Advertisement

The Interaction of U(VI) with Some Bioligands or the Influence of Different Functional Groups on Complex Formation

  • Laura Frost
  • Alfatih A.A. Osman
  • Gerhard Geipel
  • Katrin Viehweger
  • Henry Moll
  • Gert Bernhard
Chapter
  • 1.5k Downloads
Part of the Springer Geology book series (SPRINGERGEOL)

Abstract

The complex formation of U(VI) with glutathione, uric acid and benzoic acid was studied using spectroscopic techniques. Additionally glutathione was derivatized to obtain different glutathione-S-conjugates in order to assess the influence of the thiol group on complex stability. In the U(VI)-glutathione system a 1 : 1 complex with a large stability constant of 39.07 ± 0.15 could be identified. Derivatization did not lead to a decrease in complex stability. Thus a significant influence of the thiol group on U(VI) coordination can be excluded. Investigating the U(VI) complexation by uric acid and benzoic acid, for both ligands a comparably weak complexation was found. Structure-related reasons for the difference in complex stability are discussed.

Keywords

Uric Acid Benzoic Acid Stability Constant Thiol Group Volmer Equation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Ballatori N, Clarkson TW (1985) Biliary secretion of glutathione and of glutathione metal-complexes. Fundam Appl Toxicol 5: 816CrossRefGoogle Scholar
  2. Binstead RA, Zuberbühler AD, Jung B (2007) SPECFIT/32, Version 3.0.40, Spectrum Software Associates, MarlboroughGoogle Scholar
  3. Bismondo A, Rizzo L (1992) Thermodynamics of the complex formation between uranyl(VI) and some polypeptides in aqueous solution. Thermochim Acta 196: 131CrossRefGoogle Scholar
  4. Davies KJ, Sevanian A, Muakkassah-Kelly SF, Hochstein P (1986) Uric acid – iron complexes. A new aspect of the antioxidant functions of uric acid. Biochem J 235: 747CrossRefGoogle Scholar
  5. Frost L, Geipel G, Viehweger K, Bernhard G (2011a) Interaction of uranium(VI) towards glutathione – an example to study different functional groups in one molecule. Radiochim Acta, accepted 2010Google Scholar
  6. Frost L, Moll H, Bernhard G (2011b) A new uranyl benzoate species characterized by different spectroscopic techniques. Radiochim Acta, accepted 2011Google Scholar
  7. Geipel G, Acker M, Vulpius D, Bernhard G, Nitsche H, Fanghänel T (2004) An ultrafast time-resolved fluorescence spectroscopy system for metal ion complexation studies with organic ligands. Spectrochim Acta 60: 417CrossRefGoogle Scholar
  8. Glorius M, Moll H, Bernhard G (2007) Complexation of uranium(VI) with aromatic acids in aqueous solution – a comparison of hydroxamic acids and benzoic acid. Radiochim Acta 95: 151CrossRefGoogle Scholar
  9. Grenthe, I, Wanner H (2000) Guidelines for the extrapolation to zero ionic strength. TDB-2, NEA web page document, http://www.nea.fr/html/dbtdb/guidelines/tdb2.pdfGoogle Scholar
  10. Guillaumont R, Mompean FJ (2003) Update on the chemical thermodynamics of uranium, neptunium, plutonium, americium and technetium. Vol. 5, Elsevier, AmsterdamGoogle Scholar
  11. Huang C, Chen M, Huang L, Mao I (2002) Uric acid and urea in human sweat. Chinese J Physiol 45: 109Google Scholar
  12. Kidd PM (1997) Glutathione: systemic protectant against oxidative and free radical damage. Altern Med Rev 1: 155Google Scholar
  13. Marzotto A (1977) Uranyl complexes of glutathione. J Inorg Nucl Chem 39: 2193CrossRefGoogle Scholar
  14. Puigdomènech I (2004) MEDUSA Software, 16 bit version, http://www.kemi.kth.se/medusa/Google Scholar
  15. Moawad MM (2002) Complexation and thermal studies of uric acid with some divalent and trivalent metal ions of biological interest in the solid state. J Coord Chem 55: 61Google Scholar
  16. Singh BK (2005) Complexation behaviour of glutathione with metal ions. Asian J Chem 17: 1Google Scholar
  17. Rey NA, Howarth OW, Pereira-Maia EC (2004) Equilibrium characterization of the As(III)-cysteine and the As(III)-glutathione systems in aqueous solution. J Inorg Biochem 98: 1151CrossRefGoogle Scholar
  18. Roberts JKM, Ray PM, Wade-Jardetzky N, Jardetzky O (1980) Estimation of cytoplasmic and vacuolar pH in higher plant cells by 31P-NMR. Nature 283: 870CrossRefGoogle Scholar
  19. Stern O, Volmer M (1919) Über die Abklingzeit der Fluoreszenz. Physikal Z 20: 183Google Scholar
  20. Vulpius D, Geipel G, Baraniak L, Rossberg A, Bernhard G (2006) Complex formation of uranium(VI) with 4hydroxy-3-methoxybenzoic acid and related compounds. J Radioanal Nucl Chem 270: 661CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Laura Frost
    • 1
  • Alfatih A.A. Osman
    • 1
  • Gerhard Geipel
    • 1
  • Katrin Viehweger
    • 1
  • Henry Moll
    • 1
  • Gert Bernhard
    • 1
  1. 1.Institute of RadiochemistryHelmholtz-Zentrum Dresden-RossendorfDresdenGermany

Personalised recommendations