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Selenoproteins and Thyroid Cancer

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Selenoproteins and Mimics

Part of the book series: Advanced Topics in Science and Technology in China ((ATSTC))

Abstract

Selenoproteins, in which Se exists in the form of selenocysteine, are essential for protection against oxidative damage and cancer. Genetic data has provided evidence that reduced levels of these proteins, induced by loss of heterozygosity or chromosomal alterations [1], result in cellular oxidative stress as well as derangement of signaling cascades leading to inflammation, malignancy and progression. While several tumor species have been shown to be vulnerable, because of its high Se content and rich selenoprotein network, the thyroid is especially exposed to risk when intrathyroid Se content is low and Se intake is not appropriate. However, there is as yet insufficient evidence on whether Se supplementation via Se compounds and/or via fortification of food, achieves reduction in the risk of cancer, and more specifically that of thyroid cancer and whether Se is able of reducing aggression and tumor progression and whether increased availability of Se and its compounds is capable of lowering anticancer drug toxicity and drug resistance.

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Authors and Affiliations

  1. Endocrine Unit, Evgenidion Hospital, University of Athens, Greece

    Leonidas H. Duntas

  2. UCD School of Medicine and Medical Science, University College, Dublin, Ireland

    Peter P. A. Smyth

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  1. Leonidas H. Duntas
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  2. Peter P. A. Smyth
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© 2011 Zhejiang University Press, Hangzhou and Springer-Verlag Berlin Heidelberg

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Duntas, L.H., Smyth, P.P.A. (2011). Selenoproteins and Thyroid Cancer. In: Selenoproteins and Mimics. Advanced Topics in Science and Technology in China. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22236-8_12

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