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Atherogenesis in Diabetes

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Cardiovascular Risk in Type 2 Diabetes Mellitus

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Abstract

The association between diabetes mellitus and an increased risk for cardiovascular disease (CVD) has been well documented. Among diabetic patients, morbidity and mortality rates from myocardial infarction are increased, as are the risks for recurrent infarction, congestive heart failure, stroke, and peripheral vascular disease; Many efforts have been made in elucidating the relation between the metabolic derangements of diabetes and the increased risk for the development of macrovascular disease Most of the known risk factors that predict large vessel disease in the general population, including dyslipidemia, cigarette smoking, and hypertension have been shown to apply equally in the presence of diabetes and, in general, they can be treated in the same ways, but more aggressively. Overall, about 50 percent of excess heart disease in diabetes can be attributed to associated abnormalities in other known CVD risk factors. However, diabetic status appears to confer risk such that even after correction of other risk factors, the diabetic remains at high risk for macrovascular disease. The excess risk is so high that being diabetic is considered to place a patient in the same risk category as having established coronary and other atherosclerotic disease. The degree of risk is, at least in part, influenced by the degree of glycaemic control. Thus, diabetes may increase CVD risk by both direct and indirect effects.This chapter reviews current concepts of atherogenesis and highlights some of the ways in which diabetes mellitus is thought to accelerate the progress.

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Authors
  1. D. Dabelea
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Editors and Affiliations

  1. Diabetes Center and Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, 2-4 Clinicilor St., 3400, Cluj Napoca, Romania

    Nicolae Hâncu

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© 2003 Springer-Verlag Berlin Heidelberg

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Dabelea, D. (2003). Atherogenesis in Diabetes. In: Hâncu, N. (eds) Cardiovascular Risk in Type 2 Diabetes Mellitus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59352-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-59352-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63946-3

  • Online ISBN: 978-3-642-59352-9

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