Mousepox, Liver, Mouse
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The liver is a major site of viral replication in mousepox, but gross lesions, even during acute disease, are not readily apparent until shortly before death. Severely affected livers are usually swollen and friable and may occupy up to half the volume of the peritoneal cavity, whereas mildly affected livers may remain grossly normal or have sparse focal necrosis. Necrotic areas appear first as pinpoint yellow—white foci, but increase rapidly in size and number. Confluent areas of necrosis can produce a reticulated pattern of yellow—brown to pink discoloration on the surface and throughout the parenchyma. Areas of hemorrhage also may develop. The pale hue of severely affected livers is in part due to fatty change, and the fat content of such livers can be as much as four times normal. Livers from mice that survive acute infection usually have a normal gross appearance. A few small scars may be present, however, especially at the margins (Fenner 1948d, 1949b: Allen et al. 1981).
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