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Clinical Trial Principles for Evaluation of Products Used in the Management of Oral Malodour

  • Alexandrina L. Dumitrescu
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Abstract

Halitosis is a general term used to define an unpleasant or offensive odour emanating from the breath regardless of whether the odour originates from oral or non-oral sources. Other terms used are bad or foul breath, breath malodour, oral malodour, foetor ex ore, and foetor oris. Halitosis is widespread and is believed to affect one-quarter of the population around the world, and most people have this condition from time to time. Those affected are usually unaware of their condition possibly because of smell adaptation. Another explanation could be the pathways between the inhaled and exhaled air diverge—because the expelled air from the mouth travels horizontally, whereas the air breathed in travels primarily vertically; there is a lowered chance of detecting the smell from the expelled air.

References

  1. Adachi M, Ishihara K, Abe S, Okuda K, Ishikawa T. Effect of professional oral health care on the elderly living in nursing homes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94:191–5.PubMedCrossRefGoogle Scholar
  2. Awano S, Gohara K, Kurihara E, Ansai T, Takehara T. The relationship between the presence of periodontopathogenic bacteria in saliva and halitosis. Int Dent J. 2002;52 Suppl 3:212–6.PubMedGoogle Scholar
  3. Bosy A, Kulkarni GV, Rosenberg M, McCulloch CA. Relationship of oral malodor to periodontitis: evidence of independence in discrete subpopulations. J Periodontol. 1994;65:37–46.PubMedCrossRefGoogle Scholar
  4. Brunette DM, Proskin HM, Nelson BJ. The effects of ­dentifrice systems on oral malodor. J Clin Dent. 1998;9:76–82.PubMedGoogle Scholar
  5. Carvalho MD, Tabchoury CM, Cury JA, Toledo S, Nogueira-Filho GR. Impact of mouthrinses on morning bad breath in healthy subjects. J Clin Periodontol. 2004;31:85–90.PubMedCrossRefGoogle Scholar
  6. Christensen GJ. Why clean your tongue? J Am Dent Assoc. 1998;129:1605–7.PubMedGoogle Scholar
  7. Coli JM, Tonzetich J. Characterization of volatile sulphur compounds production at individual gingival crevicular sites in humans. J Clin Dent. 1992;3:97–103.PubMedGoogle Scholar
  8. Danser MM, Gómez SM, Van der Weijden GA. Tongue coating and tongue brushing: a literature review. Int J Dent Hyg. 2003;1(3):151–8.PubMedCrossRefGoogle Scholar
  9. Delanghe G, Ghyselen J, van Steenberghe D, Feenstra L. Multidisciplinary breath-odour clinic. Lancet. 1997;350(9072):187.PubMedCrossRefGoogle Scholar
  10. Donaldson AC, Riggio MP, Rolph HJ, Bagg J, Hodge PJ. Clinical examination of subjects with halitosis. Oral Dis. 2007;13:63–70.PubMedCrossRefGoogle Scholar
  11. Frascella J, Gilbert RD, Fernandez P, Hendler J. Efficacy of a chlorine dioxide-containing mouthrinse in oral malodor. Compend Contin Educ Dent. 2000;21:241–54.PubMedGoogle Scholar
  12. Gerlach RW, Hyde JD, Poore CL, Stevens DP, Witt JJ. Breath effects of three marketed dentifrices: a comparative study evaluating single and cumulative use. J Clin Dent. 1998;9:83–8.PubMedGoogle Scholar
  13. Haraszthy VI, Zambon JJ, Sreenivasan PK, Zambon MM, Gerber D, Rego R, Parker C. Identification of oral bacterial species associated with halitosis. J Am Dent Assoc. 2007;138:1113–20.PubMedGoogle Scholar
  14. Hughes FJ, McNab R. Oral malodour – a review. Arch Oral Biol. 2008;53:S1–7.PubMedCrossRefGoogle Scholar
  15. Ii H, Imai T, Yaegaki K, Irie K, Ekuni D, Morita M. Oral malodorous compound induces osteoclast differentiation without receptor activator of nuclear factor κB ligand. J Periodontol. 2010;81:1691–7.PubMedCrossRefGoogle Scholar
  16. Imai T, Ii H, Yaegaki K, Murata T, Sato T, Kamoda T. Oral malodorous compound inhibits osteoblast proliferation. J Periodontol. 2009;80:2028–34.PubMedCrossRefGoogle Scholar
  17. John M, Vandana KL. Detection and measurement of oral malodour in periodontitis patients. Indian J Dent Res. 2006;17(1):2–6.PubMedCrossRefGoogle Scholar
  18. Kazor CE, Mitchell PM, Lee AM, et al. Diversity of bacterial populations on the tongue dorsa of patients with halitosis and healthy patients. J Clin Microbiol. 2003;41:558–63.PubMedCrossRefGoogle Scholar
  19. Lee PP, Mak WY, Newsome P. The aetiology and treatment of oral halitosis: an update. Hong Kong Med J. 2004;10:414–8.PubMedGoogle Scholar
  20. Lee SS, Zhang W, Li Y. Halitosis update: a review of causes, diagnoses, and treatments. J Calif Dent Assoc. 2007;35:258–60, 262, 264–8.PubMedGoogle Scholar
  21. Morita M, Wang HL. Association between oral malodor and adult periodontitis: a review. J Clin Periodontol. 2001a;28:813–9.PubMedCrossRefGoogle Scholar
  22. Morita M, Wang HL. Relationship between sulcular sulfide level and oral malodor in subjects with periodontal disease. J Periodontol. 2001b;72:79–84.PubMedCrossRefGoogle Scholar
  23. Morita M, Wang HL. Relationship of sulcular sulfide level to severity of periodontal disease and BANA test. J Periodontol. 2001c;72:74–8.PubMedCrossRefGoogle Scholar
  24. Murata T, Yaegaki K, Qian W, Herai M, Calenic B, Imai T, Sato T, Tanaka T, Kamoda T, Ii H. Hydrogen sulfide induces apoptosis in epithelial cells derived from human gingiva. J Breath Res. 2008;2:017007.PubMedCrossRefGoogle Scholar
  25. Outhouse TL, Al-Alawi R, Fedorowicz Z, Keenan JV. Tongue scraping for treating halitosis. Cochrane Database Syst Rev. 2006;(2):CD005519. http://www.ncbi.nlm.nih.gov/pubmed?term=Outhouse%20TL%2C%20Al-Alawi%20R%2C%20Fedorowicz%20Z%2C%20Keenan%20JV.%20Tongue%20scraping%20for%20treating%20halitosis.%20Cochrane%20Database%20Syst%20Rev
  26. Pham TAV, Ueno M, Zaitsu T, Takehara S, Shinada K, Lam PH, Kawaguchi Y. Clinical trial of oral malodor treatment in patients with periodontal diseases. J Periodontal Res. 2011;46:722–9.PubMedCrossRefGoogle Scholar
  27. Quirynen M. Management of oral malodour. J Clin Periodontol. 2003;30 Suppl 5:17–8.PubMedCrossRefGoogle Scholar
  28. Quirynen M, Zhao H, van Steenberghe D. Review of the treatment strategies for oral malodour. Clin Oral Investig. 2002;6:1–10.PubMedGoogle Scholar
  29. Quirynen M, Zhao H, Soers C, et al. The impact of periodontal therapy and the adjunctive effect of antiseptics on breath odor-related outcome variables: a double-blind randomized study. J Periodontol. 2005;76:705–12.PubMedCrossRefGoogle Scholar
  30. Ramachandra SS, Mehta DS, Sandesh N, Baliga V, Amarnath J. Periodontal probing systems: a review of available equipment. Compend Contin Educ Dent. 2011;32:71–7.PubMedGoogle Scholar
  31. Ratcliff PA, Johnson PW. The relationship between oral malodor, gingivitis, and periodontitis. A review. J Periodontol. 1999;70:485–9.PubMedCrossRefGoogle Scholar
  32. Richter JL. Diagnosis and treatment of halitosis. Compend Contin Educ Dent. 1996;17:370–86.PubMedGoogle Scholar
  33. Roldan S, Winkel EG, Herrera D, Sanz M, Van Winkelhoff AJ. The effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc lactate on the microflora of oral halitosis patients: a dual-centre, double-blind placebo-controlled study. J Clin Periodontol. 2003;30:427–34.PubMedCrossRefGoogle Scholar
  34. Roldán S, Herrera D, O’Connor A, González I, Sanz M. A combined therapeutic approach to manage halitosis: a 3-month prospective case series. J Periodontol. 2005;76:1025–33.PubMedCrossRefGoogle Scholar
  35. Rosenberg M, Kulkarni GV, Bosy A, McCulloch CA. Reproducibility and sensitivity of oral malodor measurements with a portable sulphide monitor. J Dent Res. 1991;70:1436–40.PubMedCrossRefGoogle Scholar
  36. Rosenberg M, Gelernter I, Barki M, Bar-Ness R. Day-long reduction of oral malodor by a two-phase oil: water mouthrinse as compared to chlorhexidine and placebo rinses. J Periodontol. 1992;63:39–43.PubMedCrossRefGoogle Scholar
  37. Schmidt NF, Tarbet WJ. The effect of oral rinses on organoleptic mouth odor ratings and levels of volatile sulfur compounds. Oral Surg Oral Med Oral Pathol. 1978;45:876–83.PubMedCrossRefGoogle Scholar
  38. Schmidt NF, Missan SR, Cooper AD, Tarbet WJ. The correlation between organoleptic mouth-odor ratings and levels of volatile sulfur compounds. Oral Surg Oral Med Oral Pathol. 1978;45:560–7.PubMedCrossRefGoogle Scholar
  39. Scully C, Felix DH. Oral medicine – update for the dental ­practitioner: oral malodour. Br Dent J. 2005;199:498–500.PubMedCrossRefGoogle Scholar
  40. Scully C, Greenman J. Halitosis (breath odor). Periodontol 2000. 2008;48:66–75.PubMedCrossRefGoogle Scholar
  41. Seemann R, Kison A, Bizhang M, Zimmer S. Effectiveness of mechanical tongue cleaning on oral levels of volatile sulfur compounds. J Am Dent Assoc. 2001;132:1263–7.PubMedGoogle Scholar
  42. Solis-Gaffar MC, Rustogi KN, Gaffar A. Hydrogen sulfide production from gingival crevicular fluid. J Periodontol. 1980;51:603–6.PubMedCrossRefGoogle Scholar
  43. Stamou E, Kozlovsky A, Rosenberg M. Association between oral malodour and periodontal disease-related parameters in a population of 71 Israelis. Oral Dis. 2005;11 Suppl 1:72–4.PubMedCrossRefGoogle Scholar
  44. Takeuchi H, Machigashira M, Yamashita D, Kozono S, Nakajima Y, Miyamoto M, Takeuchi N, Setoguchi T, Noguchi K. The association of periodontal disease with oral malodour in a Japanese population. Oral Dis. 2010;16:702–6.PubMedCrossRefGoogle Scholar
  45. Tanaka M, Anguri H, Nishida N, Ojima M, Nagata H, Shizukuishi S. Reliability of clinical parameters for predicting the outcome of oral malodor treatment. J Dent Res. 2003;82:518–22.PubMedCrossRefGoogle Scholar
  46. Tanaka M, Yamamoto Y, Kuboniwa M, et al. Contribution of periodontal pathogens on tongue dorsa analyzed with real-time PCR to oral malodor. Microbes Infect. 2004;6:1078–83.PubMedCrossRefGoogle Scholar
  47. Tonzetich J. Oral malodour: an indicator of health status and oral cleanliness. Int Dent J. 1978;28:309–19.PubMedGoogle Scholar
  48. Tsai CC, Chou HH, Wu TL, Yang YH, Ho KY, Wu YM, Ho YP. The levels of volatile sulfur compounds in mouth air from patients with chronic periodontitis. J Periodontal Res. 2008;43:186–93.PubMedCrossRefGoogle Scholar
  49. van den Broek AM, Feenstra L, de Baat C. A review of the current literature on aetiology and measurement ­methods of halitosis. J Dent. 2007;35:627–35.PubMedCrossRefGoogle Scholar
  50. van den Broek AM, Feenstra L, de Baat C. A review of the current literature on management of halitosis. Oral Dis. 2008;14:30–9.PubMedGoogle Scholar
  51. Van der Sleen MI, Slot DE, Van Trijffel E, Winkel EG, Van der Weijden GA. Effectiveness of mechanical tongue cleaning on breath odour and tongue coating: a systematic review. Int J Dent Hyg. 2010;8:258–68.PubMedCrossRefGoogle Scholar
  52. Winkel EG, Roldán S, Van Winkelhoff AJ, Herrera D, Sanz M. Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study. J Clin Periodontol. 2003;30:300–6.PubMedCrossRefGoogle Scholar
  53. Wozniak WT. The ADA guidelines on oral malodor products. Oral Dis. 2005;11(Suppl) 1:7–9.PubMedCrossRefGoogle Scholar
  54. Yaegaki K, Coil JM. Examination, classification, and treatment of halitosis; clinical perspectives. J Can Dent Assoc. 2000a;66:257–61.PubMedGoogle Scholar
  55. Yaegaki K, Coil JM. Genuine halitosis, pseudo-halitosis, and ­halitophobia: classification, diagnosis, and treatment. Compend Contin Educ Dent. 2000b;21(10A):880–6, 888–9.PubMedGoogle Scholar
  56. Yaegaki K, Sanada K. Biochemical and clinical factors influencing oral malodor in periodontal patients. J Periodontol. 1992a;63:783–9.PubMedCrossRefGoogle Scholar
  57. Yaegaki K, Sanada K. Volatile sulfur compounds in mouth air from clinically healthy subjects and patients with periodontal disease. J Periodontal Res. 1992b;27:233–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Alexandrina L. Dumitrescu
    • 1
    • 2
  1. 1.Department of PeriodontologyUniversity of Tromsø Institute of Clinical DentistryTromsøNorway
  2. 2.Private practiceBucharestRomania

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