Glucose-regulated insulin expression following hepatic gene transfer
Insulin dependent diabetes mellitus (IDDM), along with its long-term complications, imposes a serious impact on public health. Current therapy of IDDM consists of multiple insulin injections, insulin pump, islet or whole pancreas transplantation. However, proper glycemic control is not always achieved. All treatment options have significant limitations, which lead to an intensive search for novel treatment strategies. Gene therapy using autologous hepatocytes is believed to be an effective and safe therapeutic approach to induce insulin secretion within physiologic range in response to glucose challenge.