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Humanes atriales natriuretisches Peptid bei Lebererkrankungen und Aszites

  • Johann Pidlich
  • E. Hartter
  • F. Renner
  • W. Woloszczuk
Conference paper

Zusammenfassung

Für die Ausbildung von Aszites, welcher neben einer Vielzahl von pathologischen Veränderungen in etwa 90% durch Leberzirrhose, maligne Erkrankungen oder kardiale Insuffizienz bedingt ist (2), kann nach wie vor kein einheitliches, fundiertes pathogenetisches Konzept angeführt werden, wobei sich insbesondere das variable Auftreten und Ausmaß, teilweise völlig unabhängig vom Grad der Leberfunktionsbeeinträchtigung, sowie der Zusammenhang mit der Entstehung eines hepatorenalen Syndroms nicht befriedigend erklären läßt (5, 7).

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Literatur

  1. 1.
    Arroyo V, Bosch J, Mauri M, Viver J, Mas A, Rivera F, Rodes J (1979) Renin aldosterone and renal hemodynamics in cirrhotics with ascites. Eur J Clin Invest 9: 69–73.PubMedCrossRefGoogle Scholar
  2. 2.
    Berner C, Fred HL, Riggs S, Davis JS (1964) Diagnostic proabilities in patients with conspicuous ascites. Archives of Internal Medicine 113: 687.PubMedCrossRefGoogle Scholar
  3. 3.
    Bichet DG, Van Putten VJ, Schrier RW (1982) Potential role of increased sympathetic activity in impaired sodium and water excretion in cirrhotics. N Engl J Med 30:1552–1557.CrossRefGoogle Scholar
  4. 4.
    Buckalew VM Jr, Gruber KA (1983) Naturetic hormone. In: Epstein M. (ed) 1, 2nd ed. Elsevier Biomedical, New York, S 479–499.Google Scholar
  5. 5.
    Dudley FJ, Kanel GC, Wood LJ, Reynolds TB (1986) Hepatorenal Syndrome without avid sodium retention. Hepatology 6: 248–251.PubMedCrossRefGoogle Scholar
  6. 6.
    de Wardener HE, Mills IH, Clapham WF, Hayter CJ (1961) Studies on the efferent mechanisms of the sodium diuresis which follows the administration of intravenous saline in the dog. Clin Sci 21: 249–258.Google Scholar
  7. 7.
    Epstein M (1985) Derangements of renal water handling in liver disease. Gastroenterology 89: 1415–1425.PubMedGoogle Scholar
  8. 8.
    Epstein M (1983) The kidney in liver disease, 2nd ed. Elsevier Biomedical, New York.Google Scholar
  9. 9.
    Epstein M (1986) The sodium Retention of Cirrhosis: A Reappraisal. Hepatology 6:312–315.PubMedCrossRefGoogle Scholar
  10. 10.
    Epstein M (1979) Deranged sodium homeostasis in cirrhosis. Gastroenterology 76: 622–635.PubMedGoogle Scholar
  11. 11.
    Favre R (1981) Role of the natriuretic factor in the disorders of sodium balance. In: Hamburger J, Crosnier J, Maxwell MH (eds) Advances in nephrology, Vol 11. Year Book Medical Publishers, Chicago, Inc. 3–23.Google Scholar
  12. 12.
    Fernandez-Cruz A, Marco J, Cuadrado LM, Gutkowska J, Rodriguez-Puyol D, Carmelo C, López-Novoa JM (1985) Plasma levels of atrial natriuretic peptide in cirrhotic patients. Lancet: 1439.Google Scholar
  13. 13.
    Field M, Graf LH, Jr, Laird WJ, Smith PL (1978) Proc Nate Acad Sci USA 75: 2800–1804.CrossRefGoogle Scholar
  14. 14.
    Fyhrquist F, Töttermann KJ, Tilkanen J (1985) Infusion of atrial natriuretic peptide in liver cirrhosis with ascites. Lancet: 1439.Google Scholar
  15. 15.
    Garcia R, Debinski W, Gutkowska J, Kuchel O, Thibault G, Genest J, Cantin M (1985) Gluco-and mineralocorticoids may regulate the natriuretic effect and the synthesis and release of atrial natriuretic factor by the rat atria in vivo. Biochem Biophys Res Commun 131: 806.PubMedCrossRefGoogle Scholar
  16. 16.
    Gerbes AL, Arendt RM, Ritter D, Jüngst D, Zähringer J, Paumgartner G (1986) Plasma atrial natriuretic factor in patients with cirrhosis. NEJM 313: 1609.Google Scholar
  17. 17.
    Gerbes AL, Arendt RM, Riedel A, Groß T, Schwenk H, Schnitzer W, Stangl E, Jüngst D, Paumgartner G (1986) Impact of the atrial natriuretic factor (ANF) on volume regulation in patients with cirrhosis of the liver. Abstract VII International Congress of Liver Diseases, Basel, October 16-18, 1986.Google Scholar
  18. 18.
    Hartter E, Woloszczuk W, Stummvoll HK (1986) Radioimmunoassay of atrial natriuretic peptides in human plasma. Clin Chem 32: 441–445.PubMedGoogle Scholar
  19. 19.
    Hughes JM, Murad F, Chang B, Guerrant RL (1978) Nature 271: 755–756.PubMedCrossRefGoogle Scholar
  20. 20.
    Jimenez W, Martinez-Pardo A, Arroyo V, Gaya J, Rivera F, Rodes J (1986) Atrial natriuretic factor: reduced cardiac content in cirrhotic rats with ascites. Am J Physiol 250: F749–F752.PubMedGoogle Scholar
  21. 21.
    Kramer HJ (1975) Natriuretic hormone — Its possible role in fluid an electrolyte disturbances in chronic liver disease. Postgrad Med J 51: 532–540.PubMedCrossRefGoogle Scholar
  22. 22.
    Kudo T, Baird A (1984) Nature 312: 756–757.CrossRefGoogle Scholar
  23. 23.
    Naccarato R, Messa P, Gregolin C, Zanon G (1981) Renal handling of sodium and water in early chronic liver disease. Gastroenterology 81: 205–210.PubMedGoogle Scholar
  24. 24.
    Nicholls KM, Shapiro MD, Kluge R, Chung HM, Bichet DG, Schrier RW (1986) Sodium excretion in advanced cirrhosis: effect of expansion of central blood volume and suppression of plasma aldosterone. Hepatology 6: 235–238.PubMedCrossRefGoogle Scholar
  25. 25.
    Shear L, Hall PW, Gabuzda GJ (1965) Renal failure in patients with cirrhosis of the liver. J Clinical and pathological characterists. Am J Med 39: 184–198.Google Scholar
  26. 26.
    Shenker Y, Sider RS, Ostafin EA, Grekin RJ (1985) Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with oedema. Journal of Clinical Investigation 76: 1684–1687.PubMedCrossRefGoogle Scholar
  27. 27.
    Sherlock S, Senewirantne B, Scott A, Walker JG (1966) Complications of diuretic therapy in hepatic cirrhosis. Lancet I: 1049.CrossRefGoogle Scholar
  28. 28.
    Sherlock S (1970) Aszites formation and its management. Scand J Gastroenterol 7 (Suppl): 9–15.Google Scholar
  29. 29.
    Sonnenberg H (1986) Mechanisms of release and renal tubular action of atrial natriuretic factor. Federation Proc 45: 2106–2110.Google Scholar
  30. 30.
    Steigmann F, Mejicano R (1969) The impact of diuretics on chronic liver disease. American Journal of Gastroenterology 52: 37.PubMedGoogle Scholar
  31. 31.
    Stone WD, Islam NRK, Parton A (1968) The natural history of cirrhosis. Experience of an unselected group of patients. Quarterly Journal of Medicine 37: 119.PubMedGoogle Scholar
  32. 32.
    Wernze H, Burghardt W (1986) Atrial natriuretic peptide, the sympathetic nervous system, and decompensated cirrhosis. Lancet: 331.Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1988

Authors and Affiliations

  • Johann Pidlich
    • 1
    • 4
  • E. Hartter
    • 2
  • F. Renner
    • 1
  • W. Woloszczuk
    • 3
  1. 1.II. Universitätsklinik für Gastroenterologie und HepatologieWienÖsterreich
  2. 2.II. Medizinische UniversitätsklinikWienÖsterreich
  3. 3.Ludwig Boltzmann Institut für klinische EndokrinologieWienÖsterreich
  4. 4.II. Universitätsklinik für Gastroenterologie u. HepatologieWienÖsterreich

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