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Glucose-regulated insulin expression following hepatic gene transfer

  • P. C. Nett
  • H. W. Sollinger
  • T. Alam
Conference paper
Part of the Deutsche Gesellschaft für Chirurgie book series (DTGESCHIR, volume 2003)

Abstract

Insulin dependent diabetes mellitus (IDDM), along with its long-term complications, imposes a serious impact on public health. Current therapy of IDDM consists of multiple insulin injections, insulin pump, islet or whole pancreas transplantation. However, proper glycemic control is not always achieved. All treatment options have significant limitations, which lead to an intensive search for novel treatment strategies. Gene therapy using autologous hepatocytes is believed to be an effective and safe therapeutic approach to induce insulin secretion within physiologic range in response to glucose challenge.

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • P. C. Nett
    • 1
  • H. W. Sollinger
    • 1
  • T. Alam
    • 1
  1. 1.Division of TransplantationUniversity of Wisconsin Hospital and ClinicsUSA

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