Prediction of TGEV Spike Protein Secondary Structure and B Cell Epitopes
- 156 Downloads
The spike gene of TGEV TH98 strain was translated into amino sequence by Editseq. The secondary structure and B cell epitope of spike protein of TGEV TH98 strain were predicted by Protean. Combining the results according to these methods, the spike protein of TGEV TH98 strain has complicated secondary structure. There are several epitopes of the B-cells in spike protein, including 43-56aa, 97-104aa, 117-128aa, 132-173aa, 238-257aa, 391-398aa, 535-706aa, 779-799aa, 918-987aa, 1165-1200aa, 1257-1266aa and 1430-1446aa.
KeywordsLasergene TGEV Spike protein Secondary structure Epitope
- 1.Schwegmann-Wessels, C., Herrler, G.: Transmissible gastroenteritis virus infection: a vanishing spectre. Dtsch Tierarztl Wochenschr 113(4), 157–159 (2006)Google Scholar
- 4.Sanchez, C.-M., et al.: Targeted recombination demonstrates that the spike gene of transmissible gastroenteritis coronavirus is a determinant of its enteric tropism and virulence. J. Virol. 73(9), 7607–7618 (1999)Google Scholar
- 5.Krempl, C., et al.: Characterization of the sialic acid binding activity of transmissible Gastroenteritis coronavirus by analysis of haemagglutination-deficient mutants 81(2), 489–496 (2000)Google Scholar
- 7.Persson, B.: Bioinformatics in protein analysis. EXS 88, 215–231 (2000)Google Scholar