Gentherapie — ein neuer therapeutischer Ansatz zur Behandlung des diabetischen Fußulkus?

  • M. G. Jeschke
Conference paper
Part of the Deutsche Gesellschaft für Chirurgie book series (DTGESCHIR, volume 2003)


Ziel unserer Untersuchungen ist die Anwendung des non-viralen liposomalen Gen-Transfers zur Verbesserung der Wundheilung in akuten und chronischen Wunden. Durch diese neue Technologie könnten akute Wunden signifikant schneller, in Vorläuferuntersuchungen konnten wir die Wundheilung um 200% steigern, und chronische Wunden zur Abheilung gebracht werden, welches in 4 – 6 Millionen Patienten bis dato erfolglos war.

Gene therapy — a new therapeutic approach to the treatment of diabetic foot ulcer


Cationic cholesterol-containing liposomal constructs appear to have a great potential for non-viral gene transfer in the skin. We and others demonstrated that liposomes containing DNA sequences for growth factors enhance, accelerate and improve dermal and epidermal regeneration. The exogenous applied cDNA is transcribed and translated into endogenous protein and exerts its physiologic effects. As the transcription-translation process is relatively limited to the skin with no systemic transfection, the approach of injecting DNA into the skin is relatively specific and can improve epithelization by 200%. By improving the quality and also transfection rates of liposomes they could be the delivery system of the future for gene therapy.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • M. G. Jeschke
    • 1
  1. 1.Abteilung für Plastische und HandchirurgieChirurgische UniversitätsklinikErlangenDeutschland

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