Mouse Hepatitis Viral Infection, Adrenal, Mouse

  • Stephen W. Barthold
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Mice that are ill or dying from mouse hepatitis virus (MHV) infection may have gross lesions in a number of organs, depending upon the infecting virus strain and a number of host factors. Livers may be diffusely pale, have random depressed white spots and petechiae, or be roughly nodular with depression of intervening parenchyma. Hepatitis may be accompanied by small amounts of peritoneal exudate. Mice infected with enterotropic strains may have dilated, fluid- and gasfilled intestines with thin, translucent walls. The spleen may be enlarged and the thymus reduced. The majority of infections in adult, immunocompetent mice are asymptomatic, with no gross lesions (Barthold 1987; Barthold et al. 1982, 1985; Biggers et al. 1964; Hierholzer et al. 1979; Piazza 1969). Depending upon infecting virus strain, athymic nude mice may develop wasting syndrome with neurological signs, hepatic lesions and splenomegaly (Hirano et al. 1975; Sebesteny and Hill 1974; Tamura et al. 1977). Nude mice infected with enterotropic strains of virus may have no overt disease or segmental thickening of the bowel wall, particularly the cecum and ascending colon, and mesenteric lymph node enlargement without hepatitis (Barthold et al. 1985).


Hepatoencephalitis virus murine hepatitis viral infection 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Stephen W. Barthold
    • 1
  1. 1.Comparative MedicineYale University School of MedicineNew HavenUSA

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