Heat Shock Proteins in Inflammation and Immunity

  • M. Bachelet
  • G. Multhoff
  • M. Vignola
  • K. Himeno
  • B. S. Polla
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 136)


Inflammation represents a localized or systemic response against tissue or cell injury, which, on the one hand, is essential among cell defense mechanisms and, on the other, is involved in a broad spectrum of diseases. According to the initiating event, the inflammatory response may involve, or not, an antigenspecific immune response. In the first case, the initiating agent is generally a microorganism or an antigen of unknown origin, while in the latter, cells may respond to injurious physical agents (foreign bodies, burns, radiations, trauma) or toxic chemicals. Lymphocytes are classically involved in the specific immune response, and phagocytes in its non-specific counterpart.


Major Histocompatibility Complex Heat Shock Protein Major Histocompatibility Complex Class Hsp70 Family Major Histocompatibility Complex Allele 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • M. Bachelet
  • G. Multhoff
  • M. Vignola
  • K. Himeno
  • B. S. Polla

There are no affiliations available

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