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Genetically Modified Mice: Useful Models to Study Cause and Effect of Cardiac Arrhythmias?

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Heart Rate and Rhythm

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Abstract

Genetically modified mice represent a tremendous advancement for studying effects of disease-related mutations in depth with the aim to enlighten molecular and physiological mechanisms underlying correlations between genotype and phenotype. Here we discuss some of the limitations that one may encounter with knockout, knockin and transgenic mice in the study of particular gene mutations related to human cardiac disease, with particular emphasis on channelopathies.

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Acknowledgments

We gratefully acknowledge financial support of the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie for the cardiovascular research in our laboratory.

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Authors and Affiliations

  1. Institut für Neurale Signalverarbeitung, ZMNH, University Hospital Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    Gregor Sachse, Martin Kruse & Olaf Pongs

Authors
  1. Gregor Sachse
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  2. Martin Kruse
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  3. Olaf Pongs
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Corresponding author

Correspondence to Olaf Pongs .

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Editors and Affiliations

  1. Life Sciences Academy, Usman Enclave 103, Lucknow, 226024, India

    Onkar N. Tripathi

  2. Medizinische Fakultät, Inst. für Pharmakologie u. Toxikologie, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany

    Ursula Ravens

  3. Cardiovascular Research &, Training Inst. (CVRTI), University of Utah, South 2000 East 95, Salt Lake City, 84112-5000, Utah, USA

    Michael C. Sanguinetti

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Sachse, G., Kruse, M., Pongs, O. (2011). Genetically Modified Mice: Useful Models to Study Cause and Effect of Cardiac Arrhythmias?. In: Tripathi, O., Ravens, U., Sanguinetti, M. (eds) Heart Rate and Rhythm. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-17575-6_26

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