Hantaviruses pp 135-151 | Cite as

Clinical Characteristics of Hantavirus Infections on the Eurasian Continent

  • M. Linderholm
  • F. Elgh
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 256)


In 1933 and 1934 two Swedish physicians, working in northern Sweden independently of each other, observed a previously undescribed disease (Myhrman 1934; Zetterholm 1934). It was characterized by a rapid onset of high fever, malaise, chills, headache, abdominal, back and often generalized pain, and a renal syndrome with proteinuria and oliguria followed by a diuretic phase. A spontaneous recovery followed all cases described. In 1945 Myhrman proposed nephropathia epidemica (NE) as the name for this disease. During the subsequent decades, a large number of cases of this disease were reported from Scandinavia and Finland (Myhrman 1945, 1951; Lahdevirta 1971).


Hantavirus Infection Nephropathia Epidemica Hantaan Virus Hantavirus Pulmonary Syndrome Puumala Virus 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • M. Linderholm
    • 1
    • 2
  • F. Elgh
    • 3
    • 4
    • 5
  1. 1.Department of Infectious DiseasesSweden
  2. 2.Department of MedicineUmeå UniversityUmeåSweden
  3. 3.Department of VirologyUmeå UniversityUmeåSweden
  4. 4.Department of MicrobiologyDefence Research EstablishmentUmeåSweden
  5. 5.Centre for Microbiological PreparednessSwedish Institute for Infectious Disease ControlSolnaSweden

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