Die in utero und orale Exposition zu »Non-inherited Maternal Antigens (NIMA)« bewirkt eine natürliche Transplantationstoleranz in Mäusen
In transplantation lifelong immunosuppressive therapy is usually required. This however increases the risk for infectious disease and the occurrence of de novo or recurrent malignancy. Thus the aim should be to develop new strategies to be able to either substantially decrease or even discontinue immunosuppression in transplantation. Exposure to alloantigens of mother (NIMA) was shown to have a strong beneficial effect on sibling kidney graft survival. An animal model is needed to further investigate this phenomenon. We therefore initiated different breeding schemes in mice to determine which combination best reproduces the clinical NIMA-effect in organ transplantation.