Brain Dysfunction Secondary to Sepsis
Septic encephalopathy is a reversible dysfunction of the central nervous system (CNS) that develops in seriously ill patients with sepsis. Conditions in which altered mental status results from localized infections of the CNS, such as meningitis, encephalitis and brain abscess, are not considered septic encephalopathy, and so are beyond the scope of this chapter. We will review the manifestations, incidence, etiology, and treatment of septic encephalopathy. In addition, we will review the spectrum of the systemic inflammatory response syndrome (SIRS) and sepsis, based on the American College of Chest Physicians and the Society of Critical Care Medicine (ACCP/SCCM) Consensus Conference Committee statement . This statement came in response to the need for guidelines for sepsis studies and the knowledge that as long as definitions remained ambiguous and controversial, it would be impossible to compare incidence of sepsis, outcome and effect of new therapies in different studies [1–3].
Unable to display preview. Download preview PDF.
- 6.Bolton CF, Young GB (1986) In: Sibbald WJ, Sprung CL (eds) Perspectives on Sepsis and Septic Shock. Society of Critical Care Medicine, Fullerton, pp 157–171Google Scholar
- 12.Teasdale F, Jennet B (1974) Assessment of coma and impaired consciousness. Lancet 81–84Google Scholar
- 13.Mullie A, Verstinge P, Buylaert W et al (1988) Predictive value of Glasgow Coma Score for awakening after out of hospital cardiac arrest. Lancet 137–140Google Scholar
- 20.Chaudry IH, Clemens MG, Baue AE (1986) In: Sibbald WJ, Sprung CL (eds) Perspectives on Sepsis and Septic Shock. Society of Critical Care Medicine, Fullerton, pp 61–76Google Scholar