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Molekulare Grundlagen organspezifischer Tumoren: Knochen- und Weichteilsarkome

  • Karl-Ludwig Schäfer
  • Raihanatou Diallo
  • Barbara Dockhorn-Dworniczak
  • Christopher Poremba
Chapter
Part of the Molekulare Medizin book series (MOLMED)

Zusammenfassung

Sarkome, d. h. maligne mesenchymale Tumoren, der Knochen und des Weichgewebes stellen eine große Gruppe heterogener Tumorentitäten dar. Aus molekularpathologischer Sicht sind zahlreiche dieser Tumoren durch charakteristische, chromosomale Umlagerungen gekennzeichnet (Tabelle 13.1), deren Bestimmung sowohl diagnostisch als auch für das Verständnis der Tumorgenese von hohem Wert ist. In diesem Kapitel werden schwerpunktmäßig die Sarkome behandelt, die durch ebensolche chromosomalen Umlagerungen (Translokationen) charakterisiert sind. Die einzelnen Tumorentitäten werden unter Berücksichtigung der Inzidenz und Epidemiologie, ätiologie, Pathogenese, Pathologie einschließlich molekularer Diagnostik sowie der Tumorbiologie vorgestellt.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Karl-Ludwig Schäfer
  • Raihanatou Diallo
  • Barbara Dockhorn-Dworniczak
  • Christopher Poremba

There are no affiliations available

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