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Mouse Hepatitis Virus Infection, Liver, Mouse

  • Stephen W. Barthold
Chapter
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Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Gross lesions can occur in liver, intestine, and lymphoreticular organs. Intestinal lesions are described in detail elsewhere. Affected livers have random, small, pale or hemorrhagic foci to multiple confluent foci with depression of the capsular surface. The liver may be diffusely pale and covered with fibrinous peritoneal exudate. Infant mice can be runted, jaundiced, or may manifest neurologic signs, including tremor, incoordination, or convulsions (Piazza 1969). During the acute phase of infection, involution of lymph nodes, spleen, and thymus can occur. Recovered mice develop mild splenomegaly or lymphadenomegaly, particularly in cervical nodes. Athymic nude mice can become progressively cachectic (wasting disease). Their livers are contracted with rough, nodular surfaces (Ward et al. 1977), and splenomegaly can be pronounced (Ishida et al. 1978).

Synonyms

Hepatoencephalitis virus murine hepatitis virus infection mouse Coronavirus infection 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

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  • Stephen W. Barthold

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