Mousepox, Liver, Mouse

  • Robert O. Jacoby
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The liver is a major site of viral replication in mousepox, but gross lesions, even during acute disease, are not readily apparent until shortly before death. Severely affected livers are usually swollen and friable and may occupy up to half the volume of the peritoneal cavity, whereas mildly affected livers may remain grossly normal or have sparse focal necrosis. Necrotic areas appear first as pinpoint yellow—white foci, but increase rapidly in size and number. Confluent areas of necrosis can produce a reticulated pattern of yellow—brown to pink discoloration on the surface and throughout the parenchyma. Areas of hemorrhage also may develop. The pale hue of severely affected livers is in part due to fatty change, and the fat content of such livers can be as much as four times normal. Livers from mice that survive acute infection usually have a normal gross appearance. A few small scars may be present, however, especially at the margins (Fenner 1948d, 1949b: Allen et al. 1981).


Infectious ectromelia 


  1. Allen AM, Clarke GL, Ganaway JR, Lock A, Werner RM (1981) Pathology and diagnosis of mousepox. Lab Anim Sci 31:599–608PubMedGoogle Scholar
  2. Bhatt PN, Jacoby RO (1985) The pathogenesis of mousepox in genetically resistant and genetically susceptible inbred mice (in preparation)Google Scholar
  3. Blanden RV (1974) T cell response to viral and bacterial infection. Transplant Rev 19:56–88PubMedGoogle Scholar
  4. Briody BA (1959) Response of mice to ectromelia and vaccinia viruses. Bacteriol Rev 23:61–95PubMedGoogle Scholar
  5. Briody BA (1966) The natural history of mousepox. Natl Cancer Inst Monogr 20:105–115PubMedGoogle Scholar
  6. Briody BA, Hauschka TS, Mirand EA (1956) The role of genotype in resistance to an epizootic of mouse pox (ectromelia). Am J Hyg 63:59–68PubMedGoogle Scholar
  7. Buller RM, Bhatt PN, Wallace GD (1983) Evaluation of an enzyme-linked immunosorbent assay for the detection ofectromelia (mousepox) antibody. J Clin Microbiol 18:1220–1225PubMedGoogle Scholar
  8. Cairns J (1960) The initiation of vaccinia infection. Virology 11:603–623PubMedCrossRefGoogle Scholar
  9. Christensen LR, Weisbroth S, Matanic B (1966) Detection of ectromelia virus and ectromelia antibodies by immunofluorescence. Lab Anim Care 16:129–141PubMedGoogle Scholar
  10. Collins MJ Jr, Peters RL, Parker JC (1981) Serological detection of ectromelia virus antibody. Lab Anim Sci 31:595–598PubMedGoogle Scholar
  11. De Burgh PM (1950) Cytochemical changes in early ectromelia infection of mice. Aust J Exp Biol 28:214–218Google Scholar
  12. Fenner F (1947) Studies in infectious ectromelia of mice. II. Natural transmission: the portral of entry of the virus. Aust J Exp Biol 25:275–282CrossRefGoogle Scholar
  13. Fenner F (1948a) The epizootic behavior of mouse-pox (infectious ectromelia). Br J Exp Pathol 29:69–91PubMedGoogle Scholar
  14. Fenner F (1948b) The epizootic behavior of mousepox (infectious ectromelia of mice). II. The course of events in long-continued epidemics. J Hyg 46:383–393CrossRefGoogle Scholar
  15. Fenner F (1948c) The pathogenesis of the acute exanthems. An interpretation based upon experimental investigations with mousepox (infectious ectromelia of mice). Lancet 2:915–920PubMedCrossRefGoogle Scholar
  16. Fenner F (1948d) The clinical features and pathogenesis of mousepox (infectious ectromelia of mice). J Pathol Bacteriol 60:429–552CrossRefGoogle Scholar
  17. Fenner F (1949a) Studies in mousepox (infectious ectromelia of mice). VII. The effect of the age of the host upon the response to infection. Aust J Exp Biol 27:45–53CrossRefGoogle Scholar
  18. Fenner F (1949b) Mouse-pox (infectious ectromelia of mice): a review. J Immunol 63:341–373PubMedGoogle Scholar
  19. Fenner F (1982) Mousepox. In: Foster HL, Small JD, Fox JG (eds) The mouse in biomedical research, vol II, diseases. Academic, New York, chap 11Google Scholar
  20. Gledhill AW (1962) Latent ectromelia. Nature 196:298PubMedCrossRefGoogle Scholar
  21. Greene HSN (1934) Rabbitpox. I. Pathology of the epidemic disease. J Exp Med 60:441–457PubMedCrossRefGoogle Scholar
  22. Horzinek M, Hoken W (1965) Untersuchungen Uber die inapparente Infektion mit dem Ektromelievirus. Arch Ges Virusforsch 17:125–138PubMedCrossRefGoogle Scholar
  23. Kameyama S, Takahashi M, Toyoshima K, Kato S, Kamahora J (1959) Studies on the inclusion bodies of ectromelia virus using the fluorescent antibody technique. Biken J 2:341–344Google Scholar
  24. Leduc EH, Bernhard W (1962) Electron microscope study of mouse liver infected by ectromelia virus. J Ultrastruct Res 6:466–488PubMedCrossRefGoogle Scholar
  25. Mims CA (1964) Aspects of the pathogenesis of virus diseases. Bact Rev 28:30–71PubMedGoogle Scholar
  26. O’Neill HC, Blanden RV (1983) Mechanisms determining innate resistance to ectromelia virus infection in C57BL mice. Infect Immun 41:1391–1394PubMedGoogle Scholar
  27. Roberts JA (1964) Growth of ectromelia virus in the liver parenchymal cells of different strains of mouse. Nature 202:1140–1141PubMedCrossRefGoogle Scholar
  28. Schell K (1960a) Studies on the innate resistance of mice to infection with mousepox. I. Resistance and antibody production. Aust J Exp Biol Med Sci 38:271–288PubMedCrossRefGoogle Scholar
  29. Schell K (1960b) Studies on the innate resistance of mice to infection with mousepox. II. Route of inoculation and resistance; and some observations on the inheritance of resistance. Aust J Exp Biol Med Sci 38:289–300PubMedCrossRefGoogle Scholar
  30. Schwanzer V, Deerberg F, Frost J, Liess B, Schwanzerova I, Pitterman W (1975) Zur intrauterinen Infektion der Maus mit Ektromelie-virus. Z Versuchstierkd 17:110–120PubMedGoogle Scholar
  31. Stanley NF (1974) The reovirus murine models. Prog Med Virol 18:257–272PubMedGoogle Scholar
  32. Wallace GD, Werner RM, Golway PL, Hernandez DM, Alling DW, George DA (1981) Epizootiology of an outbreak of mousepox at the National Institutes of Health. Lab Anim Sci 31:609–615PubMedGoogle Scholar
  33. Walters MN, Joske RA, Leak PJ, Stanley NF (1963) Murine infection with reovirus. I. Pathology of the acute phase. Br J Exp Pathol 44:427–436PubMedGoogle Scholar
  34. Wylekshanin AJ (1935) Transplancental transmission of the filterable virus of infectious ectromelia. Z Ihikrobiol (Moscow) 15:433Google Scholar

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© Springer-Verlag Berlin Heidelberg 1997

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  • Robert O. Jacoby

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