Herpes simplex Virus Typ 1 Pneumonie bei Langzeitintubierten - Ein unterschätztes Problem?
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Herpes simplex virus type 1 pneumonia in long term intubated patients
Objective: The aim of this study was to determine incidence and outcome of pulmonary manifestation of herpes simplex virus (HSV) infection in long-term intubated patients. Design: prospective cohort study of long-term intubated patients. Interventions: The detection of HSV in broncheoalveolar lavage (BAL) samples was performed consecutively in 81 long term and 15 short term intubated patients using a quantitative and qualitative polymerase chain reaction (PCR) on two gene loci. Main results: Thirtyeight percent of long term intubated patients were found to have HSV positive BALs. This was associated with an increased mortality of > 50% (Odds Ratio > 2). Conclusion: Nosocomial pneumonia is still a leading cause of death on intensive care units. Virus induced pneumonia may well have been underestimated.
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