Rat Coronavirus Infection, Lung, Rat

  • David G. Brownstein
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Naturally infected adult rats rarely have grossly observable lung changes. Elsewhere macroscopic lesions are absent or confined to salivary glands and periglandular tissue. Ocular changes may also occur as a consequence of keratitis sicca. Axenic rats experimentally infected with Parker’s rat coronavirus (PRC) develop gross lesions in the lung on postinnoculation days 6 and 7, which consist of randomly dispersed red-brown to gray foci less than 1mm in diameter (Bhatt and Jacoby 1977). Although PRC may cause fatal pneumonia in a high percentage of newborn and day-old rats, gross pulmonary lesions have not been described (Parker et al. 1970). Outbred young adult SPF Wistar rats experimentally infected with sialodacryoadenitis virus (SDAV) develop mild randomly dispersed red foci 5–7 days after intranasal inoculation (Wojcinski and Percy 1986).


Respiratory Syncytial Virus Infection Pneumonia Virus Harderian Gland Bronchiolar Epithelium Rhino Tracheitis 
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© Springer-Verlag Berlin Heidelberg 1996

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  • David G. Brownstein

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