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Physiologische und pathophysiologische Bedeutung des atrialen natriuretischen Peptids in der Blutdruckregulation

  • R. E. Lang
Conference paper

Zusammenfassung

Der akute blutdrucksenkende Effekt von Extrakten aus dem Vorhof des Herzens wurde 1981 zum ersten Mal von de Bold und Mitarbeitern beschrieben und später in Studien mit synthetischem atrialen natriuretischem Peptid (ANP) bestätigt (7, 10, 20, 22, 24). Unter konstanter Infusion von ANP wird ein dosisabhängiger Blutdruckabfall sowohl in wachen als auch anästhetisierten normotensiven Tieren beobachtet. Der Blutdruck fällt unmittelbar nach Beginn der Infusion ab und kehrt nach Stopp der Infusion rasch zu den Ausgangswerten zurück. Dies läßt auf eine direkte Wirkung des ANP auf das kardiovaskuläre System schließen. Trotz des blutdrucksenkenden Effektes kommt es bei Ratte und Hund nicht zu den erwarteten reflektorischen Veränderungen der Herzfrequenz (7, 22, 24). Dies gibt Anlaß zu der Vermutung, daß ANP eine vagomimetische Wirkung besitzt (1).

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Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1988

Authors and Affiliations

  • R. E. Lang
    • 1
    • 2
  1. 1.Deutsches Institut zur Bekämpfung des hohen Blutdruckes und Pharmakologisches InstitutUniversität HeidelbergDeutschland
  2. 2.Institut für PharmakologieUniversität HeidelbergHeidelbergDeutschland

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