Brain Dysfunction Secondary to Sepsis

  • A. Oppenheim
  • L. A. Eidelman
  • C. L. Sprung
Conference paper


Septic encephalopathy is a reversible dysfunction of the central nervous system (CNS) that develops in seriously ill patients with sepsis. Conditions in which altered mental status results from localized infections of the CNS, such as meningitis, encephalitis and brain abscess, are not considered septic encephalopathy, and so are beyond the scope of this chapter. We will review the manifestations, incidence, etiology, and treatment of septic encephalopathy. In addition, we will review the spectrum of the systemic inflammatory response syndrome (SIRS) and sepsis, based on the American College of Chest Physicians and the Society of Critical Care Medicine (ACCP/SCCM) Consensus Conference Committee statement [1]. This statement came in response to the need for guidelines for sepsis studies and the knowledge that as long as definitions remained ambiguous and controversial, it would be impossible to compare incidence of sepsis, outcome and effect of new therapies in different studies [1–3].


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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • A. Oppenheim
  • L. A. Eidelman
  • C. L. Sprung

There are no affiliations available

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