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Pathological Aspects of Platelet-Activating Factor (PAF)

  • F. von Bruchhausen
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 126)

Abstract

Elucidation of the involvement of platelet-activating factor (PAF) in physiological and pathological processes is hampered by analytical problems concerning the low amounts of PAF to be detected, the kinetics of this mediator when given or released endogenously, and the restrictions resulting from studies with PAF receptor antagonists, the pharmacokinetics of which are not fully understood and which also reduce actions of PAF-like lipids (Imaizumi et al. 1995). Endogenous inhibitory factors may interfere with PAF actions (Woodard et al. 1995). Another problem is presented by the fact that PAF, like other mediators or cytokines, acts within a framework (network), so that mutual influences occur on other mediators regarding their release and priming effects in the target, i.e., on the cellular level.

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