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Magen pp 659-772 | Cite as

Peptisches Ulcus

  • L. Demling
  • W. Rösch
Chapter
Part of the Handbuch der inneren Medizin book series (INNEREN, volume 3 / 2)

Zusammenfassung

Begriffsbestimmung. Das peptische Geschwür ist definitionsgemäß nur in einer Schleimhaut anzutreffen, die mit Magensaft in Berührung kommt: Oesophagus, Magen, Duodenum und, nach Magenoperationen, Jejunum. Dabei stellt die peptische Aktivität (Salzsäure und Pepsin) eine Conditio sine qua non bei der Ulcusgenese dar. Die sozioökonomische Bedeutung der Ulcuskrankheit geht daraus hervor, daß jeder Zehnte im Laufe seines Lebens an einem peptischen Geschwür erkrankt. Daraus erklärt sich das unverändert große Interesse an der Ätiologie der Geschwürskrankheit, da letztlich erst eine Kenntnis der Pathogenese eine rationale Therapie des floriden Geschwürs und eine Rezidivprophylaxe erlaubt.

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Literatur

I. Ätiologie des peptischen Geschwürs. — II. Pathologische Anatomie des peptischen Ulcus

  1. Aird, T., Bentall, H. H., Roberts, J. A. F.: Relationship between cancer of the stomach and the AB0 blood groups. Brit. med. J. 1953 I, 799Google Scholar
  2. Alvarez, A. S., Summerskill, W. H. J.: Gastrointestinal hemorrhage and salicylates. Lancet 1958 II, 920Google Scholar
  3. Alvarez, W. C., McCarthy, W. C.: Sizes of resected gastric ulcers and gastric carcinomas. J. Amer. med. Ass. 91, 226 (1924)Google Scholar
  4. Anton, A. H., Woodward, E. R.: High levels of blood histamine and peptic ulcer. Arch. Surg. 92, 96 (1966)PubMedGoogle Scholar
  5. Askanazy, M.: Über Bau und Entwicklung des chronischen Magengeschwürs sowie Soorpilzbefunde in ihm. Virchows Arch. path. Anat. 234, 111 (1921)Google Scholar
  6. Atwater, E. C., Mongan, E. S., Weiche, D. R., Jacox, R. F.: Peptic ulcer and rheumatoid arthritis. Arch. intern. Med. 115, 184 (1965)PubMedGoogle Scholar
  7. Baron, A.: Zit. in Henning, N., Demling, L.: Das experimentelle Ulkus. In Boller, R.: Der kranke Magen. München: Urban und Schwarzenberg 1950Google Scholar
  8. Bauer, J.: Is susceptibility to peptic ulcer inherited? Gastroenterology 16, 781 (1950)Google Scholar
  9. Baronofsky, J. D., Wangensteen, O. E.: The experimental production of erosion or ulcer (gastric and/or duodenal) by the intravenous injection of small amounts of fat in animals. Bull. Amer. Coll. Surg. 30, 58 (1945)Google Scholar
  10. Baronofsky, J. D.: An experimental evaluation of ligation of stomach vessels for peptic ulcer. Gastroenterology 10, 301 (1948)PubMedGoogle Scholar
  11. Barreras, R. F., Donaldson, R. M.: Role of gastric hypersecretion, parathyroid adenoma in peptic ulcer. New Engl. J. Med. 276, 1122 (1967)PubMedGoogle Scholar
  12. Becker, V.: Die fibrinoide Nekrosezone beim Ulcus ventriculi. Leber, Magen, Darm 2, 241 (1972)PubMedGoogle Scholar
  13. Berg, B. N.: Gastric ulcers produced experimentally by vascular ligation. Arch. Surg. 54, 58 (1947)PubMedGoogle Scholar
  14. Berg, M.: The experimental production and treatment of peptic ulcers. A review of the literature. Amer. J. dig. Dis. 16, 35 (1949)PubMedGoogle Scholar
  15. Bergmann, G. v.: Funktionelle Pathologie, eine klinische Sammlung von Ergebnissen und Anschauungen einer Arbeitsrichtung. Springer: Berlin 1936Google Scholar
  16. Bernhard, C.: Lesons de physiologie experimentale appliquée à la medicine. Paris: J. B. Bailliere, 1856Google Scholar
  17. Billroth, Th.: Über Duodenalgeschwüre bei Septicämie. Wien. med. Wschr. 17, 705 (1867)Google Scholar
  18. Blomquist, H. E.: Location of metaplasia in relation to duodenal and gastric ulcer. Ann. Med. intern. Fenn. 43, 241 (1954)PubMedGoogle Scholar
  19. Bonfils, S., Hardouie, J. P., Bourel, M.: L’ulcère gastrique du rat par l’ingestion de phenylbutazone. C.R. Soc. Biol. (Paris) 147, 2016 (1953)Google Scholar
  20. Bonfils, S., Liefooghe, G., Lambling, A.: L’ulcère de contrainte du rat blanc. Modifications de la frequence lesionnells par differents procedes peratoires et pharmacodynamiques. C.R. Soc. Biol. (Paris) 151, 1149 (1957)Google Scholar
  21. Boudreau, R. P., Harvey, J. P., Robbins, S. L.: Anatomic study of benign and malignant gastric ulcerations. J. Amer. med. Ass. 147, 347 (1941)Google Scholar
  22. Boyle, J. D.: Multiple gastric ulcers. Gastroenterology 61, 628 (1971)PubMedGoogle Scholar
  23. Brihaye, J., Kiekens, R., van der Voort, G., de Roy, G., Desneux, J. J., Snoeck, J. M.: Les ulcerations digestives dans les etats de stress. Acta chir. belg. Suppl. 1, 7 (1966)Google Scholar
  24. Brodie, D. A., Valitski, L. S.: Production of gastric hemorrhage in rats by multiple stresses. Proc. Soc. exp. Biol. (N.Y.) 113, 998 (1963)Google Scholar
  25. Brodie, D. A.: Neurogenic factors in experimental peptic ulceration. In: Skoryna, S. C: Pathophysiology of peptic ulcer. Montreal: McGill University Press 1963Google Scholar
  26. Brodie, D. A.: The mechanism of gastric hyperacidity produced by pyloric ligation in the rat. Amer. J. dig. Dis. 11, 231 (1966)PubMedGoogle Scholar
  27. Brodie, D. A., Chase, B.J.: Role of gastric acid in aspirin-induced gastric irritation in the rat. Gastroenterology 53, 604 (1967)PubMedGoogle Scholar
  28. Brodie, D. A.: Experimental peptic ulcer. Gastroenterology 55, 25 (1968)Google Scholar
  29. Brooks, F. P., Sandweiss, D. J., Long, J. F.: Relationship between peptic ulcer and coronary occlusion. Amer. J. med. Sci. 245, 277 (1963)PubMedGoogle Scholar
  30. Büchner, F., Siebert, P., Molloy, P. J.: Über experimentell erzeugte akute peptische Geschwüre des Rattenvormagens. Beitr. path. Anat. 81, 391 (1928)Google Scholar
  31. Byrnes, D. J., Young, J. D., Chisholm, D. J., Lazarus, L.: Serum gastrin in patients with peptic ulceration. Brit. med. J. 1970 II, 626Google Scholar
  32. Camerer, Schleicher, Die Bedeutung der Erbveranlagung für die Entstehung einiger häufig vorkommender Krankheiten nach Anamnesen von 1500 Zwillingspaaren. Erbarzt 75, (1935)Google Scholar
  33. Campbell, D. W., Marks, L. J., Karger, R.: Effect of surgical operation on the plasma clearance of injected prednisolone. Ann. Surg. 152, 22 (1060)Google Scholar
  34. Capper, W. M., Butler, T. J., Buckler, K. G., Hallett, C. P.: Variations in size of the gastric antrum: measurement of alkaline area associated with ulceration and pyloric stenosis. Ann. Surg. 163, 281 (1966)PubMedCentralPubMedGoogle Scholar
  35. Card, W. L., Marks, I. N.: The relation between the acid output of the stomach following maximal histamine stimulation and the parietal cell mass. Clin. Sci. 19, 147 (1960)PubMedGoogle Scholar
  36. Chapman, B. L., Duggan, J. M.: Environmental factors and the Australian gastric ulcer change. Med. J. Aust. 23, 1179 (1969)Google Scholar
  37. Chapman, M. L., Werther, J. L., Rudick, J., Janowitz, H. D.: Pentagastrin infusionglycine instillation as a measure of acid absorption in the human stomach: comparison to an instilled acid load. Gastroenterology 63, 962 (1972)PubMedGoogle Scholar
  38. Clark, D. H.: Peptic ulcer in women. Brit. med. J. 1953 I, 1254Google Scholar
  39. Clarke, C. A., Evans, D. A. P., McConnell, R.B., Sheppard, P. M.: Secretion of blood group antigens and peptic ulcer. Brit. med. J. 1956 II, 725Google Scholar
  40. Clarke, C. A., Price Evans, D. A., McConnell, R. B., Sheppard, P. M.: Secretion of blood groups. Antigens and peptic ulcer. Brit. med. J. 1959 I, 603Google Scholar
  41. Clemencon, G.: Gastroscopic morphology of benign gastric ulcer. Endoscopy 2, 201 (1970)Google Scholar
  42. Cohnheim, J.: Untersuchungen über embolische Prozesse. Berlin 1872Google Scholar
  43. Cooke, A. R., Goulston, K.: Failure of intravenous aspirin to increase gastrointestinal blood loss. Brit. med. J. 1969 III, 330Google Scholar
  44. Cox, A. J., Jr., Barnes, V. R.: Experimental hyperplasia of stomach mucosa. Proc. Soc. exp. Biol. (N.Y.) 60, 48 (1945)Google Scholar
  45. Cox, A. J., Jr.: Stomach size and its relation to chronic peptic ulcer. Arch. Path. 54, 407 (1952)Google Scholar
  46. Crean, G. P.: Hyperplasia of the gastric mucosa. In: Non-insulin producing tumors of the pancreas (Demling, L., Ottenjann, R., Eds.). Stuttgart: Thieme 1968Google Scholar
  47. Cummins, A. J.: Zit. in Bockus, H. L.: Gastroenterology. Philadelphia: Saunders 1963Google Scholar
  48. Cummings, G. M., Grossman, M. I., Ivy, A. C.: A study on the time of healing of peptic ulcer in a series of sixty-nine cases of duodenal and gastric craters. Gastroenterology 54, 735 (1968)Google Scholar
  49. Curling, T. B.: On acute ulceration of the duodenum in cases of burn. Trans. med. Soc. Lond. 25, 260 (1842)Google Scholar
  50. Curt, J. R. N., Pringle, R.: Viscosity of gastric mucus in duodenal ulceration. Gut 10, 931 (1969)PubMedCentralPubMedGoogle Scholar
  51. Cushing, H.: Peptic ulcer and the interbrain. Surg. Gynec. Obstet. 55, 1 (1932)Google Scholar
  52. Cutting, W. C., Dodds, E. C., Noble, R. L., Williams, P. C.: Pituitary control of alimentary blood flow and secretion. The effect of posterior pituitary extract on the alimentary secretions in intact animals. Proc. roy. Soc. B 123, 27 (1937)Google Scholar
  53. Danilevski, A. J.: Arb. d. XI. Kongr. russ. Naturf. u. Ärzte, 1901Google Scholar
  54. Davenport, H. W.: Gastric mucosal injury by fatty and acetylic acid. Gastroenterology 46, 245 (1964)PubMedGoogle Scholar
  55. Davenport, H. W.: Is the apparent hyposecretion of acid by patients with gastric ulcer a consequence of a broken barrier to diffusion of hydrogen ions into the gastric mucosa. Gut 6, 513 (1965)PubMedCentralPubMedGoogle Scholar
  56. Davenport, H. W.: Salicylate damage to the gastric mucosal barrier. New Engl. J. Med. 276, 1307 (1967)PubMedGoogle Scholar
  57. Davenport, H. W.: Gastric mucosal hemorrhage in dogs. Effects of acid, aspirin and alcohol. Gastroenterology 56, 439 (1969)PubMedGoogle Scholar
  58. Deelman, H. T.: Zur Morphogenese der Ulkuskrankheit. Ciba Symposium 7, 106 (1959)Google Scholar
  59. Delaney, J. P., Cheng, J. W. B., Butler, B. A., Ritchie, W. R.: Gastric ulcer and regurgitation gastritis. Gut 11, 715 (1970)PubMedCentralPubMedGoogle Scholar
  60. Demling, L.: Eine neue Methode zur Erfassung der arteriellen Durchblutung des menschlichen Magens. Verh. dtsch. Ges. inn. Med. 61, 161 (1955)Google Scholar
  61. Demling, L., Classen, M.: Einfluß gastrointestinaler Hormone auf Säuresekretion und Schleimhautdurchblutung des menschlichen Magens. In: Gregor, O., Riedl, O. (Eds.): Modern Gastroenterology. Stuttgart: Schattauer 1969Google Scholar
  62. Demling, L., Classen, M., Koch, H., Kozu, T.: Duodeno-Jejunoskopie heute. Fortschr. Med. 89, 359 (1971)Google Scholar
  63. Djahanguiri, B., Hemmati, S., Sadeghi, D., Firouzabadi, A.: The prevention of acute gastric ulcer in the rat by α-methyldopa. Med. Pharmacol. Exp. 17, 427 (1967)Google Scholar
  64. Dodds, E. C., Hells, G. M., Noble, R. L., Williams, P. C.: The posterior lobe of the pituitary gland. Its relationship to the stomach and to the blood picture. Lancet 1935 I, 1099Google Scholar
  65. Domschke, W., Domschke, S., Classen, M., Demling, L.: Some properties of mucus in patients with gastric ulcer: the effect of treatment with carbenoxolone sodium. Scand. J. Gastroent. 7, 647 (1972)PubMedGoogle Scholar
  66. Du Plessis, D. J.: Pathogenesis of gastric ulceration. Lancet 1965 I, 974Google Scholar
  67. Dyck, P. W., Werther, J. L., Rudick, J., Janowitz, H. D.: Electrolyte movement across canine antral and fundic gastric mocosa. Gastroenterology 56, 488 (1969)PubMedGoogle Scholar
  68. Ellison, E. H., Abram, J. S., Smith, D. J.: A postmortem analysis of 812 gastroduodenal ulcers found in 20.000 consecutive autopsies with emphasis on associated endocrine diseases. Amer. J. Surg. 97, 17 (1959)PubMedGoogle Scholar
  69. Ellison, E. H., Wilson, S. D.: The Zollinger-Ellison syndrome: reappraisal and evaluation of 260 registered cases. Ann. Surg. 160, 512 (1964)PubMedCentralPubMedGoogle Scholar
  70. Ellison, L. T., Ellison, R. G., Carter, C. H., Daniell, D., Moore, V. A.: Role of hypercapnia and hypoxia in etiology of peptic ulceration in patients with chronic obstructive pulmonary disease. Amer. Rev. resp. Dis. 89, 909 (1964)PubMedGoogle Scholar
  71. Emas, S.: Gastric acid secretion in sympathectomized gastric fistula cats, before and after reserpine treatment and in gastric fistula cats during guanethidine treatment. Acta physiol. scand. 60, 57 (1964)Google Scholar
  72. Emas, S., Grossman, M. I.: Production of duodenal ulcers by infusion of the porcine gastrin. Gastroenterology 52, 959 (1967)Google Scholar
  73. Emery, D. G.: Indomethacin and duodenal ulcer. Brit. med. J. 1967 III, 312Google Scholar
  74. Engel, F. L.: Addison’s disease and peptic ulcer. J. clin. Endocr. 15, 1300 (1955)PubMedGoogle Scholar
  75. Evans, D. A. R.: Genetic factors in the etiology of duodenal ulcer. Gastroenterology 40, 371 (1961)PubMedGoogle Scholar
  76. Fainer, D. C., Halsted, J. A.: Sources of upper alimentary tract hemorrhage in cirrhosis of the liver. J. Amer. med. Ass. 157, 413 (1955)Google Scholar
  77. Fogelman, M. J., Grossman, M. I, Ivy, A. C.: Further studies on the effect of continous intragastric infusion of acid and pepsin. Surgery 25, 60 (1949)PubMedGoogle Scholar
  78. Franco-Browder, S., Masson, G. M. C., Corcoran, A. C: Induction of acute gastric lesions by histamine liberators in rats. J. Allergy 30, 1 (1959)PubMedGoogle Scholar
  79. Friedländer, C: Über die Arteriitis obliterans. Zbl. med. Wiss. 4, 65 (1876)Google Scholar
  80. Friedmann, M. H. F.: The response of different regions of the gastrointestinal tract to normal and abnormal stimuli. J. nat. Cancer Inst. 13, 1035 (1953)Google Scholar
  81. Gear, M. W. L., Truelove, S. C., Whitehead, R.: Gastric ulcer and gastritis. Gut 12, 639 (1971)PubMedCentralPubMedGoogle Scholar
  82. Gensel, E.: Antipepsin als Ursache der Nichtselbstverdauung des Magens. Inaugur. Diss., St. Petersburg 1903; Jahrb. Physiol. 12, 212 (1903)Google Scholar
  83. Gheorghiu, Th.: Klinisch experimentelle Untersuchungen zur Pathogenese des hepatogenen Ulkus. Bedeutung der Sekretionsstörungen der Magen-Mukosasubstanzen. Habilitationsschrift, Köln 1972Google Scholar
  84. Gliedman, M. L., Girardet, R., Karlson, K. E.: Gastroduodenal congestion and the ulcer diathesis. Surgery 58, 638 (1965)Google Scholar
  85. Göksen, Y., Hardy, J. D.: Prevention of steroid ulcerogenesis by vagotomy in dogs. Surg. Gynec. Obstet. 126, 547 (1968)PubMedGoogle Scholar
  86. Gold, N. I., Singleton, E., Macfarlane, D. A., Moore, F. D.: Effects of adrenocorticotropin and complex trauma in the human. J. clin. Invest. 37, 813 (1958)PubMedCentralPubMedGoogle Scholar
  87. Good, R. A., Vernier, R. L., Smith, R. T.: Serious untoward reactions to therapy with cortisone and adrenocorticotropin in pediatric practice. Pediatrics 19, 95 (1957)PubMedGoogle Scholar
  88. Gregory, R. A.: Gastric secretory responses after portal venous ligation. J. Physiol. (Lond.) 144, 123 (1958)Google Scholar
  89. Gregory, R. A., Tracy, H. J., French, J. M., Sircus, W.: Extraction of a gastrin-like substance from a pancreatic tumor in a case of Zollinger-Ellison syndrome. Lancet 1960 I, 1045Google Scholar
  90. Haelzel, F., da Costa, E.: Production of peptic ulcers in rats and mice by diets deficient in protein. Amer. J. dig. Dis. 4, 325 (1937)Google Scholar
  91. Harjola, P. T., Sivula, A.: Gastric ulceration following experimentally induced hypoxia and hemorrhagic shock. In vivo study of pathogenesis in rabbits. Ann. Surg. 163, 21 (1966)PubMedCentralPubMedGoogle Scholar
  92. Hauser, G.: Die peptischen Schädigungen des Magens, Duodenum und der Speiseröhre und das peptische postoperative Jejunalgeschwür. In: Henke, P., Lubarsch, O.: Handbuch der speziellen pathologischen Anatomie und Histologie, Bd. IV, Teil 1. Springer: Berlin 1926Google Scholar
  93. Haverback, B. I., Bogdanski, D. F.: Gastric mucosal erosions in the rat following administration of the serotonin precursor 5-bydroxytryptophan. Proc. Soc. exp. Biol. (N.Y.) 95, 392 (1957)Google Scholar
  94. Hay, L. J., Varco, R. L., Code, D. F.: The experimental production of gastric and duodenal ulcers in laboratory animals by the intramuscular injection of histamine in beeswax. Surg. Gynec. Obstet. 75, 170 (1942)Google Scholar
  95. Himal, H. S., Young, S. B., Rudick, J., Werther, J. L., Janowitz, H. D.: Ionic flux across the duodenal mucosa: effects of varying concentrations of acid. Gastroenterology 58, 959 (1970)Google Scholar
  96. Hoffmann, V.: Das Magen-Zwölfingerdarmgeschwür, wesentlich eine Durchblutungsstörung — kein Ulcus pepticum. Münch. med. Wschr. 104, 1679 (1962)PubMedGoogle Scholar
  97. Hollander, F.: The two-component mucous barrier. Arch. intern. Med. 93, 107 (1954)Google Scholar
  98. Holle, G., Schauer, A., Fellner, K.: On the effect of selective proximal vagotomy on the parietal cells in duodenal and gastric ulcers. Acta hepato-gastroent. 1, 144 (1972)Google Scholar
  99. Hoon, J. R.: Aspirin gastritis examined with intragastric photography. Industr. Med. 38, 52 (1969)Google Scholar
  100. Hunter, J.: Essays and observations on natural history, anatomy, physiology, psychology and geology. London: J. Vavooret 1861Google Scholar
  101. Hurst, A. F., Stewart, M. J.: Gastric and duodenal ulcer. London: Oxford University Press 1929Google Scholar
  102. Ivy, A. C., Grossman, M. I., Bachrach, W. H.: Peptic ulcer. Philadelphia-Toronto: Blakiston & Co. 1950Google Scholar
  103. Ivey, K. J., DenBesten, L., Clifton, J. A.: Effect of bile salts on ionic movement across the human gastric mucosa. Gastroenterology 59, 683 (1970)PubMedGoogle Scholar
  104. Jackson, R. H., Blair, E. L., Dawson, P. J., Reed, J. D., Watts, W. P. T.: Gastrin activity of tumour tissue in a child with the Zollinger Ellison syndrome. Lancet 1963 II, 908Google Scholar
  105. Jacobson, E. D., Linford, R. H., Grossman, M. I.: Gastric secretion in relation to mucosal blood flow studied by a clearance technic. J. clin. Invest. 45, 1 (1966)PubMedCentralPubMedGoogle Scholar
  106. Janowitz, H. D.: Effect of cortisone and corticotropin on healing of gastric ulcer: experimental study. Gastroenterology 34, 11 (1958)PubMedGoogle Scholar
  107. Jenny, M., Träbert, E., Bircher, J. B., Akovbiantz, A.: Das akute postoperative gastroduodenale Stressulkus. Schweiz. med. Wschr. 98, 1507 (1968)PubMedGoogle Scholar
  108. Jonsson, S. O.: Spätresultate von Billroth I. Acta chir. scand. 78 (1936)Google Scholar
  109. Judd, E. S.: Experimental production of peptic ulcers with caffeine. Bull Amer. Coll. Surg. 28, 46 (1943)Google Scholar
  110. Kahn, J. R.: Absence of peptic ulcer in pernicious anemia. Amer. J. med. Sci. 194, 463 (1937)Google Scholar
  111. Kalk, H.: Über die Erblichkeit von Krankheiten des Verdauungskanals. Dtsch. med. Wschr. 2, 1465 (1934)Google Scholar
  112. Katsch, G., Pickert, H.: Die Krankheiten des Magens. In: Handbuch der Inneren Medizin (v. Bergmann, G., Frey, W., Schwiegk, H., Hrsg.) Berlin-Göttingen-Heidelberg: Springer 1953Google Scholar
  113. Katz, D., Siegel, H.: Erosive gastritis and acute gastrointestinal mucosal lesions. In: Progress in gastroenterology, Vol. I (Jerzy-Glass, G. B., Ed.). New York-London: Grune and Stratton 1968Google Scholar
  114. Kawai, K., Takada, H., Masuda, M.: On the genesis of the gastric linear ulcer observed endoscopically. Proc. 1st Congress Int. Soc. Endoscopy, Tokyo 1966Google Scholar
  115. Kawai, K., Murasaki, K., Misaki, P.: Endoscopic observation of the gastric ulcer. Endoscopy 1, 97 (1969)Google Scholar
  116. Keller, A. D.: Ulceration of the digestive tract of the dog following intracranial procedures: preliminary study. Arch. Path. 1, 165 (1936)Google Scholar
  117. Keller, R. J., Wolf, B. S., Khilnani, M. T.: Roentgen features of healing and healed benign gastric ulcers. Radiology 97, 353 (1970)PubMedGoogle Scholar
  118. Kern, F., Lukens, J. G., Clark, G. M.: Peptic ulceration occuring during therapy for rheumatoid arthritis. Gastroenterology 33, 25 (1958)Google Scholar
  119. Kim, Y. S., Kerr, R., Lipkin, M.: Cell proliferation during the development of stress erosion in mouse stomach. Nature (Lond.) 213, 1180 (1967)Google Scholar
  120. Kimura, K., Takemoto, An endoscopic recognition of the atrophic border and its significance in chronic gastritis. Endoscopy 1, 87 (1969)Google Scholar
  121. Kirksey, C. T., Moncrief, J. A., Pruitt, B. A., O’Neill, J. A.: Gastrointestinal complications in burns. Amer. J. Surg. 116, 627 (1968)PubMedGoogle Scholar
  122. Kirsh, I. E., Brendel, T.: Importance of giant duodenal ulcer. Radiology 91, 14 (1968)PubMedGoogle Scholar
  123. Kirsner, J. B,: Hormones and peptic ulcer. Bull. N.Y. Acad. Med. 29, 477 (1953)PubMedCentralPubMedGoogle Scholar
  124. Kirsner, J. B., Ford, H.: Phenylbutazone studies on the stimulation of gastric secretion and the formation of peptic ulcer in man. Gastroenterology 29, 1 (1955)PubMedGoogle Scholar
  125. Kirsner, J. B.: Peptic ulcer. Gastroenterology 54, 611 (1968)PubMedGoogle Scholar
  126. Kleitsch, W. P.: Fatal gastric hemorrhage following aureomycin. Amer. J. dig. Dis. 18, 166 (1951)PubMedGoogle Scholar
  127. Koch, E.: Mukoviszidose und Ulcus pepticum. In: Koch, E., Bohn, H., Koch, F.: Mucoviscidosis. Zystische Pankreasfibrose. Stuttgart: Schattauer 1964Google Scholar
  128. Köster, K. H., Sindrup, E., Seele, V.: ABO blood group and gastric acidity. Lancet 1955 II, 52Google Scholar
  129. Konjetzny, G. E.: Die Entzündungen des Magens. In: Henke, P., Lubarsch, O.: Handbuch der speziellen pathologischen Anatomie und Histologie. Springer Berlin: 1928Google Scholar
  130. Konjetzny, G. E.: Die Geschwürsbildung im Magen, Duodenum und Jejunum. Stuttgart: F. Enke 1947Google Scholar
  131. Konturek, S. J., Dubiel, J., Gabrys, B.: Effect of exclusion, acidification and excision of the duodenum on gastric secretion and the production of pentagastrin-induced peptic ulcers in cats. Gastroenterology 56, 703 (1969)Google Scholar
  132. Konturek, S. J., Solomon, T. E., McCreight, W. G., Johnson, L. R., Jacobson, E. D.: Effects of nicotine on gastrointestinal secretions. Gastroenterology 60, 1098 (1971)PubMedGoogle Scholar
  133. Kroeker, E. J.: Pulmonary emphysema and peptic ulcer. Med. Clin. N. Amer. 50, 479 (1966)PubMedGoogle Scholar
  134. Kronberger, L.: Über pH-Veränderungen im Duodenum nach einem sauren Probetrunk beim Gesunden und beim Ulkuskranken. Med. Klin. 59, 1934 (1964)PubMedGoogle Scholar
  135. Kuiper, D. H., Overholt, B. F., Fall, D. J., Pollard, H. M.: Gastroscopic findings and fecal blood loss following aspirin administration. Amer. J. dig. Dis. 14, 761 (1969)PubMedGoogle Scholar
  136. Kyle, J., Welbourn, R. B., Nevin, H. O.: The effect of histamine on gastric secretion and ulceration in the pylorus-ligated rat. Gastroenterology 30, 593 (1956)PubMedGoogle Scholar
  137. Lambert, R., Truchot, R., Andre, C., Chayvialle, J. A.: A histological study of glycoproteins in the gastric mucosa of restrained rats. In: Peptic ulcer (Pfeiffer, C. J., Ed.). Copenhagen: Munksgaard 1971Google Scholar
  138. Langman, M. J. S., Doll, R.: AB0 blood group and secretor status in relation to clinical characteristics of peptic ulcers. Gut 6, 270 (1965)PubMedCentralPubMedGoogle Scholar
  139. Lebedinskaja, S.: Über die Magensekretion bei Eckschen Fistelhunden. Z. ges. exp. Med. 88, 264 (1933)Google Scholar
  140. Lie, T. S.: Steroid ulcers: their pathogenesis, incidence, localization and sex distribution. Zbl. Chir. 93, 306 (1968)PubMedGoogle Scholar
  141. Litthauer, M.: Experimentelle Untersuchungen zur Pathogenese des runden Magengeschwürs. Virchows Arch. path. Anat. 195, 317 (1909)Google Scholar
  142. Lorenz, W., Feifel, G.: Neue Gesichtspunkte zur Pathogenese des Stress- und Steroidulkus. Dtsch. med. Wschr. 95, 1848 (1970)PubMedGoogle Scholar
  143. Lovgren, O., Allander, E.: Indomethacin and peptic ulcer. Brit. med. J. 1965 I, 996Google Scholar
  144. Lumsden, K., Mac Larnon, J. C., Dawson, J.: Giant duodenal ulcer. Gut 11, 592 (1970)PubMedCentralPubMedGoogle Scholar
  145. Lynch, T. A., Highley, W. L., Worton, A. G.: Pantothenyl alcohol effect on delta-1-cortisol induced gastric ulcers. J. pharm. Sci. 51, 529 (1962)PubMedGoogle Scholar
  146. Makishima, K.: Beitrag zur Erkenntnis der Ulkusentstehungspathogenese. Über zwei interessante Fälle von Magengeschwür. Langenbecks Arch. klin. Chir. 187, 87 (1937)Google Scholar
  147. Mangold, R.: Combined gastric and duodenal ulceration. Brit. med. J. 1958 IV, 1193Google Scholar
  148. Mann, F. C., Williamson, C. S.: The experimental production of peptic ulcer. Ann. Surg. 77, 409 (1923)PubMedCentralPubMedGoogle Scholar
  149. Maranon, G., Sala, P., Arguelles, G.: Digestive symptoms in chronic suprarenal insufficiency. Endocrinology 18, 492 (1934)Google Scholar
  150. Marshak, R. H., Yarnis, H., Friedman, A. I.: Giant benign gastric ulcers. Gastroenterology 24, 339 (1953)PubMedGoogle Scholar
  151. Menguy, R. B.: Die Ätiologie des Zwölffingerdarmgeschwürs. Münch. med. Wschr. 106, 575 (1964)PubMedGoogle Scholar
  152. Miederer, S. E., Paul, F., Stadelmann, O., Deyhle, P., Ottenjann, R.: Pyloro-kardiale Expansion der Gastritis? Endoscopy 1, 170 (1969)Google Scholar
  153. Mitchell, R. G., Code, C. F.: Urinary excretion of histamine after administration of cortisone. J. clin. Endocr. 14, 707 (1959)Google Scholar
  154. Moore, F. D.: Metabolic care of the surgical patient. Philadelphia: Saunders Co. 1959Google Scholar
  155. Muir, A., Cossar, I. A.: Aspirin and ulcer. Brit. med. J. 1955 II, 7Google Scholar
  156. Myers, R. T., Bhatti, A.: Peptic ulcer and parathyroid adenoma. Ann. Surg. 171, 647 (1970)PubMedCentralPubMedGoogle Scholar
  157. Nedzel, A. J.: Experimental gastric ulcer (pitressin episodes). Arch. Path. 26, 988 (1938)Google Scholar
  158. Niwayama, G., Terplan, K.: A study of peptic ulcer based on necroscopy records. Gastroenterology 36, 409 (1959)PubMedGoogle Scholar
  159. Oi, M., Oshida, K., Sugimura, S.: The location of gastric ulcer. Gastroenterology 36, 45 (1959)PubMedGoogle Scholar
  160. Oi, M., Oshida, K.: The association of esophageal, gastric and duodenal ulcers. Gastroenterology 36, 57 (1959)PubMedGoogle Scholar
  161. Oi, M., Sakurai, Y.: The location of duodenal ulcer. Gastroenterology 36, 60 (1959)PubMedGoogle Scholar
  162. Oi, M., Ito, Y., Kumagai, F., Yoshida, K., Tanaka, Y., Yoshikawa, K., Miho, O., Kijima, M.: A possible dual control mechanism in the origin of peptic ulcer. A study on ulcer location as affected by mucosa and musculature. Gastroenterology 57, 280 (1969)PubMedGoogle Scholar
  163. Okabe, S., Pfeiffer, C. J.: The acetic acid ulcer model — a procedure for chronic duodenal or gastric ulcer. In: Pfeiffer, C. J. (Ed.): Peptic ulcer, p. 13, Copenhagen: Munksgaard 1971.Google Scholar
  164. Okabe, S., Pfeiffer, C. J., Roth, J. L.: Experimental production of duodenal and antral ulcers in rats. Fed. Proc. 29, 255 (1970)Google Scholar
  165. Ottenjann, R.: Hyperkalzämie und Magensekretion. Dtsch. med. Wschr. 95, 2620 (1970)PubMedGoogle Scholar
  166. Ottenjann, R., Bartelheimer, W., Beck, K., Kanzler, G., Rösch, W., Elster, K.: Die blinde Aspirationsbiopsie der Magenschleimhaut. Dtsch. med. Wschr. 97, 221 (1972)PubMedGoogle Scholar
  167. Overholt, B. F., Pollard, M.: Acid diffusion into the humen gastric mucosa. Gastroenterology 54, 182 (1968)PubMedGoogle Scholar
  168. Pain, A. K.: Acute gastritis ulceration associated with drug therapy. Brit. med. J. 1967 I, 634Google Scholar
  169. Palmer, W. L., Nutter, P. B.: Peptic ulcer and achlorhydria. A further study of the role of acid gastric juice in the pathogenesis of peptic ulcer. Arch. intern. Med. 65, 499 (1940)Google Scholar
  170. Passaro, E., Basso, N.: New clinical tests in the Zollinger-Ellison syndrome. Surgery in Italy 2, 7 (1972)Google Scholar
  171. Payr, E.: Experimente über Magenveränderungen als Folge von Thrombose und Embolie im Pfortadergebiet. Langenbecks Arch. klin. Chir. 84, 799 (1870)Google Scholar
  172. Petersen, M.: Geschwürsentstehung im Magen bei chronischem Säuremangel. In Festschrift Katsch, Greifswald 1952Google Scholar
  173. Polacek, M. A., Ellison, E. H.: Parietal cell mass and gastric acid secretion in the Zollinger-Ellison syndrome. Surgery 60, 606 (1966)PubMedGoogle Scholar
  174. Porter, R. W., Movius, H. J., French, J. D.: Hypothalamic influence on hydrochloric acid secretion of the stomach. Surgery 33, 875 (1953)PubMedGoogle Scholar
  175. Portis, S. A., Jaffe, R. H.: A study of peptic ulcer based on necropsy records. J. Amer. med. Ass. 110, 6 (1938)Google Scholar
  176. Quincke, H.: Über die Entstehung des Magengeschwürs. Dtsch. med. Wschr. 8, 79 (1882)Google Scholar
  177. Rhodes, J., Barnado, D., Phillips, S., Rovelstad, R., Hofmann, A.: Increased reflux of bile into the stomach in patients with gastric ulcer. Gastroenterology 57, 241 (1969)PubMedGoogle Scholar
  178. Rider, J. A., Moeller, H. C., Gibbs, J. D.: The effect of reserpine on gastric secretion and its possible site of action. Gastroenterology 33, 737 (1957)PubMedGoogle Scholar
  179. Ritchie, W., Delaney, J.: Gastric ulcer: an experimental model. Surg. Forum 19, 312 (1968)PubMedGoogle Scholar
  180. Ritchie, W., Cheng, J. W. B., Delaney, J.: Changes in parietal and chief cell population following vagotomy and antrectomy. Surg. Forum 20, 319 (1969)PubMedGoogle Scholar
  181. Robert, A.: Duodenal ulcers in the rat: production and prevention. In: Peptic ulcer (Pfeiffer, C. J., Ed.). Copenhagen: Munksgaard 1971Google Scholar
  182. Robert, A., Nezamis, J. E.: Effect of prednisolone on gastric mucus content and on ulcer formation. Proc. Soc. exper. Biol. (N.Y.) 114, 545 (1963)Google Scholar
  183. Roberts, J. A. F.: ABO blood group and duodenal ulcer. Brit. med. J. 1957 I, 758Google Scholar
  184. Rösch, W., Schaudig, H., Elster, K., Demling, L.: Bioptische Untersuchungen zur Frage der Ulkusnarbe. Endoscopy 3, 129 (1971)Google Scholar
  185. Rokitansky, C.: A manual of pathological anatomy. Sydenham Soc. London 2, 22 (1849)Google Scholar
  186. Rosenberg, A.: Production of gastric lesions in rats by combined cold and electrostress. Amer. J. dig. Dis. 12, 1140 (1967)PubMedGoogle Scholar
  187. Roth, J. L. A., Ivy, A. C.: Experimental production of acute and subacute gastric ulcers in cats by intramuscular injection of caffeine in beeswax. Gastroenterology 2, 274 (1944)Google Scholar
  188. Roth, J. L. A., Nast, P. R., Vilardell, F.: Prevention and management of iatrogenic gastroduodenal ulcer. Postgrad. Med. 32, 442 (1962)PubMedGoogle Scholar
  189. Roth, J. L. A.: Role of drugs in production of gastroduodenal ulcer. J. Amer. med. Ass. 187, 122 (1964)Google Scholar
  190. Rowntree, L. C., Snüll, A.: Clinical study of Addison’s disease. Philadelphia: W. B. Saunders 1931Google Scholar
  191. Saegesser, M.: Zur Pathogenese des Ulcus ventriculi. Wien. klin. Wschr. 65, 7 (1953)PubMedGoogle Scholar
  192. Sandweiss, D. J., Saltzstein, H. C., Farbman, A. A.: The relation of sex hormones to peptic ulcer. Amer. J. dig. Dis. 6, 6 (1939)Google Scholar
  193. Sawrey, W. L.: Conditioned responses of fear in relationship to ulceration. J. comp, physiol. Psychol. 54, 347 (1961)Google Scholar
  194. Schade, R. O. K.: The morbid anatomy of peptic ulceration. Schweiz. Z. Path. 21, 372 (1958)Google Scholar
  195. Schellerer, W.: The role of mucosal blood flow in the pathogenesis of stress ulcers. Acta hepato-gastroent. 21, 138 (1974)Google Scholar
  196. Schimert, W.: Die Wirkung des Nikotins auf die Durchblutung des Magens. Klin. Wschr. 257 (1944)Google Scholar
  197. Schrager, J.: Sulphated mucopolysaccharides of the gastric secretion. Nature (Lond.) 201, 702 (1964)Google Scholar
  198. Schrager, J., Spink, R., Mitra, S.: The antrum in patients with duodenal and gastric ulcers. Gut 8, 497 (1967)PubMedCentralPubMedGoogle Scholar
  199. Schwartz, J. C.: Gastric histamine in the pathogenesis of experimental ulcer. In: Peptic ulcer (Pfeiffer, C. J., Ed.). Copenhagen: Munksgaard 1971Google Scholar
  200. Seley, H.: Einführung in die Lehre vom Adaptationssyndrom. Stuttgart: Thieme 1953Google Scholar
  201. Seronde, J., Jr.: The pathogenesis of duodenal ulcer disease in the pantothenate deficient rat. Yale J. Biol. Med. 36, 141 (1963)PubMedCentralPubMedGoogle Scholar
  202. Sevitt, S.: Duodenal and gastric ulceration after burning. Brit. J. Surg. 54, 32 (1967)PubMedGoogle Scholar
  203. Shay, H., Komarov, S. A., Fels, S. S., Meranze, D., Gruenstein, M., Siplet, H.: A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 5, 43 (1945)Google Scholar
  204. Shay, H., Gruenstein, M., Siplet, H., Komarov, S. A.: Protection of gastric mucosa of the rat against ulceration by prefeeding with protein hydrolysates. Proc. Soc. exp. Biol. (N.Y.) 69, 369 (1948)Google Scholar
  205. Sievers, M. L.: Hereditary aspects of gastric functions. Amer. J. Med. 27, 246 (1959)PubMedGoogle Scholar
  206. Skillman, J. J., Bushnell, L. S., Goldman, H.: Respiratory failure, hypotension, sepsis and jaundice: a clinical syndrome assoziated with lethal hemorrhage from acute stress ulceration of the stomach. Amer. J. Surg. 117, 532 (1969)Google Scholar
  207. Smith, A. W., Delamore, J. W., Williams, A. W.: Gastric acid secretions and mucosal appearances in Addison’s disease and hypopituitarism. Gut 2, 163 (1961)PubMedCentralPubMedGoogle Scholar
  208. Smith, V. M., Babb, R. R.: Azetylsalizylsäure: Ursache akuter Gastrointestinalblutung? Fortschr. Med. 87, 1153 (1969)Google Scholar
  209. Spang, K.: Das Altersulkus des Magens und Zwölffingerdarms. Klinik und Pathogenese. Dtsch. med. Wschr. 72, 605 (1947)PubMedGoogle Scholar
  210. Sparberg, M.: Addison’s disease and peptic ulcer. Gastroenterology 53, 450 (1967)Google Scholar
  211. Stadelmann, O., Elster, K., Stolte, M., Miederer, S. E., Deyhle, P., Demling, L., Siegenthaler, W.: The peptic ulcer — histotopographic and functional investigations. Scand. J. Gastroent. 6, 613 (1971)PubMedGoogle Scholar
  212. Stempien, S. J., Dagradi, A.: The histamine response of gastric mucosa in a patient with adrenal insufficiency. Effect of cortisone administration. Gastroenterology 27, 358 (1954)PubMedGoogle Scholar
  213. Störck, O.: Über Nervenveränderungen im Narbenbereich des Ulcus pepticum. Wien. klin. Wschr. 34, 109 (1921)Google Scholar
  214. Storage, R.: Effects of portacaval shunt on gastric secretion in cirrhotic dogs. Chir. Pat. sper. 13, 178 (1965)Google Scholar
  215. Strickland, R. G., Fisher, J. M., Taylor, K. B.: Effect of prednisolone on gastric function and structure in man. Gastroenterology 56, 675 (1969)PubMedGoogle Scholar
  216. Sun, D. C. H., Stempien, S.J.: Site and size of the ulcer as determinants of outcome. Gastroenterology 61, 576 (1971)PubMedGoogle Scholar
  217. Sutherland, E. W., Robinson, G. A., Butcher, R. W.: Some aspects of the biological role of adenosine 3′, 5′-monophosphate (cyclic AMP). Circulation 37, 279 (1968)Google Scholar
  218. Tafurt, C.: Zur Häufigkeit des Ulcus pepticum beim endogenen Hypercortisolismus. Endokrinologie 52, 8 (1967)PubMedGoogle Scholar
  219. Takagi, K., Okabe, S., Saziki, R.: A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on healing. Jap. J. Pharmacol. 19, 418 (1970)Google Scholar
  220. Taylor, R. T., Huskisson, E. C., Whitehouse, G. H., Hart, F. D., Trapnell, D. H.: Gastric ulceration occuring during indomethacin therapy. Brit. med. J. 1968 IV, 734Google Scholar
  221. Taylor, R. T., Huskisson, E. C., Whitehouse, G. H., Hart, F. D.: Indomethacin therapy. Brit. med. J. 1969 II, 53Google Scholar
  222. Teorell, T.: On the permeability of the stomach mucosa for acid and some other substances. J. gen. Physiol. 23, 263 (1939)PubMedCentralPubMedGoogle Scholar
  223. Thompson, H.: An investigation into the postmortem incidence of peptic ulcers and erosions. Glasg. med. J. 35, 326 (1954)Google Scholar
  224. Thompson, J. H., Angulo, M.: Chronic effects of nicotine on rat gastric secretion. Experientia (Basel) 26, 615 (1970)Google Scholar
  225. Tokoro, Y.: The correlation of gastro-duodenal ulcers. Acta path. jap. 7, 253 (1957)Google Scholar
  226. Trudeau, W. L., McGuigan, J. E.: Relations between serum gastrin levels and rates of hydrochloric acid secretion. New Engl. J. Med. 284, 408 (1971)PubMedGoogle Scholar
  227. Truelove, S. C., Reynell, P. C.: Diseases of digestive system. Oxford-London-Edinburg: Blackwell 1972Google Scholar
  228. Uebelhart, R.: Ulkuskrankheit und Leberschaden. Schweiz. med. Wschr. 87, 1325 (1957)PubMedGoogle Scholar
  229. van Wagoner, H., Churchill, T. P.: Production of gastric and duodenal ulcers in experimental cinchophen poisoning of dogs. Arch. Path. 14, 860 (1932)Google Scholar
  230. Verschuer, O. v.: Erbpathologie. Genetik des Menschen. München-Berlin: Urban und Schwarzenberg 1959Google Scholar
  231. Virchow, R.: Historisches, Kritisches und Positives zur Lehre der Unterleibsaffektionen. Virchows Arch. path. Anat. 5, 281 (1853)Google Scholar
  232. Vojtisek, V., Jelinek, V., Chlumska, A.: Experimental gastroduodenal ulcer. Amer. J. Surg. 121, 650 (1971)PubMedGoogle Scholar
  233. Wanke, M.: Der Einbau von Blutgefäßen in die Wand des menschlichen Magens. Z. Zellforsch. 50, 78 (1959)Google Scholar
  234. Wanke, M., Geiger, V., Bokelmann, D.: Pathologisch-anatomische Befunde an Leber und Pankreas bei Erkrankungen des Gallengangsystems. Med. Welt 20, 765 (1969)Google Scholar
  235. Wanke, M.: Magen. In: Spezielle pathologische Anatomie (Doerr, W., Seifert, G., Ühlinger, E., Hrsg.). Berlin-Heidelberg-New York: Springer 1971Google Scholar
  236. Washburn, R. N., Rosendaal, H. M.: Gastric lesions associated with pernicious anemia. Ann. intern. Med. 11, 2172 (1937)Google Scholar
  237. Watson, C. G., Moseley, R. V., Wheeler, H. B.: Perforated jejunal ulcer and Zollinger Ellison syndrome. Arch. Surg. 96, 274 (1968)PubMedGoogle Scholar
  238. Weigel, A. E., Artz, C. P., Reiss, E., Davis, J. H., Amspacher, W. H.: Gastrointestinal ulcerations complicating burns. A report of five cases and a review of 17 cases. Surgery 34, 826 (1953)PubMedGoogle Scholar
  239. Weitz, W.: Studien an eineiigen Zwillingen. Z. klin. Med. 101, 115 (1924)Google Scholar
  240. Wermer, P.: Genetic aspects of adenomatosis of endocrine glands. Amer. J. Med. 16, 363 (1954)PubMedGoogle Scholar
  241. Werner, J., Hoff, H. E.: The neuro-humoral aspects of peptic ulcer formation. Canad. med. Ass. J. 59, 115 (1948)Google Scholar
  242. Wilhelmi, G.: Über die ulzerogene Wirkung von 5-Hydroxytryptamin am Rattenmagen und deren Beeinflussung durch verschiedene Pharmaka. Helv. physiol. pharmacol. Acta 15, 83 (1957)Google Scholar
  243. Wilson, T. R.: Monthly variations in the severity of experimental stress ulcers in rats. In: Peptic ulcers (Pfeiffer, C. J., Ed.). Copenhagen: Munksgaard 1971Google Scholar
  244. Wissmer, B.: Le traitment de l’ulcer gastrique par l’acide pantothenique. Gastroenterology 94, 366 (1960)Google Scholar
  245. Wofford, J. D., Cummins, A.: Hemorrhage from duodenal ulcer during the administration of reserpine. New Engl. J. Med. 255, 1193 (1956)PubMedGoogle Scholar
  246. Woldman, E. E.: Acute ulcers of upper gastrointestinal tract: their relation to stress and adrenal damage. J. Amer. med. Ass. 149, 984 (1952)Google Scholar
  247. Zittel, R. X., Weynand, H., Weynand, F.: Zur Bedeutung pathologischer Leberbefunde beim Magen-Duodenal-Ulkus und beim Ulcus pepticum jejuni. Dtsch. med. Wschr. 92, 791 (1967)PubMedGoogle Scholar
  248. Zollinger, R. M., Grant, G. N.: Ulcerogenic tumor of the pancreas. J. Amer. med. Ass. 190, 181 (1964)Google Scholar
  249. Zucker, T. F.: Pantothenate deficiency in rats. Proc. Animal care Panel 7, 193 (1957)Google Scholar

III. Klinik des unkomplizierten chronischen peptischen Geschwürs

  1. Ackerman, L. V., Regato, J. A.: Diagnosis, treatment and prognosis. St. Louis: Mosby 1962Google Scholar
  2. Adamczyk, B., Durek, K.: A study of the serum protein fractions in patients with gastric ulcers. Pol. Przegl. chir. 48, 553 (1968)Google Scholar
  3. Andersson, H., Dotevall, G., Lingaas, H., Walan, A.: Correlation between radiological findings in the stomach and duodenum and gastric acid secretion in patients with peptic ulcer disease. Scand. J. Gastroent. 5, 123 (1970)PubMedGoogle Scholar
  4. Aoyagi T., Summerskill, W. H. J.: Gastric secretion with ulcerogenic islet cell tumor. Arch. intern. Med. 117, 667 (1966)PubMedGoogle Scholar
  5. Baron, H. J.: Studies of basal and peak acid output with an augmented histamine test. Gut 4, 136 (1963)PubMedCentralPubMedGoogle Scholar
  6. Barreras, R. F., Donaldson, R. M.: Role of gastric hypersecretion, parathyroid adenoma in peptic ulcer. New Engl. J. Med. 276, 1122 (1967)PubMedGoogle Scholar
  7. Beger, H. G., Meyes, M., Witte, C., Kraas, E.: The effect of the liver on the gastric secretion. Acta hepato-gastroent. 19, 2 (1972)Google Scholar
  8. Boller, R.: Methods and results in treatment of gastric and duodenal ulcer in Austria. Proc. World Congress Gastroenterol. Baltimore: Williams and Wilkins 1959Google Scholar
  9. Byrnes, D. J., Young, J. D., Chisholm, D. J., Lazarus, L.: Serum gastrin in patients with peptic ulceration. Brit. med. J. 1970 II, 626Google Scholar
  10. Chapman, B. L., Duggan, J. M.: Environmental factors and the Australian gastric ulcer change. Med. J. Aust. 1, 1179 (1969)PubMedGoogle Scholar
  11. Clemencon, G.: Gastroscopic morphology of benign gastric ulcer. Endoscopy 2, 201 (1970)Google Scholar
  12. Cocking, J. B., Mac Caig, J. N.: Fibergastroscopy and x-rays in the study of healing ulcers. A symposium on carbenoxolone sodium. London: Butterworth 1968Google Scholar
  13. Coddington, R. D.: Peptic ulcer in children. Psychosomatics 9, 38 (1968)PubMedGoogle Scholar
  14. Cohen, N. N., Hughes, R. W., Manfredo, H. E.: Experience with 1000 fibergastroscopic examinations of the stomach. Amer. J. dig. Dis. 11, 943 (1966)PubMedGoogle Scholar
  15. Demling, L., Ottenjann, R., Gebhardt, H.: Pankreas und peptisches Geschwür. Gastroenterologia (Basel) 102, 129 (1964)Google Scholar
  16. Demling, L.: Der kranke Magen. München-Berlin-Wien: Urban und Schwarzenberg 1970Google Scholar
  17. Doll, R., A very-Jones, F., Buckatsch, M.: Occupational factors in the etiology of gastric and duodenal ulcers. Spec. Rep. Ser. med. Res. Coun. (Lond.) 276 (1951)Google Scholar
  18. Dragstedt, L. R., Lawson, L. J.: Measurement of fasting gastric secretion. Arch. Surg. 88, 287 (1964)PubMedGoogle Scholar
  19. Dragstedt, L. R., Lulu, D. J., Riley, W. J., Lawson, L. J.: Cephalic hypersecreting primary gastric ulcer patients. Arch. Surg. 102, 462 (1971)PubMedGoogle Scholar
  20. Dunn, J. P., Etter, L. E.: Inadequacy of the medical history in the diagnosis of duodenal ulcer. New Engl. J. Med. 206, 72 (1962)Google Scholar
  21. Dvorsky, A.: Indirekte Bulboskopie mit dem Standardtyp des gastroduodenalen Fibroskops (ACMI) in der Diagnostik des Ulcus bulbi duodeni. Endoscopy 1, 54 (1969)Google Scholar
  22. Ellison, E. H., Wilson, S. D.: Zollinger-Ellison syndrome: reappraisal and evaluation of 260 registered cases. Ann. Surg. 160, 512 (1964)PubMedCentralPubMedGoogle Scholar
  23. Elster, K., Kudlich, W.: Die diagnostische Effektivität der Gastrobiopsie. Endoscopy 3, 126 (1971)Google Scholar
  24. Eusterman, G. B., Balfour, D. C: The stomach and duodenum. Philadelphia: W. B Saunders 1935Google Scholar
  25. Evans, R. W.: Histological appearances of tumors. Edinbourgh-London: Livingstone 1956Google Scholar
  26. Fabra, O. A.: Peptic ulcers in childhood and adolescence. Rev. esp. Enferm. Apar. dig. 27, 1147 (1968)PubMedGoogle Scholar
  27. Farman, J., Cywes, S., Werbeloff, L.: Pyloric mucosal diaphragm. Clin. Radiol. 19, 95 (1968)PubMedGoogle Scholar
  28. Findley, J. W.: Ulcers of the greater curvature of the stomach. Gastroenterology 40, 183 (1961)PubMedGoogle Scholar
  29. Friedman, A. I.: Peptic ulcer in the elderly. Gastroenterology 31, 15 (1959)Google Scholar
  30. Frühmorgen, P., Classen, M., Hermanek, P., Demling, L.: Diagnostik des Magenfrühkarzinoms mit Glasfiberendoskopen. Dtsch. med. Wschr. 97, 1443 (1972)PubMedGoogle Scholar
  31. Frühmorgen, P., Jenny, S., Classen, M., Bauerle, H., Koch, H.: Anamnese bei Ulkus und Narben im Bulbus duodeni. Dtsch. med. Wschr. 97, 188 (1972)PubMedGoogle Scholar
  32. Fruin, R. C: Gastroscopy. Gastroenterology 61, 632 (1971)PubMedGoogle Scholar
  33. Gabrielsson, N.: Benign and malignant gastric ulcers. Evaluation of the differential diagnostics in roentgen examination and endoscopy. Endoscopy 4, 73 (1972)Google Scholar
  34. Garrett, J. M., Summerskill, W. H. J., Code, C. F.: Antral motility in gastric ulcer. Amer. J. Dig. Dis. 11, 780 (1966)PubMedGoogle Scholar
  35. Garrido-Klinge, G., Pena, L.: The gastroduodenal ulcer in high altitudes (Peruvian Andes). Gastroenterology 37, 390 (1959)Google Scholar
  36. Gear, M. W. L., Truelove, S. C., Gwyn Williams, D., Massarella, G. R., Boddington, M. M.: Gastric cancer simulating benign gastric ulcer. Brit. J. Surg. 56, 739 (1969)PubMedGoogle Scholar
  37. Gear, M. W. L., Dowling, B. L.: Suture-line ulcer after gastric surgery caused by non-absorbable suture material. Brit. J. Surg. 57, 356 (1970)PubMedGoogle Scholar
  38. Glickman, M. G., Szemes, G., Loeb, P., Margulis, A. R.: Peptic ulcer of the pyloric region. Radiology 113, 147 (1971)Google Scholar
  39. Gregory, R. A., Tracy, H. J., French, J. M., Sircus, W.: Extraction of gastrin-like substance from pancreatic tumour in case of Zollinger-Ellison syndrome. Lancet 1960 I, 1045Google Scholar
  40. Gülzow, M., Koelsch, K., Kuntzen, H.: Gastroenterologie. Jena: Fischer 1969Google Scholar
  41. Gutmann, R. A.: De quelques signes radiologiques du cancer gastrique au debut: la niche en plateau. Bull. Soc. radiol. med. France 21, 347 (1933)Google Scholar
  42. Hafter, E.: Ist der periodische Verlauf des gastroduodenalen Ulkus saisongebunden? Gastroenterologia (Basel) 89, 51 (1958)Google Scholar
  43. Hafter, E.: Der operierte Magen. Dtsch. med. Wschr. 88, 937 (1963)PubMedGoogle Scholar
  44. Hafter, E.: Klinische Gastroenterologie, 4. Aufl. Stuttgart: Thieme 1970Google Scholar
  45. Halter, F., Smith, G. M.: The biological assay of gastrin. Acta hepato-gastroent. 19, 25 (1972)Google Scholar
  46. Hassan, M. A., Hobsley, M.: The accurate assessment of maximal gastric secretion in control subjects and patients with duodenal ulcer. Brit. J. Surg. 58, 171 (1971)PubMedGoogle Scholar
  47. Hauser, G.: Das chronische Magengeschwür. Leipzig: J. B. Hirschfeld 1883Google Scholar
  48. Hazzi, C. G., Lindner, A. E., Marshak, B. H.: The healing of malignant ulcer. Amer. J. Gastroent. 56, 252 (1971)PubMedGoogle Scholar
  49. Henning, N., Witte, S.: Atlas of gastrointestinal cytodiagnosis. Stuttgart: Thieme 1970Google Scholar
  50. Hirschowitz, B. J., Curties, L. E., Peters, C. W., Pollard, H. M.: Demonstration of a gastroscope “the fiberscope”. Gastroenterology 35, 50 (1958)PubMedGoogle Scholar
  51. Horner, B. A., Scudamore, H. H., Winkelmann, R. K.: Duodenal and gastric ulcers in systemic scleroderma. Amer. J. Gastroent. 43, 195 (1965)PubMedGoogle Scholar
  52. Howard, J. E., Follis, R. H., Yendt, E. R., Connor, T. B.: Hyperparathyroidism. J. clin. Endocr. 13, 997 (1953)PubMedGoogle Scholar
  53. Isenberg, J. I., Spector, H., Hootkin, L. A., Pitcher, J. L.: An apparent exception to Schwarz’s dictum, “no acid — no ulcer”. New Engl. J. Med. 286, 620 (1971)Google Scholar
  54. Jablonska, M., Souckova, E., Skop, V., Stamidis, L.: Relation between antral motility and maximal stimulated gastric secretion in patients with gastroduodenal ulcers. Shorn, lék. 70, 301 (1968)Google Scholar
  55. Jahn, D.: Das Krankheitsbild des hepatogenen Ulkus. Dtsch. med. Wschr. 74, 229 (1949)Google Scholar
  56. Jenny, S., Frühmorgen, P., Classen, M., Bauerle, H., Demling, L.: Endoskopischradiologische Diagnostik des Bulbus duodeni. Dtsch. med. Wschr. 97, 118 (1972)PubMedGoogle Scholar
  57. Jones, F. A.: Epidemiology of peptic ulcer in Great Britain with special reference to smoking. Proc. World Congress Gastroent. Baltimore: Williams and Wilkins 1959Google Scholar
  58. Jordan, S. M.: Peptic ulcer in the United States of America. Proc. World Congress Gastroenterol. Baltimore: Williams and Wilkins 1959Google Scholar
  59. Kaess, H.: Persönliche Mitteilung 1971Google Scholar
  60. Kalk, H.: Einige Beobachtungen über kriegsbedingte Veränderungen am Verdauungskanal und Kreislauf. Dtsch. Arch. klin. Med. 193, 363 (1943)Google Scholar
  61. Kawai, K., Murakami, K., Misaki, F.: Endoscopical observation of the gastric ulcer. Endoscopy 1, 98 (1969)Google Scholar
  62. Kawai, K., Murakami, K., Misaki, F.: Endoscopical observation on gastric ulcers in teenagers. Endoscopy 2, 206 (1970)Google Scholar
  63. Kay, A. W.: Effect of large doses of histamine on gastric secretion of HCl. Brit. med. J. 1953 II, 77Google Scholar
  64. Kaye, M. D., Rhodes, J., Beck, P.: Gastric secretion in duodenal ulcer with particular reference to the diagnosis of Zollinger-Ellison-syndrome. Gastroenterology 58, 476 (1970)PubMedGoogle Scholar
  65. Keller, R. J., Wolf, B. S., Khilnani, M. T.: Roentgen features of healing and healed benign gastric ulcers. Radiology 97, 353 (1970)PubMedGoogle Scholar
  66. Kinzlmeier, H., Demling, L., Mannuss, E.: Über die Säuretopik der menschlichen Magenschleimhaut. Z. ges. inn. Med. 7, 516 (1952)PubMedGoogle Scholar
  67. Kirsh, I. E.: Radiological aspects of cancer after apparent healing. Gastroenterology 61, 606 (1971)PubMedGoogle Scholar
  68. Kobayashi, S., Sugiura, H., Kasugai, T.: Reliability of endoscopic observation on diagnosis of early carcinoma of the stomach. Endoscopy 4, 181 (1972)Google Scholar
  69. Koch, H., Bauerle, H., Classen, M.: Kombinierte Ösophago-Gastro-Bulboskopie. 1. Europäischer Endoskopie-Kongress, München 1970Google Scholar
  70. Koch, H., Classen, M.: Endoskopie des Bulbus duodeni (Bulboskopie). Leber, Magen, Darm 1, 21 (1971)Google Scholar
  71. Köster, K. H.: Gastric acid secretion in patients with duodenal ulcer. Scand. J. Gastroent. 1, 199 (1966)PubMedGoogle Scholar
  72. Konjetzny, G. E.: Der Magenkrebs. Stuttgart: Enke 1938Google Scholar
  73. Korman, M. G., Soveny, C., Hansky, J.: Gastrin studies in gastric ulcer. Gut 13, 166 (1972)PubMedCentralPubMedGoogle Scholar
  74. Kukral, J. C: Gastric ulcer: an appraisal. Surgery 63, 1024 (1968)PubMedGoogle Scholar
  75. Lassrich, M. A., Schäfer, K. H.: Die Ulcuskrankheit beim Kinde. Internist 6, 40 (1965)PubMedGoogle Scholar
  76. van Lerberghe, R.: Ulcere duodenale et Polyglobulie. Acta gastro-ent. belg. 14, 509 (1951)Google Scholar
  77. Levin, E., Kirsner, J. B., Palmer, W. L.: Nocturnal gastric secretion: studies on normal subjects and on patients with duodenal ulcer, gastric ulcer and gastric carcinoma. Arch. Surg. 56, 345 (1958)Google Scholar
  78. Levrat, M., Pasquier, J., Lambert, R., Tissot, A.: Peptic ulcer in patients over 60. Experience in 287 cases. Amer. J. dig. Dis. 11, 279 (1966)PubMedGoogle Scholar
  79. Malhotra, S. L.: Peptic ulcer in India and its etiology. Gut 5, 412 (1964)PubMedCentralPubMedGoogle Scholar
  80. Marcussen, H., Wulff, H. R., Wulff, M. R.: Evaluation of acid secretion in gastric ulcer. A combined radiological and secretory study. Scand. J. Gastroent. 5, 65 (1970)PubMedGoogle Scholar
  81. Marks, I. N., Selzer, G., Louw, J. H., Bank, S.: Zollinger-Ellison syndrome in a Bantu woman, with isolation of a gastrin-like substance from the primary and secondary tumors. Gastroenterology 41, 77 (1961)PubMedGoogle Scholar
  82. Marshall, S. F., Adamson, N. E.: Cancer of stomach: follow-up study of 1708 patients. Sth. med. J. (Bgham, Ala.) 50, 776 (1957)Google Scholar
  83. Masuda, H.: Zur Verbesserung der Prognose des Magenkarzinoms. Therapiewoche 20, 1753 (1970)Google Scholar
  84. McGuigan, J. E., Trudeau, W. L.: Immunochemical measurement of elevated levels of gastrin in the serum of patients with pancreatic tumor of the Zollinger-Ellison variety. New Engl. J. Med. 278, 1308 (1968)PubMedGoogle Scholar
  85. Morris, R. S., Schiff, L., Foulger, M.: Erythremia (polycythemia very): a theory regarding etiology. J. Med. 13, 318 (1932)Google Scholar
  86. Myers, R. T., Bhatti, A.: Peptic ulcer and parathyroid adenoma. Ann. Surg. 171, 647 (1970)PubMedCentralPubMedGoogle Scholar
  87. Ostrow, J. D., Blanshard, G., Gray, S. J.: Peptic ulcer in primary hyperparathyroidism. Amer. J. Med. 29, 769 (1960)PubMedGoogle Scholar
  88. Ottenjann, R., Gall, F., Elster, K.: Tumorförmige Hyperplasie der Magenschleimhaut bei Zollinger-Ellison-Syndrom. Dtsch. med. Wschr. 92, 1538 (1967)PubMedGoogle Scholar
  89. Ottenjann, R.: Der operierte Magen. In: Demling, L., Elster, K., Frik, W., Gall, F., Ottenjann, R.: Der kranke Magen. München-Berlin-Wien: Urban und Schwarzenberg 1970Google Scholar
  90. Paul, F., Seifert, E.: Der Pseudopylorus — Häufigkeit und diagnostische Bedeutung. Endoscopy 3, 65 (1971)Google Scholar
  91. Petersen, H.: Relationship between gastric and pancreatic secretion in patients with duodenal ulcer. Scand. J. Gastroent. 5, 321 (1970)PubMedGoogle Scholar
  92. Proctor, O. S.: Chronic peptic ulcer in children. Surg. Gynec. Obstet. 41, 63 (1925)Google Scholar
  93. Reeder, D. D., Jackson, B. M., Ban, J., Clendinnen, B. G., Davidson, W. D., Thompson, J. C.: Influence of hypercalcemia on gastric secrection and serum gastrin concentrations in man. Ann. Surg. 172, 540 (1970)PubMedCentralPubMedGoogle Scholar
  94. Rhodes, J., Lawrie, J. H., Evans, K. T.: Coarse duodenal folds in patients with peptic ulcer. Gut 9, 609 (1968)PubMedCentralPubMedGoogle Scholar
  95. Ricketts, W. E., Palmer, W. L., Kirsner, J. B.: Achlorhydria and peptic ulcer: a further study of the role of peptic activity in the pathogenesis and course of peptic ulcer. Ann. intern. Med. 30, 24 (1949)PubMedGoogle Scholar
  96. Rösch, W.: Early carcinoma. Endoscopy 2, 64 (1970)Google Scholar
  97. Rösch, W., Ottenjann, R.: Endoskopischen Verlaufsbeobachtung der Ulkusheilung am Beispiel des Carbenoxolon-Natriums. Endoscopy 2, 31 (1970)Google Scholar
  98. Rösch, W.: Suture material and suture-line ulcer following gastric surgery. Endoscopy 2, 247 (1970)Google Scholar
  99. Rösch, W., Schaudig, H., Elster, K., Demling, L.: Bioptische Untersuchungen zur Frage der Ulkusnarbe. Endoscopy 3, 129 (1971)Google Scholar
  100. Rösch, W., Dette, G.: Primärmanifestation der Ulkuskrankheit im Senium. Z. präklin. Ger. 3, 119 (1973)Google Scholar
  101. Romeo, S., Libra, S., Gruttadaura, G.: Study of some enzyme activities, serum iron levels, and serum proteine in patients with peptic ulcers. Fegato 14, (3) 405 (1968)Google Scholar
  102. Roulet, F., Frutiger, V.: Welche Schlüsse lassen sich aus der pathologischen Anatomie des Magengeschwürs für die Praxis ziehen? Schweiz. med. Wschr. 1, 47 (1943)Google Scholar
  103. Rune, S. J.: Duodenal pH values in normal controls and in patients with duodenal ulcer. Gut 10, 569 (1969)PubMedCentralPubMedGoogle Scholar
  104. Ruppert, R. D., Greenberger, N. J.: Gastric secretion in ulcerogenic tumor of the pancreas (Zollinger-Ellison syndrome). Clin. Res. 14, 433 (1966)Google Scholar
  105. Sakita, T., Oguro, Y., Takasu, S., Fukutomi, H., Miwa, T., Yoshimort, M.: Observations on the healing of ulcerations in early gastric cancer. Gastroenterology 60, 835 (1971)PubMedGoogle Scholar
  106. Salmon, P. R., Brown, P., Htut, T., Read, A. E.: Endoscopic examination of the duodenal bulb: clinical evaluation of forward-and side-viewing fibreoptic systems in 200 cases. Gut 13, 170 (1972)PubMedCentralPubMedGoogle Scholar
  107. Sanders, D. B., Johns, T. R.: Peptic ulcer in myasthenia gravis. J. Amer. med. Ass. 207, 1875 (1969)Google Scholar
  108. Schindler, R.: Ein völlig ungefährliches flexibles Gastroskop. Münch. med. Wschr. 78, 1268 (1932)Google Scholar
  109. Schreiber, H. W., Luchmann, A., Schriefers, K. H., Esser, G.: Über das Ulkus bei der Leberzirrhose. Dtsch. med. Wschr. 89, 1787 (1964)PubMedGoogle Scholar
  110. Schumacher, F. V., Hampton, A. O.: Radiographic differentiation of benign and malignant gastric ulcers. Clinical symposia, Ciba 8, 161 (1956)Google Scholar
  111. Schwarz, K.: Über penetrierende Magen- und Jejunalgeschwüre. Bruns Beitr. klin. Chir. 67, 96 (1910)Google Scholar
  112. Shirakabe, H., Kumakura, K., Koyama, R., Ichikawa, H.: X-ray diagnosis of gastric and duodenal ulcer. Proceedings 47th Annual Congress, Japan Gastroenterologie Society 1961Google Scholar
  113. Singer, K.: Gibt es eine gastrogene Polyglobulie? Klin. Wschr. 14, 751 (1935)Google Scholar
  114. Small, W. P., Smith, A. N., Falconer, C. W. A., Sircus, W., Sir Bruce, J.: Suture line ulcer after gastric surgery. Amer. J. Surg. 115, 477 (1968)PubMedGoogle Scholar
  115. Spiro, H. M.: Clinical gastroenterology. Toronto: Macmillan 1970Google Scholar
  116. Stadelmann, O., Elster, K., Ottenjann, R., Demling, L.: Endoskopische-bioptische Untersuchungen zur Histotopographie des Magenulkus. In: R. Ottenjann: Fortschritte der Endoskopie. Stuttgart: Schattauer 1970Google Scholar
  117. Stadelmann, O., Elster, K., Stolte, M., Miederer, S. E., Deyhle, P., Demling, L., Siegenthaler, W.: The peptic ulcer of the stomach — histotopographie and functional investigation. Scand. J. Gastroent. 6, 613 (1971)PubMedGoogle Scholar
  118. Stelzner, F.: Die Frage des hepatogenen Ulkus. Deutung des peptischen Geschwürs als Folge einer Regulationsstörung der Leber im Widerstreit zur ulzerogenen Hepatopathie. Münch. med. Wschr. 107, 773 (1965)PubMedGoogle Scholar
  119. Stevenson, J. K.: Gastric carcinoma. In: Harkins-Hyhus: Surgery of the stomach and duodenum. Boston: Little, Brown and Co. 1962Google Scholar
  120. Strang, R. R.: The occurence of peptic ulceration in patients with parkinsonism. Acta neurol. scand. 42, 124 (1966)Google Scholar
  121. Thomas, N. B., Jr., Jewett, T. C., Jr.: Peptic ulcers in infancy and childhood. J. Amer. med. Ass. 189, 539 (1964)Google Scholar
  122. Thomson, C. G., Cleator, I. G. M., Sircus, W.: Experiences with a rat bio-assay in the diagnosis of the Zollinger-Ellison syndrome. Gut 11, 409 (1970)PubMedCentralPubMedGoogle Scholar
  123. Trudeau, W. L., McGuigan, J. E.: Serum gastrin levels in patients with peptic ulcer disease. Gastroenterology 59, 6 (1970)PubMedGoogle Scholar
  124. Tuchfeld, F.: Ulcus duodeni und Polyglobulie. Med. Klin. 27, 130 (1931)Google Scholar
  125. Vega, J. M. de la, Naves, J., Gonzales-Montesinos, F., Ponce de Leon, A.: An analysis of possible etiologic factors in peptic ulcer disease. Proc. World Congress Gastroenterol. Baltimore: Williams and Wilkins 1959Google Scholar
  126. Vesely, K., Kubickova, Z., Dvorakova, M., Zvolankova, K.: Clinical data and characteristics differentiating types of peptic ulcer. Gut 9, 57 (1968)PubMedCentralPubMedGoogle Scholar
  127. Vilardell, J.: Verh. Internat. Kongr. Gastroenterol., Brüssel 1935Google Scholar
  128. Voronina, L. N., Sharova, I. A., Dubrovina, N. A.: The hemocoagulation system in patients with gastroduodenal ulcer during the phase of exacerbation. Ter. Arkh. 40, 27 (1968)PubMedGoogle Scholar
  129. Wanke, M.: Magen. In: Doerr, W., Seifert, G., Uehlinger, E.: Spezielle pathologische Anatomie. Berlin-Heidelberg-New York: Springer 1971Google Scholar
  130. Wermer, P.: Genetic aspects of adenomatosis of endocrine glands. Amer. J. Med. 16, 363 (1954)PubMedGoogle Scholar
  131. West, W. O., Burns, R. O., Daniels, J. M., Jackson, H. A.: The syndrome of chronic pulmonary disease and gastroduodenal ulceration. Arch. intern. Med. 103, 65 (1959)Google Scholar
  132. Wolf, B. S., Marshak, R. H.: Profile features of benign gastric niches on roentgen examination. J. Mt Sinai Hosp. 24, 604 (1957)Google Scholar
  133. Wormsley, K. G.: Pancreatic exocrine function in patients with gastric ulceration before and after gastrectomy. Lancet 1972 II, 682Google Scholar
  134. Wilbur, D. L., Ochsner, H. C.: The association of polycythemia vera and peptic ulcer. Ann. intern. Med. 8, 1667 (1935)Google Scholar
  135. Winship, D. H.: Problems in the diagnosis of Zollinger-Ellison syndrome by analysis of gastric secretion. In: Demling, L., Ottenjann, R.: Non-insulin-producing tumors of the pancreas. Stuttgart: Thieme 1969Google Scholar
  136. Zollinger, R. M., Ellison, E. H.: Primary peptic ulcerations of jejunum associated with islet cell tumors of pancreas. Ann. Surg. 142, 709 (1955)PubMedCentralPubMedGoogle Scholar

IV. Konservative Therapie des peptischen Geschwürs

  1. Amure, B. O.: Clinical study of duogastrone in the treatment of duodenal ulcers. Gut 11, 171 (1970)PubMedCentralPubMedGoogle Scholar
  2. Anderson, W., Baillie, A. J., Harthill, J. E.: Peptic inhibition by macroanions. J. Pharm. Pharmacol. 20, 715 (1968)PubMedGoogle Scholar
  3. Babkin, B. P., Kays, D.: Effect of quinine and atabrine on gastric secretion. Canad. med. Ass. J. 56, 137 (1947)PubMedCentralGoogle Scholar
  4. Babouris, N., Fletcher, J., Lennard-Jones, J. B.: Effect of varying the size and frequency of meals. Gut. 6, 118 (1965)PubMedCentralPubMedGoogle Scholar
  5. Bank, S., Marks, I. N.: Maintenance carbenoxolone sodium in the prevention of gastric ulcer recurrence. Carbenoxolone sodium. London: Butterworths 1970Google Scholar
  6. Barnes, P. C., Leonard, J. H. C: Hypokalemic myopathy and myoglobulinuria due to carbenoxolone sodium. Postgrad, med. J. 47, 813 (1971)Google Scholar
  7. Baron, J. H., Elkeles, R. S., Lloyd-Mostyn, R. H., Watt, I.: The effect of carbenoxolone sodium on carbohydrate metabolism. In: Baron, J. H., Sullivan, F. M.: Carbenoxolone sodium. London: Butterworths 1970Google Scholar
  8. Barreras, R. F., Donaldson, R. M.: Effects of induced hypercalcemia on human gastric secretion. Gastroenterology 53, 670 (1967)Google Scholar
  9. Barreras, R. F.: Oral calcium carbonate and gastric secretion. Clin. Res. 16, 446 (1968)Google Scholar
  10. Bedi, B. S., Gillespie, G.: Effects of a specific gastrin antagonist on gastric acid secretion. Lancet 1967 I, 1240Google Scholar
  11. Berndt, H., Gütz, H.-J., Jacobasch, K.-H., Marquardt, K., Prahl, B., Wolff, G.: Klinische Versuche zur Therapie des Ulcus pepticum. Dtsch. Z. Gesundh.-Wes. 25, 12 (1970)Google Scholar
  12. Berstad, A.: Inhibition of peptic activity in man by carbenoxolone sodium. Scand. J. Gastroent. 7, 129 (1972)PubMedGoogle Scholar
  13. Bianchi, P. G., Saccabusi, E.: Attivita terapeutica nelle ulcere gastriche e duodenali, nelle gastriti e gastroduodeniti di un farmaco antisecretivo, non anticholiergico. Minerva med. 60, 1044 (1969)PubMedGoogle Scholar
  14. Birnbaum, D., Karmell, F., Tefera, M.: The effect of diazepam on human gastric secretion. Gut 12, 616 (1971)PubMedCentralPubMedGoogle Scholar
  15. Blendis, L. M., Cameron, A. J., Hadley: Analysis of 400 examinations using the gastrocamera. Gut 8, 38 (1967)Google Scholar
  16. Bodi, T.: Use of meprobamate for control of stress associated with intractable peptic ulcer. Curr. ther. Res. 11, 216 (1969)PubMedGoogle Scholar
  17. Borellini, D., Milvio, C.: Therapia dell’ ulcera gastro-duodenale, gastriti e gastroduodeniti con un farmaco antisecretivo non anticholinergico. Minerva med. 60, 1053 (1969)PubMedGoogle Scholar
  18. Brodie, D. A., Marshall, R. W., Moreno, O. M.: The effect of ulcerogenic drugs on gastric acidity in the rat with chronic fistula. Gastroenterology 43, 675 (1962)PubMedGoogle Scholar
  19. Bronzini, C: X-ray therapy for duodenal ulcer. Rass. int. Clin. Ter. 48, 1512 (1968)Google Scholar
  20. Brown, P., Salmon, P. R., Thien-Htut, Read, A. E.: Double-blind trial of carboxolone sodium capsules in duodenal ulcer therapy, based on endoscopic diagnosis and follow-up. Brit. med. J. 1972 III, 661Google Scholar
  21. Buchman, E., Kaung, D. T., Dolan, K., Knapp, R. N.: Unrestricted diet in the treatment of duodenal ulcer. Gastroenterology 56, 1016 (1969)PubMedGoogle Scholar
  22. Burn, J. H., Vane, J. R.: The inhibitory effect of paludrine on the secretion of gastric juice. Brit. J. Pharmacol. 3, 346 (1948)PubMedCentralPubMedGoogle Scholar
  23. Burnett, C. H., Commins, R. R., Albright, F., Howard, J. E.: Hypercalcemia without hypercalcuria or hypophosphatemia, calcinosis and renal insufficiency: a syndrome following prolonged intake of milk and alkali. New Engl. J. Med. 240, 787 (1949)PubMedGoogle Scholar
  24. Butler, E. D., Purdon, R. A., Bass, P.: Developments in non-anticholinergic anti-ulcer drugs. Amer. J. dig. Dis. 15, 157 (1970)PubMedGoogle Scholar
  25. Cammarata, P. S., Bianchi, R. G., Fago, F. J.: Mechanism of the antipeptic action of amylopectin sulfate (SN-263), an antiulcer, mucin-like agent. Gastroenterology 61, 850 (1971)PubMedGoogle Scholar
  26. Caron, H. S., Roth, H. P.: Objective assessment of cooperation with an ulcer diet: relation to antacid intake and to assigned physician. Amer. J. med. Sci. 261, 112 (1971)Google Scholar
  27. Clark, T., Hunt, J. N.: The laboratory assessment of aluminium glycinate in the treatment of peptic ulcer. Practitioner 180, 334 (1958)PubMedGoogle Scholar
  28. Classen, M.: Neubewertung der herkömmlichen Behandlung des unkomplizierten Ulcus duodeni-Leidens. Medizin u. Ernährung 12, 1 (1971)Google Scholar
  29. Clayman, C. B., Palmer, W. L., Kirsner, J. B.: Gastric irradiation in the treatment of peptic ulcer. Gastroenterology 55, 403 (1968)Google Scholar
  30. Cliff, J. M., Milton-Thompson, G. J.: A double-blind trial of carbenoxolone sodium capsules in the treatment of duodenal ulcer. Gut 11, 167 (1970)PubMedCentralPubMedGoogle Scholar
  31. Cocking, J. B., Mac Caig, J. N.: Effect of low dosage of carbenoxolone sodium on gastric ulcer healing and acid secretion. Gut 10, 219 (1969)PubMedCentralPubMedGoogle Scholar
  32. Cocking, J. B., Chir, M. B.: A trial of amylopectin sulfate (SN-263) and propantheline bromide in the long term treatment of chronic duodenal ulcer. Gastroenterology 62, 6 (1972)PubMedGoogle Scholar
  33. Cohen, N. N., Hughes, R. W., Manfredo, H. E.: Experience with 1000 fibergastroscopic examinations of the stomach. Amer. J. dig. Dis. 11, 943 (1966)PubMedGoogle Scholar
  34. Connell, A. M., Hill, R. A., Macleod, I. B., Sircus, W., Thompson, C. G.: Effects of SC-15396 on gastric secretion. Gut 9, 641 (1968)PubMedCentralPubMedGoogle Scholar
  35. Cooke, W. M., Baron, J. H.: Metabolic studies of deglycyrrhizinised liquorice in two patients with gastric ulcer. Digestion 4, 264 (1971)PubMedGoogle Scholar
  36. Craig, O., Hunt, T., Kimerling, J. J., Parks, D. V.: Carbenoxolone in the treatment of duodenal ulcer. Practitioner 199, 109 (1967)PubMedGoogle Scholar
  37. Debas, H. T., Bedi, B. S., Gillespie, G., Gillespie, I. E.: Mechanism by which fat in the upper small intestine inhibits gastric acid. Gastroenterology 56, 483 (1969)PubMedGoogle Scholar
  38. Dekkers, H. J. N.: Carbohydrate diet for duodenal ulcer. Gastroenterologia (Basel) 86, 496 (1956)Google Scholar
  39. Demling, L.: Untersuchungen zur therapeutischen Beeinflussung der Darm- und Pfortaderdurchblutung des Menschen. Verh. dtsch. Ges. inn. Med. 65, 838 (1959)PubMedGoogle Scholar
  40. Demling, L.: Magenvereisung. Dtsch. med. Wschr. 90, 1370 (1965)Google Scholar
  41. Demling, L.: Konservative Behandlung des Geschwürsleidens. Chirurg 39, 485 (1968)PubMedGoogle Scholar
  42. Demling, L., Classen, M.: The influence of gastrointestinal hormones on local blood flow and H-ion concentration of the human gastric mucosa. In: Physiology of gastric secretion (Semb, L. S., Myken, J., Eds.). Oslo: Universitetsforlaget 1968Google Scholar
  43. Demling, L.: Klinische Gastroenterologie. Stuttgart: Thieme 1973Google Scholar
  44. Deyle, P., Nitzsche, R., Miederer, S. E., Ottenjann, R.: Über die Wirkung von Glukagon auf die Magensekretion. Verh. dtsch. Ges. inn. Med. 76, 973 (1970)Google Scholar
  45. Doll, R., Pygott, F.: Factors influencing the rate of healing of gastric ulcers. Lancet 1952 I, 171Google Scholar
  46. Doll, R., Jones, F. A., Pygott, F.: Effect of smoking on the production and maintainance of gastric ulcer and duodenal ulcer. Lancet 1958 I, 657Google Scholar
  47. Doll, R., Hill, I. D., Hutton, C. F., Underwood, D. J.: Clinical trial of a triterpenoid liquorice compound in gastric and duodenal ulcer. Lancet 1962 II, 793Google Scholar
  48. Doll, R.: Medical treatment of gastric ulcer. Scot. med. J. 9, 183 (1964)PubMedGoogle Scholar
  49. Doll, R., Langmann, M. J. S., Shawdon, H. H.: Treatment of gastric ulcer with carbenoxolone: antagonistic effect of spironolactone. Gut 9, 42 (1968)PubMedCentralPubMedGoogle Scholar
  50. Doll, R., Langman, M. J. S., Shawdon, H. H.: Treatment of gastric ulcer with oestrogens. Gut 9, 46 (1968)PubMedCentralPubMedGoogle Scholar
  51. Dombro, R., Ragins, H.: Effect of promethazine HCl on the release of gastrin in the dog. Nature (Lond.) 216, 1225 (1967)Google Scholar
  52. Domschke, W., Domschke, S., Classen, M., Demling, L.: Some properties of mucus in patients with gastric ulcer. Effect of treatment with carbenoxolone sodium. Scand. J. Gastroent. 7, 647 (1972)PubMedGoogle Scholar
  53. Ellis, C., Nicoloff, D. M.: Protease inhibitors: their effect on peptic ulceration. Gastroenterology 56, 1155 (1969)Google Scholar
  54. Fordtran, J. S., Collyns, J. A. H.: Antacid pharmacology in duodenal ulcer, effect of antacids on postcibal gastric acidity and peptic activity. New Engl. J. Med. 274, 922 (1966)Google Scholar
  55. Fordtran, J. S.: Acid rebound. New Engl. J. Med. 279, 900 (1968)PubMedGoogle Scholar
  56. Fraser, P. M., Doll, R., Langman, M. J. S., Misiewicz, J. J., Shawdon, H. H.: Clinical trial of a new carbenoxolone analogue (BX 24), zinc sulphate and vitamin A in the treatment of gastric ulcer. Gut 13, 459 (1972)PubMedCentralPubMedGoogle Scholar
  57. Gerzner, L. F. J.: Treatment of gastric and duodenal ulcer by splanchnic nerve block. Med. J. Aust. 1, 1052 (1969)PubMedGoogle Scholar
  58. Gheorgiu, Th, Frotz, H., Klein, H. J.: Experimentelle und klinische Untersuchungen zum Mechanismus der Carbenoxolonwirkung. I. Einfluß von Carbenoxolon auf die Magen-saft-Mukus-Sekretion der Ratte. Verh. dtsch. Ges. inn. Med. 77, 511 (1971)Google Scholar
  59. Giordano, G., Comi, L.: Attivita terapeutica del Milid nel trattamento dell’ulcera gastroduodenale antisecretiva. Minerva med. 58, 3688 (1967)PubMedGoogle Scholar
  60. Glatzel, H.: Die Gewürze. Ihre Wirkungen auf den gesunden und den kranken Menschen. Herford: Nicolai 1968Google Scholar
  61. Göbel, D., Witte, S.: Carbenoxolon-Natrium in der Behandlung von Magen- und Zwölffingerdarmgeschwüren. Med. Welt 22, 1394 (1971)PubMedGoogle Scholar
  62. Grossman, M. I.: Physiologie approach to medical management of duodenal ulcer. Amer. J. dig. Dis. 6, 56 (1961)PubMedGoogle Scholar
  63. Grossman, M. I.: Treatment of duodenal ulcer with secretin: a speculative proposal. Gastroenterology 50, 912 (1966)PubMedGoogle Scholar
  64. Grote, I. W., Woods, M.: Studies in antacids: absorption effects of various aluminium antacids upon simultaneously administered anticholinergic drugs. J. Amer. pharm. Ass. 42, 319 (1953)Google Scholar
  65. Hafter, E.: Praktische Gastroenterologie, 4. Aufl. Stuttgart: Thieme 1970Google Scholar
  66. Hardt, L. L., Rivers, A. B.: Toxic manifestations following alkaline treatment of peptic ulcer. Arch. intern. Med. 31, 171 (1923)Google Scholar
  67. Henman, F. D.: Inhibition of peptic activity by carbenoxolone and glycyrrhetinic acid. Gut 11, 344 (1970)PubMedCentralPubMedGoogle Scholar
  68. Hoon, J. R.: Does an antacid really coat the stomach? Industr. Med. 38, 117 (1969)Google Scholar
  69. Horwich, L., Galloway, R. W.: Treatment of gastric ulceration with carbenoxolone sodium: clinical and radiological evaluation. Brit. med. J. 1965 II, 1274Google Scholar
  70. Hunt, J. N., Wales, R. C.: Progress in patients with peptic ulceration treated for more than 5 years with poldine including double-blind study. Brit. med. J. 1966 II, 13Google Scholar
  71. Ingelfinger, F. J.: Let the ulcer patient enjoy his food. In: Controversy in internal medicine. Philadelphia: Saunders 1966Google Scholar
  72. Innes, I. R., Nickerson, M.: Drugs inhibiting the action of acetylcholine on structures innervated by postganglionic parasympathetic nerves (antimuscarinic or atropinic drugs). In: Pharmac. basis of therapeutics (Goodman, L. S., Gilman, A., Eds.). New York: Macmillan 1965Google Scholar
  73. Janowitz, H. D., Colcher, H., Hollander, F.: Inhibition of gastric secretion of acid in dogs by carbonic anhydrase inhibitor, 2-acetyl-amino-, l,3,4-thiadiazole-5-sulfonamide. Amer. J. Physiol. 171, 325 (1952)PubMedGoogle Scholar
  74. Johnston, D., Goligher, J. C., Duthie, H. L.: Medical vagotomy: an assessment. Brit. med. J. 1966 II, 1481Google Scholar
  75. Jow, E., Webster, D. R., Skoryna, S. C.: Effects of glucagon and insulin on gastric secretion in rats. Gastroenterology 38, 732 (1960)PubMedGoogle Scholar
  76. Kahlson, G., Rosengreen, E., Svensson, S. E.: Mode of action of a gastric-secretion antagonist. Brit. J. Pharmacol. 33, 493 (1968)PubMedCentralPubMedGoogle Scholar
  77. Kahn, I., Yatjre, G.: Zur Frage der Entstehung der Reaktion des Magensaftes bei der Verdauung. Pflügers Arch. ges. Physiol. 206, 119 (1924)Google Scholar
  78. Kalk, H.: Die Therapie des Ulcus ventriculi und duodeni. Klin. Wschr. 2, 2254 (1928)Google Scholar
  79. Kasper, H.: Neue Aspekte in der Diätetik von Magen- und Darmerkrankungen. Med. Klin. 65, 329 (1970)PubMedGoogle Scholar
  80. Kawakami, S., Soejima, K., Kawashima, S.: Experience with an antipepsin drug, Ulcerlmin. Shinryo-to-Shinyaka 6, 830 (1969)Google Scholar
  81. Kaye, M. D., Rhodes, J., Beck, P., Sweetnam, P. M., Davies, G. T., Evans, K. T.: A controlled trial of glycopyrronium and 1-hyoscyamine in the long-term treatment of duodenal ulcer. Gut 11, 559 (1970)PubMedCentralPubMedGoogle Scholar
  82. Keel, H. J., Goldstein, M. L., Haubrich, W. S., Roth, J. L. A.: The effect of unsaturated fatty acids in food products on gastric acidity, gastric motility and blood lipids. Schweiz. med. Wschr. 98, 288 (1968)Google Scholar
  83. Kinzlmeier, H., Henning, N., Demling, L.: Über die Testung säurebindender und sekretionshemmender Substanzen mit Hilfe der intragastralen pH-Messung. Klin. Wschr. 32, 40 (1954)PubMedGoogle Scholar
  84. Kirsner, J. B.: Fact and fallacies of current medical therapy for uncomplicated duodenal ulcer. J. Amer. med. Ass. 187, 423 (1964)Google Scholar
  85. Kuruvilla, J. T.: Antipeptic activity of antacids. Gut 12, 897 (1971)PubMedCentralPubMedGoogle Scholar
  86. Langman, M. J. S.: Carbenoxolone sodium. Gut 9, 5 (1968)PubMedCentralPubMedGoogle Scholar
  87. Lawrence, J. S.: Dietetic and other methods in the treatment of peptic ulcer. Lancet 1952 I, 482Google Scholar
  88. Lee, Y. H., Thompson, J. H.: Inhibition of gastric secretion in the rat by SC 15 396. Europ. J. Pharmacol. 3, 366 (1968)Google Scholar
  89. Lennard-Jones, J. E., Fletcher, J., Shaw, D. G.: Effect of different foods on the acidity of the contents in patients with duodenal ulcer. Gut 9, 177 (1969)Google Scholar
  90. Lenz, J., Hartel, W., Schuster, G.: Behandlung florider Gastroduodenalulzera mit Carbenoxolon vor der Magenresektion. Med. Klin. 66, 553 (1971)PubMedGoogle Scholar
  91. Lerner, H. J., Thompson, J. C.: Heparin suppression of gastric acid secretion. Proc. Soc. exp. Biol. (N.Y.) 112, 730 (1963)Google Scholar
  92. Lindup, W. E., Parke, D. V., Colin-Jones, D.: The absorption of carbenoxolone administered orally as a positioned-release capsule. Gut 11, 555 (1970)PubMedCentralPubMedGoogle Scholar
  93. Lineham, W. D., Nash, J.: The influence of prodexin on gastric acidity. J. Irish med. Ass. 44, 145 (1959)Google Scholar
  94. Lipkin, M.: Carbenoxolone sodium and the rate of extrusion of gastric epithelial cells. In: Carbenoxolone sodium (Baron, J. H., Sullivan, F. M., Eds.). London: Butterworth 1970Google Scholar
  95. Littman, A.: Reactive and nonreactive aluminium hydroxide gels. Gastroenterology 52, 918 (1967)Google Scholar
  96. Lösel, H.: Über die ambulante Infusionstherapie mit Rheomacrodex 10%. Med. Welt 13, 709 (1965)Google Scholar
  97. Lotz, M., Ziman, E., Bartter, F. C.: Evidence for a phosphorous-depletion syndrome in man. New Engl. J. Med. 278, 409 (1969)Google Scholar
  98. Malis, J. L.: The effects of oxethazaine HCl, a potent local anesthetic on the secretion from the rat stomach. Pharmacologist 8, 186 (1966)Google Scholar
  99. Marcos Perez, V. M. de: Carbenoxolon in der Behandlung von Duodenalulzera. Referat XI Kongreß f. Verdauungspathologie, Barcelona 1968Google Scholar
  100. Melrose, A. G., Pinkerton, I. W.: Clinical evaluation of poldine methylsulphate. Brit. med. J. 1961 I, 1076Google Scholar
  101. Meulengracht, E.: Treatment of hematemesis and melena with food. Lancet 1935 II, 1220Google Scholar
  102. Middleton, W. R. J., Cooke, A. R., Stephan, D., Skyring, A. P.: Biogastrone in patient treatment of gastric ulcer. Lancet 1965 I, 1030Google Scholar
  103. Mitchell, A. B. S.: Duogastrone-induced hypokalaemic nephropathy and myopathy with myoglobinuria. Postgrad, med. J. 47, 807 (1971)Google Scholar
  104. Mohamed, S. D., Chapman, R. S., Crooks, J.: Hypokalemia, flaccid quadruparesis, and myoglobinuria with carbenoxolone. Hypokalemia, flaccid quadruparesis, and myoglobinuria with carbenoxolone 1966 I, 1581Google Scholar
  105. Montgomery, R. D.: Side effects of carbenoxolone sodium: a study of ambulant therapy of gastric ulcer. Gut 8, 148 (1967)PubMedCentralPubMedGoogle Scholar
  106. Morley, J. S.: Structure-function relationship in gastrin-like peptides. Proc. roy. Soc. B 170, 97 (1968)Google Scholar
  107. Muir, A., Laithwaite, J. A., Wood, W.: Hypokalemia complicating carbenoxolone therapy. Brit. med. J. 1969 I, 512Google Scholar
  108. Mulficentre, Trial: Treatment of duodenal ulcer with glycyrrhizinic-acid-reduced liquorice. Brit. med. J. 1971 III, 501Google Scholar
  109. Myhill, J., Piper, D. W.: Antacid therapy for peptic ulcer. A mathematical determination of antacids. Gut 5, 581 (1964)PubMedCentralPubMedGoogle Scholar
  110. Namekata, M.: Studies on oxidized starch sulfates for medical purposes. Investigations on the complex of pepsin with sulfates of oxidized starch and its reduced products. Chem. Pharm. Bull. (Tokyo) 10, 182 (1962)Google Scholar
  111. Norgaad, R. P., Polter, D. E., Wheeler, J. W., Fordtran, J. S.: Effect of long-term anticholinergic therapy on gastric acid secretion with observations on the serial measurement of peak acid output. Gastroenterology 58, 750 (1970)Google Scholar
  112. Ohnhaus, E., Koch, H., Deyhle, P. Treatment of pentagastrin-induced duodenal ulcers by glucagon. 4. World Congress of Gastroenterology, Copenhagen 1970Google Scholar
  113. Ottenjann, R., Widmaier, F., Demling, L.: Magensekretion bei akuter Hyperkalzämie und Hypermagnesiämie. Verh. dtsch. Ges. inn. Med. 71, 160 (1965)Google Scholar
  114. Ottenjann, R., Rösch, W.: Therapie des peptischen Geschwürs mit Carbenoxolon-Natrium. Med. Klin. 65, 74 (1970)PubMedGoogle Scholar
  115. Ottenjann, R.: Neue Gesichtspunkte in der Therapie des peptischen Geschwürs. Therapiewoche 12, 473 (1970)Google Scholar
  116. Ottenjann, R., Rösch, W., Deyhle, P.: Der Einfluß von Depot-Glukagon auf die Magensekretion beim Menschen. Med. Klin. 67, 479 (1972)PubMedGoogle Scholar
  117. Parade, D., Baas, E. U.: Schwere Hypokaliämie nach Carbenoxolon. Therapiewoche 20, 3384 (1970)Google Scholar
  118. Parke, D. V., Hunt, T. C., Iveson, P.: The fate of 14-C Carbenoxolone in patients with gastric ulcer. Clin. Sci. 43, 393 (1972)PubMedGoogle Scholar
  119. Paul, H. E., Harrington, C. M.: Absorption characteristics of aureomycin and terramycin on aluminium hydroxyde gel and on bismuth subsalicylate preparations. J. Amer. pharm. Ass. 41, 50 (1952)PubMedGoogle Scholar
  120. Piper, D. W., Stiel, M. C.: The effect of anticholinergic drugs on the mucus content of gastric juice. Gut 3, 177 (1962)PubMedCentralPubMedGoogle Scholar
  121. Piper, D. W., Fenton, B. H.: An evaluation of antacids in vitro. Gut 5, 585 (1964)PubMedCentralPubMedGoogle Scholar
  122. Piper, D. W., Fenton, B. H.: pH-stability and activity curves of pepsin with special references to their clinical importance. Gut 6, 506 (1965)PubMedCentralPubMedGoogle Scholar
  123. Piper, D. W.: Studies on gastric secretion. M. D. Thesis, University of Sidney 1966Google Scholar
  124. Piper, D. W.: Antacid and anticholinergic drug therapy of peptic ulcer. Gastroenterology 53, 1009 (1967)Google Scholar
  125. Piper, D. W.: Milk in treatment of gastric diseases. Amer. J. clin. Nutr. 22, 191 (1969)PubMedGoogle Scholar
  126. Pollard, H. M., Augur, N. A.: Peptic ulcer over the past one hundred years. Practitioner 201, 139 (1968)PubMedGoogle Scholar
  127. Redford, M., Schofield, B.: The effect of local anesthesia of the pyloric antral mucosa on acid inhibition of gastrin mediated acid secretion. J. Physiol. (Lond.) 180, 304 (1965)PubMedCentralGoogle Scholar
  128. Reeder, D. D., Conlee, J. L., Thompson, J. C: Changes in gastric secretion and serum gastrin concentration in duodenal ulcer patients after oral calcium antacid. In: Demling, L.: Gastrointestinal Hormones. Stuttgart: Thieme 1972Google Scholar
  129. Revers, F. E.: De behandeling van ulcus ventriculi en ulcus duodeni met succus liquiritiae. Ned. T. Geneesk 92, 2968 (1948)PubMedGoogle Scholar
  130. Rösch, W., Ottenjann, R.: Low molecular weight dextran in patients with peptic ulcer. Germ. med. Mth. 14, 350 (1969)Google Scholar
  131. Rösch, W., Ottenjann, R.: Endoskopische Verlaufsbeobachtung der Ulkusheilung am Beispiel des Carbenoxolon-Natrium. Endoscopy 2, 31 (1970)Google Scholar
  132. Rösch, W., Ottenjann, R.: Doppelblindstudie mit Carbenoxolon-Natrium bei Ulcus ventriculi. Med. Klin. 66, 383 (1971)PubMedGoogle Scholar
  133. Roth, H. P.: Healing of initial ulcers in relation to age and race. Gastroenterology 61, 570 (1971)PubMedGoogle Scholar
  134. Rudick, J., Finkelstein, J., Kark, A., Dreiling, D.: Effect of low molecular weight dextran on gastric ulceration and gastric secretion in pylorus-ligated rats. Proc. Soc. exp. Biol. (N.Y.) 127, 781 (1968)Google Scholar
  135. Sanchez-Palomera, E.: The action of spices on the acid secretion, on the appetite and on the caloric intake. Gastroenterology 18, 254 (1951)PubMedGoogle Scholar
  136. Sandweiss, D. J., Sugarman, M. H., Berman, C. M.: Peptic ulcer, ulcer diets and arteriosclerotic (coronary) heart disease. Hebrew med. J. 2, 272 (1960)Google Scholar
  137. Sarvanov, A. M.: Estrogen therapy of peptic ulcer. Probl. Endokr. Hormonotherap. 12, 48 (1966)Google Scholar
  138. Schiemann, W. H. L.: Moderne Ulkustherapie mit klinischer, röntgenologischer und endoskopischer Abheilungskontrolle. Landarzt 48, 71 (1972)Google Scholar
  139. Schiff, E. R.: Treatment of uncomplicated peptic ulcer disease. Med. Clin. N. Amer. 55, 305 (1971)PubMedGoogle Scholar
  140. Schneider, M. A., de Luca, V., Gray, B. J.: The effect of spice ingestion upon the stomach. Amer. J. Gastroent. 26, 722 (1956)PubMedGoogle Scholar
  141. Schüle, A.: Untersuchungen über die Sekretion und Motilität des Magens. Z. klin. Med. 28, 461 (1895)Google Scholar
  142. Schulze, E., Franke, R., Keller, N.: Über die Wirkungen von Succus liquiritiae. Dtsch. med. Wschr. 79, 716 (1954)PubMedGoogle Scholar
  143. Siurala, M., Varis, K., Gorbatow, O., Krause, P., Laulajainen, M., Nyberg, L. O.: The effect of estriol succinate upon healing of duodenal ulcer: a controlled study. Scand. J. Gastroent. 4, 469 (1969)PubMedGoogle Scholar
  144. Stadelmann, O., Miederer, S. E., Werning, C., Zimmermann, K. G., Frost, H.: Aktuelle Probleme in der Pathogenese und Therapie des Magen-Duodenal-Ulkus. Fortschr. Med. 90, 123 (1972)Google Scholar
  145. Stiel, J. N., Mitchell, C. A., F. J. Radcliff, Piper, D. W.: Hypercalcemia in patients with peptic ulceration receiving large doses of calcium carbonate. Gastroenterology 53, 900 (1967)PubMedGoogle Scholar
  146. Stokes, J. F.: Antacids. Practitioner 206, 35 (1971)PubMedGoogle Scholar
  147. Stockstad, E. L. R., Pemsack, J. M., Nuhtanen, C. N.: The effect of calcium salts on chlortetracycline absorption. Antibiot. Ann. 879 (1959–1960)Google Scholar
  148. Sun, D. C. H., Shay, H.: Optimal effective dose of anticholinergic drug in peptic ulcer therapy. Arch. intern. Med. 97, 442 (1956)Google Scholar
  149. Sun, D. C. H., Shay, H.: Mechanism for the inhibition of gastric secretion by chlorpromazine in the dog. J. Pharmacol. 126, 155 (1959)Google Scholar
  150. Sun, D. C. H.: Long-term anticholinergic therapy for the prevention of recurrences in duodenal ulcers. Amer. J. dig. Dis. 9, 706 (1964)PubMedGoogle Scholar
  151. Sun, D. C. H.: Effect of a synthetic sulfated polysaccharide on gastric peptic activity in humans. Ann. N.Y. Acad. Sci. 140, 747 (1967)PubMedGoogle Scholar
  152. Sun, D. C. H., Ryan, M. L.: A controlled study on the use of propantheline and amylopectin sulfate (SN-263) for recurrences in duodenal ulcer. Gastroenterology 58, 756 (1970)PubMedGoogle Scholar
  153. Sun, D. C. H., Stempien, S. J.: Site and size of the ulcer as determinants of outcome. Gastroenterology 61, 576 (1971)PubMedGoogle Scholar
  154. Tewari, S. N., Trembalowicz, F. C: Some experience with deglycyrrhizinated liquorice in the treatment of gastric and duodenal ulcers with special reference to its spasmolytic effect. Gut 9, 48 (1968)PubMedCentralPubMedGoogle Scholar
  155. Thaler, H.: Zit. in Martini, G. A.: Was ist gesichert in der Therapie der Geschwürskrankheit? Internist 12, 493 (1971)Google Scholar
  156. Trevino, H., Anderson, J., Davey, P. G., Henley, K. S.: The effect of glycopyrrolate on the course of symptomatic duodenal ulcer. Amer. J. dig. Dis. 12, 983 (1967)PubMedGoogle Scholar
  157. Truelove, S. C.: Stilboestrol, phenobarbitone and diet in chronic duodenal ulcer. Brit. med. J. 1960 II, 559Google Scholar
  158. Turpie, A. G. G., Runcie, J., Thomson, T. J.: Deglycyrrhizinized liquorice in the treatment of gastric ulcer. Gut 9, 363 (1968)Google Scholar
  159. #x00DC;stün, F.: Carbenoxolon bei der Behandlung therapieresistenter Magen- und Duodenalulzera. Med. Welt 22, 1527 (1971)Google Scholar
  160. van Goidsenhoven, G. M., Gray, O. V., Price, A. V., Sanderson, P.H.: Effect of prolonged administration of large doses of sodium bicarbonate in man. Clin. Sci. 13, 383 (1954)Google Scholar
  161. Wangensteen, O. H., Salmon, P. A., Griffen, W. O., Paterson, J. R., Fattah, F.: Studies of local gastric cooling as related to peptic ulcer. Ann. Surg. 150, 346 (1959)PubMedCentralPubMedGoogle Scholar
  162. Watkinson, G.: Treating ulcer disease with Carbenoxolone sodium. Postgrad. Med. 44, 92 (1968)PubMedGoogle Scholar
  163. Wenger, J., Kirsner, J. B., Palmer, W. L.: The milk-alkali syndrome: hypercalcemia, alkalosis, and azotemia following calcium carbonate and milk therapy of peptic ulcer. Gastroenterology 33, 745 (1957)PubMedGoogle Scholar
  164. Werning, C., Bayer, J. M., Fischer, N., Schweikert, H. U., Siegenthaler, W.: Die Wirkung von Carbenoxolon-Natrium auf den Blutdruck, die Plasma-Renin-Aktivität und die Serumelektrolyte bei adrenalektomierten Patienten. Dtsch. med. Wschr. 97, 91 (1972)PubMedGoogle Scholar
  165. Wormsley, K. G.: Response to duodenal acidification in man. Scand. J. Gastroent. 8, 717 (1969)Google Scholar
  166. Zimmon, D. S., Miller, G., Cox, G., Tesler, M. A.: Specific inhibition of gastric pepsin in the treatment of gastric ulcer. Gastroenterology 56, 19 (1969)PubMedGoogle Scholar
  167. Zupko, A. G.: An investigational study of hydroxyaluminium magnesium aminoacetate, a new antacid. J. Amer, pharm. Ass. 45, 208 (1965)Google Scholar

V. Komplikation des peptischen Geschwürs

  1. Avery-Jones, F.: Management of complications of peptic ulcer. Med. J. Aust. 1, 49 (1953)Google Scholar
  2. Avery-Jones, F.: Problems of alimentary bleeding. Brit. med. J. 1969 II, 267Google Scholar
  3. Bakey, M. E. de: Acute perforated gastroduodenal ulceration. Surgery 8, 852 (1940)Google Scholar
  4. Balint, J. A., Spence, S.: Pyloric stenosis. Brit. med. J. 1959 I, 890Google Scholar
  5. Berndt, V., Konrad, R. M., Biermann, B., Gräbensee, B.: Katamnestische Beurteilung der Übernähung perforierter Magen- und Zwölffingerdarmgeschwüre. Chirurg 41, 549 (1970)PubMedGoogle Scholar
  6. Cassel, C., Ruffin, J. M., Bone, F. C.: The clinical features of walled-off perforated peptic ulcer. Sth. med. J. (Bgham, Ala.) 44, 1021 (1951)Google Scholar
  7. Cassell, P.: The prognosis of the perforated acute duodenal ulcer. Gut 10, 574 (1969)Google Scholar
  8. Cohen, M. M.: Perforated peptic ulcer in the Vancouver area. Canad. med. Ass. J. 104. 201 (1971)PubMedCentralPubMedGoogle Scholar
  9. David, E., Mcilrath, D. C., Higgins, J. A.: Clinical experience with acute peptic gastro-intestinal ulcers. Proc. Mayo Clin. 46, 15 (1971)PubMedGoogle Scholar
  10. Donaldson, R. M., Handy, J., Solomon, P.: Five-year follow-up study of patients with bleeding duodenal ulcer with and without surgery. New Engl. J. Med. 259, 201 (1958)PubMedGoogle Scholar
  11. Elliott, J. L., Lane, J. D.: Perforated peptic ulcer treated by non-operative method. Amer. J. dig. Dis. 4, 950 (1959)PubMedGoogle Scholar
  12. Enquist, O. F., Karson, K. E., Dennis, C., Fierst, S. M., Shafton, G. W.: Statistically valid ten-year comparative evaluation of three methods of management of massive gastroduodenal hemorrhage. Ann. Surg. 162, 550 (1965)PubMedCentralPubMedGoogle Scholar
  13. Frimann-Dahl, J.: Positive contrast medium in perforated ulceration. Acta radiol. (Stockh.) 57, 449 (1962)Google Scholar
  14. Gardiner, G. C., Pinsky, W., Myerson, R. M.: The seasonal incidence of peptic ulcer activity-fact or fancy? With special reference to gastrointestinal hemorrhage. Amer. J. Gastroent. 45, 22 (1966)PubMedGoogle Scholar
  15. Gall, F.: Die großen Blutungen aus dem Magen-Darm-Trakt. Med. Klin. 62, 450 (1967)PubMedGoogle Scholar
  16. Gimes, B.: Gastrobronchiale Fistel. Fortschr. Röntgenstr. 112, 275 (1970)Google Scholar
  17. Goldstein, H., Janin, M., Shapiro, M., Boyle, J. D.: Gastric retention associated with gastroduodenal disease. A. study of 217 cases. Amer. J. dig. Dis. 11, 887 (1966)PubMedGoogle Scholar
  18. Grossman, M. I.: Resume and comment. Gastroenterology 61, 635 (1971)PubMedGoogle Scholar
  19. Hafter, E.: Praktische Gastroenterologie. Stuttgart: Thieme 1970Google Scholar
  20. Haubrich, W. S.: Complications of peptic ulcer disease. In: Bockus, H. L.: Gastroenterology. Philadelphia: Saunders 1966Google Scholar
  21. Hauser, G.: Die peptischen Schädigungen des Magens, des Duodenums und der Speiseröhre und das peptische postoperative Jejunalgeschwür. In: Henke-Lubarsch: Handbuch der speziellen pathologischen Anatomie und Histologie. Berlin: Springer 1926Google Scholar
  22. Ivy, A. C., Grossman, M. I., Bachrach, W.: Peptic ulcer. Philadelphia: Blakiston 1950Google Scholar
  23. Jennings, G. H.: Causal influences in haematemesis and melaena. Gut 6, 1 (1965)PubMedCentralPubMedGoogle Scholar
  24. Kalk, H.: Ulcus pepticum (ventriculi, duodeni). In: Handbuch der Inneren Medizin. Berlin: Springer 1938Google Scholar
  25. Koch, H., Frühmorgen, P., Rösch, W., Bauerle, H., Classen, M., Demling, L.: Urgent endoscopy with special reference to duodenoscopy. 2° Congres Europeen d’Endoscopie digestive, Paris 1972Google Scholar
  26. Kortilla, K.: Bacterial studies in cases of perforated gastroduodenal ulcers with reference to clinical and pathological spects. Acta chir. scand. Suppl. 163 (1951)Google Scholar
  27. Kunzman, J.: Management of bleeding stress ulcers. Amer. J. Surg. 119, 637 (1970)PubMedGoogle Scholar
  28. Langman, M. J.: Relationship between preoperative bleeding and perforation and bleeding after operation for duodenal ulcer. Gut 6, 134 (1965)PubMedCentralPubMedGoogle Scholar
  29. Langman, M. J., Doll, R.: Blood group and secretor status in relation to clinical characteristics of peptic ulcer. Gut 6, 270 (1965)PubMedCentralPubMedGoogle Scholar
  30. Mikal, S., Morrison, W. R.: Acute perforated peptic ulcer: criteria for operation and analysis of 500 cases. New Engl. J. Med. 247, 119 (1952)PubMedGoogle Scholar
  31. Moody, F. G., Cornell, G. N., Beal, J. M.: Pyloric obstruction complicating peptic ulcer. Arch. Surg. 88, 865 (1964)Google Scholar
  32. Mur, J., Kralik, J.: Magenulkusperforation in den Ventrikel. Ref. Excerpta med. (Amst.) 9, 680 (1956)Google Scholar
  33. Neilson, J.: Perforated peptic ulcer in south west Scotland. J. roy. Coll. Surg. 13, 40 (1968)Google Scholar
  34. Norberg, P. B.: Results of surgical treatment of perforated peptic ulcer: a clinical and roentgenological study. Acta chir. scand. Suppl. 249 (1959)Google Scholar
  35. Palmer, E. D.: Diagnosis of upper gastrointestinal hemorrhage. Springfield: Thomas 1961Google Scholar
  36. Palmer, E. D.: The vigorous diagnostic approach to upper gastrointestinal tract hemorrhage. A 23-year prospective study. J. Amer. med. Ass. 207, 1477 (1969)Google Scholar
  37. Pears, M. A., Pickering, G. W.: Changes in the fundus oculi after hemorrhage. Quart. J. Med. 29, 153 (1960)PubMedGoogle Scholar
  38. Pendl, O.: Durchbruch eines peptischen Magengeschwürs in die linke Herzkammer. Wien. klin. Wschr. 70, 301 (1958)PubMedGoogle Scholar
  39. Quervain, F. de, Lenggenhager, K.: Spezielle chirurgische Diagnostik. Berlin-Göttingen-Heidelberg: Springer 1950Google Scholar
  40. Rappert, E.: Penetration eines Magenulkus in die linke Herzkammer. Med. Welt 5, 367 (1950)Google Scholar
  41. Read, R. C., Huebl, H. C., Thal, A. P.: Randomized study of massive bleeding from peptic ulceration. Ann. Surg. 162, 561 (1965)PubMedCentralPubMedGoogle Scholar
  42. Ritz, A., Fischer, R.: Perforation eines Ulcus ventriculi in die linke Herzkammer. Schweiz. med. Wschr. 96, 327 (1966)PubMedGoogle Scholar
  43. Rösch, W.: Diagnose und klinische Bedeutung der Magenerosionen. Dtsch. med. Wschr. 98, 1491 (1970)Google Scholar
  44. Roth, H.: Zur operativen Behandlung des blutenden gastroduodenalen Stressulkus. Schweiz. med. Wschr. 100, 1278 (1970)PubMedGoogle Scholar
  45. Schiller, K. F. R., Truelove, S. C., Williams, D. G.: Haematemesis and melaena with special reference to factors influencing the aoutcome. Brit. med. J. 1970 IV, 7Google Scholar
  46. Spiro, H. M.: Clinical gastroenterology. London: Macmillan 1970Google Scholar
  47. Taylor, H.: The non-surgical treatment of perforated peptic ulcer. Gastroenterology 33, 353 (1957)PubMedGoogle Scholar
  48. Wangensteen, O. H.: Non-operative treatment of localized perforations of the duodenum. Minn. Med. 18, 477 (1935)Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • L. Demling
    • 1
  • W. Rösch
    • 1
  1. 1.ErlangenDeutschland

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