (1922)Google Scholar
  21. Carlson, H. C., Code, C. F., Nelson, R. A.: Motor action of the canine gastroduodenal junction. A cineradiography, pressure and electric study. Amer. J. dig. Dis. 11, 155–172 (1966)PubMedGoogle Scholar
  22. Castell, H. C., Code, C. F., Nelson, R. A.: Hormonal control of gastroesophageal sphincter strength. New Engl. J. Med. 282, 886 (1970)PubMedGoogle Scholar
  23. Chang, C. A., McKenna, R. D., Beck, I. T.: Gastric emptying rate of the water and fat phases of a mixed test meal in man. Gut 9, 420–424 (1968)PubMedCentralPubMedGoogle Scholar
  24. Chawla, R. C., Eisenberg, M. M.: Prostaglandin inhibition of innervated antral motility in dogs. Proc. Soc. exp. Biol. (N. Y.) 132, 1081–1086 (1969)Google Scholar
  25. Chey, W. Y., Kosay, S., Hendricks, J., Braverman, S., Lorber, H.: Effect of secretin on motor activity of stomach and Heidenhain pouch in dogs. Amer. J. Physiol. 217, 848–852 (1969)PubMedGoogle Scholar
  26. Christensen, J.: A new neural inhibitor in the gut. Gastroenterology 60, 1130 (1971)PubMedGoogle Scholar
  27. Classen, M., Neuwirth, R., Demling, L.: Telemetrie der gastrointestinalen Motilität mit besonderer Berücksichtigung des Magens. In: Demling, L., Bachmann, K.: Biotelemetrie (Symposium am 29./30. November 1968) Stuttgart: Thieme 1970Google Scholar
  28. Cohen, S., Lipshutz, W.: Hormonal regulation of human lower esophageal sphincter competence: interaction of gastrin and secretin. J. clin. Invest. 50, 449 (1971)PubMedCentralPubMedGoogle Scholar
  29. Cooke, A. R., Moulang, J.: Control of gastric emptying by amino acids. Gastroenterology 62, 528–532 (1972)PubMedGoogle Scholar
  30. Daniel, E. E.: The electrical and contractile activity of the pyloric region in dogs and the effects of drugs. Gastroenterology 49, 403–418 (1965)PubMedGoogle Scholar
  31. Daniel, E. E., Chapman, K. M.: Electrical activity of the gastrointestinal tract as an indication of mechanical activity. Amer. J. dig. Dis. N. S. 8, 54–102 (1963)Google Scholar
  32. Daniel, E. E., Irwing, J.: Electrical activity of gastric musculature. In: Code, Ch. F.: Handbook of physiology, Sect. 6, Vol. IV, Motility, Chapt. 94. Baltimore: Williams and Wilkins 1968Google Scholar
  33. Davenport, H. W.: Physiology of the digestive tract. Chicago: Yearbook Medical Publ. Inc. 1961Google Scholar
  34. Demling, L.: The motility of the gastro-intestinal tract. Digestion 2, 362–368 (1969)PubMedGoogle Scholar
  35. Demling, L., Classen, M.: Biotelemetrische Messungen von pH und Druckwerten im menschlichen Magendarmtrakt. Sonderdruck aus Dtsch. Z. Verdau.- u. Stoffwechselkr. 30, Heft 1/2 (1970)Google Scholar
  36. Demling, L., Ottenjann, R.: Gastrointestinal motility. International symposium on motility of the gastrointestinal tract. (15./16. Juli 1969). Stuttgart: Thieme 1971Google Scholar
  37. Demling, L., Wachsmann, F., Bünte, H.: Über eine Methode zur kontinuierlichen Motilitäts-und Druckregistrierung im Verdauungskanal mit Hilfe von Dehnungsmeßstreifen. Klin. Wschr. 35, 586–590 (1957)PubMedGoogle Scholar
  38. Duthie, H. J., Kwong, N. K., Brown, B. H., Whittaker, G. E.: Pace setter potential of the human gastroduodenal junction. Gut 12, 250–256 (1971)PubMedCentralPubMedGoogle Scholar
  39. Elias, E., Gibson, G. J., Greenwood, L. F., Hunt, J. N., Tripp, J. H.: The slowing of gastric emptying by monosaccharides and disaccharides in test meals. J. Physiol. (Lond.) 194, 317–326 (1968)Google Scholar
  40. Feldman, S., Gibaldi, M.: Effect of bile salts on gastric emptying and intestinal transit in the rat. Gastroenterology 54, 918–921 (1968)PubMedGoogle Scholar
  41. Fisher, R. S., Cohen, S.: Physiologic characteristics of the human pyloric sphincter. Gastroenterology 64, 67 (1973)PubMedGoogle Scholar
  42. Garrett, J. M., Godwin, D. H., Hirschowitz, B. I.: Differential stimulation of gastric motility and secretion in the fistula dog by insulin hypoglycemia. Gastroenterology 54, 1235 (1968)Google Scholar
  43. Garrett, J. M., Summersexll, W. H. J., Code, C. F.: Antral motility in patients with gastric ulcer. Amer. J. dig. Dis. N. S. 11, 780–789 (1966)Google Scholar
  44. Gershon, M. D.: Serotonin and the motility of the gastrointestinal tract. Gastroenterology 54, 453–456 (1968)PubMedGoogle Scholar
  45. Grahame, G. R., Garrett, J. M., Hirschowitz, B. I.: 2-Deoxy-glucose and histamine effects on gastric motility and secretion in dog. Amer. J. Physiol. 215, 243–248 (1968)PubMedGoogle Scholar
  46. Gregory, R. A., Tracy, H. J.: The constitution and properties of two extracted from hog antral mucosa. Gut 5, 103–117 (1964)PubMedCentralPubMedGoogle Scholar
  47. Griffith, G. H., Owen, G. M., Kjrkman, S., Shields, R.: Measurement of rate of gastric emptying using chromium 51. Lancet 1966 I, 1244–1245Google Scholar
  48. Hightower, N. C., Jr., Code, C. F.: The quantitative analysis of antral gastric motility records in normal human beings, with a study of the effects of neostigmine. Proc. Mayo Clin. 25, 697–704 (1950)Google Scholar
  49. Hollander, F., Penner, A.: History and development of gastric analysis procedure. Amer. J. dig. Dis. 5, 22–25, 739–743, 786–791 (1939)Google Scholar
  50. Hopkins, A.: The pattern of gastric emptying. J. Physiol. (Lond.) 182, 144–149 (1966)Google Scholar
  51. Hunt, J. N.: Gastric emptying and secretion in man. Physiol. Rev. 39, 491–533 (1959)PubMedGoogle Scholar
  52. Hunt, J. N., McDonald, I.: The influence of volume on gastric emptying. J. Physiol. (Lond.) 126, 459–474 (1954)Google Scholar
  53. Hunt, J. N., Knox, M. T.: Regulation of gastric emptying. In: Code, C. F.: Handbook of physiology, Sect. 6, Vol. IV, Motility, Chapt. 94. Baltimore: Williams and Wilkins 1968Google Scholar
  54. Hunt, J. N., Spurrell, W. R.: The pattern of emptying of the human stomach. J. Physiol. (Lond.) 113, 157–168 (1951)Google Scholar
  55. Iggo, A.: Intragastric pressure and frequency of discharge in goat afferent fiber. J. Physiol. (Lond.) 128, 593–607 (1955);Google Scholar
  56. Iggo, A.: Intragastric pressure and frequency of discharge in goat afferent fiber. In: Davenport, H. W.: Physiology of the digestive tract. Chicago: Yearbook Medical Publ. Inc. 1961Google Scholar
  57. Johnson, L. R., Brown, J. C., Magee, D. F.: Effect of secretin and cholecystokinin-pankreozymin extracts on gastric motility in man. Gut 7, 52–57 (1966)PubMedCentralPubMedGoogle Scholar
  58. Johnson, L. R., Grossman, M. I.: Progress in gastroenterology. Intestinal hormones as inhibitors of gastric secretion. Gastroenterology 60, 120–144 (1971)PubMedGoogle Scholar
  59. Johnson, L. R., Magee, D. F.: Cholecystokinin-pankreozymin extracts and gastric motility. Surg. Gynec. Obstet. 121, 557–562 (1965)PubMedGoogle Scholar
  60. Kelly, K. A., Woodward, E. R., Code, C. F.: Effect of secretin and cholecystokinin on canine gastric electrical activity. Proc. Soc. exp. Biol. (N. Y.) 130, 1060–1063 (1969)Google Scholar
  61. Koch, N. G., Berger, T., Rosenberger, B.: The gastroduodenal junction in man studied with a photoelectrical technique and pressure recordings. In: Semb, L. S., Myren, J.: The physiology of gastric secretion. Oslo: Universitätsforlaget 1968Google Scholar
  62. Kramer, P., Ingelfinger, F. J., Atkinson, M.: The motility and pharmacology of the esophagus in cardiospasm. Gastroenterology 30, 174 (1956)Google Scholar
  63. Lewi, Z., Chey, W. Y., Lorber, S. H.: The effect of secretin on motor activity. Clin. Res. 13, 257 (1965)Google Scholar
  64. Lind, J. F., Duthie, H. L., Schlegel, J. F., Code, C. F.: Motility of the gastric fundus. Amer. J. Physiol. 201, 197–202 (1961)PubMedGoogle Scholar
  65. Lorber, S. H., Chey, W. Y., Lewi, Z.: Effect of secretin on motor activity in the main stomach and Heidenhain pouch of dogs. Gastroenterology 48, 866 (1965)Google Scholar
  66. Louckes, H. S., Quigley, J. P., Kersey, J.: Inductograph method for recording muscle activity, especially pyloric sphincter physiology. Amer. J. Physiol. 199, 301–310 (1960)PubMedGoogle Scholar
  67. Lucien, H. W., Itoh, Z., Schally, A. V.: Inhibitory effects of a purified enterogastrone, secretin and cholecystokinin on histamine — stimulated gastric acid secretion. Gastroenterology 59, 707–711 (1970)PubMedGoogle Scholar
  68. Meyer, J. H., Grossman, M. I.: Release of secretin and cholecystokinin. In: Demling, L.: Gastrointestinal hormones. Int. Sympos. at Erlangen, August 1971. Stuttgart: Thieme 1972Google Scholar
  69. Nielsen, N. A., Christiansen, H.: Tracings of x-ray photographs of the stomach of a young man. Acta radiol. (Stockh.) 13, 678–685 (1932);Google Scholar
  70. Nielsen, N. A., Christiansen, H.: Tracings of x-ray photographs of the stomach of a young man. In: Davenport, H. W.: Physiology of the digestive tract. Chicago: Yearbook Medical Publ. Inc. 1961Google Scholar
  71. Pederson, R. A., Brown, J. C.: Inhibition of histamine-, pentagastrin-, and insulin-stimulated canine gastric secretion by pure “gastric inhibitory polypeptide”. Gastroenterology 62, 393–400 (1972)PubMedGoogle Scholar
  72. Quigley, J. P.: A modern explanation of the gastric emptying mechanism. Amer. J. dig. Dis. 10, 418–421 (1943)Google Scholar
  73. Quigley, J. P., Johnson, V., Solomon, E. I.: Action of insulin on the motility of the gastrointestinal tract. Amer. J. Physiol. 90, 89–98 (1929)Google Scholar
  74. Quigley, J. P., Louckes, H. S.: Gastric emptying. Amer. J. dig. Dis., N. S. 7, 672–676 (1962)Google Scholar
  75. Quigley, J. P., Meschan, I.: The gastric evacuation of fats with especial reference to the pyloric sphincter activity. Rev. Gastroent. 4, 272–275 (1937)Google Scholar
  76. Quigley, J. P., Meschan, I.: Inhibition of the pyloric sphincter region by the digestion products of fat. Amer. J. Physiol. 134, 803–807 (1941)Google Scholar
  77. Quigley, J. P., Phelps, K. R.: The mechanism of gastric motor inhibition from ingested carbohydrate. Amer. J. Physiol. 109, 133–138 (1934)Google Scholar
  78. Quigley, J. P., Read, M. R., Radzow, K. H., Meschan, I., Werle, J. M.: The effect of hydrochloric acid on the pyloric sphincter, the adjacent portions of the digestive tract and on the process of gastric evacuation. Amer. J. Physiol. 137, 153–159 (1942)Google Scholar
  79. Quigley, J. P., Templeton, R. D.: Action of insulin on the motility of the gastrointestinal tract. Amer. J. Physiol. 91, 475–495 (1930)Google Scholar
  80. Quigley, J. P., Werle, J. M., Ligon, E. E., Jr., Read, M. R., Radzow, K. H., Meschan, I.: The influence of fats on the motor activity of the pyloric sphincter and on the process of gastric evacuation studied by the balloon-water manometer and by the optical manometer-fluoroscopic technics. Amer. J. Physiol. 134, 132–140 (1941)Google Scholar
  81. Resin, H., Stern, D. H., Sturdevant, R. A. L., Isenberg, J.: Effect of the C-terminal octapeptide of cholecystokinin on lower oesophageal sphincter pressure in man. Gastroenterology 64, 946–949 (1973)PubMedGoogle Scholar
  82. Ruch, Th. C., Patton, H. D.: Physiology and biophysics. Philadelphia and London: W. B. Saunders Comp. 1965Google Scholar
  83. Salamanca de, F. E., Jr.: Las technicas de exploración funcional gastrica aplicadas al estudio de la fisiologia del perro. Medicina 18, 2–29 (1950)Google Scholar
  84. Sharma, K. N., Anand, B. K., Dua, S., Singh, B.: Role of stomach in regulation of activities of hypothalamic feeding centers. Amer. J. Physiol. 201, 593–598 (1961)PubMedGoogle Scholar
  85. Silverstone, J. T., Smith, G. P., Stunkard, A. J.: Gastric pressures recorded by a telemetering capsule. Amer. J. dig. Dis., N. S. 13, 615–618 (1968)Google Scholar
  86. Skala, L., Pirk, F.: X-ray study of gastrointestinal motility after administration of medium-chain triglycerides and olive oil. Cs. Gastroent. Výž. 22, 174–179 (1968)Google Scholar
  87. Smith, A. W. M., Code, C. F.: The effect of an ordinary and of an excessively fatty breakfast on human gastric antral motility. Gastroenterology 35, 398–405 (1958)PubMedGoogle Scholar
  88. Stunkard, A. J., Bloom, P. B., Ftlion, R. D. L., Fox, S., Stellar, E.: Gastric and duodenal motility, food intake and hunger measured in man during a 24-hr period. Amer. J. dig. Dis., N. S. 15, 719–725 (1970)Google Scholar
  89. Sugawara, K.: An electromyographic study on the motility of canine stomach after transection and end-to-end anastomosis. Tohoku J. exp. Med. 84, 113–124 (1964)PubMedGoogle Scholar
  90. Sugawara, K., Isaza, J., Curt, J., Woodward, E. R.: Effect of secretin and cholecystokinin on gastric motility. Amer. J. Physiol. 217, 1633–1638 (1969)PubMedGoogle Scholar
  91. Sugawara, K., Isaza, J., Curt, J., Woodward, E. R.: The effect of pentagastrin on gastric motility following vagotomy. J. Surg. Res. 10, 73–80 (1970)PubMedGoogle Scholar
  92. Sugawara, K., Isaza, J., Woodward, E. R., Dragstedt, L. R.: The short-term effect of vagotomy on gastric motility. Arch Surg 99, 1–5 (1969)PubMedGoogle Scholar
  93. Texter, E. C., Jr.: Pressure and transit in the small intestine: The concept of propulsion and peripheral resistance in the alimentary canal. Amer. J. dig. Dis., N. S. 13, 443–454 (1968)Google Scholar
  94. Thomas, J. E.: Mechanics and regulation of gastric emptying. Physiol. Rev. 37, 453–474 (1957)PubMedGoogle Scholar
  95. Thomas, J. E., v. Baldwin, M.: Pathways and mechanisms of regulation of gastric motility. In: Code, C. F.: Handbook of physiology, Sect. 6, Vol. IV, Motility, Chapt. 95. Baltimore: Williams and Wilkins 1968Google Scholar
  96. Thomas, J. E., Crider, J. O.: Inhibition of gastric motility associated with the presence of products of protein hydrolysis in the upper small intestine. Amer. J. Physiol. 126, 28–38 (1939)Google Scholar
  97. Thomas, J. E., Crider, J. O., Morgan, C. J.: A study of reflexes involving the pyloric sphincter and antrum and their role in gastric evacuation. Amer. J. Physiol. 108, 683–700 (1934)Google Scholar
  98. Tinker, J., Kocak, N., Jones, T., Glass, H. I., Cox, A. G.: Supersensitivity and gastric emptying after vagotomy. Gut 11, 502–505 (1970)PubMedCentralPubMedGoogle Scholar
  99. Tracy, H. J., Gregory, R. A.: Physiological properties of a series of synthetic peptides structurally related to gastrin I. Nature (Lond.) 204, 935–938 (1964)Google Scholar
  100. Tripp, J. H.: Location of an alimentary osmoreceptor. J. Physiol. (Lond.) 180, 28 (1965)Google Scholar
  101. Vagne, M., Andre, C.: The effect of secretin on gastric emptying in man. Gastroenterology 60, 421–424 (1971)PubMedGoogle Scholar
  102. Vendel, S.: Evacuation of stomach in infants and prematures. Acta physiol. scand. 11, 380–385 (1946)Google Scholar
  103. Vizi, S. E., Bertaccini, G., Impicciatore, M., Knoll, J.: Evidence that acetylcholine released by gastrin and related polypeptides contributes to their effect on gastrointestinal motility. Gastroenterology 64, 268–277 (1973)PubMedGoogle Scholar
  104. Waller, S. L.: Progress report. Prostaglandine and the gastrointestinal tract. Gut 14, 402–417 (1973)PubMedCentralPubMedGoogle Scholar
  105. Wünsch, E., Brown, J. C., Deimer, K. H., Drees, F., Jaeger, E., Musiol, J., Scharf, R., Stocker, H.: Zur Synthese von Norleucin-13-Motilin. Z. Naturforsch. 28, 235–240 (1973)Google Scholar
  106. Youmans, W. B.: Extrinsic intestino-gastric reflexes elicited by mechanical stimuli. In: Nervous and neuro-humoral regulation of intestinal motility. New York: Interscience 1949Google Scholar
  107. Youmans, W. B., Karstens, A. O., Aumann, K. W.: Nervous pathways for reflex regulation of intestinal pressure. Amer. J. Physiol. 135, 619–627 (1941)Google Scholar
  108. Zeller, W., Burget, G. E.: A study of the cardia. Amer. J. dig. Dis. 4, 113 (1937)Google Scholar

Die Durchblutung des Magens

  1. Barclay, A. E., Bentley, F. H.: The vascularisation of the human stomach. A preliminary note on the shunting effect of trauma. Brit. J. Radiol. 22, 62 (1969)Google Scholar
  2. Barlow, T. E., Bentley, F. H., Walder, D. N.: Arteries, veins and arteriovenous anastomoses in the human stomach. Surg. Gynec. Obstet. 93, 657 (1951)PubMedGoogle Scholar
  3. Bell, P. R. F., Shelley, T.: Gastric mucosal blood flow and acid secretion in conscious animals measured by heat clearance. Amer. J. dig. Dis., N. S. 13, 685–696 (1968)Google Scholar
  4. Delaney, P., Grim, E.: Canine gastric blood flow and its distribution. Amer. J. Physiol. 207, 1195–1202 (1964)PubMedGoogle Scholar
  5. Delaney, P., Grim, E.: Experimentally induced variations in canine gastric blood flow and its distribution. Amer. J. Physiol. 208, 353–358 (1965)PubMedGoogle Scholar
  6. Demling, L.: Erste Erfahrungen mit einer neuen Methode zur fortlaufenden Bestimmung der enteroportalen Durchblutung. Gastroenterologia (Basel) Suppl. 90, 52 (1958)Google Scholar
  7. Demling, L., Gromotka, R.: Über eine unblutige kalorimetrische Methode zur fortlaufenden Bestimmung der enteroportalen Durchblutung. Dtsch. med. Wschr. 82, 1826 (1957)Google Scholar
  8. Demling, L., Koch, H.: Durchblutung der Magenschleimhaut und Säureproduktion bei der Katze. XIV. Congressus Gastroenterologicus, Prag 1972 (im Druck)Google Scholar
  9. Demling, L., Ottenjann, R.: Gleichzeitige Durchblutungs- und pH-Messung an der menschlichen Magenschleimhaut. II. Weltkongreß für Gastroenterologie, München 1962, Vol. II. Basel: Karger 1963Google Scholar
  10. Demling, L., Ottenjann, R., Gebhardt, H.: Pankreas und peptisches Geschwür. Gastroenterologia (Basel) 102, 129 (1964)Google Scholar
  11. Demling, L., Ottenjann, R., Wachsmann, F.: Method for measurement of blood flow and acidity in the human stomach. Amer. J. dig. Dis., N. S. 9, 517–524 (1964)Google Scholar
  12. Demling, L., Wachsmann, F.: Neue Methode zur Messung von Durchblutungsänderungen an der Magenschleimhaut. Dtsch. med. Wschr. 86, 944 (1961)PubMedGoogle Scholar
  13. Grayson, J.: The measurement of intestinal blood flow in man. J. Physiol. (Lond.) 14, 419 (1951)Google Scholar
  14. Grayson, J.: Internal calormetry in the determination of terminal conductivity and blood flow. J. Physiol. (Lond.) 118, 54 (1952)Google Scholar
  15. Grossman, M. I.: Treatment of duodenal ulcer with secretin: a speculative proposal. Gastroenterology 50, 912 (1966)PubMedGoogle Scholar
  16. Hensel, H.: Kritische Betrachtungen zur Messung der Hautdurchblutung mit thermischen Methoden. Klin. Wschr. 34, 1273 (1956)PubMedGoogle Scholar
  17. Hensel, H., Ruff, J., Golenhofen, K.: Fortlaufende Registrierung der Muskeldurchblutung am Menschen mit einer Kalorimetersonde. Pflügers Arch. ges. Physiol. 259, 267 (1964)Google Scholar
  18. Jacobsen, E. D.: Progress in gastroenterology: The circulation of the gastrointestinal tract. Gastroenterology 52, 98–112 (1967)Google Scholar
  19. Jacobsen, E. D.: Clearance of the gastric mucosa. Gastroenterology 54, 434 (1968)Google Scholar
  20. Koch, H.: Tierexperimentelle Untersuchungen zur Messung der Schleimhautdurchblutung des Magens mit der Wärmeleitsonde. Habilitationsschrift, Erlangen 1973Google Scholar
  21. Sapirstein, L. A.: Fractionation of the cardiac of rats with isotopic potassium. Circulat. Res. 4, 689 (1956)PubMedGoogle Scholar
  22. Sapirstein, L. A.: The indicator fractionation technique for the study of regional blood flow. Gastroenterology 52, 365–371 (1967)PubMedGoogle Scholar

Die Physiologie der „Oberbaucheinheit”

  1. Andersson, S.: Secretion of gastrointestinal hormones. Ann. Rev. Physiol. 35, 431–452 (1973)Google Scholar
  2. Chandler, J. G., Rosen, H., Kester, R. C., Orloff, M. J.: Extraction of the hormone responsible for the intestinal phase of gastric secretion from the intestinal mucosa of the pig. Gastroenterology (Abstr.) 64, 707 (1973)Google Scholar
  3. Demling, L., Classen, M., Koch, H., Domschke, W.: The effect of an new depot secretin on the gastric and pancreatic secretions in humans. Acta hepato-gastroent. 20, 234–330 (1973)Google Scholar
  4. Demling, L.: Physiologie der Oberbaucheinheit. Dtsch. med. Wschr. 99, 1029–1032 (1974)PubMedGoogle Scholar
  5. Jorpes, J. E., Mutt, V. (Eds.): Secretin, cholecystokinin, pancreozymin and gastrin. Beilin-Heidelberg-New York: Springer 1973Google Scholar
  6. Petersen, H., Berstad, A.: Effect of commercial cholecystokinin (CCK-PZ) on acid and pepsin secretion in man. Acta hepato-gastroent. 20, 330–337 (1973)Google Scholar
  7. Wünsch, E.: Pers. MitteilungGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • L. Demling
    • 1
  1. 1.ErlangenDeutschland

Personalised recommendations