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Regeneration, Hyperplasie und Onkogenese der lymphoretikulären Organe

  • H. Cottier
  • M. W. Hess
  • B. Roos
  • P. A. Grétillat
Chapter
  • 220 Downloads
Part of the Handbuch der Allgemeinen Pathologie book series (PATHOLOGIE, volume 6 / 2)

Zusammenfassung

Im nachfolgenden Beitrag sollen die Vorgänge der Regeneration, Hyperplasie und Cancerisierung am Beispiel des lymphoretikulären Systems besprochen werden. Die Berechtigung zu diesem Vorhaben, wenig mehr als 10 Jahre nach Erscheinen des Handbuchartikels von Masshoff (1955) über „die physiologische Regeneration“, ergibt sich aus dem Umstand, daß in der Zwischenzeit die Erforschung der immunbiologisch aktiven Zellsysteme umwälzende Fortschritte gebracht hat. Eine erneute Bearbeitung dieser Fragen erschien daher unumgänglich. Die Gründe für die rasche Entwicklung auf dem Gebiet der Immunologie, in deren Rahmen das lymphoretikuläre System gehört, liegen vor allem in der Verfeinerung der Untersuchungsmethoden. Es ist heute möglich, Zellen stabil zu markieren und auf diese Weise deren Schicksal zu verfolgen. Wir sind ferner in der Lage, biochemische Vorgänge auf cellulärer Ebene zu verfolgen und makromolekulare Bestandteile des Gewebes aufgrund ihrer Antigeneigenschaften immuno-histochemisch zu erfassen. Diese und weitere Gegebenheiten gestatten es, experimentell belegbare Aussagen zu machen, wo früher nur Vermutungen möglich waren. Wie wir sehen werden, haben die neu gewonnenen Erkenntnisse auch für die Beurteilung von Regeneration, Hyperplasie und Cancerisierung ihre große Bedeutung. Allerdings bleibt hervorzuheben, daß die Geschwindigkeit der heutigen wissenschaftlichen Entwicklung wenig mehr als eine Standortbestimmung zuläßt.

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