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Akutes Leberversagen

  • K. H. W. Böker
  • M. P. Manns
Chapter
  • 69 Downloads

Zusammenfassung

Als akutes Leberversagen bezeichnet man den Ausfall der Leberfunktion bei Patienten die vorher keine chronische Leberkrankheit hatten. Diese Definition trennt das akute Leberversagen von Endstadien chronischer Leberkrankheiten, bei denen es ebenfalls zum Leberausfall kommen kann. Stellt sich ein solcher terminaler Leberausfall bei chronischer Leberkrankheit als rasch progredientes Ereignis dar, spricht man gelegentlich von einem „akut auf chronischen“ Leberversagen. Strenggenommen handelt es sich dabei aber nicht um ein akutes Leberversagen im eigentlichen Sinne.

Literatur

  1. Acharya SK, Dasarathy S, Irshad M (1995) Prospective study of plasma fibronectin in fulminant hepatitis: association with infection and mortality. J Hepatol 23(1): 8–13PubMedCrossRefGoogle Scholar
  2. Aggarwal S, Kramer D, Yonas H et al. (1994) Cerebral hemodynamic and metabolic changes in fulminant hepatic failure: a retrospective study. Hepatology 19(1): 80–87PubMedCrossRefGoogle Scholar
  3. Alexander WF, Spindel E, Harty RF et al. (1989) The usefulness of branched chain amino acids in patients with acute or chronic hepatic encephalopathy. Am J Gastroenterol 84(2): 91–96PubMedGoogle Scholar
  4. Anand AC, Nightingale P, Neuberger JM (1997) Early indicators of prognosis in fulminant hepatic failure: an assessment of the King’s criteria. J Hepatol 26(1): 62–68PubMedCrossRefGoogle Scholar
  5. Ascher NL, Lake JR, Emond JC et al. (1993) Liver transplantation for fulminant hepatic failure. Arch Surg 128(6): 677–682PubMedCrossRefGoogle Scholar
  6. Baez TA, Gonzalez KC (1994) Acute fatty liver of pregnancy. Case report and review of the literature. P R Health Sci J 13(1): 9–12Google Scholar
  7. Barber JR, Teasley KM (1984) Nutritional support of patients with severe hepatic failure. Clin Pharm 3(3): 245–253PubMedGoogle Scholar
  8. Belay ED, Bresee JD, Holman RC et al. (1999) Reye’s syndrome in the United States from 1981 through 1997. N Engl J Med 340: 1377–1382PubMedCrossRefGoogle Scholar
  9. Berman DH, Leventhal RI, Gavaler JS et al. (1991) Clinical differentiation of fulminant Wilsonian hepatitis from other causes of hepatic failure. Gastroenterology 100(4): 1129–1134PubMedGoogle Scholar
  10. Bernuau J, Rueff B, Benhamou JP (1986) Fulminant and subfulminant liver failure: definitions and causes. Semin Liver Dis 6(2): 97–106PubMedCrossRefGoogle Scholar
  11. Bihari DJ, Gimson AE, Williams R (1986) Cardiovascular, pulmonary and renal complications of fulminant hepatic failure. Semin Liver Dis 6(2): 119–128PubMedCrossRefGoogle Scholar
  12. Bismuth H, Samuel D, Castaing D et al. (1996) Liver transplantation in Europe for patients with acute liver failure. Semin Liver Dis 16(4): 415–425PubMedCrossRefGoogle Scholar
  13. Blei AT (1995) Pathogenesis of brain edema in fulminant hepatic failure. Prog Liver Dis 13(311): 311–330PubMedGoogle Scholar
  14. Blei AT, Olafsson S, Webster S et al. (1993) Complications of intracranial pressure monitoring in fulminant hepatic failure. Lancet 341: 157–158PubMedCrossRefGoogle Scholar
  15. Bray GP, Harrison PM, O’Grady JG et al. (1992) Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure. Hum Exp Toxicol 11(4): 265–270PubMedCrossRefGoogle Scholar
  16. Cattral MS, Altraif I, Greig PD et al. (1994) Toxic effects of intravenous and oral prostaglandin E therapy in patients with liver disease. Am J Med 97(4): 369–373PubMedCrossRefGoogle Scholar
  17. Cordoba J, Blei AT (1995) Cerebral edema and intracranial pressure monitoring. Liver Transpl Surg 1(3): 187–194PubMedCrossRefGoogle Scholar
  18. Davies MH, Mutimer D, Lowes J et al. (1994) Recovery despite impaired cerebral perfusion in fulminant hepatic failure. Lancet 343: 1329–1330PubMedCrossRefGoogle Scholar
  19. Davison AM (1996) Hepatorenal failure. Nephrol Dial Transplant 8(24): 24–31CrossRefGoogle Scholar
  20. Devlin J, Ellis AE, McPeake J et al. (1997) N-acetylcysteine improves indocyanine green extraction and oxygen transport during hepatic dysfunction. Crit Care Med 25(2): 236–242PubMedCrossRefGoogle Scholar
  21. Ellis A, Wendon J (1996) Circulatory, respiratory, cerebral, and renal derangements in acute liver failure: pathophysiology and management. Semin Liver Dis 16(4): 379–388PubMedCrossRefGoogle Scholar
  22. Ellison RT, Perez PG, Welsh CH et al. (1996) Risk factors for upper gastrointestinal bleeding in intensive care unit patients: role of helicobacter pylori. Federal Hyperimmune Immunoglobulin Therapy Study Group. Crit Care Med 24(12): 1974–1981PubMedCrossRefGoogle Scholar
  23. Feller RB, Wilson JS (1994) Hepatic failure in fatal exertional heatstroke. Aust N Z J Med 24: 69PubMedCrossRefGoogle Scholar
  24. Fiaccadori F, Pedretti G, Ferrari C et al. (1991) Insulin and glucagon levels in fulminant hepatic failure in man. Dig Dis Sci 36(6): 801–808PubMedCrossRefGoogle Scholar
  25. Gimson AE (1996) Fulminant and late onset hepatic failure. Br J Anaesth 77(1): 90–98PubMedCrossRefGoogle Scholar
  26. Gimson A, Tedder R, White Y (1983) Serological markers in fulminant Hepatitis B. Gut 24: 615PubMedCrossRefGoogle Scholar
  27. Gubernatis G, Pichlmayr R, Kemnitz J et al. (1991) Auxiliary partial orthotopic liver transplantation (APOLT) for fulminant hepatic failure: first successful case report. World J Surg 15(5): 660–665PubMedCrossRefGoogle Scholar
  28. Gyr K, Meier R (1991) Flumazenil in the treatment of portal systemic encephalopathy — an overview. Intensive Care Med 17 (Suppl 1): S39–S42PubMedCrossRefGoogle Scholar
  29. Harrison PM, Keays R, Bray GP et al. (1990) Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine. Lancet 335(8705): 1572–1573PubMedCrossRefGoogle Scholar
  30. Häussinger D, Gerok W (1986) The effect of urea synthesis on extracellular pH in isolated perfused rat liver. Biochem J 236: 261–265PubMedGoogle Scholar
  31. Hoofnagle JH, Carithers RJ, Shapiro C et al. (1995) Fulminant hepatic failure: summary of a workshop. Hepatology 21(1): 240–252PubMedGoogle Scholar
  32. Hughes RD, Zhang L, Tsubouchi H et al. (1994) Plasma hepatocyte growth factor and biliprotein levels and outcome in fulminant hepatic failure. J Hepatol 20(1): 106–111PubMedCrossRefGoogle Scholar
  33. Irshad M (1997) Hepatitis E virus: a global view of its seroepidemiology and transmission pattern. Trop Gastroenterol 18(2): 45–49PubMedGoogle Scholar
  34. Jain SK, Rohatgi A, Raman KK et al. (1995) Study of serum prealbumin and serum alpha fetoprotein in cases of fulminant hepatic failure. J Assoc Physicians India 43(7): 462–463PubMedGoogle Scholar
  35. Janes J, Routledge PA (1992) Recent developments in the management of paracetamol (acetaminophen) poisoning. Drug Saf 7(3): 170–177PubMedCrossRefGoogle Scholar
  36. Jauregui HO, Chowdhury NR, Chowdhury JR (1996) Use of mammalian liver cells for artificial liver support. Cell Transplant 5(3): 353–367PubMedCrossRefGoogle Scholar
  37. Jones EA, Schäfer DF, Ferenci P et al. (1984) The GABA hypothesis of the pathogenesis of hepatic encephalopathy: current status. Yale J Biol Med 57(3): 301–316PubMedGoogle Scholar
  38. Jones EA, Basile AS, Skolnick P (1990) Hepatic encephalopathy, GABA-ergic neurotransmission and benzodiazepine receptor ligands. Adv Exp Med Biol 272(121): 121–134PubMedCrossRefGoogle Scholar
  39. Karvoutzis G, Redecker A, Peters R (1974) Long term follow up of patients surviving fulminant viral hepatitis. Gastroenterology 67: 870Google Scholar
  40. Keays R, Potter D, O’Grady J et al. (1991) Intracranial and cerebral perfusion pressure changes before, during and immediately after orthotopic liver transplantation for fulminant hepatic failure. QJM 79(289): 425–433PubMedGoogle Scholar
  41. Koppel C (1993) Clinical symptomatology and management of mushroom poisoning. Toxicon 31(12): 1513–1540PubMedCrossRefGoogle Scholar
  42. Krowka MJ (1993) Clinical management of hepatopulmonary syndrome. Sem Liver Dis 13: 414–422CrossRefGoogle Scholar
  43. Kuo PC, Johnson LB, Hastings G et al. (1996) Fulminant hepatic failure from the Budd-Chiari syndrome. A bridge to transplantation with transjugular intrahepatic portosystemic shunt. Transplantation 62(2): 294–296PubMedCrossRefGoogle Scholar
  44. Lake JR, Sussman NL (1995) Determining prognosis in patients with fulminant hepatic failure: when you absolutely, positively have to know the answer. Hepatology 21(3): 879–882PubMedCrossRefGoogle Scholar
  45. Langley P, Hughes R, Williams R (1985) Increased Faktor VIII complex in fulminant hepaic failure. Thromb Haemost 54: 693–696PubMedGoogle Scholar
  46. Langley PG, Forbes A, Hughes RD et al. (1990) Thrombinantithrombin III complex in fulminant hepatic failure: evidence for disseminated intravascular coagulation and relationship to outcome. Eur J Clin Invest 20(6): 627–631PubMedCrossRefGoogle Scholar
  47. Langley PG, Keays R, Hughes RD et al. (1991) Antithrombin III supplementation reduces heparin requirement and platelet loss during hemodialysis of patients with fulminant hepatic failure. Hepatology 14(2): 251–256PubMedCrossRefGoogle Scholar
  48. Larsen FS, Ejlersen E, Clemmesen JO et al. (1996) Preservation of cerebral oxidative metabolism in fulminant hepatic failure: an autoregulation study. Liver Transpl Surg 2(5): 348–353PubMedCrossRefGoogle Scholar
  49. Lee WM (1996) Management of acute liver failure. Semin Liver Dis 16(4): 369–378PubMedCrossRefGoogle Scholar
  50. Liang TJ, Hasegawa K, Rimon N et al. (1991) A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. N Engl J Med 324(24): 1705–1709PubMedCrossRefGoogle Scholar
  51. Malchesky PS (1994) Nonbiological liver support: historic overview. Artif Organs 18(5): 342–347PubMedCrossRefGoogle Scholar
  52. McCashland TM, Shaw BJ, Tape E (1996) The American experience with transplantation for acute liver failure. Semin Liver Dis 16(4): 427–433PubMedCrossRefGoogle Scholar
  53. McGuire BM, Sielaff TD, Nyberg SL et al. (1995) Review of support systems used in the management of fulminant hepatic failure. Dig Dis 13(6): 379–388PubMedCrossRefGoogle Scholar
  54. Mendez L, Reddy KR, Di PR et al. (1991) Fulminant hepatic failure due to acute hepatitis B and delta co-infection. Am J Gastroenterol 86(7): 895–897PubMedGoogle Scholar
  55. Mendoza A, Fernandez F, Mutimer DJ (1997) Liver transplantation for fulminant hepatic failure: importance of renal failure. Transpl Int 10(1): 55–60PubMedCrossRefGoogle Scholar
  56. Meyer RA, Duffy MC (1993) Spontaneous reactivation of chronic hepatitis B infection leading to fulminant hepatic failure. Report of two cases and review of the literature. J Clin Gastroenterol 17(3): 231–234PubMedCrossRefGoogle Scholar
  57. Munoz SJ (1993) Difficult management problems in fulminant hepatic failure. Semin Liver Dis 13(4): 395–413PubMedCrossRefGoogle Scholar
  58. Munoz SJ, Moritz MJ, Martin P et al. (1993) Relationship between cerebral perfusion pressure and systemic hemodynamics in fulminant hepatic failure. Transplant Proc 25(2): 1776–1778PubMedGoogle Scholar
  59. Neuberger JM (1990) Halothane and hepatitis. Incidence, predisposing factors and exposure guidelines. Drug Saf 5(1): 28–38PubMedCrossRefGoogle Scholar
  60. O’Brien BK (1996) A fatal Sunday brunch: Amanita mushroom poisoning in a Gulf Coast family. Am J Gastroenterol 91(3): 581–583PubMedGoogle Scholar
  61. O’Grady J (1992) Management of acute and fulminant hepatitis A. Vaccine 10 (Suppl 1): S21–S23PubMedCrossRefGoogle Scholar
  62. O’Grady JG (1996) Pathogenesis of acute liver failure. Trop Gastroenterol 17(4): 199–201PubMedGoogle Scholar
  63. O’Grady JG (1997 a) Paracetamol hepatotoxicity: how to prevent. J R Soc Med 90(7): 368–370PubMedGoogle Scholar
  64. O’Grady JG (1997 b) Paracetamol-induced acute liver failure: prevention and management. J Hepatol 1(41): 41–46CrossRefGoogle Scholar
  65. Pandha HS (1992) Treating acidosis in fulminant hepatic failure: the case against use of bicarbonate solutions [letter; comment]. N Z Med J 105: 937Google Scholar
  66. Pereira LM, Langley PG, Hayllar KM et al. (1992) Coagulation factor V and VIII/V ratio as predictors of outcome in paracetamol induced fulminant hepatic failure: relation to other prognostic indicators. Gut 33(1): 98–102PubMedCrossRefGoogle Scholar
  67. Pereira SP, Langley PG, Williams R (1996) The management of abnormalities of hemostasis in acute liver failure. Semin Liver Dis 16(4): 403–414PubMedCrossRefGoogle Scholar
  68. Pohl L (1990) Drug induced allergic hepatitis. Semin Liver Dis 10: 305–315PubMedCrossRefGoogle Scholar
  69. Riely CA (1994) Hepatic disease in pregnancy. Am J Med 96: 18S–22SPubMedCrossRefGoogle Scholar
  70. Rolando N, Wade JJ, Fagan E et al. (1992) An open, comparative trial of aztreonam with vancomycin and gentamicin with piperacillin in patients with fulminant hepatic failure. J Antimicrob Chemother 30(2): 215–220PubMedCrossRefGoogle Scholar
  71. Rolando N, Philpott HJ, Williams R (1996) Bacterial and fungal infection in acute liver failure. Semin Liver Dis 16(4): 389–402PubMedCrossRefGoogle Scholar
  72. Sanchez-Tapias J, Mas A, Costa J (1987) Recombinant interferon therapy in fulminant viral hepatitis. J Hepatol 5: 205–210PubMedCrossRefGoogle Scholar
  73. Stremmel W, Meyerrose KW, Niederau C et al. (1991) Wilson disease: clinical presentation, treatment, and survival. Ann Intern Med 115(9): 720–726PubMedGoogle Scholar
  74. Theilmann L, Solbach C, Toex U et al. (1992) Role of hepatitis C virus infection in German patients with fulminant and subacute hepatic failure. Eur J Clin Invest 22(8): 569–571PubMedCrossRefGoogle Scholar
  75. Vallbracht A, Gabriel P, Maier K (1986) Cell mediated cytotoxicity in hepatitis A virus infection. Hepatology 6: 1308–1314PubMedCrossRefGoogle Scholar
  76. Van Pelt F, Sträub P, Manns M (1995) Molecular basis of drug induced immunological liver injury. Semin Liver Dis 15: 283–300PubMedCrossRefGoogle Scholar
  77. Wendon JA, Harrison PM, Keays R et al. (1992) Effects of vasopressor agents and epoprostenol on systemic hemodynamics and oxygen transport in fulminant hepatic failure. Hepatology 15(6): 1067–1071PubMedCrossRefGoogle Scholar
  78. Wijdicks EF, Plevak DJ, Rakela J et al. (1995) Clinical and radiologic features of cerebral edema in fulminant hepatic failure. Mayo Clin Proc 70(2): 119–124PubMedCrossRefGoogle Scholar
  79. Williams R (1996) Classification, etiology, and considerations of outcome in acute liver failure. Semin Liver Dis 16(4): 343–348PubMedCrossRefGoogle Scholar
  80. Williams R, Gimson AE (1991) Intensive liver care and management of acute hepatic failure. Dig Dis Sci 36(6): 820–826PubMedCrossRefGoogle Scholar
  81. Williams R, Wendon J (1994) Indications for orthotopic liver transplantation in fulminant liver failure. Hepatology 20: 5S–10SGoogle Scholar
  82. Williams R, O’Grady JG, Davies SE et al. (1992) Liver transplantation and hepatitis viruses. Arch Virol Suppl 4(11): 311–316PubMedCrossRefGoogle Scholar
  83. Woolf GM, Redeker AG (1991) Treatment of fulminant hepatic failure with insulin and glucagon. A randomized, controlled trial. Dig Dis Sci 36(1): 92–96PubMedCrossRefGoogle Scholar
  84. Wyke RJ (1989) Bacterial infections complicating liver disease. Baillieres Clin Gastroenterol 3(1): 187–210PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2000

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  • K. H. W. Böker
  • M. P. Manns

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