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Animal Models in Periodontal Research

  • Alexandrina L. Dumitrescu
Chapter
  • 82 Downloads

Abstract

Animal models have been used to evaluate the pathogenesis of periodontal diseases and various periodontal treatment modalities. Human longitudinal studies of periodontal diseases pose many problems such as determining the level of disease activity, individuals at risk and susceptibility to disease progression. It is important to choose a laboratory animal model that has similar characteristics of human anatomy and periodontal disease. Features of periodontal diseases in humans and animals vary greatly depending upon which form of the disease is present and the stage of the development. Inflammatory destruction of the periodontium can be spontaneous or experimentally induced in most mammalian species.

References

  1. Aaboe M, Pinholt EM, Hjørting-Hansen E. Unicortical critical size defect of rabbit tibia is larger than 8 mm. J Craniofac Surg. 1994;5:201–3.PubMedCrossRefGoogle Scholar
  2. Abukawa H, Zhang W, Young CS, Asrican R, Vacanti JP, Kaban LB, Troulis MJ, Yelick PC. Reconstructing mandibular defects using autologous tissue-engineered tooth and bone constructs. J Oral Maxillofac Surg. 2009;67:335–47.PubMedCrossRefGoogle Scholar
  3. Achong R, Nishimura I, Ramachandran H, Howell TH, Fiorellini JP, Karimbux NY. Membrane type (MT) 1-matrix metalloproteinase (MMP) and MMP-2 expression in ligature-induced periodontitis in the rat. J Periodontol. 2003;74:494–500.PubMedCrossRefGoogle Scholar
  4. Aizawa-Abe M, Ogawa Y, Masuzaki H, et al. Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest. 2000;105:1243–52.PubMedCrossRefGoogle Scholar
  5. Akizuki T, Oda S, Komaki M, Tsuchioka H, Kawakatsu N, Kikuchi A, Yamato M, Okano T, Ishikawa I. Application of periodontal ligament cell sheet for periodontal regeneration: a pilot study in beagle dogs. J Periodontal Res. 2005;40:245–51.PubMedCrossRefGoogle Scholar
  6. Almeida JM, Theodoro LH, Bosco AF, Nagata MJ, Oshiiwa M, Garcia VG. In vivo effect of photodynamic therapy on periodontal bone loss in dental furcations. J Periodontol. 2008;79(6):1081–8.PubMedCrossRefGoogle Scholar
  7. Alayan J, Ivanovski S, Gemmell E, Ford P, Hamlet S, Farah CS. Deficiency of iNOS contributes to Porphyromonas gingivalis-induced tissue damage. Oral Microbiol Immunol. 2006;21:360–5.PubMedCrossRefGoogle Scholar
  8. Albuquerque C, Morinha F, Requicha J, Martins T, Dias I, Guedes-Pinto H, Bastos E, Viegas C. Canine periodontitis: the dog as an important model for periodontal studies. Vet J. 2012;191(3):299–305. Epub 2011 Sep 21.PubMedCrossRefGoogle Scholar
  9. Alhezaimi K, Al-Shalan T, O’Neill R, Shapurian T, Naghshbandi J, Levi Jr P, Griffin T. Connective tissue-cementum regeneration: a new histologic regeneration following the use of enamel matrix derivative in dehiscence-type defects. A dog model. Int J Periodontics Restorative Dent. 2009;29:425–33.PubMedGoogle Scholar
  10. Alikhani M, Alikhani Z, He H, Liu R, Popek BI, Graves DT. Lipopolysaccharides indirectly stimulate apoptosis and global induction of apoptotic genes in fibroblasts. J Biol Chem. 2003;278:52901–8.PubMedCrossRefGoogle Scholar
  11. Al-Mashat HA, Kandru S, Liu R, Behl Y, Desta T, Graves DT. Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing. Diabetes. 2006;55:487–95.PubMedCrossRefGoogle Scholar
  12. Alnaeeli M, Penninger JM, Teng YT. Immune interactions with CD4+ T cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells. J Immunol. 2006;177:3314–26.PubMedGoogle Scholar
  13. Alnaeeli M, Park J, Mahamed D, Penninger JM, Teng YT. Dendritic cells at the osteo-immune interface: implications for inflammation-induced bone loss. J Bone Miner Res. 2007;22:775–80.PubMedCrossRefGoogle Scholar
  14. Al-Qareer AH, Afsah MR, Müller HP. A sheep cadaver model for demonstration and training periodontal surgical methods. Eur J Dent Educ. 2004;8:78–83.PubMedCrossRefGoogle Scholar
  15. Arai K, Tanaka S, Yamamoto-Sawamura T, Sone K, Miyaishi O, Sumi Y. Aging changes in the periodontal bone of F344/N rat. Arch Gerontol Geriatr. 2005;40:225–9.PubMedCrossRefGoogle Scholar
  16. Araujo MG, Lindhe J. GTR treatment of degree III furcation defects following application of enamel matrix proteins. An experimental study in dogs. J Clin Periodontol. 1998;25:524–30.PubMedCrossRefGoogle Scholar
  17. Araújo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005;32:212–8.PubMedCrossRefGoogle Scholar
  18. Araujo MG, Berglundh T, Lindhe J. GTR treatment of degree III furcation defects with 2 different resorbable barriers: an experimental study in dogs. J Clin Periodontol. 1998;25:253–9.PubMedCrossRefGoogle Scholar
  19. Araujo MG, Berglundh T, Albrektsson T, Lindhe J. Bone formation in furcation defects. An experimental study in the dog. J Clin Periodontol. 1999;26:643–52.PubMedCrossRefGoogle Scholar
  20. Araújo MG, Sukekava F, Wennström JL, Lindhe J. Ridge alterations following implant placement in fresh extraction sockets: an experimental study in the dog. J Clin Periodontol. 2005;32:645–52.PubMedCrossRefGoogle Scholar
  21. Arce RM, Barros SP, Wacker B, Peters B, Moss K, Offenbacher S. Increased TLR4 expression in murine placentas after oral infection with periodontal pathogens. Placenta. 2009;30:156–62.PubMedCrossRefGoogle Scholar
  22. Artzi Z, Weinreb M, Tal H, Nemcovsky CE, Rohrer MD, Prasad HS, Kozlovsky A. Experimental intrabony and periodontal defects treated with natural mineral combined with a synthetic cell-binding Peptide in the canine: morphometric evaluations. J Periodontol. 2006;77:1658–64.PubMedCrossRefGoogle Scholar
  23. Baik DH, Hwang SJ, Kim CS, Lee YK, Cho CS, Chai JK, Kim CK, Choi SH. The effects of noncrystalline calcium phosphate glass on the healing of 1-wall intrabony defcts in beagle dogs. J Korean Acad Periodontol. 2004;34:113–20.Google Scholar
  24. Bain JL, Lester SR, Henry WD, Bishop CM, Turnage AA, Naftel JP, Johnson RB. Comparative gender differences in local and systemic concentrations of proinflammatory cytokines in rats with experimental periodontitis. J Periodontal Res. 2009;44:133–40.PubMedCrossRefGoogle Scholar
  25. Baker PJ. Genetic control of the immune response in pathogenesis. J Periodontol. 2005;76(11 Suppl):2042–6.PubMedCrossRefGoogle Scholar
  26. Baker PJ, Evans RT, Roopenian DC. Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice. Arch Oral Biol. 1994;39: 1035–40.PubMedCrossRefGoogle Scholar
  27. Baker PJ, Carter S, Dixon M, Evans RT, Roopenian DC. Serum antibody response to oral infection precedes but does not prevent Porphyromonas gingivalis induced alveolar bone loss in mice. Oral Microbiol Immunol. 1999a;14:194–6.PubMedCrossRefGoogle Scholar
  28. Baker PJ, Dixon M, Evans RT, Dufour L, Johnson E, Roopenian DC. CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immun. 1999b;67:2804–9.PubMedGoogle Scholar
  29. Baker PJ, Dixon M, Evans RT, Roopenian DC. Heterogeneity of Porphyromonas gingivalis strains in the induction of alveolar bone loss in mice. Oral Microbiol Immunol. 2000a;15:27–32.PubMedCrossRefGoogle Scholar
  30. Baker PJ, Dixon M, Roopenian DC. Genetic control of susceptibility to Porphyromonas gingivalis-induced alveolar bone loss in mice. Infect Immun. 2000b;68: 5864–8.PubMedCrossRefGoogle Scholar
  31. Baron R, Saffar JL. A quantitative study of bone remodeling during experimental periodontal disease in the golden hamster. J Periodontal Res. 1978;13:309–15.PubMedCrossRefGoogle Scholar
  32. Baroukh B, Saffar JS. The effect of leukotriene synthesis inhibitors on hamster periodontitis. Arch Oral Biol. 1990;35(Suppl):189S–92.PubMedCrossRefGoogle Scholar
  33. Baroukh B, Saffar JL. Identification of osteoclasts and their mononuclear precursors. A comparative histological and histochemical study in hamster periodontitis. J Periodontal Res. 1991;26(3 Pt 1):161–6.PubMedCrossRefGoogle Scholar
  34. Barros SP, Arce RM, Galloway P, Lawter JR, Offenbacher S. Therapeutic effect of a topical CCR2 antagonist on induced alveolar bone loss in mice. J Periodontal Res. 2011;46:246–51.PubMedCrossRefGoogle Scholar
  35. Bartold PM, Marshall RI, Haynes DR. Periodontitis and rheumatoid arthritis: a review. J Periodontol. 2005;76(11 Suppl):2066–74.PubMedCrossRefGoogle Scholar
  36. Bartold PM, Marino V, Cantley M, Haynes DR. Effect of Porphyromonas gingivalis-induced inflammation on the development of rheumatoid arthritis. J Clin Periodontol. 2010;37:405–11.PubMedCrossRefGoogle Scholar
  37. Behbehani MJ, Jordan HV, Heeley JD. Oral colonization and pathogenicity of Actinomyces israelii in gnotobiotic rats. J Dent Res. 1983;62:69–74.PubMedCrossRefGoogle Scholar
  38. Benatti BB, César-Neto JB, Gonçalves PF, Sallum EA, Nociti Jr FH. Smoking affects the self-healing capacity of periodontal tissues. A histological study in the rat. Eur J Oral Sci. 2005;113:400–3.PubMedCrossRefGoogle Scholar
  39. Benatti BB, César-Neto JB, Casati MZ, Sallum EA, Sallum AW, Nociti Jr FH. Periodontal healing may be affected by aging: a histologic study in rats. J Periodontal Res. 2006;41:329–33.PubMedCrossRefGoogle Scholar
  40. Bendyk A, Marino V, Zilm PS, Howe P, Bartold PM. Effect of dietary omega-3 polyunsaturated fatty acids on experimental periodontitis in the mouse. J Perio­dontal Res. 2009;44:211–6.PubMedCrossRefGoogle Scholar
  41. Bergenholtz G, Wikesjö UM, Sorensen RG, Xiropaidis AV, Wozney JM. Observations on healing following endodontic surgery in nonhuman primates (Macaca fascicularis): effects of rhBMP-2. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:116–25.PubMedCrossRefGoogle Scholar
  42. Björnsson MJ, Velschow S, Stoltze K, Havemose-Poulsen A, Schou S, Holmstrup P. The influence of diet consistence, drinking water and bedding on periodontal disease in Sprague–Dawley rats. J Periodontal Res. 2003;38:543–50.PubMedCrossRefGoogle Scholar
  43. Björnsson MJ, Havemose-Poulsen A, Stoltze K, Holmstrup P. Influence of the matrix metalloproteinase inhibitor batimastat (BB-94) on periodontal bone destruction in Sprague–Dawley rats. J Periodontal Res. 2004;39:269–74.PubMedCrossRefGoogle Scholar
  44. Blumenthal NM, Alves ME, Al-Huwais S, Hofbauer AM, Koperski RD. Defect-determined regenerative options for treating periodontal intrabony defects in baboons. J Periodontol. 2003;74:10–24.PubMedCrossRefGoogle Scholar
  45. Bobetsis YA, Barros SP, Offenbacher S. Exploring the relationship between periodontal disease and pregnancy complications. J Am Dent Assoc. 2006;137zc(Suppl):7S–13.PubMedGoogle Scholar
  46. Boyce BF, Aufdemorte TB, Garrett IR, Yates AJ, Mundy GR. Effects of interleukin-1 on bone turnover in normal mice. Endocrinology. 1989;125:1142–50.PubMedCrossRefGoogle Scholar
  47. Bezerra MM, de Lima V, Alencar VB, Vieira IB, Brito GA, Ribeiro RA, Rocha FA. Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats. J Periodontol. 2000 Jun;71(6):1009–14.PubMedCrossRefGoogle Scholar
  48. Branch-Mays GL, Dawson DR, Gunsolley JC, Reynolds MA, Ebersole JL, Novak KF, Mattison JA, Ingram DK, Novak MJ. The effects of a calorie-reduced diet on periodontal inflammation and disease in a non-human primate model. J Periodontol. 2008;79:1184–91.PubMedCrossRefGoogle Scholar
  49. Brecx M, Patters MR. Morphology of polymorphonuclear neutrophils during periodontal disease in the cynomolgus monkey. J Clin Periodontol. 1985;12:591–606.PubMedCrossRefGoogle Scholar
  50. Brecx MC, Nalbandian J, Ooya K, Kornman KS, Robertson PB. Morphological studies on periodontal disease in the cynomolgus monkey. II. Light microscopic observations on ligature-induced periodontitis. J Periodontal Res. 1985;20:165–75.PubMedCrossRefGoogle Scholar
  51. Breivik T, Opstad PK, Gjermo P, Thrane PS. Effects of hypothalamic-pituitary-adrenal axis reactivity on periodontal tissue destruction in rats. Eur J Oral Sci. 2000a;108:115–22.PubMedCrossRefGoogle Scholar
  52. Breivik T, Sluyter F, Hof M, Cools A. Differential susceptibility to periodontitis in genetically selected Wistar rat lines that differ in their behavioral and endocrinological response to stressors. Behav Genet. 2000b;30:123–30.PubMedCrossRefGoogle Scholar
  53. Breivik T, Gundersen Y, Myhrer T, Fonnum F, Osmundsen H, Murison R, et al. Enhanced susceptibility to periodontitis in an animal model of depression: reversed by chronic treatment with the anti-depressant tianeptine. J Clin Periodontol. 2006;33:469–77.PubMedCrossRefGoogle Scholar
  54. Brodala N, Merricks EP, Bellinger DA, Damrongsri D, Offenbacher S, Beck J, et al. Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigs. Arterioscler Thromb Vasc Biol. 2005;25:1446–51.PubMedCrossRefGoogle Scholar
  55. Burckhardt JJ, Gaegauf-Zollinger R, Schmid R, Guggenheim B. Alveolar bone loss in rats after immunization with Actinomyces viscosus. Infect Immun. 1981;31:971–7.PubMedGoogle Scholar
  56. Burns E, Bachrach G, Shapira L, Nussbaum G. Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption. J Immunol. 2006;177(12):8296-300PubMedGoogle Scholar
  57. Busch L, Sterin-Borda L, Borda E. Beta-adrenoceptor alterations coupled with secretory response and experimental periodontitis in rat submandibular glands. Arch Oral Biol. 2008;16:53–509.Google Scholar
  58. Buser D, Hoffmann B, Bernard JP, Lussi A, Mettler D, Schenk RK. Evaluation of filling materials in membrane – protected bone defects. A comparative histomorphometric study in the mandible of miniature pigs. Clin Oral Implants Res. 1998;9:137–50.PubMedCrossRefGoogle Scholar
  59. Caffesse RG, Dominguez LE, Nasjleti CE, Castelli WA, Morrison EC, Smith BA. Furcation defects in dogs treated by guided tissue regeneration (GTR). J Periodontol. 1990;61:45–50.PubMedCrossRefGoogle Scholar
  60. Calvo-Guirado JL, Delgado-Ruíz RA, Ramírez-Fernández MP, Maté-Sánchez JE, Ortiz-Ruiz A, Marcus A. Histomorphometric and mineral degradation study of Ossceram: a novel biphasic B-tricalcium phosphate, in critical size defects in rabbits. Clin Oral Implants Res. 2012;23:667–75.Google Scholar
  61. Cantley MD, Bartold PM, Marino V, Reid RC, Fairlie DP, Wyszynski RN, Zilm PS, Haynes DR. The use of live-animal micro-computed tomography to determine the effect of a novel phospholipase A2 inhibitor on alveolar bone loss in an in vivo mouse model of periodontitis. J Periodontal Res. 2009;44:317–22.PubMedCrossRefGoogle Scholar
  62. Cantley MD, Haynes DR, Marino V, Bartold PM. Pre-existing periodontitis exacerbates experimental arthritis in a mouse model. J Clin Periodontol. 2011;38:532–41.PubMedCrossRefGoogle Scholar
  63. Caplanis N, Lee MB, Zimmerman GJ, Selvig KA, Wikesjö UM. Effect of allogenic freeze-dried demineralized bone matrix on guided tissue regeneration in dogs. J Periodontol. 1998;69:851–6.PubMedCrossRefGoogle Scholar
  64. Cappelli D, Steffen MJ, Holt SC, Ebersole JL. Periodontitis in pregnancy: clinical and serum antibody observations from a baboon model of ligature-induced disease. J Periodontol. 2009;80:1154–65.PubMedCrossRefGoogle Scholar
  65. Casati MZ, Sallum EA, Caffesse RG, Nociti Jr FH, Sallum AW, Pereira SL. Guided tissue regeneration with a bioabsorbable polylactic acid membrane in gingival recessions: a histometric study in dogs. J Periodontol. 2000;71:238–48.PubMedCrossRefGoogle Scholar
  66. Caton J, Mota L, Gandini L, Laskaris B. Non-human primate models for testing the efficacy and safety of periodontal regeneration procedures. J Periodontol. 1994;65:1143–50.PubMedCrossRefGoogle Scholar
  67. César-Neto JB, Benatti BB, Sallum EA, Casati MZ, Nociti Jr FH. The influence of cigarette smoke inhalation and its cessation on the tooth-supporting alveolar bone: a histometric study in rats. J Periodontal Res. 2006;41:118–23.PubMedCrossRefGoogle Scholar
  68. Chang KM, Ramamurthy NS, McNamara TF, Genco RJ, Golub LM. Infection with a gram-negative organism stimulates gingival collagenase production in non-diabetic and diabetic germfree rats. J Periodontal Res. 1988;23:239–44.PubMedCrossRefGoogle Scholar
  69. Chang KM, Ramamurthy NS, McNamara TF, Evans RT, Klausen B, Murray PA, Golub LM. Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism. J Periodontal Res. 1994;29:242–9.PubMedCrossRefGoogle Scholar
  70. Cheng W-C, Huang R-Y, Chiang C-Y, Chen J-K, Liu C-H, Chu C-L, Fu E. Ameliorative effect of quercetin on the destruction caused by experimental periodontitis in rats. J Periodontal Res. 2010;45:788–95.PubMedCrossRefGoogle Scholar
  71. Chiang CY, Kyritsis G, Graves DT, Amar S. Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide. Infect Immun. 1999;67:4231–6.PubMedGoogle Scholar
  72. Choi SY, Nilvéus RE, Minutello RD, Zimmerman GJ, Wikesjö UM. Effect of a collagen matrix on healing in periodontal fenestration defects in dogs. J Periodontol. 1993;64:878–82.PubMedCrossRefGoogle Scholar
  73. Choi SH, Kim CK, Cho KS, Huh JS, Sorensen RG, Wozney JM, Wikesjö UM. Effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) on healing in 3-wall intrabony defects in dogs. J Periodontol. 2002;73:63–72.PubMedCrossRefGoogle Scholar
  74. Collins JG, Smith MA, Arnold RR, Offenbacher S. Effects of Escherichia coli and Porphyromonas gingivalis lipopolysaccharide on pregnancy outcome in the golden hamster. Infect Immun. 1994a;62:4652–5.PubMedGoogle Scholar
  75. Collins JG, Windley 3rd HW, Arnold RR, Offenbacher S. Effects of a Porphyromonas gingivalis infection on inflammatory mediator response and pregnancy outcome in hamsters. Infect Immun. 1994b;62:4356–61.PubMedGoogle Scholar
  76. Corrêa MG, Campos ML, Benatti BB, Marques MR, Casati MZ, Nociti Jr FH, Sallum EA. The impact of cigarette smoke inhalation on the outcome of enamel matrix derivative treatment in rats: histometric analysis. J Periodontol. 2010;81:1820–8.PubMedCrossRefGoogle Scholar
  77. Craig RG, Kallur SP, Inoue M, Rosenberg PA, LeGeros RZ. Effect of enamel matrix proteins on the periodontal connective tissue-material interface after wound healing. J Biomed Mater Res A. 2004;69:180–7.PubMedCrossRefGoogle Scholar
  78. Craig RG, Kamer AR, Kallur SP, Inoue M, Tarnow DP. Effects of periodontal cell grafts and enamel matrix proteins on the implant connective tissue interface: a pilot study in the minipig. J Oral Implantol. 2006;32:228–36.PubMedCrossRefGoogle Scholar
  79. Crawford JM, Taubman MA, Smith DJ. The natural history of periodontal bone loss in germfree and gnotobiotic rats infected with periodontopathic microorganisms. J Periodontal Res. 1978;13:316–25.PubMedCrossRefGoogle Scholar
  80. da Monteiro Silva AM, Newman HN, Oakley DA. Psychosocial factors in inflammatory periodontal diseases. A review. J Clin Periodontol. 1995;22:516–26.CrossRefGoogle Scholar
  81. da Silva Pereira SL, Sallum AW, Casati MZ. Comparison of bioabsorbable and non-resorbable membranes in the treatment of dehiscence-type defects: a histomorphometric study in dogs. J Periodontol. 2000;71:1306–14.PubMedCrossRefGoogle Scholar
  82. Danesh-Meyer MJ, Pack AR, McMillan MD. A comparison of 2 polytetrafluoroethylene membranes in guided tissue regeneration in sheep. J Periodontal Res. 1997;32(1 Pt 1):20–30.PubMedCrossRefGoogle Scholar
  83. de Aquino SG, Guimaraes MR, Stach-Machado DR, da Silva JA, Spolidorio LC, Rossa Jr C. Differential regulation of MMP-13 expression in two models of experimentally induced periodontal disease in rats. Arch Oral Biol. 2009;54:609–17.PubMedCrossRefGoogle Scholar
  84. DeCarlo AA, Huang Y, Collyer CA, Langley DB, Katz J. Feasibility of an HA2 domain-based periodontitis vaccine. Infect Immun. 2003;71:562–6.PubMedCrossRefGoogle Scholar
  85. Decker JF, Lee J, Cortella CA, Polimeni G, Rohrer MD, Wozney JM, Hall J, Susin C, Wikesjö UM. Evaluation of implants coated with recombinant human bone morphogenetic protein-2 and vacuum-dried using the critical-size supraalveolar peri-implant defect model in dogs. J Periodontol. 2010;81:1839–49.PubMedCrossRefGoogle Scholar
  86. DeLaurier A, Boyde A, Jackson B, Horton MA, Price JS. Identifying early osteoclastic resorptive lesions in feline teeth: a model for understanding the origin of multiple idiopathic root resorption. J Periodontal Res. 2009;44:248–57.PubMedCrossRefGoogle Scholar
  87. Di Paola R, Mazzon E, Muia’ C, Terrana D, Greco S, Britti D, Santori D, Oteri G, Cordasco G, Cuzzocrea S. 5-aminoisoquinolin-1(2H)-one, a water soluble poly (ADP-ribose) polymerase (PARP) inhibitor reduces the evolution of experimental periodontitis in rats. J Clin Periodontol. 2007;34:95–102.PubMedCrossRefGoogle Scholar
  88. Ding G, Liu Y, Wang W, Wei F, Liu D, Fan Z, An Y, Zhang C, Wang S. Allogeneic periodontal ligament stem cell therapy for periodontitis in swine. Stem Cells. 2010;28:1829–38.PubMedCrossRefGoogle Scholar
  89. Dogan A, Ozdemir A, Kubar A, Oygür T. Assessment of periodontal healing by seeding of fibroblast-like cells derived from regenerated periodontal ligament in artificial furcation defects in a dog: a pilot study. Tissue Eng. 2002;8:273–82.PubMedCrossRefGoogle Scholar
  90. Dogan A, Ozdemir A, Kubar A, Oygur T. Healing of artificial fenestration defects by seeding of fibroblast-like cells derived from regenerated periodontal ligament in a dog: a preliminary study. Tissue Eng. 2003;9:1189–96.PubMedCrossRefGoogle Scholar
  91. Donos N, Sculean A, Glavind L, Reich E, Karring T. Wound healing of degree III furcation involvements following guided tissue regeneration and/or Emdogain. A histologic study. J Clin Periodontol. 2003;30:1061–8.PubMedCrossRefGoogle Scholar
  92. Doxey DL, Cutler CW, Iacopino AM. Diabetes prevents periodontitis-induced increases in gingival platelet derived growth factor-B and interleukin 1-beta in a rat model. J Periodontol. 1998;69:113–9.PubMedCrossRefGoogle Scholar
  93. Dreyer WP, Basson NJ. Porphyromonas gingivalis as putative pathogen in ovine periodontitis. J Dent Assoc S Afr. 1992;47:513–6.PubMedGoogle Scholar
  94. Duarte PM, Tezolin KR, Figueiredo LC, Feres M, Bastos MF. Microbial profile of ligature-induced periodontitis in rats. Arch Oral Biol. 2010;55:142–7.PubMedCrossRefGoogle Scholar
  95. Dumitrescu AL, Abd-El-Aleem S, Morales-Aza B, Donaldson LF. A model of periodontitis in the rat: effect of lipopolysaccharide on bone resorption, osteoclast activity, and local peptidergic innervation. J Clin Periodontol. 2004;31:596–603.PubMedCrossRefGoogle Scholar
  96. Duncan WJ, Persson GR, Sims TJ, Braham P, Pack ARC, Page RC. Ovine periodontitis as a potential model for periodontal studies. Cross-sectional analysis of clinical, microbiological, and serum immunological parameters. J Clin Periodontol. 2003;30:63–72.PubMedCrossRefGoogle Scholar
  97. Dyer BL, Caffesse RG, Nasjleti CE, Morrison EC. Guided tissue regeneration with dentin biomodification. J Periodontol. 1993;64:1052–60.PubMedCrossRefGoogle Scholar
  98. Ebersole JL, Kraig E, Bauman G, Spitznagel JK, Kolodrubetz D. Molecular approaches to leucotoxin as a virulence component in Actinobacillus actinomycetemcomitans. Arch Oral Biol. 1990;35(Suppl):69S–78.PubMedCrossRefGoogle Scholar
  99. Ebersole JL, Brunsvold M, Steffensen B, Wood R, Holt SC. Effects of immunization with Porphyromonas gingivalis and Prevotella intermedia on progression of ligature-induced periodontitis in the nonhuman primate Macaca fascicularis. Infect Immun. 1991;59:3351–9.PubMedGoogle Scholar
  100. Ebersole JL, Cappelli D, Holt SC, Singer RE, Filloon T. Gingival crevicular fluid inflammatory mediators and bacteriology of gingivitis in nonhuman primates related to susceptibility to periodontitis. Oral Microbiol Immunol. 2000;15:19–26.PubMedCrossRefGoogle Scholar
  101. Ebersole JL, Cappelli D, Mathys EC, Steffen MJ, Singer RE, Montgomery M, Mott GE, Novak MJ. Periodontitis in humans and non-human primates: oral-systemic linkage inducing acute phase proteins. Ann Periodontol. 2002;7:102–11.PubMedCrossRefGoogle Scholar
  102. Ebersole JL, Steffen MJ, Holt SC, Kesavalu L, Chu L, Cappelli D. Systemic inflammatory responses in progressing periodontitis during pregnancy in a baboon model. Clin Exp Immunol. 2010;162:550–9.PubMedCrossRefGoogle Scholar
  103. Ekuni D, Firth JD, Putnins EE. Regulation of epithelial cell growth factor receptor protein and gene expression using a rat periodontitis model. J Periodontal Res. 2006;41:340–9.PubMedCrossRefGoogle Scholar
  104. Ekuni D, Tomofuji T, Tamaki N, Sanbe T, Azuma T, Yamanaka R, Yamamoto T, Watanabe T. Mechanical stimulation of gingiva reduces plasma 8-OHdG level in rat periodontitis. Arch Oral Biol. 2008;53:324–9.PubMedCrossRefGoogle Scholar
  105. Ekuni D, Tomofuji T, Sanbe T, Irie K, Azuma T, Maruyama T, Tamaki N, Murakami J, Kokeguchi S, Yamamoto T. Periodontitis-induced lipid peroxidation in rat descending aorta is involved in the initiation of atherosclerosis. J Periodontal Res. 2009;44:434–42.PubMedCrossRefGoogle Scholar
  106. Ekuni D, Tomofuji T, Irie K, Kasuyama K, Umakoshi M, Azuma T, Tamaki N, Sanbe T, Endo Y, Yamamoto T, Nishida T, Morita M. Effects of periodontitis on aortic insulin resistance in an obese rat model. Lab Invest. 2010;90:348–59.PubMedCrossRefGoogle Scholar
  107. Elharar F, Rodriguez HJ, Benque EP, Caffesse RG. Guided tissue regeneration with bioabsorbable and expanded polytetrafluoroethylenebarrier membranes in the treatment of naturally occurring periodontal defects in dogs. J Periodontol. 1998;69:1218–28.PubMedCrossRefGoogle Scholar
  108. Endo Y, Tomofuji T, Ekuni D, Irie K, Azuma T, Tamaki N, Yamamoto T, Morita M. Experimental periodontitis induces gene expression of proinflammatory cytokines in liver and white adipose tissues in obesity. J Periodontol. 2010;81:520–6.PubMedCrossRefGoogle Scholar
  109. Escartin Q, Lallam-Laroye C, Baroukh B, Morvan FO, Caruelle JP, Godeau G, Barritault D, Saffar JL. A new approach to treat tissue destruction in periodontitis with chemically modified dextran polymers. FASEB J. 2003;17:644–51.PubMedCrossRefGoogle Scholar
  110. Evans RT, Klausen B, Sojar HT, Bedi GS, Sfintescu C, Ramamurthy NS, Golub LM, Genco RJ. Immunization with Porphyromonas (Bacteroides) gingivalis fimbriae protects against periodontal destruction. Infect Immun. 1992;60:2926–35.PubMedGoogle Scholar
  111. Faggion CM Jr, Listl S, Giannakopoulos NN. The methodological quality of systematic reviews of animal studies in dentistry. Vet J. 2012;192:140–7.Google Scholar
  112. Faggion Jr CM, Schmitter M, Tu YK. Assessment of replication of research evidence from animals to humans in studies on peri-implantitis therapy. J Dent. 2009;37:737–47.PubMedCrossRefGoogle Scholar
  113. Faggion Jr CM, Chambrone L, Gondim V, Schmitter M, Tu YK. Comparison of the effects of treatment of peri-implant infection in animal and human studies: systematic review and meta-analysis. Clin Oral Implants Res. 2010;21:137–47.PubMedCrossRefGoogle Scholar
  114. Faggion Jr CM, Giannakopoulos NN, Listl S. Risk of bias of animal studies on regenerative procedures for periodontal and peri-implant bone defects – a systematic review. J Clin Periodontol. 2011;38:1154–60.PubMedCrossRefGoogle Scholar
  115. Felipe ME, Andrade PF, Novaes Jr AB, Grisi MF, Souza SL, Taba Jr M, Palioto DB. Potential of bioactive glass particles of different size ranges to affect bone formation in interproximal periodontal defects in dogs. J Periodontol. 2009;80:808–15.PubMedCrossRefGoogle Scholar
  116. Fernandes MI, Gaio EJ, Oppermann RV, Rados PV, Rosing CK. Comparison of histometric and morphometric analyses of bone height in ligature-induced periodontitis in rats. Braz Oral Res. 2007;21:216–21.PubMedGoogle Scholar
  117. Fernandes LA, Martins TM, de Almeida JM, Nagata MJ, Theodoro LH, Garcia VG, Bosco AF. Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats. J Appl Oral Sci. 2010;18:635–40.PubMedCrossRefGoogle Scholar
  118. Fischer RG, Klinge B. Clinical and histiological evaluation of ligature-induced periodontitis in the domestic ferret. J Clin Periodontol. 1994;21:230–9.PubMedCrossRefGoogle Scholar
  119. Fischer RG, Edwardsson S, Klinge B. Oral microflora of the ferret at the gingival sulcus and mucosa membrane in relation to ligature-induced periodontitis. Oral Microbiol Immunol. 1994;9:40–9.PubMedCrossRefGoogle Scholar
  120. Fisher RG, Klinge B, Attsrom R. Normal histologic features of domestic ferret periodontium. Scand J Dent Res. 1993;101:357–62.Google Scholar
  121. Frisken KW, Laws AJ, Tagg JR, Orr MB. Environmental influences on the progression of clinical and microbiological parameters of sheep periodontal disease. Res Vet Sci. 1989;46:147–52.PubMedGoogle Scholar
  122. Fujishiro N, Anan H, Hamachi T, Maeda K. The role of macrophages in the periodontal regeneration using Emdogain® gel. J Periodontal Res. 2008;43:143–55.PubMedCrossRefGoogle Scholar
  123. Garant PR. An electron microscopic study of the periodontal tissues of germfree rats and rats monoinfected with Actinomyces naeslundii. J Periodontal Res. 1976a;15:3–79.PubMedGoogle Scholar
  124. Garant PR. Light and electron microscopic observations of osteoclastic alveolar bone resorption in rats monoinfected with Actinomyces naeslundii. J Periodontol. 1976b;47:717–23.PubMedGoogle Scholar
  125. Garlet GP, Cardoso CR, Silva TA, Ferreira BR, Avila-Campos MJ, Cunha FQ, Silva JS. Cytokine pattern determines the progression of experimental periodontal disease induced by Actinobacillus actinomycetemcomitans through the modulation of MMPs, RANKL, and their physiological inhibitors. Oral Microbiol Immunol. 2006;21:12–20.PubMedCrossRefGoogle Scholar
  126. Garlet GP, Cardoso CR, Mariano FS, Claudino M, de Assis GF, Campanelli AP, Ávila-Campos MJ, Silva JS. Regulatory T cells attenuate experimental periodontitis progression in mice. J Clin Periodontol. 2010;37:591–600.PubMedCrossRefGoogle Scholar
  127. Gašperšič R, Ŝtiblar-Martinčič D, Skalerič U. Influence of restraint stress on ligature-induced periodontitis in rats. Eur J Oral Sci. 2002;110:125–9.PubMedCrossRefGoogle Scholar
  128. Gavin JB. Ultrastructural features of chronic marginal gingivitis. J Periodontal Res. 1970;5:19–29.PubMedCrossRefGoogle Scholar
  129. Gemmell E, Bird PS, Ford PJ, Ashman RB, Gosling P, Hu Y, Seymour GJ. Modulation of the antibody response by Porphyromonas gingivalis and Fusobacterium nucleatum in a mouse model. Oral Microbiol Immunol. 2004;19:247–51.PubMedCrossRefGoogle Scholar
  130. Genco CA, Cutler CW, Kapczynski D, Maloney K, Arnold RR. A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis. Infect Immun. 1991;59:1255–63.PubMedGoogle Scholar
  131. Genco CA, Kapczynski DR, Cutler CW, Arko RJ, Arnold RR. Influence of immunization on Porphyromonas gingivalis colonization and invasion in the mouse chamber model. Infect Immun. 1992;60:1447–54.PubMedGoogle Scholar
  132. Genco CA, Odusanya BM, Potempa J, Mikolajczyk-Pawlinska J, Travis J. A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice. Infect Immun. 1998a;66:4108–14.PubMedGoogle Scholar
  133. Genco CA, Van Dyke T, Amar S. Animal models for Porphyromonas gingivalis-mediated periodontal disease. Trends Microbiol. 1998b;6:444–9.PubMedCrossRefGoogle Scholar
  134. Germanier Y, Tosatti S, Broggini N, Textor M, Buser D. Enhanced bone apposition around biofunctionalized sandblasted and acid etched titanium implant surfaces. A histomorphometric study in miniature pigs. Clin Oral Implants Res. 2006;17:251–7.PubMedCrossRefGoogle Scholar
  135. Giannobile WV, Finkelman RD, Lynch SE. Comparison of canine and non-human primate animal models for periodontal regenerative therapy: Results following a single administration of PDGF/IGF-I. J Periodontol. 1994;65:1158–68.PubMedCrossRefGoogle Scholar
  136. Gibson 3rd FC, Genco CA. Prevention of Porphyromonas gingivalis-induced oral bone loss following immunization with gingipain R1. Infect Immun. 2001;69:7959–63.PubMedCrossRefGoogle Scholar
  137. Gibson 3rd FC, Hong C, Chou HH, Yumoto H, Chen J, Lien E, Wong J, Genco CA. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004;109:2801–6.PubMedCrossRefGoogle Scholar
  138. Gineste L, Gineste M, Bluche L, et al. Histomorphometric comparison of three bioabsorbable GTR barrier membranes in the canine model. Int J Periodontics Restorative Dent. 2005a;25:61–71.PubMedGoogle Scholar
  139. Gineste L, Gineste M, Bluche L, Guilhem A, Elefterion A, Frayssinet P, Duran D, Wang HL. Histomorphometric comparison of three bioabsorbable GTR barrier membranes in the canine model. Int J Periodontics Restorative Dent. 2005b;25:61–71.PubMedGoogle Scholar
  140. Gitlin JM, Loftin CD. Cyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in mice. Cardiovasc Res. 2009;81:400–7.PubMedCrossRefGoogle Scholar
  141. Garant PR, Cho MI. Histopathogenesis of spontaneous periodontal disease in conventional rats. II. Ultrastructural features of the inflamed subepithelial connective tissue. J Periodontal Res. 1979a;14(4):310–22.Google Scholar
  142. Garant PR, Cho MI. Histopathogenesis of spontaneous periodontal disease in conventional rats. I. Histometric and histologic study. J Periodontal Res. 1979b;14(4):297–309.CrossRefGoogle Scholar
  143. Graves DT, Oskoui M, Volejnikova S, Naguib G, Cai S, Desta T, Kakouras A, Jiang Y. Tumor necrosis factor modulates fibroblast apoptosis, PMN recruitment, and osteoclast formation in response to P. gingivalis infection. J Dent Res. 2001;80:1875–9.PubMedCrossRefGoogle Scholar
  144. Graves DT, Naguib G, Lu H, Desta T, Amar S. Porphyromonas gingivalis fimbriae are pro-inflammatory but do not play a prominent role in the innate immune response to P. gingivalis. J Endotoxin Res. 2005a;11:13–8.PubMedGoogle Scholar
  145. Graves DT, Naguib G, Lu H, Leone C, Hsue H, Krall E. Inflammation is more persistent in type 1 diabetic mice. J Dent Res. 2005b;84:324–8.PubMedCrossRefGoogle Scholar
  146. Graves DT, Fine D, Teng Y-T, Van Dyke TE, Hajishengallis G. The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J Clin Periodontol. 2008;35:89–105.PubMedCrossRefGoogle Scholar
  147. Graves DT, Kang J, Andriankaja O, Wada K, Rossa Jr C. Animal models to study host-bacteria interactions involved in periodontitis. Front Oral Biol. 2012;15:117–32.PubMedCrossRefGoogle Scholar
  148. Graziani F, Laurell L, Tonetti M, Gottlow J, Berglundh T. Periodontal wound healing following GTR therapy of dehiscence-type defects in the monkey: short-, medium- and long-term healing. J Clin Periodontol. 2005;32:905–14.PubMedCrossRefGoogle Scholar
  149. Guiha R, el Khodeiry S, Mota L, Caffesse R. Histological evaluation of healing and revascularization of the subepithelial connective tissue graft. J Periodontol. 2001;72:470–8.PubMedCrossRefGoogle Scholar
  150. Gaegauf-Zollinger R, Burckhardt JJ, Guggenheim B. Radiographic measurements of alveolar bone loss in the rat. Arch Oral Biol. 1982;27(8):651–8.PubMedCrossRefGoogle Scholar
  151. Hachicha M, Pouliot M, Petasis NA, Serhan CN. Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis. J Exp Med. 1999;189:1923–30.PubMedCrossRefGoogle Scholar
  152. Hackam DG, Redelmeier DA. Translation of research evidence from animals to humans. JAMA. 2006;296: 1731–2.PubMedCrossRefGoogle Scholar
  153. Hajishengallis G, Shakhatreh MA, Wang M, Liang S. Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo. J Immunol. 2007;179: 2359–67.PubMedGoogle Scholar
  154. Hayashi C, Gudino CV, Gibson FC 3rd, Genco CA. Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol Oral Microbiol. 2010;25(5):305-16.PubMedCrossRefGoogle Scholar
  155. Hammarström L, Heijl L, Gestrelius S. Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J Clin Periodontol. 1997;24:669–77.PubMedCrossRefGoogle Scholar
  156. Haney JM, Zimmerman GJ, Wikesjo UME. Periodontal repair in dogs: evaluation of the natural disease model. J Clin Periodontol. 1995;22:208–13.PubMedCrossRefGoogle Scholar
  157. Hanisch O, Sorensen RG, Kinoshita A, Spiekermann H, Wozney JM, Wikesjö UM. Effect of recombinant human bone morphogenetic protein-2 in dehiscence defects with non-submerged immediate implants: an experimental study in Cynomolgus monkeys. J Periodontol. 2003;74:648–57.PubMedCrossRefGoogle Scholar
  158. Hardham J, Reed M, Wong J, King K, Laurinat B, Sfintescu C, Evans RT. Evaluation of a monovalent companion animal periodontal disease vaccine in an experimental mouse periodontitis model. Vaccine. 2005;23:3148–56.PubMedCrossRefGoogle Scholar
  159. Harper DS, Mann PH, Regnier S. Measurement of dietary and dentifrice effects upon calculus accumulation rates in the domestic ferret. J Dent Res. 1990;69:447–50.PubMedCrossRefGoogle Scholar
  160. Hardt AB. Bisphosphonate effects on alveolar bone during rat molar drifting. J Dent Res. 1988;67:1430–3.PubMedCrossRefGoogle Scholar
  161. Hart GT, Shaffer DJ, Akilesh S, Brown AC, Moran L, Roopenian DC, Baker PJ. Quantitative gene expression profiling implicates genes for susceptibility and resistance to alveolar bone loss. Infect Immun. 2004;72:4471–9.PubMedCrossRefGoogle Scholar
  162. Hasturk H, Kantarci A, Ebrahimi N, Andry C, Holick M, Jones VL, Van Dyke TE. Topical H2 antagonist prevents periodontitis in a rabbit model. Infect Immun. 2006a;74:2402–14.PubMedCrossRefGoogle Scholar
  163. Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, Petasis NA, Levy BD, Serhan CN, Van Dyke TE. RvE1 protects from local inflammation and osteoclast-mediated bone destruction in periodontitis. FASEB J. 2006b;20:401–3.PubMedGoogle Scholar
  164. Hasturk H, Jones VL, Andry C, Kantarci A. 1-Tetradecanol complex reduces progression of Porphyromonas gingivalis-induced experimental periodontitis in rabbits. J Periodontol. 2007a;78:924–32.PubMedCrossRefGoogle Scholar
  165. Hasturk H, Kantarci A, Goguet-Surmenian E, Blackwood A, Andry C, Serhan CN, Van Dyke TE. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol. 2007b;179:7021–9.PubMedGoogle Scholar
  166. Hasturk H, Goguet-Surmenian E, Blackwood A, Andry C, Kantarci A. 1-Tetradecanol complex: therapeutic actions in experimental periodontitis. J Periodontol. 2009;80:1103–13.PubMedCrossRefGoogle Scholar
  167. Hasturk H, Kantarci A, Ghattas M, Schmidt M, Giordano RA, Ashman A, Diekwisch TG, Van Dyke T. The use of light/chemically-hardened poly-methyl-methacrylate, poly-hydroxyl-ethyl-methacrylate and calcium hydroxide graft material in combination with polyanhydride around implants in minipigs: part I: immediate stability and function. J Periodontol. 2011;82:1339–52.PubMedCrossRefGoogle Scholar
  168. Hasturk H, Kantarci A, Van Dyke TE. Paradigm shift in the pharmacological management of periodontal diseases. Front Oral Biol. 2012;15:160–76.PubMedCrossRefGoogle Scholar
  169. Hautamäki MP, Aho AJ, Alander P, Rekola J, Gunn J, Strandberg N, Vallittu PK. Repair of bone segment defects with surface porous fiber-reinforced polymethyl methacrylate (PMMA) composite prosthesis: histomorphometric incorporation model and characterization by SEM. Acta Orthop. 2008;79:555–64.PubMedCrossRefGoogle Scholar
  170. Hayashi C, Kinoshita A, Oda S, Mizutani K, Shirakata Y. Ishikawa Injectable calcium phosphate bone cement provides favorable space and a scaffold for periodontal regeneration in dogs. J Periodontol. 2006;77:940–6.PubMedCrossRefGoogle Scholar
  171. Heijl L, Wennstrom J, Lindhe J, Socransky SS. Periodontal disease in gnatobiotic rats. J Periodontal Res. 1980;15:405–19.PubMedCrossRefGoogle Scholar
  172. Hernández M, Gamonal J, Salo T, Tervahartiala T, Hukkanen M, Tjäderhane L, Sorsa T. Reduced expression of LIX/CXCL5 in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice. J Periodontal Res. 2011;46:58–66.PubMedCrossRefGoogle Scholar
  173. Hickey JS, O’Neal RB, Scheidt MJ, Strong SL, Turgeon D, Van Dyke TE. Microbiologic characterization of ligature-induced peri-implantitis in the microswine model. J Periodontol. 1991;62:548–53.PubMedCrossRefGoogle Scholar
  174. Hojo K, Tamura A, Mizoguchi C, Kato D, Ohshima T, Maeda N. Predominant bacteria recovered from a periodontitis site in a hamster model raised by silk-ligature with Porphyromonas gingivalis infection. Biosci Biotechnol Biochem. 2008;72:1348–51.PubMedCrossRefGoogle Scholar
  175. Holt SC, Ebersole J, Felton J, Brunsvold M, Kornman KS. Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis. Science. 1988;239(4835):55–7.PubMedCrossRefGoogle Scholar
  176. Holzhausen M, Rossa Júnior C, Marcantonio Júnior E, Nassar PO, Spolidório DM, Spolidório LC. Effect of selective cyclooxygenase-2 inhibition on the development of ligature-induced periodontitis in rats. J Perio­dontol. 2002;73:1030–6.PubMedCrossRefGoogle Scholar
  177. Holzhausen M, Garcia DF, Pepato MT, Marcantonio Jr E. The influence of short-term diabetes mellitus and insulin therapy on alveolar bone loss in rats. J Periodontal Res. 2004;39:188–93.PubMedCrossRefGoogle Scholar
  178. Hu SW, Huang CH, Huang HC, Lai YY, Lin YY. Transvascular dissemination of Porphyromonas gingivalis from a sequestered site is dependent upon activation of the kallikrein/kinin pathway. J Periodontal Res. 2006;41:200–7.PubMedCrossRefGoogle Scholar
  179. Huang KK, Shen C, Chiang CY, Hsieh YD, Fu E. Effects of bone morphogenetic protein-6 on periodontal wound healing in a fenestration defect of rats. J Periodontal Res. 2005;40:1–10.PubMedCrossRefGoogle Scholar
  180. Huang S, Lu F, Zhang Z, Yang X, Chen Y. The role of psychological stress induced hypoxia-inducible factor-1α in rat experimental periodontitis. J Periodontol. 2010;82:934–41.PubMedCrossRefGoogle Scholar
  181. Hyvärinen K, Tuomainen AM, Laitinen S, Bykov IL, Törmäkangas L, Lindros K, Käkelä R, Alfthan G, Salminen I, Jauhiainen M, Kovanen PT, Leinonen M, Saikku P, Pussinen PJ. Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice. Infect Immun. 2009;77:3442–9.PubMedCrossRefGoogle Scholar
  182. Ijuhin N, Miyauchi M, Ito H, Takata T, Ogawa I, Nikai H. Enhanced collagen phagocytosis by rat molar periodontal fibroblasts after topical application of lipopolysaccharide – ultrastructural observations and morphometric analysis. J Periodontal Res. 1992;27:167–75.PubMedCrossRefGoogle Scholar
  183. Irokawa T, Ishida E, Fukuoka Y, Maita E, Yanagawa S. A study on the effects of continuous mechanical irritation to the periodontal tissues of germ-free and conventional rats (in Japanese). Nippon Shishubyo Gakkai Kaishi. 1977;19:333–40.PubMedCrossRefGoogle Scholar
  184. Irving JT, Socransky SS, Heeley JD. Histological changes in experimental periodontal disease in gnotobiotic rats and conventional hamsters. J Periodontal Res. 1974;9:73–80.PubMedCrossRefGoogle Scholar
  185. Irving JT, Newman MG, Socransky SS, Heely JD. Histological changes in experimental periodontal disease in rats mono-infected with a gram-negative organism. Arch Oral Biol. 1975a;20:219–20.PubMedCrossRefGoogle Scholar
  186. Irving JT, Heeley JD, Socransky SS. Cellular response to subgingival injection of bacterial products in the rat. J Periodontal Res. 1975b;10:324–31.PubMedCrossRefGoogle Scholar
  187. Irving JT, Socransky SS, Tanner AC. Histological changes in experimental periodontal disease in rats monoinfected with gram-negative organisms. J Periodontal Res. 1978;13:326–32.PubMedCrossRefGoogle Scholar
  188. Irving JT, Heeley JD, Amdur BH, Socransky SS. Pathological changes caused by the injection of lipids isolated from gram-positive organisms into the gingiva of rats. J Periodontal Res. 1979;14:160–6.PubMedCrossRefGoogle Scholar
  189. Ismaiel MO, Greenman J, Morgan K, Glover MG, Rees AS, Scully C. Periodontitis in sheep: a model for human periodontal disease. J Periodontol. 1989;60:279–84.PubMedCrossRefGoogle Scholar
  190. Iwatsuka H, Shino A, Suzuoki Z. General survey of diabetic features of yellow KK mice. Endocrinol Jpn. 1970;17:23–35.PubMedCrossRefGoogle Scholar
  191. Jain A, Batista Jr EL, Serhan C, Stahl GL, Van Dyke TE. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun. 2003;71:6012–8.PubMedCrossRefGoogle Scholar
  192. Janssen U, Phillips AO, Floege J. Rodent models of nephropathy associated with type II diabetes. J Nephrol. 1999;12:159–72.PubMedGoogle Scholar
  193. Jensen SS, Broggini N, Weibrich G, Hjôrting-Hansen E, Schenk R, Buser D. Bone regeneration in standardized bone defects with autografts or bone substitutes in combination with platelet concentrate: a histologic and histomorphometric study in the mandibles of minipigs. Int J Oral Maxillofac Implants. 2005;20:703–12.PubMedGoogle Scholar
  194. Jensen S, Broggini N, Hjørting-Hansen E, Schenk R, Buser D. Bone healing and graft resorption of autograft, anorganic bovine bone and b-tricalcium phosphate. A histologic and histomorphometric study in the mandibles of mini-pigs. Clin Oral Implants Res. 2006;17:237–43.PubMedCrossRefGoogle Scholar
  195. Jogahara T, Oda S, Kawai T, Hanamura H, Koyasu K. Numerical variation of teeth in the wild house musk shrew Suncus murinus captured from Nagasaki, Japan. Arch Oral Biol. 2008;53:617–21.PubMedCrossRefGoogle Scholar
  196. Jones WA, O’Leary TJ. The effectiveness of in vivo root planing in removing bacterial endotoxin from the roots of periodontally involved teeth. J Periodontol. 1978;49:337–42.PubMedCrossRefGoogle Scholar
  197. Jordan HV, Keyes PH. Aerobic, gram-positive, filamentous bacteria as etiologic agents of experimental periodontal disease in hamsters. Arch Oral Biol. 1964;9:401–14.PubMedCrossRefGoogle Scholar
  198. Jordan HV, Keyes PH, Bellack S. Periodontal lesions in hamsters and gnotobiotic rats infected with actinomyces of human origin. J Periodontal Res. 1972;7:21–8.PubMedCrossRefGoogle Scholar
  199. Jovanovic SA, Hunt DR, Bernard GW, Spiekermann H, Wozney JM, Wikesjö UM. Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects. Clin Oral Implants Res. 2007;18:224–30.PubMedCrossRefGoogle Scholar
  200. Jung UW, Chang YY, Um YJ, Kim CS, Cho KS, Choi SH. Interproximal periodontal defect model in dogs: a pilot study. Oral Dis. 2011;17:26–32.PubMedCrossRefGoogle Scholar
  201. Karimbux NY, Ramamurthy NS, Golub LM, Nishimura I. The expression of collagen I and XII mRNAs in Porphyromonas gingivalis-induced periodontitis in rats: the effect of doxycycline and chemically modified tetracycline. J Periodontol. 1998;69:34–40.PubMedCrossRefGoogle Scholar
  202. Kasiske BL, O’Donnell MP, Keane WF. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension. 1992;19 Suppl 1:I110–5.PubMedCrossRefGoogle Scholar
  203. Katz J, Ward DC, Michalek SM. Effect of host responses on the pathogenicity of strains of Porphyromonas gingivalis. Oral Microbiol Immunol. 1996;11:309–18.PubMedCrossRefGoogle Scholar
  204. Katz J, Black KP, Michalek SM. Host responses to recombinant hemagglutinin B of Porphyromonas gingivalis in an experimental rat model. Infect Immun. 1999;67:4352–9.PubMedGoogle Scholar
  205. Kawai T, Eisen-Lev R, Seki M, Eastcott JW, Wilson ME, Taubman MA. Requirement of B7 costimulation for Th1-mediated inflammatory bone resorption in experimental periodontal disease. J Immunol. 2000;164:2102–9.PubMedGoogle Scholar
  206. Kebschull M, Demmer RT, Papapanou PN. “Gum bug, leave my heart alone!” – epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis. J Dent Res. 2010;89:879–902.PubMedCrossRefGoogle Scholar
  207. Kesavalu L, Chandrasekar B, Ebersole JL. In vivo induction of proinflammatory cytokines in mouse tissue by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2002;17:177–80.PubMedCrossRefGoogle Scholar
  208. Kesavalu L, Sathishkumar S, Bakthavatchalu V, Matthews C, Dawson D, Steffen M, Ebersole JL. Rat model of polymicrobial infection, immunity, and alveolar bone resorption in periodontal disease. Infect Immun. 2007;75:1704–12.PubMedCrossRefGoogle Scholar
  209. Kiel RA, Kornman KS, Robertson PB. Clinical and microbiological effects of localized ligature-induced periodontitis on non-ligated sites in the cynomolgus monkey. J Periodontal Res. 1983;18:200–11.PubMedCrossRefGoogle Scholar
  210. Kilkenny C, Parsons N, Kadyszewski E, Festing MFW, Cuthill IC, et al. Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS One. 2009;4(11):e7824. doi: 10.1371/journal.pone.0007824.PubMedCrossRefGoogle Scholar
  211. Kim CK, Kim HY, Chai JK, et al. Effect of a calcium sulfate implant with calcium sulfate barrier on periodontal healing in 3-wall intrabony defects in dogs. J Periodontol. 1998;69:982–8.PubMedCrossRefGoogle Scholar
  212. Kim HY, Kim CS, Jhon GJ, Moon IS, Choi SH, Cho KS, Chai JK, Kim CK. The effect of safflower seed extract on periodontal healing of 1-wall intrabony defects in beagle dogs. J Periodontol. 2002;73:1457–66.PubMedCrossRefGoogle Scholar
  213. Kim CS, Choi SH, Chai JK, et al. Periodontal repair in surgically created intrabony defects in dogs: influence of the number of bone walls on healing response. J Periodontol. 2004;75:229–35.PubMedCrossRefGoogle Scholar
  214. Kim CS, Choi SH, Cho KS, Chai JK, Wikesjo UM, Kim CK. Periodontal healing in one-wall intra-bony defects in dogs following implantation of autogenous bone or a coral-derived biomaterial. J Clin Periodontol. 2005;32:583–9.PubMedCrossRefGoogle Scholar
  215. Kim IY, Jung UW, Kim CS, Lee YK, Cho KS, Chai JK, Kim CK, Choi SH. Effects of a tetracycline blended polylactic and polyglycolic acid membrane on the healing of one-wall intrabony defects in beagle dogs. Biomed Mater. 2007;2:S106–10.PubMedCrossRefGoogle Scholar
  216. Kim TG, Wikesjö UM, Cho KS, Chai JK, Pippig SD, Siedler M, Kim CK. Periodontal wound healing⁄regeneration following implantation of recombinant human growth ⁄ differentiation factor-5 (rhGDF-5) in an absorbable collagen sponge carrier into one-wall intrabony defects in dogs: a dose-range study. J Clin Periodontol. 2009;36:589–97.PubMedCrossRefGoogle Scholar
  217. Kim CS, Um YJ, Chai JK, Cho KS, Moon IS, Choi SH, Jung UW, Lee DW, Kim CK. A canine model for histometric evaluation of periodontal regeneration. Periodontol 2000. 2011;56:209–26.PubMedCrossRefGoogle Scholar
  218. King GN, King N, Cruchley AT, Wozney JM, Hughes FJ. Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J Dent Res. 1997;76:1460–70.PubMedCrossRefGoogle Scholar
  219. King GN, King N, Hughes FJ. The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects. J Periodontol. 1998;69:561–70.PubMedCrossRefGoogle Scholar
  220. Kirkham J, Robinson C, Spence JA. Effect of periodontal disease (“broken mouth”) on the distribution of matrix macromolecules in the sheep periodontium. Arch Oral Biol. 1991;36:257–63.PubMedCrossRefGoogle Scholar
  221. Kirkwood KL, Li F, Rogers JE, Otremba J, Coatney DD, Kreider JM, D’Silva NJ, Chakravarty S, Dugar S, Higgins LS, Protter AA, Medicherla S. A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss. J Pharmacol Exp Ther. 2007;320:56–63.PubMedCrossRefGoogle Scholar
  222. Klausen B. Microbiological and immunological aspects of experimental periodontal disease in rats: a review article. J Periodontol. 1991;62:59–73.PubMedCrossRefGoogle Scholar
  223. Klausen B, Evans RT, Sfintescu C. Two complementary methods of assessing periodontal bone level in rats. Scand J Dent Res. 1989a;97:494–9.PubMedGoogle Scholar
  224. Klausen B, Hougen HP, Fiehn NE. Increased periodontal bone loss in temporarily B lymphocyte-deficient rats. J Periodontal Res. 1989b;24:384–90.PubMedCrossRefGoogle Scholar
  225. Klepp M, Hinrichs JE, Eastlund T, Schaffer EM. Histologic evaluation of demineralized freeze-dried bone allografts in barrier membrane covered periodontal fenestration wounds and ectopic sites in dogs. J Clin Periodontol. 2004;31:534–44.PubMedCrossRefGoogle Scholar
  226. Koo KT, Polimeni G, Albandar JM, Wikesjö UM. Periodontal repair in dogs: analysis of histometric assessments in the supraalveolar periodontal defect model. J Periodontol. 2004a;75:1688–93.PubMedCrossRefGoogle Scholar
  227. Koo KT, Polimeni G, Albandar JM, Wikesjö UM. Periodontal repair in dogs: examiner reproducibility in the supraalveolar periodontal defect model. J Clin Periodontol. 2004b;31:439–42.PubMedCrossRefGoogle Scholar
  228. Koo KT, Polimeni G, Qahash M, Kim CK, Wikesjö UM. Periodontal repair in dogs: guided tissue regeneration enhances bone formation in sites implanted with a coral-derived calcium carbonate biomaterial. J Clin Periodontol. 2005;32(1):104–10.PubMedCrossRefGoogle Scholar
  229. Kornman KS, Holt SC, Roberston PB. The microbiology of ligature-induced periodontitis in the cynomolgus monkey. J Periodontal Res. 1981a;16:363–71.PubMedCrossRefGoogle Scholar
  230. Kornman KS, Siegrist B, Soskolne WA, Nuki K. The predominant cultivable subgingival flora of beagle dogs following ligature placement and metronidazole therapy. J Periodontal Res. 1981b;16:251–8.PubMedCrossRefGoogle Scholar
  231. Kornman KS, Manti F, Goldschneider I. Peripheral blood lymphocyte populations in ligature-induced periodontitis. J Periodontal Res. 1982;17:469–71.PubMedCrossRefGoogle Scholar
  232. Kostopoulos L, Karring T. Susceptibility of GTR-regenerated periodontal attachment to ligature-induced periodontitis. J Clin Periodontol. 2004;31:336–40.PubMedCrossRefGoogle Scholar
  233. Kozlovsky A, Tal H, Laufer BZ, Leshem R, Rohrer MD, Weinreb M, Artzi Z. Impact of implant overloading on the peri-implant bone in inflamed and non-inflamed peri-implant mucosa. Clin Oral Implants Res. 2007;18:601–10.PubMedCrossRefGoogle Scholar
  234. Kuhr A, Popa-Wagner A, Schmoll H, Schwahn C, Kocher T. Observations on experimental marginal periodontitis in rats. J Periodontal Res. 2004;39:101–6.PubMedCrossRefGoogle Scholar
  235. Kurtis B, Balos K, Oygür T. Effect of a collagen membrane enriched with fibronectin on guided tissue regeneration in dogs. Periodontal Clin Investig. 2002;24:11–9.PubMedGoogle Scholar
  236. Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. J Pharmacol Pharmacother. 2010;1(2):94–9.PubMedCrossRefGoogle Scholar
  237. Lalla E, Lamster IB, Feit M, Huang L, Schmidt AM. A murine model of accelerated periodontal disease in diabetes. J Periodontal Res. 1998;33:387–99.PubMedCrossRefGoogle Scholar
  238. Lalla E, Lamster IB, Feit M, Huang L, Spessot A, Qu W, Kislinger T, Lu Y, Stern DM, Schmidt AM. Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest. 2000;105: 1117–24.PubMedCrossRefGoogle Scholar
  239. Lalla E, Lamster IB, Hofmann MA, Bucciarelli L, Jerud AP, Tucker S, Lu Y, Papapanou PN, Schmidt AM. Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol. 2003;23:1405–11.PubMedCrossRefGoogle Scholar
  240. Lang H, Schüler N, Nolden R. Attachment formation following replantation of cultured cells into periodontal defects – a study in minipigs. J Dent Res. 1998;77:393–405.PubMedCrossRefGoogle Scholar
  241. Le Guehennec L, Goyenvalle E, Aguado E, Houchmand-Cuny M, Enkel B, Pilet P, Daculsi G, Layrolle P. Small-animal models for testing macroporous ceramic bone substitutes. J Biomed Mater Res B Appl Biomater. 2005;72:69–78.PubMedCrossRefGoogle Scholar
  242. Lee JY, Yi NN, Kim US, Choi JS, Kim SJ, Choi JI. Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria. J Periodontal Res. 2006;41:10–4.PubMedCrossRefGoogle Scholar
  243. Lee J, Tran Q, Seeba G, Wikesjö UM, Susin C. The critical-size supraalveolar peri-implant defect model: reproducibility in histometric data acquisition of alveolar bone formation and osseointegration. J Clin Periodontol. 2009;36:1067–74.PubMedCrossRefGoogle Scholar
  244. Lekic P, Klausen B, Friis-Hasche E, Beloica D, Knezevic M, Hougen HP. Influence of age and immunization on development of gingivitis in rats. Acta Odontol Scand. 1989;47:233–8.PubMedCrossRefGoogle Scholar
  245. Lekovic V, Klokkevold PR, Kenney EB, Dimitrijelic B, Nedic M, Weinlaender M. Histologic evaluation of guided tissue regeneration using 4 barrier membranes: a comparative furcation study in dogs. J Periodontol. 1998;69:54–61.PubMedCrossRefGoogle Scholar
  246. Leone CW, Bokhadhoor H, Kuo D, Desta T, Yang J, Siqueira MF, Amar S, Graves DT. Immunization enhances inflammation and tissue destruction in response to Porphyromonas gingivalis. Infect Immun. 2006;74:2286–92.PubMedCrossRefGoogle Scholar
  247. Li CH, Amar S. Morphometric, histomorphometric, and microcomputed tomographic analysis of periodontal inflammatory lesions in a murine model. J Periodontol. 2007;78(6):1120–8.PubMedCrossRefGoogle Scholar
  248. Li L, Khansari A, Shapira L, Graves DT, Amar S. Contribution of interleukin-11 and prostaglandin(s) in lipopolysaccharide-induced bone resorption in vivo. Infect Immun. 2002a;70:3915–22.PubMedCrossRefGoogle Scholar
  249. Li L, Messas E, Batista Jr EL, Levine RA, Amar S. Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model. Circulation. 2002b;105(7):861–7.PubMedCrossRefGoogle Scholar
  250. Liang S, Hosur KB, Domon H, Hajishengallis G. Periodontal inflammation and bone loss in aged mice. J Periodontal Res. 2010;45:574–8.PubMedGoogle Scholar
  251. Liao F, Li Z, Wang Y, Shi B, Gong Z, Cheng X. Porphyromonas gingivalis may play an important role in the pathogenesis of periodontitis-associated rheumatoid arthritis. Med Hypotheses. 2009;72:732–5.PubMedCrossRefGoogle Scholar
  252. Liberman DN, Pilau RM, Gaio EJ, Orlandini LF, Rösing CK. Low concentration alcohol intake may inhibit spontaneous alveolar bone loss in Wistar rats. Arch Oral Biol. 2011;56:109–13.PubMedCrossRefGoogle Scholar
  253. Lin D, Smith MA, Champagne C, Elter J, Beck J, Offenbacher S. Porphyromonas gingivalis infection during pregnancy increases maternal tumor necrosis factor alpha, suppresses maternal interleukin-10, and enhances fetal growth restriction and resorption in mice. Infect Immun. 2003;71:5156–62.PubMedCrossRefGoogle Scholar
  254. Lindhe J, Ericsson I. Effect of ligature placement and dental plaque on periodontal tissue breakdown in the dog. J Periodontol. 1978;49:343–50.PubMedGoogle Scholar
  255. Lindhe J, Rylander H. Experimental gingivitis in young dogs. Scand J Dent Res. 1975;83:314–26.PubMedGoogle Scholar
  256. Lindhe J, Hamp SE, Löe H. Plaque induced periodontal disease in beagle dogs. A 4-year clinical, roentgenographical and histometrical study. J Periodontal Res. 1975;10:243–55.PubMedCrossRefGoogle Scholar
  257. Lindhe J, Berglundh T, Ericsson I, Liljenberg B, Marinello CP. Experimental breakdown of periimplant and periodontal tissues. A study in the beagle dog. Clin Oral Implants Res. 1992;3:9–16.PubMedCrossRefGoogle Scholar
  258. Listgarten MA, Johnson D, Nowotny A, Tanner AC, Socransky SS. Histopathology of periodontal disease in gnotobiotic rats monoinfected with Eikenella corrodens. J Periodontal Res. 1978;13:134–48.PubMedCrossRefGoogle Scholar
  259. Listagarten MA, Johnson D, Nowotny A, Tanner AC, Socransky SS. Histopathology of periodontal disease in gnotobiotic rats monoinfected with Eikenella corrodens. J Periodontal Res. 1978;13(2):134-48.PubMedCrossRefGoogle Scholar
  260. Liu R, Bal HS, Desta T, Behl Y, Graves DT. Tumor necrosis factor-alpha mediates diabetes-enhanced apoptosis of matrix-producing cells and impairs diabetic healing. Am J Pathol. 2006;168:757–64.PubMedCrossRefGoogle Scholar
  261. Liu Y, Zheng Y, Ding G, et al. Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells. 2008;26:1065–73.PubMedCrossRefGoogle Scholar
  262. Liu PF, Haake SK, Gallo RL, Huang CM. A novel vaccine targeting Fusobacterium nucleatum against abscesses and halitosis. Vaccine. 2009;27:1589–95.PubMedCrossRefGoogle Scholar
  263. Liu PF, Shi W, Zhu W, Smith JW, Hsieh SL, Gallo RL, Huang CM. Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: implication for treatment of periodontal infection and halitosis. Vaccine. 2010a;28(19):3496–505.PubMedCrossRefGoogle Scholar
  264. Liu Y-F, Wu L-A, Wang J, Wen L-Y, Wang X-J. Micro-computerized tomography analysis of alveolar bone loss in ligature- and nicotine-induced experimental periodontitis in rats. J Periodontal Res. 2010b;45:714–9.PubMedCrossRefGoogle Scholar
  265. Llavaneras A, Ramamurthy NS, Heikkila P, Teronen O, Salo T, Rifkin BR, Ryan ME, Golub LM, Sorsa T. A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats. J Periodontol. 2001;72:1069–77.PubMedCrossRefGoogle Scholar
  266. Lohinai Z, Benedek P, Feher E, Gyorfi A, Rosivall L, Fazekas A, Salzman AL, Szabo C. Protective effects of mercaptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat. Br J Pharmacol. 1998;123:353–60.PubMedCrossRefGoogle Scholar
  267. Ma JL, Pan JL, Tan BS, Cui FZ. Determination of critical size defect of minipig mandible. J Tissue Eng Regen Med. 2009;3:615–22.PubMedCrossRefGoogle Scholar
  268. Mahamed DA, Marleau A, Alnaeeli M, Singh B, Zhang X, Penninger JM, Teng YT. G(−) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice. Diabetes. 2005;54:1477–86.PubMedCrossRefGoogle Scholar
  269. Mallison 3rd SM, Szakal AK, Ranney RR, Tew JG. Antibody synthesis specific for nonoral antigens in inflamed gingiva. Infect Immun. 1988;56:823–30.PubMedGoogle Scholar
  270. Mallonee DH, Harvey CE, Venner M, Hammond BF. Bacteriology of periodontal disease in the cat. Arch Oral Biol. 1988;33:677–83.PubMedCrossRefGoogle Scholar
  271. Mann PH, Harper DS, Regnier S. Reduction of calculus accumulation in domestic ferrets with two dentifrices containing pyrophosphate. J Dent Res. 1990;69:451–3.PubMedCrossRefGoogle Scholar
  272. Manti F, Kornman K, Goldschneider I. Effects of an immunomodulating agent on peripheral blood lymphocytes and subgingival microflora in ligature-induced periodontitis. Infect Immun. 1984;45:172–9.PubMedGoogle Scholar
  273. Martí A, Marcos A, Martínez JA. Obesity and immune function relationships. Obes Rev. 2001;2:131–40.PubMedCrossRefGoogle Scholar
  274. Matsson L, Attstrom R. Histologic characteristics of experimental gingivitis in the juvenile and adult beagle dog. J Clin Periodontol. 1979;6:334–50.PubMedCrossRefGoogle Scholar
  275. McCourtie J, Poxton IR, Brown R, Whittaker CR, Spence JA, Aitchison GU. A longitudinal study of the cultivable subgingival anaerobic bacteria isolated from sheep during the development of broken mouth periodontitis. J Med Microbiol. 1990;31:275–83.PubMedCrossRefGoogle Scholar
  276. Meng H, Xie H, Chen Z. Evaluation of ligature-induced periodontitis in minipig. Zhonghua Kou Qiang Yi Xue Za Zhi. 1996;31:333–6.PubMedGoogle Scholar
  277. Mignini LE, Khan KS. Methodological quality of systematic reviews of animal studies: a survey of reviews of basic research. BMC Med Res Methodol. 2006;6:10.PubMedCrossRefGoogle Scholar
  278. Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC. Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol. 2009;9:38–42.PubMedCrossRefGoogle Scholar
  279. Min DH, Kim MJ, Yun JH, Kim CS, Lee YK, Choi SH, Kim KN, Kim CK. Effect of calcium phosphate glass scaffold with chitosan membrane on the healing of alveolar bone in 1-wall intrabony defect in beagle dogs. Key Eng Mater. 2005;284–286:851–4.CrossRefGoogle Scholar
  280. Min C-K, Wikesjö UME, Park J-C, Chae G-J, Pippig SD, Bastone P, Kim C-S, Kim C-K. Wound healing/regeneration using recombinant human growth/ differentiation factor-5 in an injectable poly-lactide-co-glycolide-acid composite carrier and a one-wall intra-bony defect model in dogs. J Clin Peridontol. 2011;38:261–8.CrossRefGoogle Scholar
  281. Mitsuta T, Horiuchi H, Shinoda H. Effects of topical administration of clodronate on alveolar bone resorption in rats with experimental periodontitis. J Periodontol. 2002;73:479–86.PubMedCrossRefGoogle Scholar
  282. Miyauchi M, Takata T, Ito H, Ogawa I, Kudo Y, Takekoshi T, Nikai H. Distribution of macrophage lineage cells in rat gingival tissue after topical application of lipopolysaccharide: an immunohistochemical study using monoclonal antibodies: OX6, ED1 and ED2. J Periodontal Res. 1998;33:345–51.PubMedCrossRefGoogle Scholar
  283. Moher D, Schulz KF, Altman DG for the CONSORT Group. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet. 2011;357:1191–4.Google Scholar
  284. Monjo M, Rubert M, Wohlfahrt JC, Rønold HJ, Ellingsen JE, Lyngstadaas SP. In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects. Acta Biomater. 2010;6:1405–12.PubMedCrossRefGoogle Scholar
  285. Moritz AJ, Cappelli D, Lantz MS, Holt SC, Ebersole JL. Immunization with Porphyromonas gingivalis cysteine protease: effects on experimental gingivitis and ligature-induced periodontitis in Macaca fascicularis. J Periodontol. 1998;69:686–97.PubMedCrossRefGoogle Scholar
  286. Nagini S. Of humans and hamsters: the hamster buccal pouch carcinogenesis model as a paradigm for oral oncogenesis and chemoprevention. Anticancer Agents Med Chem. 2009;9:843–52.PubMedCrossRefGoogle Scholar
  287. Nakajima K, Hamada N, Takahashi Y, Sasaguri K, Tsukinoki K, Umemoto T, Sato S. Restraint stress enhances alveolar bone loss in an experimental rat model. J Periodontal Res. 2006;41:527–34.PubMedCrossRefGoogle Scholar
  288. Naguib G, Al-Mashat H, Desta T, Graves DT. Diabetes prolongs the inflammatory response to a bacterial stimulus through cytokine dysregulation. J Invest Dermatol. 2004;123(1):87–92.Google Scholar
  289. Nisengard R, Blann D, Zelonis L, McHenry K, Reynolds H, Zambon J. Effects of immunization with B. macacae on induced periodontitis–preliminary findings. Immunol Invest. 1989;18:225–37.PubMedCrossRefGoogle Scholar
  290. Nishimura M. Breeding of mice strains for diabetes mellitus. Exp Anim. 1969;18:147–57.Google Scholar
  291. Nkenke E, Lehner B, Weinzierl K, et al. Bone contact, growth, and density around immediately loaded implants in the mandible of minipigs. Clin Oral Implants Res. 2003;14:312–21.PubMedCrossRefGoogle Scholar
  292. Nkenke E, Lehner B, Fenner M, et al. Immediate versus delayed loading of dental implants in the maxillae of minipigs: follow-up of implant stability and implant failures. Int J Oral Maxillofac Implants. 2005;20:39–47.PubMedGoogle Scholar
  293. Nociti Jr FH, Nogueira-Filho GR, Primo MT, Machado MA, Tramontina VA, Barros SP, et al. The influence of nicotine on the bone loss rate in ligature-induced periodontitis. A histometric study in rats. J Periodontol. 2000;71:1460–4.PubMedCrossRefGoogle Scholar
  294. Nogueira-Filho GR, Froes Neto EB, Casati MZ, Reis SR, Tunes RS, Tunes UR. Nicotine effects on alveolar bone changes induced by occlusal trauma: a histometric study in rats. J Periodontol. 2004;75:348–52.PubMedCrossRefGoogle Scholar
  295. Nowotny A, Sanavi F. Induction of nonspecific tolerance to endotoxins reduces the alveolar bone resorption in ligature-treated rats. Infect Immun. 1983;39:873–8.PubMedGoogle Scholar
  296. Núñez J, Caffesse R, Vignoletti F, Guerra F, San Roman F, Sanz M. Clinical and histological evaluation of an acellular dermal matrix allograft in combination with the coronally advanced flap in the treatment of Miller class I recession defects: an experimental study in the mini-pig. J Clin Periodontol. 2009;36:523–31.PubMedCrossRefGoogle Scholar
  297. Nuñez J, Sanz-Blasco S, Vignoletti F, Muñoz F, Caffesse RG, Sanz M, Villalobos C, Nuñez L. 17beta-estradiol promotes cementoblast proliferation and cementum formation in experimental periodontitis. J Periodontol. 2010;81:1064–74.PubMedCrossRefGoogle Scholar
  298. O’Brien-Simpson NM, Paolini RA, Reynolds EC. RgpA-Kgp peptide-based immunogens provide protection against Porphyromonas gingivalis challenge in a murine lesion model. Infect Immun. 2000;68:4055–63.PubMedCrossRefGoogle Scholar
  299. O’Brien-Simpson NM, Pathirana RD, Paolini RA, Chen YY, Veith PD, Tam V, Ally N, Pike RN, Reynolds EC. An immune response directed to proteinase and adhesion functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss. J Immunol. 2005;175:3980–9.PubMedGoogle Scholar
  300. Oates TW, Graves DT, Cochran DL. Clinical, radiographic and biochemical assessment of IL-1/TNF-alpha antagonist inhibition of bone loss in experimental periodontitis. J Clin Periodontol. 2002;29:137–43.PubMedCrossRefGoogle Scholar
  301. Ohnishi T, Bandow K, Kakimoto K, Machigashira M, Matsuyama T, Matsuguchi T. Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes. J Periodontal Res. 2009;44:43–51.PubMedCrossRefGoogle Scholar
  302. Okada Y, Hamada N, Kim Y, Takahashi Y, Sasaguri K, Ozono S, Sato S. Blockade of sympathetic b-receptors inhibits Porphyromonas gingivalis-induced alveolar bone loss in an experimental rat periodontitis model. Arch Oral Biol. 2010;55:502–8.PubMedCrossRefGoogle Scholar
  303. Onodera H, Shibukawa Y, Sugito H, Ota M, Yamada S. Periodontal regeneration in intrabony defects after application of enamel matrix proteins with guided tissue regeneration: an experimental study in dogs. Biomed Res. 2005;26:69–77.PubMedCrossRefGoogle Scholar
  304. Oortgiesen DA, Meijer GJ, Bronckers AL, Walboomers XF, Jansen JA. Fenestration defects in the rabbit jaw: an inadequate model for studying periodontal ­regeneration. Tissue Eng Part C Methods. 2010;16: 133–40.PubMedCrossRefGoogle Scholar
  305. Oz HS, Ebersole JL. A novel murine model for chronic inflammatory alveolar bone loss. J Periodontal Res. 2010;45:94–9.PubMedCrossRefGoogle Scholar
  306. Oz HS, Chen T, Ebersole JL. A model for chronic mucosal inflammation in IBD and periodontitis. Dig Dis Sci. 2010;55:2194–202.PubMedCrossRefGoogle Scholar
  307. Oz HS, Puleo DA. Animal models for periodontal disease. J Biomed Biotechnol. 2011:754–857.PubMedCrossRefGoogle Scholar
  308. Ozmeric N, Bal B, Oygur T, Balos K. The effect of a collagen membrane in regenerative therapy of two-wall intrabony defects in dogs. Periodontal Clin Invest. 2000;22:22–30.Google Scholar
  309. Papageorgiou A, Vouros I, Konstantinidis A. Treatment outcomes of ligature-induced recession in the dog model using guided tissue regeneration or coronally positioned flap procedures. J Int Acad Periodontol. 2009;11:177–87.PubMedGoogle Scholar
  310. Park WY, Cho CS, Chai JK, Kim CK, Choi SH. The effects of bioactive glass on the periodontal healing of 1-wall intrabony defects in dogs. J Korean Acad Periodontol. 1998;28:145–60.Google Scholar
  311. Park JS, Choi SH, Moon IS, Cho KS, Chai JK, Kim CK. Eight-week histological analysis on the effect of chitosan on surgically created one-wall intrabony defects in beagle dogs. J Clin Periodontol. 2003;30:443–53.PubMedCrossRefGoogle Scholar
  312. Park CH, Abramson ZR, Taba Jr M, Jin Q, Chang J, Kreider JM, Goldstein SA, Giannobile WV. Three-dimensional micro-computed tomographic imaging of alveolar bone in experimental bone loss or repair. J Periodontol. 2007;78:273–81.PubMedCrossRefGoogle Scholar
  313. Pathirana RD, O’Brien-Simpson NM, Brammar GC, Slakeski N, Reynolds EC. Kgp and RgpB, but not RgpA, are important for Porphyromonas gingivalis virulence in the murine periodontitis model. Infect Immun. 2007;75:1436–42.PubMedCrossRefGoogle Scholar
  314. Pellegrini G, Seol YJ, Gruber R, Giannobile WV. Pre-clinical models for oral and periodontal reconstructive therapies. J Dent Res. 2009;88:1065–76.PubMedCrossRefGoogle Scholar
  315. Perel P, Roberts I, Sena E, Wheble P, Briscoe C, Sandercock P, Macleod M, Mignini LE, Jayaram P, Khan KS. Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ. 2007;334(7586):197.PubMedCrossRefGoogle Scholar
  316. Perlstein MI, Bissada NF. Influence of obesity and hypertension on the severity of periodontitis in rats. Oral Surg Oral Med Oral Pathol. 1977;43:707–19.PubMedCrossRefGoogle Scholar
  317. Persson GR. Immune responses and vaccination against periodontal infections. J Clin Periodontol. 2005;32 Suppl 6:39–53.PubMedCrossRefGoogle Scholar
  318. Persson GR, Engel D, Whitney C, Darveau R, Weinberg A, Brunsvold M, Page RC. Immunization against Porphyromonas gingivalis inhibits progression of experimental periodontitis in nonhuman primates. Infect Immun. 1994a;62:1026–31.PubMedGoogle Scholar
  319. Persson GR, Engel LD, Whitney CW, Weinberg A, Moncla BJ, Darveau RP, Houston L, Braham P, Page RC. Macaca fascicularis as a model in which to assess the safety and efficacy of a vaccine for periodontitis. Oral Microbiol Immunol. 1994b;9:104–11.PubMedCrossRefGoogle Scholar
  320. Persson LG, Berglundh T, Sennerby L, Lindhe J. Reosseointegration after treatment of peri-implantitis at different implant surfaces. An experimental study in the dog. Clin Oral Implnts Res. 2001a;12:595–603.CrossRefGoogle Scholar
  321. Persson LG, Ericsson I, Berglundh T, Lindhe J. Osseintegration following treatment of peri-implantitis and replacement of implant components. An experimental study in the dog. J Clin Periodontol. 2001b;28:258–63.PubMedCrossRefGoogle Scholar
  322. Peruzzo DC, Benatti BB, Antunes IB, Andersen ML, Sallum EA, Casati MZ, et al. Chronic stress may modulate periodontal disease: a study in rats. J Periodontol. 2008;79:697–704.PubMedCrossRefGoogle Scholar
  323. Pieri F, Lucarelli E, Corinaldesi G, Fini M, Aldini NN, Giardino R, Donati D, Marchetti C. Effect of mesenchymal stem cells and platelet-rich plasma on the healing of standardized bone defects in the alveolar ridge: a comparative histomorphometric study in minipigs. J Oral Maxillofac Surg. 2009;67:265–72.PubMedCrossRefGoogle Scholar
  324. Pimentel SP, Sallum AW, Saldanha JB, Casati MZ, Nociti Jr FH, Sallum EA. Enamel matrix derivative versus guided tissue regeneration in the presence of nicotine: a histomorphometric study in dogs. J Clin Periodontol. 2006;33:900–7.PubMedCrossRefGoogle Scholar
  325. Polak D, Wilensky A, Shapira L, Halabi A, Goldstein D, Weiss EI, Houri-Haddad Y. Mouse model of experimental periodontitis induced by Porphyromonas gingivalis/Fusobacterium nucleatum infection: bone loss and host response. J Clin Periodontol. 2009;36:406–10.PubMedCrossRefGoogle Scholar
  326. Polak D, Wilensky A, Shapira L, Weiss EI, Houri-Haddad Y. Vaccination of mice with Porphyromonas gingivalis or Fusobacterium nucleatum modulates the inflammatory response, but fails to prevent experimental periodontitis. J Clin Periodontol. 2010;37:812–7.PubMedCrossRefGoogle Scholar
  327. Polimeni G, Albandar JM, Wikesjö UME. Prognostic factors for alveolar regeneration: osteogenic potential of resident bone. J Clin Periodontol. 2004a;31:840–4.PubMedCrossRefGoogle Scholar
  328. Polimeni G, Koo K-T, Qahash M, Xiropaidis AV, Albandar JM, Wikesjö UME. Prognostic factors for alveolar regeneration: bone formation at teeth and titanium implants. J Clin Periodontol. 2004b;31:927–32.PubMedCrossRefGoogle Scholar
  329. Polimeni G, Koo K-T, Qahash M, Xiropaidis AV, Albandar JM, Wikesjö UME. Prognostic factors for alveolar regeneration: effect of tissue occlusion on alveolar bone regeneration with guided tissue regeneration. J Clin Periodontol. 2004c;31:730–5.PubMedCrossRefGoogle Scholar
  330. Polimeni G, Koo K-T, Qahash M, Xiropaidis AV, Albandar JM, Wikesjö UME. Prognostic factors for alveolar regeneration: effect of a space-providing biomaterial on guided tissue regeneration. J Clin Periodontol. 2004d;31:725–9.PubMedCrossRefGoogle Scholar
  331. Polimeni G, Albandar JM, Wikesjö UME. Prognostic factors for alveolar regeneration: effect of space provision. J Clin Periodontol. 2005;32:951–4.PubMedCrossRefGoogle Scholar
  332. Polimeni G, Susin C, Wikesjö UME. Regenerative potential and healing dynamics of the periodontium: a critical-size supra-alveolar periodontal defect study. J Clin Periodontol. 2009;36:258–64.PubMedCrossRefGoogle Scholar
  333. Polimeni G, Xiropaidis AV, Wikesjö UM. Biology and principles of periodontal wound healing/regeneration. Periodontol 2000. 2006;41:30-47.Google Scholar
  334. Pontes Andersen CC, Flyvbjerg A, Buschard K, Holmstrup P. Relationship between periodontitis and diabetes: lessons from rodent studies. J Periodontol. 2007;78:1264–75.PubMedCrossRefGoogle Scholar
  335. Pouliot M, Clish CB, Petasis NA, Van Dyke TE, Serhan CN. Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. Biochemistry. 2000;39:4761–8.PubMedCrossRefGoogle Scholar
  336. Pound P, Ebrahim S, Sandercock P, Bracken MB, Roberts I, Reviewing Animal Trials Systematically (RATS) Group. Where is the evidence that animal research benefits humans? BMJ. 2004;328(7438):514–7.PubMedCrossRefGoogle Scholar
  337. Powell CA, Bannister SR, Mackey SA, Maller SC, McDonnell HT, Deas DE. Periodontal wound healing with and without platelet-rich plasma: histologic observations and assessment of flap tensile strength. J Periodontol. 2009;80:985–92.PubMedCrossRefGoogle Scholar
  338. Rajapakse PS, O’Brien-Simpson NM, Slakeski N, Hoffmann B, Reynolds EC. Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model. Infect Immun. 2002;70:2480–6.PubMedCrossRefGoogle Scholar
  339. Romanowski AW, Squier CA, Lesch CA. Permeability of rodent junctional epithelium to exogenous protein. J Periodontal Res. 1988;23:81–6.PubMedCrossRefGoogle Scholar
  340. Ramamurthy NS, Rifkin BR, Greenwald RA, Xu JW, Liu Y, Turner G, Golub LM, Vernillo AT. Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines. J Periodontol. 2002a;73:726–34.PubMedCrossRefGoogle Scholar
  341. Ramamurthy NS, Xu JW, Bird J, Baxter A, Bhogal R, Wills R, Watson B, Owen D, Wolff M, Greenwald RA. Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in experimental periodontal disease. J Periodontal Res. 2002b;37:1–7.PubMedCrossRefGoogle Scholar
  342. Ramamurthy NS, Greenwald RA, Celiker MY, Shi EY. Experimental arthritis in rats induces biomarkers of periodontitis which are ameliorated by gene therapy with tissue inhibitor of matrix metalloproteinases. J Periodontol. 2005;76:229–33.PubMedCrossRefGoogle Scholar
  343. Reichart PA, Dürr UM, Triadan H, Vickendey G. Periodontal disease in the domestic cat. A histopathologic study. J Periodontal Res. 1984;19:67–75.PubMedCrossRefGoogle Scholar
  344. Repeke CE, Ferreira Jr SB, Claudino M, Silveira EM, de Assis GF, Avila-Campos MJ, Silva JS, Garlet GP. Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL+ cell migration throughout experimental periodontitis in mice. Bone. 2010;46:1122–30.PubMedCrossRefGoogle Scholar
  345. Reymond F, Cimasoni G. Radiographic measurement of alveolar bone loss in the living rat. J Periodontol. 1997;68:141–4.PubMedCrossRefGoogle Scholar
  346. Rizzo AA, Mitchell CT. Chronic allergic inflammation induced by repeated deposition of antigen in rabbit gingival pockets. Periodontics. 1966;4:5–10.PubMedGoogle Scholar
  347. Rogers JE, Li F, Coatney DD, Rossa C, Bronson P, Krieder JM, Giannobile WV, Kirkwood KL. Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis. J Periodontol. 2007;78:550–8.PubMedCrossRefGoogle Scholar
  348. Roriz VM, Souza SL, Taba Jr M, Palioto DB, Grisi MF. Treatment of class III furcation defects with expanded polytetrafluoroethylene membrane associated or not with anorganic bone matrix/synthetic cell-binding peptide: a histologic and histomorphometric study in dogs. J Periodontol. 2006;77:490–7.PubMedCrossRefGoogle Scholar
  349. Ross BC, Czajkowski L, Vandenberg KL, Camuglia S, Woods J, Agius C, Paolini R, Reynolds E, Barr IG. Characterization of two outer membrane protein antigens of Porphyromonas gingivalis that are protective in a murine lesion model. Oral Microbiol Immunol. 2004;19:6–15.PubMedCrossRefGoogle Scholar
  350. Ryder MI. Histological and ultrastructural characteristics of the periodontal syndrome in the rice rat. I. General light microscopic observations and ultrastructural observations of initial inflammatory changes. J Periodontal Res. 1980;15:502–15.PubMedCrossRefGoogle Scholar
  351. Sallum EA, Pimentel SP, Saldanha JB, Nogueira-Filho GR, Casati MZ, Nociti FH, Sallum AW. Enamel matrix derivative and guided tissue regeneration in the treatment of dehiscence-type defects: a histomorphometric study in dogs. J Periodontol. 2004;75(10):1357–63.PubMedCrossRefGoogle Scholar
  352. Sallay K, Sanavi F, Ring I, Pham P, Behling UH, Nowotny A. Alveolar bone destruction in the immunosuppressed rat. J Periodontal Res. 1982;17(3):263–74.PubMedCrossRefGoogle Scholar
  353. Saito E, Saito A, Kawanami M. Favorable healing following space creation in rhBMP-2-induced periodontal regeneration of horizontal circumferential defects in dogs with experimental periodontitis. J Periodontol. 2003;74:1808–15.PubMedCrossRefGoogle Scholar
  354. Sakata J, Abe H, Ohazama A, et al. Effects of combined treatment with porous bovine inorganic bone grafts and bilayer porcine collagen membrane on refractory one-wall intrabony defects. Int J Periodontics Restorative Dent. 2006;26:161–9.PubMedGoogle Scholar
  355. Sasaki H, Hou L, Belani A, Wang CY, Uchiyama T, Müller R, Stashenko P. IL-10, but not IL-4, suppresses infection-stimulated bone resorption in vivo. J Immunol. 2000;165:3626–30.PubMedGoogle Scholar
  356. Sasaki H, Suzuki N, AlShwaimi E, Xu Y, Battaglino R, Morse L, Stashenko P. 18b-Glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-jB inactivation in interleukin-10-deficient mice. J Periodontal Res. 2010;45:757–63.PubMedCrossRefGoogle Scholar
  357. Schenkein HA. Failure of Bacteroides gingivalis W83 to accumulate bound C3 following opsonization with serum. J Periodontal Res. 1989;24:20–7.PubMedCrossRefGoogle Scholar
  358. Schliephake H, Aleyt J. Mandibular onlay grafting using prefabricated bone grafts with primary implant placement: an experimental study in minipigs. Int J Oral Maxillofac Implants. 1998;13:384–93.PubMedGoogle Scholar
  359. Schmitt JM, Buck DC, Joh SP, Lynch SE, Hollinger JO. Comparison of porous bone mineral and biologically active glass in critical-sized defects. J Periodontol. 1997;68:1043–53.PubMedCrossRefGoogle Scholar
  360. Schou S, Holmstrup P, Kornman KS. Non-human primates used in studies of periodontal disease pathogenesis: a review of the literature. J Periodontol. 1993;64:497–508.PubMedCrossRefGoogle Scholar
  361. Schou S, Holmstrup P, Stoltze K, Hjørting-Hansen E, Fiehn NE, Skovgaard LT. Probing around implants and teeth with healthy or inflamed peri-implant mucosa/gingiva. Clin Oral Implants Res. 2002;13:113–26.PubMedCrossRefGoogle Scholar
  362. Schulz KF, Altman DG, Moher D, The CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c332.PubMedCrossRefGoogle Scholar
  363. Schwarz F, Herten M, Sager M, Bieling K, Sculean A, Becker J. Comparison of naturally occurring and ligature-induced periimplantitis bone defects in humans and dogs. Clin Oral Implants Res. 2007;18:161–70.PubMedCrossRefGoogle Scholar
  364. Sculean A, Karring T, Theilade J, Lioubavina N. The regenerative potential of oxytalan fibers: an experimental study in the monkey. J Clin Periodontol. 1997;24:932–6.PubMedCrossRefGoogle Scholar
  365. Sculean A, Donos N, Reich E, Karring T, Brecx M. Regeneration of oxytalan fibres in different types of periodontal defects: a histological study in monkeys. J Prriodontal Res. 1998;33:453–9.CrossRefGoogle Scholar
  366. Sculean A, Donos N, Brecx M, Karring T, Reich E. Healing of fenestration-type defects following treatment with guided tissue regeneration or enamel matrix proteins: an experimental study in monkeys. Clin Oral Investig. 2000a;4:50–6.PubMedCrossRefGoogle Scholar
  367. Sculean A, Donos N, Brecx M, Reich E, Karring T. Treatment of intrabony defects with guided tissue regeneration and enamel matrix-proteins: an experimental study in monkeys. J Clin Periodontol. 2000b;27:466–72.PubMedCrossRefGoogle Scholar
  368. Sculean A, Berakdar M, Pahl S, Windisch P, Brecx M, Reich E, Donos N. Patterns of cytokeratin expression in monkey and human periodontium following regenerative and conventional periodontal surgery. J Periodontal Res. 2001;36:260–8.PubMedCrossRefGoogle Scholar
  369. Sculean A, Nikolidakis D, Schwarz F. Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials – biological foundation and preclinical evidence: a systematic review. J Clin Periodontol. 2008;35(8 Suppl):106–16.PubMedCrossRefGoogle Scholar
  370. Selvig KA, Wikesjö UM, Bogle GC, Finkelman RD. Impaired early bone formation in periodontal fenestration defects in dogs following application of insulin-like growth factor (II). Basic fibroblast growth factor and transforming growth factor beta 1. J Clin Periodontol. 1994;21:380–5.PubMedCrossRefGoogle Scholar
  371. Semenoff Segundo A, Semenoff TA, Borges AH, Pedro FL, Sakai VT. Methodological model of chronic stress associated with ligature-induced periodontitis in rats: a radiographic study. Braz Oral Res. 2010;24:455–9.PubMedCrossRefGoogle Scholar
  372. Serhan CN, Jain A, Marleau S, et al. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol. 2003;171:6856–65.PubMedGoogle Scholar
  373. Seto H, Toba Y, Takada Y, Kawakami H, Ohba H, Hama H, Horibe M, Nagata T. Milk basic protein increases alveolar bone formation in rat experimental periodontitis. J Periodontal Res. 2007;42:85–9.PubMedCrossRefGoogle Scholar
  374. Sharma A, Honma K, Evans RT, Hruby DE, Genco RJ. Oral immunization with recombinant Streptococcus gordonii expressing porphyromonas gingivalis FimA domains. Infect Immun. 2001;69:2928–34.PubMedCrossRefGoogle Scholar
  375. Sharma A, Inagaki S, Honma K, Sfintescu C, Baker PJ, Evans RT. Tannerella forsythia-induced alveolar bone loss in mice involves leucine-rich-repeat BspA protein. J Dent Res. 2005;84:462–7.PubMedCrossRefGoogle Scholar
  376. Shirakata Y, Oda S, Kinoshita A, Kikuchi S, Tsuchioka H, Ishikawa I. Histocompatible healing of periodontal defects after application of an injectable calcium phosphate bone cement. A preliminary study in dogs. J Periodontol. 2002;73:1043–53.PubMedCrossRefGoogle Scholar
  377. Shirakata Y, Yoshimoto T, Goto H, Yonamine Y, Kadomatsu H, Miyamoto M, Nakamura T, Hayashi C, Izumi Y. Favorable periodontal healing of 1-wall infrabony defects after application of calcium phosphate cement wall alone or in combination with enamel matrix derivative: a pilot study with canine mandibles. J Periodontol. 2007;78:889–98.PubMedCrossRefGoogle Scholar
  378. Shoji K, Horiuchi H, Shinoda H. Inhibitory effects of a bisphosphonate (risedronate) on experimental periodontitis in rats. J Periodontal Res. 1995;30:277–84.PubMedCrossRefGoogle Scholar
  379. Shoji K, Ohtsuka-Isoya M, Shimauchi H, Shinoda H. Effects of lactation on alveolar bone loss in experimental periodontitis. J Periodontol. 2007;78:152–6.PubMedCrossRefGoogle Scholar
  380. Siegrist B, Kornman KS. The effect of supragingival plaque control on the composition of the subgingival microbial flora in ligature-induced periodontitis in the monkey. J Dent Res. 1982;61:936–41.PubMedCrossRefGoogle Scholar
  381. Singh G, O’Neal RB, Brennan WA, Strong SL, Horner JA, Van Dyke TE. Surgical treatment of induced periimplantitis in the micro pig: clinical and histological analysis. J Periodontol. 1993;64:984–9.PubMedCrossRefGoogle Scholar
  382. Sluyter F, Breivik T, Cools A. Manipulations in maternal environment reverse periodontitis in genetically predisposed rats. Clin Diagn Lab Immunol. 2002;9:931–2.PubMedGoogle Scholar
  383. Soames JV, Davies RM. Lymphocyte-macrophage and lymphocyte-lymphocyte associations in early gingivitis in beagle dogs. J Periodontal Res. 1980;15:341–4.PubMedCrossRefGoogle Scholar
  384. Socransky SS, Hubersak C, Propas D. Induction of periodontal destruction in gnotobiotic rats by a human oral strain of Actinomyces naeslundii. Arch Oral Biol. 1970;15:993–5.PubMedCrossRefGoogle Scholar
  385. Soletti AC, Gaio EJ, Rosing CK. Effect of neonatal clomipramine in the pathogenesis of ligature-induced periodontitis in Lewis rats. Acta Odontol Scand. 2009;67:94–8.PubMedCrossRefGoogle Scholar
  386. Song WS, Kim CS, Choi SH, Jhon GJ, Kim HY, Cho KS, Kim CK, Chai JK. The effects of a bioabsorbable barrier membrane containing safflower seed extracts on periodontal healing of 1-wall intrabony defects in beagle dogs. J Periodontol. 2005;76:22–33.PubMedCrossRefGoogle Scholar
  387. Stavropoulos A, Wikesjö UME. Influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a bovine bone biomaterial and provisions for guided tissue regeneration: an experimental study in the dog. J Clin Periodontol. 2010;37:534–43.PubMedCrossRefGoogle Scholar
  388. Struillou X, Boutigny H, Soueidan A, Layrolle P. Experimental animal models in periodontology: a review. Open Dent J. 2010;4:37–47.PubMedCrossRefGoogle Scholar
  389. Suaid FF, Ribeiro FV, Rodrigues TL, Silvério KG, Carvalho MD, Nociti FH Jr, Casati MZ, Sallum EA. Autologous periodontal ligament cells in the treatment of class II furcation defects: a study in dogs. J Clin Periodontol. 2011;38:491–8.Google Scholar
  390. Suzumura Y, Kameyama Y, Mizutani M, Kato M, Kondo K, Mabuchi R. Long junctional epithelium produced by application of bacterial protease in rats. J Periodontal Res. 1989;24:217–21.PubMedCrossRefGoogle Scholar
  391. Takahashi D, Odajima T, Morita M, Kawanami M, Kato H. Formation and resolution of ankylosis under application of recombinant human bone morphogenetic protein-2 (rhBMP-2) to class III furcation defects in cats. J Periodontal Res. 2005;40:299–305.PubMedCrossRefGoogle Scholar
  392. Takano M, Nishihara R, Sugano N, Matsumoto K, Yamada Y, Takane M, Fujisaki Y, Ito K. The effect of systemic anti-tumor necrosis factor-alpha treatment on Porphyromonas gingivalis infection in type 2 diabetic mice. Arch Oral Biol. 2010;55:379–84.PubMedCrossRefGoogle Scholar
  393. Takata T, Matsuura M, Murashima M, Miyauchi M, Nikai H. Periodontitis in the house musk shrew (Suncus murinus): a potential animal model for human periodontal disease. J Periodontol. 1999;70:195–200.PubMedCrossRefGoogle Scholar
  394. Tal H, Pitaru S, Moses O, Kozlovsky A. Collagen gel and membrane in guided tissue regeneration in periodontal fenestration defects in dogs. J Clin Periodontol. 1996;23:1–6.PubMedCrossRefGoogle Scholar
  395. Tal H, Artzi Z, Moses O, Nemcovsky C, Kozlovsky A. Guided periodontal regeneration using bilayered collagen membranes and bovine bone mineral in fenestration defects in the canine. Int J Periodontics Restorative Dent. 2005;25:509–18.PubMedGoogle Scholar
  396. Teng YT, Nguyen H, Gao X, Kong YY, Gorczynski RM, Singh B, Ellen RP, Penninger JM. Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest. 2000;106(6):R59–67.PubMedCrossRefGoogle Scholar
  397. Teng YT, Nguyen H, Hassanloo A, Ellen RP, Hozumi N, Gorczynski RM. Periodontal immune responses of human lymphocytes in Actinobacillus actinomycetemcomitans-inoculated NOD/SCID mice engrafted with peripheral blood leukocytes of periodontitis patients. J Periodontal Res. 1999;34(1):54–61.PubMedCrossRefGoogle Scholar
  398. Teng YT. Mixed periodontal Th1-Th2 cytokine profile in Actinobacillus actinomycetemcomitans-specific osteoprotegerin ligand (or RANK-L)- mediated alveolar bone destruction in vivo. Infect Immun. 2002;70:5269–73.PubMedCrossRefGoogle Scholar
  399. Teng YT. The role of acquired immunity and periodontal disease progression. Crit Rev Oral Biol Med. 2003;14:237–52.PubMedCrossRefGoogle Scholar
  400. Teng YT, Hu W. Expression cloning of a periodontitis-associated apoptotic effector, cagE homologue, in Actinobacillus actinomycetemcomitans. Biochem Biophys Res Commun. 2003;303:1086–94.PubMedCrossRefGoogle Scholar
  401. Teng YT, Zhang X. Apoptotic activity and sub-cellular localization of a T4SS-associated CagE-homologue in Actinobacillus actinomycetemcomitans. Microb Pathog. 2005;38:125–32.PubMedCrossRefGoogle Scholar
  402. Teng YT, Mahamed D, Singh B. Gamma interferon positively modulates Actinobacillus actinomycetemcomitans-specific RANKL+ CD4+ Th-cell-mediated alveolar bone destruction in vivo. Infect Immun. 2005;73: 3453–61.PubMedCrossRefGoogle Scholar
  403. Thoma DS, Halg GA, Dard MM, Seibl R, Hammerle CH, Jung RE. Evaluation of a new biodegradable membrane to prevent gingival ingrowth into mandibular bone defects in minipigs. Clin Oral Implants Res. 2009;20:7–16.PubMedCrossRefGoogle Scholar
  404. Toker H, Ozan F, Ozer H, Ozdemir H, Eren K, Yeler H. A morphometric and histopathologic evaluation of the effects of propolis on alveolar bone loss in experimental periodontitis in rats. J Periodontol. 2008;79(6):1089–94.PubMedCrossRefGoogle Scholar
  405. Tomita S, Yamamoto S, Shibukawa Y, Kaneko T, Miyakoshi S, Shimono M, Yamada S. Application of 4-META/MMA-TBB resin for fixation of membrane to tooth in guided tissue regeneration in dog. Dent Mater J. 2010;29:690–6.PubMedCrossRefGoogle Scholar
  406. Tomofuji T, Ekuni D, Yamanaka R, Kusano H, Azuma T, Sanbe T, et al. Chronic administration of lipopolysaccharide and proteases induces periodontal inflammation and hepatic steatosis in rats. J Periodontol. 2007;78: 1999–2006.PubMedCrossRefGoogle Scholar
  407. Tomofuji T, Sanbe T, Ekuni D, Azuma T, Irie K, Maruyama T, Tamaki N, Yamamoto T. Oxidative damage of rat liver induced by ligature-induced periodontitis and chronic ethanol consumption. Arch Oral Biol. 2008;53:1113–8.PubMedCrossRefGoogle Scholar
  408. Tomofuji T, Ekuni D, Irie K, Azuma T, Endo Y, Tamaki N, Sanbe T, Murakami J, Yamamoto T, Morita M. Preventive effects of a cocoa-enriched diet on gingival oxidative stress in experimental periodontitis. J Periodontol. 2009a;80:1799–808.PubMedCrossRefGoogle Scholar
  409. Tomofuji T, Ekuni D, Sanbe T, Azuma T, Tamaki N, Irie K, Maruyama T, Yamamoto T, Watanabe T, Miyauchi M, Takata T. Effects of improvement in periodontal inflammation by toothbrushing on serum lipopolysaccharide concentration and liver injury in rats. Acta Odontol Scand. 2009b;67:1–6.CrossRefGoogle Scholar
  410. Tomofuji T, Ekuni D, Sanbe T, et al. Effects of improvement in periodontal inflammation by toothbrushing on serum lipopolysaccharide concentration and liver injury in rats. Acta Odontol Scand. 2009c;67:200–5.PubMedCrossRefGoogle Scholar
  411. Tomofuji T, Yamamoto T, Tamaki N, Ekuni D, Azuma T, Sanbe T, Irie K, Kasuyama K, Umakoshi M, Murakami J, Kokeguchi S, Morita M. Effects of obesity on gingival oxidative stress in a rat model. J Periodontol. 2009d;80:1324–9.PubMedCrossRefGoogle Scholar
  412. Tyrrell KL, Citron DM, Jenkins JR, Goldstein EJ. Periodontal bacteria in rabbit mandibular and maxillary abscesses. J Clin Microbiol. 2002;40:1044–7.PubMedCrossRefGoogle Scholar
  413. Vardar-Sengul S, Buduneli E, Turkoglu O, Buduneli N, Atilla G, Wahlgren J, Sorsa T, Baylas H. The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis. J Periodontol. 2008;79: 1934–41.PubMedCrossRefGoogle Scholar
  414. Vastardis S, Yukna RA, Mayer ET, Atkinson BL. Periodontal regeneration with peptide-enhanced anorganic bone matrix in particulate and putty form in dogs. J Periodontol. 2005;76:1690–6.PubMedCrossRefGoogle Scholar
  415. Verma RK, Bhattacharyya I, Sevilla A, Lieberman I, Pola S, Nair M, Wallet SM, Aukhil I, Kesavalu L. Virulence of major periodontal pathogens and lack of humoral immune protection in a rat model of periodontal disease. Oral Dis. 2010;16:686–95.PubMedCrossRefGoogle Scholar
  416. Villaca JH, Novaes Jr AB, Souza SL, Taba Jr M, Molina GO, Carvalho TL. Bioactive glass efficacy in the periodontal healing of intrabony defects in monkeys. Braz Dent J. 2005;16:67–74.PubMedCrossRefGoogle Scholar
  417. Wang HL, Pappert TD, Castelli WA, Chiego Jr DJ, Shyr Y, Smith BA. The effect of platelet-derived growth factor on the cellular response of the periodontium: an autoradiographic study on dogs. J Periodontol. 1994;65:429–36.PubMedCrossRefGoogle Scholar
  418. Wang M, Shakhatreh MA, James D, Liang S, Nishiyama S, Yoshimura F, Demuth DR, Hajishengallis G. Fimbrial proteins of porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages. J Immunol. 2007a;179:2349–58.PubMedGoogle Scholar
  419. Wang S, Liu Y, Fang D, Shi S. The miniature pig: a useful large animal model for dental and orofacial research. Oral Dis. 2007b;13:530–7.PubMedCrossRefGoogle Scholar
  420. Watanabe K, Petro BJ, Shlimon AE, Unterman TG. Effect of periodontitis on insulin resistance and the onset of type 2 diabetes mellitus in Zucker diabetic fatty rats. J Periodontol. 2008;79:1208–16.PubMedCrossRefGoogle Scholar
  421. Watanabe K, Iizuka T, Adeleke A, Pham L, Shlimon AE, Yasin M, Horvath P, Unterman TG. Involvement of toll-like receptor 4 in alveolar bone loss and glucose homeostasis in experimental periodontitis. J Periodontal Res. 2011;46(1):21–30.PubMedCrossRefGoogle Scholar
  422. Weinberg MA, Bral M. Laboratory animals models in periodontology. J Clin Priodontol. 1999;26:335-40.CrossRefGoogle Scholar
  423. Weng D, Hurzeler MB, Quinones CR, Pechstadt B, Mota L, Caffesse RG. Healing patterns in recession defects treated with ePTFE membranes and with free connective tissue grafts: a histologic and histometric study in the beagle dog. J Clin Periodontol. 1998;25:238–45.PubMedCrossRefGoogle Scholar
  424. Wikesjö UM, Nilvéus R. Periodontal repair in dogs: effect of wound stabilization on healing. J Periodontol. 1990;61:719–24.PubMedCrossRefGoogle Scholar
  425. Wikesjö UM, Selvig KA. Periodontal wound healing and regeneration. Periodontol 2000. 1999;19:21–39.PubMedCrossRefGoogle Scholar
  426. Wikesjö UM, Hagen K, Nielsen DD. Periodontal repair in dogs: effect of saliva contamination of the root surface. J Periodontol. 1990;61:559–63.PubMedCrossRefGoogle Scholar
  427. Wikesjö UM, Selvig KA, Zimmerman G, Nilvéus R. Periodontal repair in dogs: healing in experimentally created chronic periodontal defects. J Periodontol. 1991;62:258–63.PubMedCrossRefGoogle Scholar
  428. Wikesjo UME, Kean CJC, Zimmerman GJ. Periodontal repair in dogs: supraalveolar defect models for evaluation of safety and efficacy of periodontal reconstructive therapy. J Periodontol. 1994;65:1151–7.PubMedCrossRefGoogle Scholar
  429. Wikesjö UM, Xiropaidis AV, Thomson RC, Cook AD, Selvig KA, Hardwick WR. Periodontal repair in dogs: rhBMP-2 significantly enhances bone formation under provisions for guided tissue regeneration. J Clin Periodontol. 2003a;30:705–14.PubMedCrossRefGoogle Scholar
  430. Wikesjö UME, Lim WH, Thomson RC, Hardwick WR. Periodontal repair in dogs: gingival tissue occlusion, a critical requirement for GTR? J Clin Periodontol. 2003b;30:655–64.PubMedCrossRefGoogle Scholar
  431. Wikesjö UME, Susin C, Qahash M, Polimeni G, Leknes KN, Shanaman RH, Prasad HS, Rohrer MD, Hall J. The critical-size supraalveolar peri-implant defect model: characteristics and use. J Clin Periodontol. 2006;33:846–54.PubMedCrossRefGoogle Scholar
  432. Wilensky A, Polak D, Awawdi S, Halabi A, Shapira L, Houri-Haddad Y. Strain-dependent activation of the mouse immune response is correlated with Porphyromonas gingivalis-induced experimental periodontitis. J Clin Periodontol. 2009;36:915–21.PubMedCrossRefGoogle Scholar
  433. Wirthlin MR, Yeager JE, Hancock EB, Gaugler RW. The healing of gingival wounds in miniature swine. J Periodontol. 1980;51:318–27.PubMedCrossRefGoogle Scholar
  434. Wyss C, Guggenheim B. Effects of the association of conventional rats with Actinomyces viscosus Nyl and Bacteroides gingivalis W83. J Periodontal Res. 1984;19(6):574–7.PubMedCrossRefGoogle Scholar
  435. Wong DM, Tam V, Lam R, Walsh KA, Tatarczuch L, Pagel CN, Reynolds EC, O’Brien-Simpson NM, Mackie EJ, Pike RN. Protease-activated receptor 2 has pivotal roles in cellular mechanisms involved in experimental periodontitis. Infect Immun. 2010;78:629–38.PubMedCrossRefGoogle Scholar
  436. Yaffe A, Shoshan S. Re-attachment of periodontal ligament by collagen in experimentally-induced alveolar bone dehiscence in dogs. Arch Oral Biol. 1987;32:69–73.PubMedCrossRefGoogle Scholar
  437. Yamamoto S, Masuda H, Shibukawa Y, Yamada S. Combination of bovine-derived xenografts and enamel matrix derivative in the treatment of intrabony periodontal defects in dogs. Int J Periodontics Restorative Dent. 2007;27:471–9.PubMedGoogle Scholar
  438. Yamamoto T, Tomofuji T, Tamaki N, Ekuni D, Azuma T, Sanbe T. Effects of topical application of lipopolysaccharide and proteases on hepatic injury induced by high-cholesterol diet in rats. J Periodontal Res. 2010;45:129–35.PubMedCrossRefGoogle Scholar
  439. Yamanaka A, Yasui K, Sonomura T, Uemura M. Development of heterodont dentition in house shrew (Suncus murinus). Eur J Oral Sci. 2007;115:433–40.PubMedCrossRefGoogle Scholar
  440. Yamazaki Y. Effects of destructive periodontitis, induced by diet, on the mechanical properties of the periodontal ligament of the mandibular first molar in golden hamsters. J Periodontal Res. 1992;27:149–58.PubMedCrossRefGoogle Scholar
  441. Yeo YJ, Jeon DW, Kim CS, Choi SH, Cho KS, Lee YK, Kim CK. Effects of chitosan nonwoven membrane on periodontal healing of surgically created one-wall intrabony defects in beagle dogs. J Biomed Mater Res B Appl Biomater. 2005;72:86–93.PubMedCrossRefGoogle Scholar
  442. Yu JJ, Ruddy MJ, Wong GC, Sfintescu C, Baker PJ, Smith JB, Evans RT, Gaffen SL. An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood. 2007;109:3794–802.PubMedCrossRefGoogle Scholar
  443. Yu G, Yu Y, Li YN, Shu R. Effect of periodontitis on susceptibility to atrial fibrillation in an animal model. J Electrocardiol. 2010;43(4):359-66.PubMedCrossRefGoogle Scholar
  444. Zechner W, Tangl S, Tepper G, et al. Influence of platelet-rich plasma on osseous healing of dental implants: a histologic and histomorphometric study in minipigs. Int J Oral Maxillofac Implants. 2003;18:15–22.PubMedGoogle Scholar
  445. Zhang X, Teng YT. Interleukin-10 inhibits gram-negative-microbe-specific human receptor activator of NF-kappa B ligand-positive CD4+ −Th1-cell-associated alveolar bone loss in vivo. Infect Immun. 2006;74:4927–31.PubMedCrossRefGoogle Scholar
  446. Zhang MZ, Li CL, Jiang YT, et al. Porphyromonas gingivalis infection accelerates intimal thickening in iliac arteries in a balloon-injured rabbit model. J Periodontol. 2008;79:1192–9.PubMedCrossRefGoogle Scholar
  447. Zhao M, Jin Q, Berry JE, Nociti Jr FH, Giannobile WV, Somerman MJ. Cementoblast delivery for periodontal tissue engineering. J Periodontol. 2004;75:154–61.PubMedCrossRefGoogle Scholar
  448. Zhou Q, Desta T, Fenton M, Graves DT, Amar S. Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun. 2005;73:935–43.PubMedCrossRefGoogle Scholar
  449. Zubery Y, Dunstan CR, Story BM, Kesavalu L, Ebersole JL, Holt SC, Boyce BF. Bone resorption caused by three periodontal pathogens in vivo in mice is mediated in part by prostaglandin. Infect Immun. 1998;66:4158–62.PubMedGoogle Scholar
  450. Zucker LM. Hereditary obesity in the rat associated with hyperlipemia. Ann N Y Acad Sci. 1965;131:447–58.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Alexandrina L. Dumitrescu
    • 1
    • 2
  1. 1.Department of PeriodontologyUniversity of Tromsø Institute of Clinical DentistryTromsøNorway
  2. 2.Private practiceBucharestRomania

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