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Herpes simplex Virus Typ 1 Pneumonie bei Langzeitintubierten - Ein unterschätztes Problem?

  • W. LamadéEmail author
  • P. Schnitzler
  • S. Cox
  • J. Motsch
  • F. Martinez
  • J. Haas
  • U. Meyding-Lamadé
Conference paper
  • 9 Downloads
Part of the Deutsche Gesellschaft für Chirurgie book series (DTGESCHIR, volume 33)

Herpes simplex virus type 1 pneumonia in long term intubated patients

Abstract

Objective: The aim of this study was to determine incidence and outcome of pulmonary manifestation of herpes simplex virus (HSV) infection in long-term intubated patients. Design: prospective cohort study of long-term intubated patients. Interventions: The detection of HSV in broncheoalveolar lavage (BAL) samples was performed consecutively in 81 long term and 15 short term intubated patients using a quantitative and qualitative polymerase chain reaction (PCR) on two gene loci. Main results: Thirtyeight percent of long term intubated patients were found to have HSV positive BALs. This was associated with an increased mortality of > 50% (Odds Ratio > 2). Conclusion: Nosocomial pneumonia is still a leading cause of death on intensive care units. Virus induced pneumonia may well have been underestimated.

Literatur

  1. 1.
    Ramsey PG, Fife KH, Hackmann RC, Meyers JD, Corey L (1982) Herpes simplex virus pneumonia: clinical, virologie, and pathological features in 20 patients. Ann Int Med 97:813–820PubMedGoogle Scholar
  2. 2.
    Graham BS, Snell JD (1983) Herpes simplex virus infection of the adult lower respiratory tract. Medicine 62:384–393PubMedCrossRefGoogle Scholar
  3. 3.
    Meyding-Lamadé U, Haas J, Lamadé W, Stingele K, Kehm R, Fäth A, Heinrich K, Storch Hagenlocher B, Wildemann B (1998) Herpes simplex virus encephalitis: long-term comparative study of viral load and the expression of immunologic nitric oxide synthase in mouse brain tissue. Neurose Lett 244:9–12CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • W. Lamadé
    • 2
    Email author
  • P. Schnitzler
    • 3
  • S. Cox
    • 4
  • J. Motsch
    • 1
  • F. Martinez
    • 4
  • J. Haas
    • 4
  • U. Meyding-Lamadé
    • 4
  1. 1.Anästhesiologische KlinikUniversität HeidelbergGermany
  2. 2.Abt.für Allgemein-, Viszeral- und UnfallchirurgieRobert-Bosch-KrankenhausStuttgart
  3. 3.Institut für medizinische VirologieUniversität HeidelbergGermany
  4. 4.Neurologische Universitätsklinik HeidelbergGermany

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