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NeuroIntensiv pp 483-550 | Cite as

Infektionen

  • Stefan Schwab
  • Peter Schellinger
  • Christian Werner
  • Andreas Unterberg
  • Werner Hacke
Chapter
  • 3.2k Downloads

Zusammenfassung

Trotz Weiterentwicklung moderner Antibiotika in den letzten Jahren sind die Letalitätszahlen der bakteriellen (eitrigen) Meningitis weiterhin hoch; Überlebende haben häufig neurologische Residuen. Die ungünstigen klinischen Verläufe der bakteriellen Meningitis sind meist Folge intrakranieller Komplikationen, wie z. B. eines generalisierten Hirnödems, einer zerebrovaskulären arteriellen oder venösen Beteiligung oder eines Hydrozephalus.

Literatur

Zu 32.1

  1. 1.
    RKI (Robert Koch Institut). Aktuelle Statistik meldepflichtiger Infektionskrankheiten, Deutschland. Epidemiol Bull 2011; 3:21Google Scholar
  2. 2.
    Centers for Disease Control. Progress toward elimination of Haemophilus influenzae type b invasive disease among infants and children – United States 1998–2000. MMWR 2002; 51:234–237Google Scholar
  3. 3.
    Pfister HW, Eiffert H, Nau R, Schmutzhard E, Tauber MG. Bakterielle (eitrige) Meningoenzephalitis. Leitlinien für Diagnostik und Therapie in der Neurologie der DGN 2008, 4. Aufl . Thieme, StuttgartGoogle Scholar
  4. 4.
    Kastenbauer S, Pfister HW. Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases. Brain 2003; 126(Pt 5):1015–1025PubMedCrossRefGoogle Scholar
  5. 5.
    Koedel U, Klein M, Pfister HW. New understandings on the pathophysiology of bacterial meningitis. Curr Opin Infect Dis 2010; 23(3):217–223PubMedCrossRefGoogle Scholar
  6. 6.
    Klein M, Obermaier B, Angele B et al. Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4. J Infect Dis 2008; 198(7):1028–1036PubMedCrossRefGoogle Scholar
  7. 7.
    Klein M, Paul R, Angele B, Popp B, Pfister HW, Koedel U. Protein expression pattern in experimental pneumococcal meningitis. Microbes Infect 2006; 8(4):974–983PubMedCrossRefGoogle Scholar
  8. 8.
    Klein M, Koedel U, Pfister HW. Oxidative stress in pneumococcal meningitis: a future target for adjunctive therapy? Prog Neurobiol 2006; 80(6):269–280PubMedCrossRefGoogle Scholar
  9. 9.
    Heckenberg SG, de Gans J, Brouwer MC et al. Clinical features, outcome, and meningococcal genotype in 258 adults with meningococcal meningitis: a prospective cohort study. Medicine (Baltimore) 2008; 87(4):185–192CrossRefGoogle Scholar
  10. 10.
    Pfister HW, Feiden W, Einhaupl KM. Spectrum of complications during bacterial meningitis in adults. Results of a prospective clinical study. Arch Neurol 1993; 50(6):575–581PubMedCrossRefGoogle Scholar
  11. 11.
    Schut ES, Brouwer MC, de GJ, Florquin S, Troost D, van de BD. Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis. Neurology 2009; 73(23):1988–1995PubMedCrossRefGoogle Scholar
  12. 12.
    Klein M, Koedel U, Kastenbauer S et al. Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis? Neurology 2010; 75(2):193–194PubMedCrossRefGoogle Scholar
  13. 13.
    Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J. Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series. Lancet Neurol 2006; 5(2):123–129PubMedCrossRefGoogle Scholar
  14. 14.
    Klein M, Pfister HW, Leib SL, Koedel U. Therapy of communityacquired acute bacterial meningitis: the clock is running. Expert Opin Pharmacother 2009; 10(16):2609–2623PubMedCrossRefGoogle Scholar
  15. 15.
    Nathan BR, Scheld WM. The potential roles of C-reactive protein and procalcitonin concentrations in the serum and cerebrospinal fluid in the diagnosis of bacterial meningitis. Curr Clin Top Infect Dis 2002; 22:155–165PubMedGoogle Scholar
  16. 16.
    Casado FJ, Blanco QA. Procalcitonin. A new marker for bacterial infection. An Esp Pediatr 2001; 54(1):69–73Google Scholar
  17. 17.
    Dubos F, Korczowski B, Aygun DA, et al. Serum procalcitonin level and other biological markers to distinguish between bacterial and aseptic meningitis in children: a European multicenter case cohort study. Arch Pediatr Adolesc Med 2008; 162(12):1157–1163PubMedCrossRefGoogle Scholar
  18. 18.
    Krysan D. Serum procalcitonin levels aid in distinguishing bacterial from aseptic meningitis in children. J Pediatr 2009; 154(5):773PubMedCrossRefGoogle Scholar
  19. 19.
    Chaudhuri A, Martin PM, Kennedy PG, et al. EFNS guideline on the management of community-acquired bacterial meningitis: report of an EFNS Task Force on acute bacterial meningitis in older children and adults. Eur J Neurol 2008; 15(7):649–659PubMedCrossRefGoogle Scholar
  20. 20.
    Winkler F, Kastenbauer S, Yousry TA, Maerz U, Pfister HW. Discrepancies between brain CT imaging and severely raised intracranial pressure proven by ventriculostomy in adults with pneumococcal meningitis. J Neurol 2002; 249(9):1292–1297PubMedCrossRefGoogle Scholar
  21. 21.
    Imohl M, Van Der LM, Mutscher C, Reinert RR. Serotype distribution of invasive pneumococcal disease during the first 60 days of life. Vaccine 2010; 28(30):4758–4762PubMedCrossRefGoogle Scholar
  22. 22.
    Ntziora F, Falagas ME. Linezolid for the treatment of patients with central nervous system infection. Ann Pharmacother 2007; 41(2):296–308PubMedCrossRefGoogle Scholar
  23. 23.
    Rupprecht TA, Pfister HW. Clinical experience with linezolid for the treatment of central nervous system infections. Eur J Neurol 2005; 12(7):536–542PubMedCrossRefGoogle Scholar
  24. 24.
    Auburtin M, Wolff M, Charpentier J et al. Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study. Crit Care Med 2006; 34(11):2758–2765PubMedCrossRefGoogle Scholar
  25. 25.
    Proulx N, Frechette D, Toye B, Chan J, Kravcik S. Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM 2005; 98(4):291–298PubMedCrossRefGoogle Scholar
  26. 26.
    Kramer AH, Bleck TP. Neurocritical care of patients with central nervous system infections. Curr Treat Options Neurol 2008; 10(3):201–211PubMedCrossRefGoogle Scholar
  27. 27.
    Southwick FS. Septic thrombophlebitis of major dural venous sinuses. Curr Clin Top Infect Dis 1995; 15:179–203PubMedGoogle Scholar
  28. 28.
    de Gans J, van de Beek D. Dexamethasone in adults with bacterial meningitis. N Engl J Med 2002; 347(20):1549–1556PubMedCrossRefGoogle Scholar
  29. 29.
    van de Beek D, de Gans J, McIntyre P, Prasad K. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev 2007; (1):CD004405PubMedGoogle Scholar
  30. 30.
    Brouwer MC, Heckenberg SG, de GJ, Spanjaard L, Reitsma JB, van de BD. Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis. Neurology 2010; 75(17):1533–1539PubMedCrossRefGoogle Scholar
  31. 31.
    Brouwer MC, McIntyre P, de GJ, Prasad K, van de BD. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev 2010; (9):CD004405PubMedGoogle Scholar
  32. 32.
    Molyneux EM, Walsh AL, Forsyth H et al. Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomised controlled trial. Lancet 2002; 360(9328):211–218PubMedCrossRefGoogle Scholar
  33. 33.
    van de Beek D, Farrar JJ, de GJ et al. Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data. Lancet Neurol 2010; 9(3):254–263PubMedCrossRefGoogle Scholar
  34. 34.
    Nguyen TH, Tran TH, Thwaites G et al. Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis. N Engl J Med 2007; 357(24):2431–2440PubMedCrossRefGoogle Scholar
  35. 35.
    RKI (Robert Koch Institut). Meningokokkenerkrankungen. RKI Ratgeber Infektionskrankheiten – Merkblätter für Ärzte. www rki de 2010
  36. 36.
    RKI (Robert Koch Institut). Empfehlung und Begründung einer postexpositionellen Meningokokken-Impfung. Epidemiol Bull 2009; 31:314–317Google Scholar
  37. 37.
    Stephens DS, Greenwood B, Brandtzaeg P. Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet 2007; 369(9580):2196–2210PubMedCrossRefGoogle Scholar
  38. 38.
    Durand ML, Calderwood SB, Weber DJ, et al. Acute bacterial meningitis in adults. A review of 493 episodes. N Engl J Med 1993; 328(1):21–28PubMedCrossRefGoogle Scholar

Zu 32.2

  1. 39.
    Baddley JW, Salzman D, Pappas PG (2000) Fungal brain abscess in transplant recipients: epidemiologic microbiologic, and clinical features. Clin Transplant 16:419–424CrossRefGoogle Scholar
  2. 40.
    Bernal E, Munoz A, Nunez ML, Cano A (2010) Multidrug-resistant spinal tuberculosis and giant paraspinal abscess. Med Clin (Barc) Nov 10 (Epub ahead of print)Google Scholar
  3. 41.
    Boviatsis EJ, Kouyialis AT, Stranjalis G, et al. (2003) CT-guided stereotactic biopsies of brain stem lesions: personal experience and literature review. Neurol Sci 24:97–102PubMedCrossRefGoogle Scholar
  4. 42.
    Chang MC, Wu HT, Lee CH, et al. (2006) Tuberculous spondylitis and pyogenic spondylitis:comparative magnetic resonance imaging features. Spine 31:782–288PubMedCrossRefGoogle Scholar
  5. 43.
    Demir MK, Hakan T, Kilicoglu G, et al. (2007) Bacterial brain abscesses: prognostic value of an imaging severity index. Clin Radiol 62:564–572PubMedCrossRefGoogle Scholar
  6. 44.
    Greenberg BM (2008) Central nervous system infections in the intensive care unit. Semin Neurol 28:682–689PubMedCrossRefGoogle Scholar
  7. 45.
    Honda H, Warren DK (2009) Central nervous system infections: meningitis and brain abscess. Infect Dis Clin North Am 23:609–623PubMedCrossRefGoogle Scholar
  8. 46.
    Jansson AK, Enblad P, Sjolin J (2004) Efficacy and safety of cefotaxime in combination with metronidazole for empirical treatment of brain abscess in clinical practice: a retrospective study of 66 consecutive cases. Eur J Clin Microbiol Infect Dis 23:7–14PubMedCrossRefGoogle Scholar
  9. 47.
    Kang K, Lim I, Roh JK (2007) Positron emission tomographic findings in a tuberculous brain abscess. Ann Nucl Med 21:303–306PubMedCrossRefGoogle Scholar
  10. 48.
    Kao PT, Tseng HK, Liu CP, et al. (2003) Brain abscess: clinical analysis of 53 cases. J Microbiol Immunol Infect 36:129–136PubMedGoogle Scholar
  11. 49.
    Kupila L, Rantakokoo-Jalava K, Jalava J, et al (2003) Aetiological diagnosis of brain abscesses and spinal infections: application of broad range bacterial polymerase chain reaction analysis. J Neurol Neurosurg Psychiatry 74:728–733PubMedCrossRefGoogle Scholar
  12. 50.
    Kutlay M, Colak A, Yildiz S, et al. (2005) Stereotactic aspiration and antibiotic treatment combined with hyperbaric oxygen therapy in the management of bacterial brain abscess. Neurosurg 57:1140–1146CrossRefGoogle Scholar
  13. 51.
    Le Moal G, Landron C, Grollier G, et al. (2003) Characteristics of brain abscess with isolation of anaerobic bacteria. Scand J Infect Dis 35:318–321PubMedCrossRefGoogle Scholar
  14. 52.
    Leuthardt EC, Wippold FJ, Oswood MC, et al (2002) Diffusionweighted MR imaging in the preoperative assessment of brain abscesses. Surg Neurol 58:395–402PubMedCrossRefGoogle Scholar
  15. 53.
    Livraghi S, Melancia JP, Antunes jL (2003) The management of brain abscesses. Adv Tech Stand Neurosurg 28:285–313PubMedCrossRefGoogle Scholar
  16. 54.
    Lu CH, Chang WN, Lui CC (2006) Strategies for the management of bacterial brain abscess. J Clin Neurosci 13:979–985PubMedCrossRefGoogle Scholar
  17. 55.
    Lumbiganon P, Chaikitpinyo A (2007) Antibiotics for brain abscesses in people with cyanotic congenital heart disease. Cochrane Database Syst Rev 18:CD004469Google Scholar
  18. 56.
    McClelland S, Hall WA (2007) Postoperative central nervous system infection: incidence and associated factors in 2111 nerosurgical procedures. Clin Infect Dis 45:55–59PubMedCrossRefGoogle Scholar
  19. 57.
    Mueller-Mang C, Castillo M, Mang TG, et al. (2007) Fungal versus bacterial brain abscesses: is diffusion-weighted MR imaging a useful tool in the differential diagnosis? Neuroradiol 49:651–657CrossRefGoogle Scholar
  20. 58.
    Pfister HW, Feiden W, Einhäupl KM (1993) The spectrum of complications during bacterial meningitis in adults: Results of a prospective clinical study. Arch Neurol 50:575–580PubMedCrossRefGoogle Scholar
  21. 59.
    Saez-Llorens X (2003) Brain abscess in children. Semin Pediatr Infect Dis 2003 14:108–114PubMedCrossRefGoogle Scholar
  22. 60.
    Skoutelis AT, Gogos CA, Maraziotis TE, et al. (2000) Managment of brain abscesses with sequential intravenous/oral antibiotic therapy. Eur J Clin Microbiol Infect Dis 19:332–335PubMedCrossRefGoogle Scholar
  23. 61.
    Su TM, Lan CM, Tsai YD, et al (2003) Multilocated pyogenic brain abscess: experience in 25 patients. Neurosurgery 52:1075–1079PubMedCrossRefGoogle Scholar
  24. 62.
    Tahir MZ, Hassan RU, Enam SA (2010) Management of an extensive spinal epidural abscess from C-1 to the sacrum. J Neurosurg Spine 13:780–783PubMedCrossRefGoogle Scholar
  25. 63.
    Tattevin P, Bruneel F, Clair B, et al. (2003) Bacterial brain abscesses: a retrospective study of 94 patients admitted to an intensive care Unit (1980–1999). Am J Med 115:143–146PubMedCrossRefGoogle Scholar
  26. 64.
    The “Infection in Neurosurgery” Working Party of the British Society for Antimicrobial Therapy (2000) The rational use of antibiotics in the treatment of brain abscess. Br J Neurosurg 14:525–530Google Scholar
  27. 65.
    Tsai YD, Chang WN, Shen CC, et al. (2003) Intracranial suppuration: a clinical comparison of subdural empyemas and epidural abscesses. Surg Neurol 59:191–196PubMedCrossRefGoogle Scholar
  28. 66.
    Tseng JH, Tseng MY (2006) Brain abscess in 142 patients: factors influencing outcome and mortality. Surg Neurol 65:557–562PubMedCrossRefGoogle Scholar
  29. 67.
    Tung GA, Rogg JM (2003) Diffusion-Weighted Imaging of Cerebritis. Am J Neuroradiol 24:1110–1113PubMedGoogle Scholar
  30. 68.
    Visani P, Schmutzhard E, Trinka E, et al. (2006) Subcortical deficit pattern after brain abscess: a neuropsychological study. Eur J Neurol 13:599–603PubMedCrossRefGoogle Scholar
  31. 69.
    Wang VY, Chou D, Chin C (2010) Spine and spinal cord emergencies: vascular and infectious causes. Neuroimaging Clin N Am 20:639–650PubMedCrossRefGoogle Scholar
  32. 70.
    Yilmaz MH, Mete B, Kantarci F, et al. (2007) Tuberculous, brucellar and pyogenic spondylitis: comparison of magnetic resonance imaging findings and assessment of its value. South Med J 100:613–614PubMedCrossRefGoogle Scholar
  33. 71.
    Younis RT, Lazar RH, Anand VK (2002) Intracranial complications of sinusitis: a 15-year review of 39 cases. Ear Nose Throat J 81:636–638, 640–642, 644PubMedGoogle Scholar

Zu 32.3

  1. 72.
    Aksamit AJ (2010) Whipple’s disease of the central nervous system. Handb Clin Neurol 96:231–237PubMedCrossRefGoogle Scholar
  2. 73.
    Anderson M (2000) Neurology of Whipple’s disease. J Neurol Neurosurg Psychiatry 68:2–5PubMedCrossRefGoogle Scholar
  3. 74.
    Andronikou S, Smith B, Hatherhill M, et al. (2004) Definitive neuroradiological diagnostic features of tuberculous meningitis in children. Pediatr Radiol 34:876–885PubMedCrossRefGoogle Scholar
  4. 75.
    Asselman V, Thienemann F, Pepper DJ, et al. (2010) Central nervous system disorders after starting antiretroviral therapy in South Africa. AIDS 24:2871–2876PubMedCrossRefGoogle Scholar
  5. 76.
    Banerjee B, Petersen K (2009) Psychosis following mycoplasma pneumonia. Mil Med 174: 1001–1004PubMedGoogle Scholar
  6. 77.
    Bhigjee AI, Padayachee R, Paruk H et al (2007) Diagnosis of tuberculous meningitis: clinical and laboratory parameters. Int J Infect Dis 11:348–354PubMedCrossRefGoogle Scholar
  7. 78.
    Black DF, Aksamit AJ, Morris JM (2010) MR imaging of central nervous system Whipple disease: a 15-year review. AJNR Am J Neuroradiol 31:1493–1497PubMedCrossRefGoogle Scholar
  8. 79.
    Boillat N, Greub G (2007) Rickettsiosis: a clinical approach. Rev Med Suisse 16:1222–1227Google Scholar
  9. 80.
    Brinar VV, Habek M (2010) Rare infections mimicking MS. Clin Neurol Neurosurg 112:625–628PubMedCrossRefGoogle Scholar
  10. 81.
    Bross JE, Gordon G (1991) Nocardial Meningitis: Case Reports and Review. Rev. Infect Dis 13:160–165PubMedCrossRefGoogle Scholar
  11. 82.
    Christmann D, Hansmann Y, Remy V, et al. (2002) Tick-borne neurological diseases. Rev Neurol 158:993–997PubMedGoogle Scholar
  12. 83.
    Chotmongkol V, Teerajetgul Y, Yodwut C (2006) Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in adults. SE Asian J Trop Med Public Health 37:948–952Google Scholar
  13. 84.
    Cunha BA, Pherez FM (2009) C. pneumoniae communityacquired pneumonia (CAP) in mimicking Mycoplasma pneumonia meningoencephalitis complicated by asthma. Heart Lung 38:530–533PubMedCrossRefGoogle Scholar
  14. 85.
    Dumler J, Madigan JE, Pusterlia N, et al. (2007) Ehrlichioses in Humans: Epidemiology, clinical Presentations, Diagnosis and Treatment. Clin Infect 45:45–51CrossRefGoogle Scholar
  15. 86.
    Fenollar F, Puechal X, Raoult D (2007) Whipple’s disease. N Engl Med 356:55–56CrossRefGoogle Scholar
  16. 87.
    Garcia Monco JC (2006) Tuberculosis and other mycobacterial Infections. In: Noseworthy JH (ed) Neurological Therapeutics – Principles and Practice, 2nd ed. Informa Health Care Abingdon, Oxon, pp 1011–1020Google Scholar
  17. 88.
    Godia CE, Esteve CM, Campello RA, et al. (2007) Cerebral saltwasting syndrome due to infectious diseases of the central nervous system. Med Clin 128:278–279CrossRefGoogle Scholar
  18. 89.
    Gouriet F, Lepidi H, Habib G, et al. (2007) From Cat Scratch disease to endocarditis, the possible natural history of Bartonella henselae infection. BMC Inf Dis 7:30–35CrossRefGoogle Scholar
  19. 90.
    Hainard A, Tiberti N, Robin X, et al (2010) Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis. Trop Med Int Health 16:119–126PubMedCrossRefGoogle Scholar
  20. 91.
    Hongo I, Bloch KC (2006) Ehrlichia infection of the central nervous system. Curr Treat Options Neurol 8:179–184PubMedCrossRefGoogle Scholar
  21. 92.
    Jha DK, Mishra V, Choudhary A, et al. (2007) Factors affecting the outcome of neuroendoscopy in patients with tuberculous meningitis hydrocephalus: a preliminary study. Surg Neurol 68:35–41PubMedCrossRefGoogle Scholar
  22. 93.
    Inan AS, Ceran N, Erdem I, et al (2010). Neurobrucellosis with transient ischemic attack, vasculopathic changes, intracerebral granulomas and basal ganglia infarction: a case report. J Med Case Reports 4:340–342PubMedCrossRefGoogle Scholar
  23. 94.
    Kalita J, Misra UK, Ranjan P (2007) Predictors of long-term neurological sequelae of tuberculous meningitis: a multivariate analysis. Eur J Neurol 14:33–37PubMedCrossRefGoogle Scholar
  24. 95.
    Kazar J (2005) Coxiella burnetii infection. Ann NY Academy Sci 1063:105–114CrossRefGoogle Scholar
  25. 96.
    Koskiniemi M (1993) CNS manifestations associated with Mycoplasma pneumoniae infections: summary of cases at the University of Helsinki and review. Clin Infect Dis 17: 52–57CrossRefGoogle Scholar
  26. 97.
    Kuo VC, Sloan LM, Emmett M (2010) Central nervous system tuberculosis. Proc Bayl Univ Med Cent 23:359–360PubMedGoogle Scholar
  27. 98.
    Lee CH, Lui CC, Liu JW (2007) Immune reconstitution syndrome in a patient with AIDS with paradoxically deteriorating brain tuberculoma. AIDS Patient Care 21:234–239CrossRefGoogle Scholar
  28. 99.
    Lin JJ, Harn JH, Hsu YD, et al. (1995) Rapid diagnosis of tuberculous meningitis by polymerase chain reaction assay of cerebrospinal fluid. J Neurol 242:147–152PubMedCrossRefGoogle Scholar
  29. 100.
    Mahajan SK, Rolain JM, Kanga A, Raoult D (2010) Scrub typhus involving central nervous system, India, 2004–2006. Emerg Infect Dis 16:1641–1643PubMedGoogle Scholar
  30. 101.
    Masoodi I, Farooq O, Ahmad I, et al. (2010) Acute disseminated encephalomyelitis as the first presentation of CNS tuberculosis: report of a case with brief review. Ger Med Sci 8:1–4Google Scholar
  31. 102.
    Noyola DE, Holder DL, Fishman MA, et al. (1999) Recurrent encephalopathy in cat-scratch disease. Pediatr Infect Dis 18:567–568CrossRefGoogle Scholar
  32. 103.
    Pappas G, Papadimitriou P, Akriditis N, et al. (2006) The new global map of human brucellosis. Lancet Infect Dis 6:91–99PubMedCrossRefGoogle Scholar
  33. 104.
    Pfister HW (2002) Meningits. Kohlhammer, StuttgartGoogle Scholar
  34. 105.
    Prasad K, Singh MB (2008) Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev 2008:CD002244Google Scholar
  35. 106.
    Przybojewski, Andronikou S. Wilmshurst J, et al. (2006) Objective CT criteria to determine the presence of abnormal basal enhancement in children with suspected tuberculous meningitis. Pediatr Radiol 36:687–696PubMedCrossRefGoogle Scholar
  36. 107.
    Rafi W, Venkataswamy MM, Ravi V, et al. (2007) Rapid diagnosis of tuberculous meningitis: a comparative evaluation of in-house PCR assays involving three mycobacterial DNA sequences, IS6110-MPB-64 and 65 kDa antigen. J Neurol Sci 252:163–168PubMedCrossRefGoogle Scholar
  37. 108.
    Raoult D, Birg MI, La Scola B, et al. (2000) Cultivation of the bacillus of Whipple’s disease. N Engl J Med 342:620–625PubMedCrossRefGoogle Scholar
  38. 109.
    Renard D, Morales R, Heroum C (2007) Tuberculous meningovasculitis. Neurology 68:1745PubMedCrossRefGoogle Scholar
  39. 110.
    Roca B, Bahamonde D (2006) Tuberulous Meningitis Presenting with Unusually Severe Hyponatremia. The Mount Sinai J Med 73:1029–1030Google Scholar
  40. 111.
    Schiffer JT, Sterling TR (2007) Timing of antiretroviral therapy initiation in tuberculosis patients with AIDS: a decision analysis. J Acquir Immune Defic Syndr 44:229–234PubMedCrossRefGoogle Scholar
  41. 112.
    Schmutzhard E (2008) Atypische erregerbedingte Meningoencephalitis. In: Diener HC, et al. (Hrsg) Leitlinien für Diagnostik und Therapie in der Neurologie, 4. Aufl . Thieme, StuttgartGoogle Scholar
  42. 113.
    Schmutzhard E, Pfister HW (2001) Seltene bakterielle Infektionen des Nervensystems. Akt Neurol 28:373–382CrossRefGoogle Scholar
  43. 114.
    Schoeman J, Mansvelt E, Springer P, et al. (2007) Coagulant and fibrinolytic status in tuberculous meningitis. Pediatr Infect Di J 26:428–431CrossRefGoogle Scholar
  44. 115.
    Skiba V, Barner KC (2009) Central nervous system manifestations of Q fever responsive to steroids. Mil Med 174:857–859PubMedGoogle Scholar
  45. 116.
    Socan M. Beovic B, Kese D (1994) Chlamydia pneumoniae and meningoencephalitis. N Engl J Med 11:331–406Google Scholar
  46. 117.
    Srikanth SG, Taly AB, Nagarajan K, et al. (2007) Clinicoradiological features of tuberculous meningitis in patients over 50 years of age. J Neurol Neurosurg Psychiatr 78:536–538PubMedCrossRefGoogle Scholar
  47. 118.
    Tezer H, Kara A, Haliloglu G, et al. (2008) Mycoplasma pneumonia-associated transverse myelitis with unexpected rapid response to macrolide therapy: a case report. Turk J Pediatr 50:585–588PubMedGoogle Scholar
  48. 119.
    Thurtell MJ, Keed AB, Yan M, et al. (2007) Tuberculous cranial pachymeningitis. Neurology 68:298–300PubMedCrossRefGoogle Scholar
  49. 120.
    Wang VY, Chou D, Chin C (2010) Spine and spinal cord emergencies: vascular and infectious causes. Neuroimaging Clin N Am 20:639–650PubMedCrossRefGoogle Scholar
  50. 121.
    Yis U, Kurul SH, Cakmakci H, Dirik E (2008) Mycoplasma pneumonia: nervous system complications in childhood and review of the literature. Eur J Pediatr 167:973–978PubMedCrossRefGoogle Scholar

Zu 32.4

  1. 122.
    Aguero-Rosenfeld ME, Wang G, Schwartz I, Wormser GP (2005) Diagnosis of Lyme borreliosis. Clin Microbiol Rev 18:484–509PubMedCrossRefGoogle Scholar
  2. 123.
    Blank LJ, Rompalo AM, Erbelding EJ, Zenilman JM, Ghanem KG (2011) Treatment of syphilis in HIV-infected subjects: a systematic review of the literature. Sex Transm Infect 87:9–16PubMedCrossRefGoogle Scholar
  3. 124.
    Ghanem KG (2010) Review: Neurosyphilis: A historical perspective and review. CNS Neurosci Ther 16:157–168CrossRefGoogle Scholar
  4. 125.
    Hajjaj, Kissani N (2010) Status epilepticus revealing syphilitic meningoencephalitis. Acta Neurol Belg 110:263–267PubMedGoogle Scholar
  5. 126.
    Halperin JJ (2007) Diagnosis and treatment of the neuromuscular manifestations of Lyme disease. Curr Treat Options Neuro 9:93–100CrossRefGoogle Scholar
  6. 127.
    Halperin JJ (2006) Is neuroborreliosis a medical emergency? Neurocrit Care 4:260–266PubMedCrossRefGoogle Scholar
  7. 128.
    Halperin JJ, Shapiro ED, Logigian E, et al. (2007) Practice parameter: treatment of nervous system Lyme disease (an evidence based review): report of the Quality of Standards Subcommittee of the American Academy of Neurology. Neurology 69:91–102PubMedCrossRefGoogle Scholar
  8. 129.
    Jenke AC, Stoek LM, Zilbauer M, Wirth S, Borusiak P (2011) Facial palsy: Etiology, outcome and management in children. Eur J Paediatr Neurol 15:209–213PubMedCrossRefGoogle Scholar
  9. 130.
    Kobayashi J, Nakagawa Y, Tobisawa S, Isozaki E, Koide R (2011) Deterioration of MRI findings related to Jarisch-Herxheimer reaction in a patient with neurosyphilis. J Neurol 258:699–701PubMedCrossRefGoogle Scholar
  10. 131.
    Makhani N, Morris SK, Page AV, et al. (2011) A Twist On Lyme: The challenge of Diagnosing European Lyme Neuroborreliosis. J Clin Microbiol 49:455–457PubMedCrossRefGoogle Scholar
  11. 132.
    Richter D, Postic D, Sertour N, et al. (2006) Delineation of Borrelia burgdorferi sensu lato species by multilocus sequence analysis and confirmation of the delineation of Borrelia spielmanii sp. nov. Int J Syst Evol Microbiol 56:873–881PubMedCrossRefGoogle Scholar
  12. 133.
    Robertson J, Guy E, Andrews N, et al. (2000) European multicenter study of immunoblotting in serodiagnosis of lyme borreliosis. J Clin Microbiol 38:2097–2102PubMedGoogle Scholar
  13. 134.
    Roos K (2006) Neurosyphilis. In: Noseworthy JH (ed) Neurological Therapeutics-Principles and Practice, 2nd ed. Informa Health Care, Abingdon, Oxon, pp 1021–1024Google Scholar
  14. 135.
    Schmutzhard E, Pfausler B, Gasse T, et al. (1995) Verlauf und Langzeitfolgen der chronischen Neuroborreliose. Wien Med Wochenschr 145:183–186PubMedGoogle Scholar
  15. 136.
    van Burgel ND, Oosterloo M, Kroon FP, van Dam AP (2010) Severe course of Lyme neuroborreliosis in an HIV-1 positive patient; case report and review of the literature. BMC Neurol 10:117–121PubMedCrossRefGoogle Scholar
  16. 137.
    Wilske B (2005) Epidemiology and diagnosis of Lyme Borreliosis. Ann Med 37:568–579PubMedCrossRefGoogle Scholar
  17. 138.
    Wilske B, Fingerle V, Schulte-Spechtel U (2007) Microbiological and serological diagnosis of Lyme Borreliosis. FEMS Immunol Med Microbiol 49:13–21PubMedCrossRefGoogle Scholar
  18. 139.
    Workowski KA, Berman SM (2010) Sexually transmitted diseases treatment. Guidelines 59 (RR12) 1–110Google Scholar
  19. 140.
    Wormser GP, Nadelman RB, Dattwyler RJ, et al. (2000) Practice guidelines for the treatment of Lyme disease. The Infectious Diseases Society of America. Clin Infect Dis 31:1–14PubMedCrossRefGoogle Scholar

Zu 32.5

  1. 141.
    Abzug MJ, Cloud G, Bradley J, Sanchez PJ, Romero J, Powel, D, Lepow M, Mani C, Capparelli EV, Blount S, Lakeman F, Whitley RJ, Kimberlin DW (2003) Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis. Pediatr Infect Dis J 22:335–341PubMedGoogle Scholar
  2. 142.
    Baringer JR, Pisani P (1994) Herpes simplex virus genomes in human nervous system tissue analyzed by polymerase chain reaction. Ann Neurol 36: 823–829PubMedCrossRefGoogle Scholar
  3. 143.
    Bossart KN, Zhu Z, Middleton D, et al. (2009) A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection. Plos Pathog 5:e1000642PubMedCrossRefGoogle Scholar
  4. 144.
    Center for Disease Control and Prevention (2004) Recovery of a Patient from Clinical Rabies. MMW 53:1171–1173Google Scholar
  5. 145.
    CDC (1999) Update: Outbreak of Nipah virus – Malaysia and Singapore. MMWR 48:335–337Google Scholar
  6. 146.
    Chadha MS, Comer JA, Lowe L, et al. (2006) Nipah virusassociated encephalitis outbreak, Siliguri, India. Emerg Infect Dis 12:235–240PubMedCrossRefGoogle Scholar
  7. 147.
    Chaudhuri A, Kennedy PG (2002) Diagnosis and treatment of viral encephalitis. Postgrad Med J 78:575–583PubMedCrossRefGoogle Scholar
  8. 148.
    Cinque P, Bossolasco S, Lundkvist A (2003) Molecular analysis of cerebrospinal fluid in viral diseases of the central nervous system. J Clin Virol 26:1–28PubMedCrossRefGoogle Scholar
  9. 149.
    Corssmit EP, Leverstein-van Hall MA, Portegies,P, Bakker P (1997) Severe neurological complications in association with Epstein- Barr virus infection. J Neurovirol 3:460–464PubMedCrossRefGoogle Scholar
  10. 150.
    Defang GN, Khetawat D, Broder CC, Quinnan GV Jr. (2010) Induction of neutralizing antibodies to Hendra and Nipah glycoproteins using a Venezuelan equine encephalitis virus in vivo expression system. Vaccine 29:212–220PubMedCrossRefGoogle Scholar
  11. 151.
    Falcone S, Post MJ (2000) Encephalitis, cerebritis, and brain abscess: pathophysiology and imaging findings. Neuroimaging Clin N Am 10:333–353PubMedGoogle Scholar
  12. 152.
    Fusco D, Krawitz P, La Russa P,Steinberg S, Gershon A (2010) Jacobs J VZV meningitis following varicella vaccine. J Clin Virol 48:275–277PubMedCrossRefGoogle Scholar
  13. 153.
    Gurley ES, Montgomery JM, Hossain MJ, et al. Person-to-person transmission of Nipah virus in Bangladeshi community. Emerg Infect Dis 2007; 13(7): 1031–1037PubMedGoogle Scholar
  14. 154.
    Haglund M, Forsgren M, Lindh G, Lindquist L (1996) A 10-year follow-up study of tick-borne encephalitis in the Stockholm area and a review of the literature: need for a vaccination strategy. Scand J Infect Dis 28:217–224PubMedCrossRefGoogle Scholar
  15. 155.
    Hauser SL (2006) Harrison’s Neurology in Clinical Medicine. McGraw-Hill, New YorkGoogle Scholar
  16. 156.
    Henquell C, Chambon M, Bailly JL, Alcaraz S, De Champs C, Archimbaud C, Labbe A, Charbonne F, Peigue-Lafeuille H (2001) Prospective analysis of 61 cases of enteroviral meningitis: interest of systematic genome detection in cerebrospinal fluid irrespective of cytologic examination results. J Clin Virol 21:29–35PubMedCrossRefGoogle Scholar
  17. 157.
    Kaiser R (2002) Tick-borne encephalitis (TBE) in Germany and clinical course of the disease. Int J Med Microbiol 291 (Suppl 33):58–61PubMedCrossRefGoogle Scholar
  18. 158.
    Kamei S (2006) Trends in the management of herpes simplex encephalitis. Rinsho Shinkeigaku 46: 950–953PubMedGoogle Scholar
  19. 159.
    Kennedy PGE (2005) Viral Encephalitis. J Neurol 252:268–272PubMedCrossRefGoogle Scholar
  20. 160.
    Lee KE, Umapathi T, Tan CB, et al. (1999) The neurological manifestations of Nipah virus encephalitis, a novel paramyxovirus. Ann Neurol 464:28–32Google Scholar
  21. 161.
    Leitlinie der DGPI. Varizellen-Zoster. www.uni-duesseldorf.de/WWW/AWMF/II/048
  22. 162.
    Meyding-Lamade UK, Lamade WR, Wildemann BT, Sarto, K, Hacke W (1999) Herpes simplex virus encephalitis: chronic progressive cerebral magnetic resonance imaging abnormalities in patients despite good clinical recovery. Clin Infect Dis 28:148–149PubMedCrossRefGoogle Scholar
  23. 163.
    Ooi MH, Wong SC, Lewthwaite P, Cardosa MJ, Solomon T (2010) Clinical features, diagnosis, and management of enterovirus 71. Lancet Neurol 9:1097–1105PubMedCrossRefGoogle Scholar
  24. 164.
    Porotto M, Rockx B, Yokoyama CC, Talekar A, Devito I, Palermo LM, Liu J, Cortese R, Lu M, Feldmann H, Pessi A (2010) Moscona A Inhibition of Nipah virus infection in vivo: targeting an early stage of paramyxovirus fusion activation during viral entr. PLoS Pathog 6:e1001168PubMedCrossRefGoogle Scholar
  25. 165.
    Reiber H, Felgenhauer K (1987) Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system. Clin Chim Acta 163:319–328PubMedCrossRefGoogle Scholar
  26. 166.
    Romero JR, Newland JG (2003) Viral meningitis and encephalitis: traditional and emerging viral agents. Semin Pediatr Infect Dis 14:72–82PubMedCrossRefGoogle Scholar
  27. 167.
    Schmutzhard E (2001) Viral infections of the CNS with special emphasis on herpes simplex infections. J Neurol 248:469–477PubMedCrossRefGoogle Scholar
  28. 168.
    Schwab S, Junger E, Spranger M, Dorfler A, Albert F, Steiner HH, Hacke W (1997) Craniectomy: an aggressive treatment approach in severe encephalitis. Neurology 48:412–417PubMedGoogle Scholar
  29. 169.
    Sener RN (2002) Diffusion MRI in Rasmussen’s encephalitis, herpes simplex encephalitis, and bacterial meningoencephalitis. Comput Med Imaging Graph 26:327–332PubMedCrossRefGoogle Scholar
  30. 170.
    Sivertsen B, Christensen PB (1996) Acute encephalitis. Acta Neurol Scand 93:156–159PubMedCrossRefGoogle Scholar
  31. 171.
    Steiner I, Budka H, Chaudhuri A, Koskiniemi M, Sainio K, Salonen O, Kennedy PG (2010) Viral meningoencephalitis: a review of diagnostic methods and guidelines for management. Eur J Neurol 17:999–e57PubMedCrossRefGoogle Scholar
  32. 172.
    Tan CT, Goh KJ, Wong KT, et al. (2002) Relapsed and late-onset Nipah encephalitis. Ann Neurol 51:703–708PubMedCrossRefGoogle Scholar
  33. 173.
    Thomson RB Jr., Bertram H (2001) Laboratory diagnosis of central nervous system infections. Infect Dis Clin North Am 15:1047–1071PubMedCrossRefGoogle Scholar
  34. 174.
    Tyler KL (2004) Update on herpes simplex encephalitis. Rev Neurol Dis 1:169–178PubMedGoogle Scholar
  35. 175.
    Tyler KL (2009) Emerging Viral Infections of the Central Nervous System, Part 2. Arch Neurol 66:1065–1074PubMedCrossRefGoogle Scholar
  36. 176.
    Utley TF, Ogden JA, Gibb A, McGrath N, Anderson NE (1997) The long-term neuropsychological outcome of herpes simplex encephalitis in a series of unselected survivors. Neuropsychiatry Neuropsychol Behav Neurol 10:180–189PubMedGoogle Scholar
  37. 177.
    Whitley RJ, Gnann JW (2002) Viral encephalitis: familiar infections and emerging pathogens. Lancet 359:507–513PubMedCrossRefGoogle Scholar
  38. 178.
    Wildemann B, Ehrhart K, Storch-Hagenlocher B, Meyding- Lamade U, Steinvorth S, Hacke W, Haas J (1997) Quantitation of herpes simplex virus type 1 DNA in cells of cerebrospinal fluid of patients with herpes simplex virus encephalitis. Neurology 48:1341–1346PubMedGoogle Scholar
  39. 179.
    Wong M, Connolly AM, Noetzel MJ (1999) Poliomyelitis-like syndrome associated with Epstein-Barr virus infection. Pediatr Neurol 20:235–237PubMedCrossRefGoogle Scholar
  40. 180.
    Wong KT, Shieh WJ, Kumar S, et al. (2002) Nipah Virus Pathology Working Group. Nipah virus Infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am J Pathol 161: 2153–2167PubMedCrossRefGoogle Scholar

Zu 32.6

  1. 181.
    Hauser S, et al. (2006) Harrison’s Neurology in Clinical Medicine. McGraw-Hill, New YorkGoogle Scholar
  2. 182.
    Manning L, Laman M, Edoni H, Mueller I, Karunajeewa HA, Smith D, Hwaiwhanje I, Siba PM, Davis TM (2011) Subacute sclerosing panencephalitis in papua new guinean children: the cost of continuing inadequate measles vaccine coverage. PLoS Negl Trop Dis 5:e932PubMedCrossRefGoogle Scholar
  3. 183.
    Molloy ES, Calabrese LH (2008) Progressive multifocal leukoencephalopathy in patients with rheumatic diseases: are patients with systemic lupus erythematosus at particular risk? Autoimmun Rev 8: 144–146PubMedCrossRefGoogle Scholar
  4. 184.
    Nagoshi K, Sadakane A, Nakamura Y, Yamada M, Mizusawa H (2011) Duration of Prion Disease is Longer in Japan Than in Other Countries. J Epidemiol May 28, Epub ahead of printGoogle Scholar
  5. 185.
    Owens GP, Ritchie AM, Gilden DH, Borgoon MP, Becker D, Bennet JL (2007) Measles virus-specific plasma cells are prominent in subacute sclerosing panencephalitis CSF. Neurology 68:1815–1819PubMedCrossRefGoogle Scholar
  6. 186.
    Sharma S, Kumar S (2010) Case report: Cervical spinal cord signal changes in a case of adult-onset subacute sclerosing panencephalitis. Indian J Radiol Imaging 20; 202–204PubMedCrossRefGoogle Scholar
  7. 187.
    Tatli B, Ekici B, Ozmen M (2010) Flurpirtine may Stopp the progressive course of subacute sclerosing panencephalitis. Med Hypotheses 75:576–577PubMedCrossRefGoogle Scholar
  8. 188.
    Warnke C, Menge T, Hartung HP, Racke MK, Cravens PD, Bennett JL, Frohman EM, Greenberg BM, Zamvil SS, Gold R, Hemmer B, Kieseier BC, Stüve O (2010) Natalizumab and progressive multifocal leukencephalopathy: what are the causal factors and can it be avoided? Arch Neurol 67: 923–930PubMedCrossRefGoogle Scholar
  9. 189.
    White MK, Khalil K (2011) Pathogenesis of progressive multifocal leukoencephalopathy-revisited. J Infect Dis 203:578–586PubMedCrossRefGoogle Scholar
  10. 190.
    Yilmaz C, Caksen H, Yilmaz N, Güven HS, Bayram I (2007) Two cases of Subacute Sclerosing Panencephalitis associated with Brainstem involvement. Trop Pediatr 53:280–283CrossRefGoogle Scholar

Zu 32.7

  1. 191.
    Anduze-Faris BM, Fillet AM, Gozlan J, Lancar R, Boukli N, Gasnault J, Caumes E, Livartowsky J, Matheron S, Leport C, Salmon D, Costagliola D, Katlama C (2000) Induction and maintenance therapy of cytomegalovirus central nervous system infection in HIV-infected patients. Aids 14:517–524PubMedCrossRefGoogle Scholar
  2. 192.
    Bucher HC, Griffith L, Guyatt GH, Opravil M (1997) Meta-analysis of prophylactic treatments againts pneumocystis carinii and toxoplasma encephalitis. J Acquir Immune Defic Syndr Hum Retrovirol 15:104–114PubMedCrossRefGoogle Scholar
  3. 193.
    Cardo DM, Culver DH, Ciesielsky CA, Srivastava PU, Marcus R, Abiteboul D, Heptonstall J, Ippolito G, Lot F, McKibben PS, Bell DM (1997) A case-control study of HIVseroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group. N Engl J Med 337:1485–1490PubMedCrossRefGoogle Scholar
  4. 194.
    Centers for Disease Control (1992) 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Morbidity and Mortality Weekly Report 41 (RR-17):1–19Google Scholar
  5. 195.
    Chaisson RE, Keruly JC, Moore RD (2000) Association of initial CD4 cell count and viral load with response to highly active antiretroviral therapy. J Am Med Assoc 248:3128–3129CrossRefGoogle Scholar
  6. 196.
    Dworkin MS, Wan PC, Hanson DL, Jones JL (1999) Progressive multifocal leucoencephalopathy: improved survival of human immunodeficiency virus-infected patients in the protease inhibitor era. J Infect Dis 180:621–625PubMedCrossRefGoogle Scholar
  7. 197.
    Henderson DK (1999) Postexposure chemoprophylaxis for occupational exposures to the human immunodeficiency virus. J Am Med Assoc 281:931–936CrossRefGoogle Scholar
  8. 198.
    Hoffmann C, Rockstroh JK, Kamps BS (Hrsg) (2007) HIV.Net 2007. www.hiv.net. Steinhäuser, Wuppertal-Beyenburg
  9. 199.
    Joint United Nations Programme on HIV/AIDS (UNAIDS) and World Health Organization (2010) UNAIDS Report on the global AIDS Epidemic 2010Google Scholar
  10. 200.
    Louie M, Markowitz M (2002) Goals and milestones during treatment of HIV-1 infection with antiretroviral therapy: a pathogenesis-based perspective. Antiviral Res 55:15–25PubMedCrossRefGoogle Scholar
  11. 201.
    Mellors JW, Rinaldo CRJ, Gupta P, White RM, Todd JA, Kingsley LA (1996) Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 272:1167–1170PubMedCrossRefGoogle Scholar
  12. 202.
    Panel on Antiretroviral Guidelines for Adult and Adolescents (2006) Guidelines for the use of antiretroviral agents in HIVinfected adults and adolescents. Department of Health and Human Services. October 10, 2006:1–113Google Scholar
  13. 203.
    Portegies P, Solod L, Cinque P, Chaudhuri A, Begovac J, Everall I, Weber T, Bojar M, Martinez-Martin P, Kennedy PG (2004) Guidelines for the diagnosis and management of neurological complications of HIV infection. Eur J Neurol 11:297–304PubMedCrossRefGoogle Scholar
  14. 204.
    Saag MS, Graybill RJ, Larsen RA, Pappas PG, Perfect JR, Powderly WG, Sobel JD, Dismukes WE (2000) Practice guidelines for the management of cryptococcal disease. Infectious diseases Society of America. Clin Infect Dis 30:710–718PubMedCrossRefGoogle Scholar
  15. 205.
    Sackto, N, McArthur JC (1997) Prospects for therapy of HIVassociated neurologic diseases. J Neurovirol 3:89–101CrossRefGoogle Scholar
  16. 206.
    Schabet M, Herrlinger U, Weller M, Bamberg M, Clemens R, Dichgans J (1997) Neue Entwicklungen in Diagnostik und Therapie primärer Non-Hodgkin-Lymphome des zentralen Nervensystems. Nervenarzt 68:298–308PubMedCrossRefGoogle Scholar
  17. 207.
    Wildemann B, Haas J, Lynen N, Stingele K, Storch-Hagenlocher B (1998) Diagnosis of cytomegalovirus encephalitis in patients with AIDS by quantitation of cytomegalovirus genomes in cells of cerebrospinal fluid. Neurology 50:693–697PubMedGoogle Scholar
  18. 208.
    Centers for Disease Control, United States Health Department: http://www.cdc.gov/hiv/resources/guidelines
  19. 209.
    Joint United Nations Programme on HIV/AIDS (UNAIDS): http://www.unaids.org
  20. 210.
    Robert Koch Institut: http://www.rki.de
  21. 211.
    AIDSinfo: U.S. Department of Health and Human Services (DHHS): http://aidsinfo.nih.gov/
  22. 212.
    Deutsch-Österreichische Leitlinien zur antiretroviralen Therapie der HIV-Infektion. http://www.daignet.de
  23. 213.
    Leitlinien der Deutschen Gesellschaft für Neurologie zur Diagnostik und Therapie HIV-1-assoziierter Erkrankungen. www.dgn.org

Zu 32.8

  1. 214.
    Balasegaram M, Harris S, Checchi F, et al. (2006) Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo. Bulletin WHO 84:783–791Google Scholar
  2. 215.
    Birbeck GL, Beare N, Lewallen S, et al. (2010) Identification of malaria retinopathy improves the specificity of the clinical diagnosis of cerebral malaria: findings from a prospective cohort study. Am J Trop Med Hyg 82:231–234PubMedCrossRefGoogle Scholar
  3. 216.
    Birbeck GL, Molyneux ME, Kaplan PW, et al. (2010) Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study. Lancet Neurol 9:1173–1181PubMedCrossRefGoogle Scholar
  4. 217.
    Braakman H, Fred MM, van de Molengraft JJ, et al. (2006) Lethal African trypanosomiasis in a traveler: MRI and neuropathology, Neurology 66:1094–1096PubMedCrossRefGoogle Scholar
  5. 218.
    Burgos JM, Begher S, Silva HM, et al. (2008) Molecular identification of Trypanosoma cruzi I tropism for central nervous system in Chagas reactivation due to AIDS. Am J Trop Med Hyg 78:294–297PubMedGoogle Scholar
  6. 219.
    Carod-Artal FJ (2009) Tropical causes of epilepsy. Rev Neurol 49:475–482PubMedGoogle Scholar
  7. 220.
    Chacko G (2010) Parasitic diseases of the central nervous system. Semin Diagn Pathol 27:167–185PubMedCrossRefGoogle Scholar
  8. 221.
    Córdova E, Maiolo E, Corti M, Orduna T (2010) Neurological manifestations of Chagas’ disease. Neurol Res 32:238–244PubMedCrossRefGoogle Scholar
  9. 222.
    Corpelet C, Vacher P, Coudore F, et al. (2005) Role of quinine in life-threatening Babesia divergens infection successfully treated with clindamycin. Eur J Clin Microbiol Infect Dis 24:74–75PubMedCrossRefGoogle Scholar
  10. 223.
    Dauriac-Le Masson V, Chochon F, Demeret S, et al. (2005) Toxocara canis meningomyelitis. J Neurol 252:1267–1268PubMedCrossRefGoogle Scholar
  11. 224.
    Davis TME, White NJ, Looareesuwan S, Silamut K, Warrell DA (1988) Quinine pharmacokinetics in cerebral malaria: predicted plasma concentrations after rapid intravenous loading using a two compartment mode. Trans R Soc Trop Med Hyg 82:542–547PubMedCrossRefGoogle Scholar
  12. 225.
    Del Brutto OH, Roos KL, Coffey CS, et al. (2006) Meta-Analysis: Cysticidal Drugs for Neurocysticercosis: Albendazole and Praziquantel. Ann Intern Med 145:43–51PubMedGoogle Scholar
  13. 226.
    Deo I, Robledo L, Meza A, et al. (2000) Encephalitis due to a free-living amoeba (Balamuthia mandrillaris), case report with literature review. Surg Neurol 53:611–616CrossRefGoogle Scholar
  14. 227.
    Dondorp AM, Fanello CI, Hendriksen IC, et al. (2010) Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomized trial. Lancet 376:1647–1657PubMedCrossRefGoogle Scholar
  15. 228.
    Dondorp A, Nosten F, Stepniewska K, et al. (2005). Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial. Lancet 366:717–725PubMedCrossRefGoogle Scholar
  16. 229.
    Ellrodt A, Halfon P, Le Bras P, Halimi P, Bouree P, Desi M, Caquet R (1987) Multifocal central nervous system lesions in three patients with trichinosis. Arch Neurol 44: 432–434PubMedCrossRefGoogle Scholar
  17. 230.
    Dulac O (2010) Cerebral malaria and epilepsy. Lancet Neurol 9:1144–1145PubMedCrossRefGoogle Scholar
  18. 231.
    Elsheikha HM, Khan NA (2010) Protozoa traversal of the bloodbrain barrier to invade the central nervous system. FEMS Microbiol 34:532–553Google Scholar
  19. 232.
    Fan KJ, Pezeshkpour GH (1986) Cerebral sparganosis. Neurology 36:1249–1251PubMedGoogle Scholar
  20. 233.
    Feely NM, Waghorn DJ, Dexter T, Gallen I, Chioidini P (2010) Strongyloides stercoralis hyperinfection: difficulties in diagnosis and treatment. Anaesthesia 65:298–301PubMedCrossRefGoogle Scholar
  21. 234.
    Garcia HH, Pretell EJ, Gilman RH, et al. (2004) A trial of antiparasitic treatment to reduce the rate of seizures due to cerebral cysticercosis. N Engl J Med 350:249–258PubMedCrossRefGoogle Scholar
  22. 235.
    Golenser J, McQuillain J, Hee L, et al. (2006) Conventional and experimental treatment of cerebral malaria. Internat J Parasitol 36:583–593CrossRefGoogle Scholar
  23. 236.
    Hainard A, Tiberti N, Robin X, et al. (2011) Matrix metalloproteinase-9 and intercellulara adhesion molecule 1 are powerful staging markers for human African Trypanosomiasis. Trop Med Int Health 16:119–126PubMedCrossRefGoogle Scholar
  24. 237.
    Helbok R, Brenneis C, Beer R, et al. (2007) A rare case of Toxocara canis cerebral vasculitis. Europ J Neurol 14:117–120CrossRefGoogle Scholar
  25. 238.
    Herman JS, Chiodini PL (2009) Gnathostomiasis, another emerging imported disease. Clin Microbiol Rev 22:484–492PubMedCrossRefGoogle Scholar
  26. 239.
    Häselbarth K, Tenter AM, Brade V, et al. (2007) First case of human babesiosis in Germany – Clinical presentation and molecular characterisation of the pathogen. Internat J Med Microbiol 297:197–204CrossRefGoogle Scholar
  27. 240.
    Intapan PM, Khotsri P, Kanpittaya J, et al. (2010) Immunoblot diagnostic test for neurognathostomiasis. Am J Trop Med Hyg 83:927–929PubMedCrossRefGoogle Scholar
  28. 241.
    Katchanov J, Nawa Y (2010) Helminthic invasion of the central nervous system: many roads lead to Rome. Parasitol Int 59:491–496PubMedCrossRefGoogle Scholar
  29. 242.
    Kennedy PG (2004) Human African trypanosomiasis of the CNS: current issues and challenges. J Clin Invest 113:496–504PubMedGoogle Scholar
  30. 243.
    Krishnan A, Karnad DR (2003) Severe falciparum malaria: an important cause of multiple organ failure in Indian intensive care unit patients. Crit Care Med 31:2278–2284PubMedCrossRefGoogle Scholar
  31. 244.
    Khan NA (2010) Novel in vitro and in vivo models to study central nervous system infections due to Acanthamoeba spp. Exp Parasitol 126:69–72PubMedCrossRefGoogle Scholar
  32. 245.
    Kristensson K, Nygard M, Bertini G, Bentivoglio (2010) African trypanosome infections of the nervous system: parasite entry and effects on sleep and synaptic functions. Prog Neurobiol 91:152–171PubMedCrossRefGoogle Scholar
  33. 246.
    Lackner P, Beer R, Broessner G, et al. (2010) Acute granulomatous acanthamoeba encephalitis in an immunocompetent patient. Neurocrit Care 12:91–94PubMedCrossRefGoogle Scholar
  34. 247.
    Lacout A, Guidoux C, Carlier RY (2010) Posterior reversible encephalopathy syndrome in neuro-malaria. Indian J Radiol Imaging 20:198–201PubMedCrossRefGoogle Scholar
  35. 248.
    Lee MB (2000) Everyday and exotic foodborne parasites. Can J Infect Dis 11:155–158PubMedGoogle Scholar
  36. 249.
    Lv S, Zhang Y, Steinmann P, Utzinger J (2010) Helminth infections of the central nervous system occurring in Southeast Asia and the Far East. Adv Parasitol 72:351–408PubMedCrossRefGoogle Scholar
  37. 250.
    Mace SE (2010) Central nervous system infections as a cause of an altered mental status? What is the pathogen growing in your central nervous system? Emerg Med Clin North Am 28:535–570PubMedCrossRefGoogle Scholar
  38. 251.
    Marr JJ, Docampo R (1986) Chemotherapy for Chagas’ disease: a perspective of current therapy and considerations for future research. Rev Infect Dis 8:884–903PubMedCrossRefGoogle Scholar
  39. 252.
    Michal A, Regli F, Campiche R, Cavallo RJ, de Crousaz G, Oberson R, Rabinowicz T (1977) Cerebral coenurosis. Report of a case with arteritis. J Neurol 216:265–272PubMedCrossRefGoogle Scholar
  40. 253.
    Michelet L, Fleury A, Sciutto E, et al. (2011) Human neurocysticercosis: Comparision of different diagnostic tests in cerebrospinal fluid. J Clin Microbiol 49:195–200PubMedCrossRefGoogle Scholar
  41. 254.
    Molyneux ME, Taylor TE, Wirima JJ, Borgstein A (1989) Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. O J Med 71:441–459Google Scholar
  42. 255.
    Nanda NC, Rath P, Acharya J, Mishra P, Mishra SK (2011) Falciparum Malaria in Children-A Brief Report of 305 Patients from Rourkela, Eastern India. Indian J Pediatr 78:475–477PubMedCrossRefGoogle Scholar
  43. 256.
    Nkouawa A, Sako Y, Itoh S, et al. (2010) Serological studies of neurologic helminthic infections in rural areas of southwest Cameroon: toxocariasis, cysticercosis and paragonimiasis. PLoS Negl Trop Dis 4:e732PubMedCrossRefGoogle Scholar
  44. 257.
    Onyeyili PA, Onwualu JE (1991) Efficacy of combination of DFMO and diminazene aceturate in the treatment of latestage Trypanosoma brucei infection in rats. Trop Med Parasitol 42:143–145PubMedGoogle Scholar
  45. 258.
    Pitella JEH (1984) Ischemic cerebral changes in the chronic chagasic cardiopathy. Arq Neuropsiquiatr 42:105–115PubMedGoogle Scholar
  46. 259.
    Poltera AA (1985) Pathology of human African trypanosomiasis with reference to experimental African trypanosomiasis and infections of the central nervous system. Br Med Bull 41:169–174PubMedGoogle Scholar
  47. 260.
    Potchen MJ, Birbeck GL, Demarco JK, et al. (2010) Neuroimaging findings in children with retinopathy-confirmed cerebral malaria. Eur J Radiol 74:262–268PubMedCrossRefGoogle Scholar
  48. 261.
    Russegger L, Schmutzhard E (1989) Spinal toxocara abscess. Lancet 2:398PubMedCrossRefGoogle Scholar
  49. 262.
    Saddler M, Barry M, Ternouth I, Emmanuel J (1990) Treatment of severe malaria by exchange transfusion. N Engl J Med 322:58CrossRefGoogle Scholar
  50. 263.
    Saleem T, Rabbani M, Jamil B (2009) Primary amoebic meningoencephalitis: two new cases from Pakistan. Trop Doct 39:242–243PubMedCrossRefGoogle Scholar
  51. 264.
    Sattar MA, Hoque HW, Amin MR, Faiz MA, Rahman MR (2009) Neurological findings and outcome in adult cerebral malaria. Bangladesh Med Res Counc Bull 35:15–17PubMedCrossRefGoogle Scholar
  52. 265.
    Schmutzhard E (2010) Parasitic diseases of the central nervous system. Nervenarzt 81:162–171PubMedCrossRefGoogle Scholar
  53. 266.
    Schmutzhard E (2006) Protozoal Infections. In: Noseworthy JH (ed) Neurological Therapeutics – Principles and Practice. Informa Health Care, Abingdon, Oxon, pp 1116–1132Google Scholar
  54. 267.
    Schmutzhard E, Mayr U, Rumpl E, Prugger M, Pohl P (1986) Secondary cerebral amebiasis due to infection with Entamoeba histolytica. Eur Neurol 25:161–165PubMedCrossRefGoogle Scholar
  55. 268.
    Schmutzhard E, Boongird P, Vejjajiva A (1988) Eosinophilic meningitis and radiculomyelitis in Thailand, caused by CNS invasion of Gnathostoma spingerum and Angiostrongylus cantonensis. J Neurol Neurosurg Psychiatry 51:80–87PubMedCrossRefGoogle Scholar
  56. 269.
    Scowden EB, Schaffner W, Stone WJ (1978) Overwhelming strongyloidiasis: an unappreciated opportunistic infection. Medicine (Baltimore) 57:527–544Google Scholar
  57. 270.
    Silva AA, Roffe E, Santiago H, et al. (2007) Trypanosoma cruzitriggered meningoencephalitis is a CCR1/CCR5-independent inflammatory process. J Neuroimmunol 184:156–163PubMedCrossRefGoogle Scholar
  58. 271.
    Solaymani-Mohammadi S, Lam MM, Zunt JR, Petri WA, et al. (2007) Entamoeba histolytica encephalitis diagnosed by PCR of cerebral spinal fluid. Trans R Soc Trop Med Hyg 101:311–313PubMedCrossRefGoogle Scholar
  59. 272.
    Sotelo-Avila C (1987) Naegleria and Acanthamoeba. Free-living amebas pathogenic for man. Perspect Pediatr Pathol 10:51–58PubMedGoogle Scholar
  60. 273.
    Taelman H, Schaechter PJ, Marcelis L (1987) Difluoromethylornithine, an effective new treatment of Gambian trypanosomiasis. Am J Med 82:607–614PubMedCrossRefGoogle Scholar
  61. 274.
    Tran TH, Dolecek C, Pham PM, et al. (2004) Dihydroartemisininpiperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial. Lancet 363:18–22PubMedCrossRefGoogle Scholar
  62. 275.
    Urbina JA, Docampo R (2003) Specific chemotherapy of Chagas disease: controversies and advances. Trends Parasiotol 11:495–501CrossRefGoogle Scholar
  63. 276.
    Utzinger J, Bergquist R, Olveda R, Zhou XN (2010) Important helminth infections in Southeast Asia diversity, potential for control and prospects for elimination. Adv Parasitol 72:1–30PubMedCrossRefGoogle Scholar
  64. 277.
    Visvesvara GS (2010) Amebic meningoencephalitides and keratitis: challenges in diagnosis and treatment. Curr Opin Infect Dis 23:590–594PubMedCrossRefGoogle Scholar
  65. 278.
    Wang J, Qi H, Diao Z, et al. (2010) An outbreak of angiostrongyliasis cantonensis in Beijing. J Parasitol 96:377–381PubMedCrossRefGoogle Scholar
  66. 279.
    Wang P, Wu MC, Chen SJ, et al. (2010) Research development of the pathogenesis pathways for neuroschistosomiasis. Neurosci Bull 26:168–174PubMedCrossRefGoogle Scholar
  67. 280.
    Warrell DA. Looareesuwan S, Warrell MJ, Kasemarn P, Intaraprasert R, Bunnag D, Harinasuta T (1982) Dexamethasone proves deleterious in cerebral malaria. A double blind trial in 100 comatose patients. N Engl J Med 306:313–319PubMedCrossRefGoogle Scholar
  68. 281.
    Watt G, Long GW, Ranoa CP, Adapon B, Fernando MT, Cross JH (1989) Praziquantel in treatment of cerebral schistosomiasis. Lancet 2:262–263Google Scholar
  69. 282.
    Wenzler T, Boykin DW, Ismail MA, et al. (2009) New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289 Antimicrobiob Agents Chemother 53:4185–4192CrossRefGoogle Scholar
  70. 283.
    Winkler AS, Willingham AL 3rd, Sikasunge CS, et al. (2009) Epilepsy and neurocysticercosis in sub-Saharan Africa. Wien Klin Wochenschr 3:3–12CrossRefGoogle Scholar
  71. 284.
    Wittner M, Rowin KS, Tanowitz HB, et al. (1982) Successful chemotherapy of transfusion babesiosis. An Intern Med 96:601–604Google Scholar
  72. 285.
    World Health Organization (2000) Managment of Servere Malaria: A practical Handbook, 2nd ed. World Health Organization, GenevaGoogle Scholar
  73. 286.
    Zimmerman GA, Castro-Faria-Neto H (2010) Persistent cognitive impairment after cerebral malaria: models, mechanisms and adjunctive therapies. Expert Rev Anti Infect Ther 8:1209–1212PubMedCrossRefGoogle Scholar
  74. 287.
    Zlobl TL (2001) Amebiasis. Prim Care Update 8:65–68CrossRefGoogle Scholar

Zu 32.9

  1. 288.
    Abbott SP, et al. (1995) Fatal cerebral mycoses caused by the ascomycete Chaetomium strumarium. J Clin Microbiol 33:2692–2698PubMedGoogle Scholar
  2. 289.
    Al-Jehani H, Guiot Mc, Torres C, Marcoux J (2010) Scedosporium cerebral abscesses after extra-corporeal membrane oxygenation. Can J Neurol Sci 37:671–678PubMedGoogle Scholar
  3. 290.
    Andreoni SC (2004) Medical Mycology Atlas. S-Systems, Milano 291. Bennett JE (1987) Rapid diagnosis of candidiasis and aspergillosis. Rev Infect Dis 9:398–402Google Scholar
  4. 292.
    Berger JR, Greenberg RN (2010) Isolated central nervous system histoplasmosis in an immunocompetent patient: 53-month hiatus to diagnosis and treatment. J Neurovirol 16:472–474PubMedGoogle Scholar
  5. 293.
    Black KE, Baden LR (2007) Fungal infections of the CNS: treatment strategies for the immunocompromised patient. CNS Drugs 21:293–318PubMedCrossRefGoogle Scholar
  6. 294.
    Blyth CC, Hale K, Palasanthiran P, O’Brian T, Bennett HMl (2010) Antifungal therapy in infants and children with proven, probable or suspected invasive fungal infections. Cochrane Database Syst Rev Feb 17:CD006343Google Scholar
  7. 295.
    Christophe C, Azzi N, Bouche B, et al. (1999) Magnetic resonance imaging and angiography in cerebral fungal vasculitis. Neuropediatrics 30:218–220PubMedCrossRefGoogle Scholar
  8. 296.
    Cuenca-Estrella M, Gomez-Lopez A, Garcia-Effron G, et al. (2005) Combined activity in vitro of Caspofungin, amphothericin B, and azole agents against itraconazloe-resistant clinical isolates of Aspergillus fumigatus. Antimicrob Agents Chemother 49:1232–1235PubMedCrossRefGoogle Scholar
  9. 297.
    Diekema DJ, Messer SA, Hollis RJ, et al. (2003) Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi. J Clin Microbiol 41:3623–3626PubMedCrossRefGoogle Scholar
  10. 298.
    Dupont B (2002) Overview of the lipid formulations of amphotericin B. J Antimicrob Chemother 49:31–36PubMedCrossRefGoogle Scholar
  11. 299.
    Feltracco P, Barbieri S, Furnari M, et al. (2010) Central nervous system infectious complications early after liver transplantation. Transplant Proc 42:1216–1222PubMedCrossRefGoogle Scholar
  12. 300.
    Fica A, Diaz MC. Luppi M, et al. (2003) Unsuccessful treatment with voriconazole of a brain abscess due to Cladophialophora bantiana. Scand J Infect Dis 35:892–893PubMedCrossRefGoogle Scholar
  13. 301.
    Friedman JA, Wijdicks EF, Fulgham JR (2000) Meningoencephalitis due to Blastomyces dermatitidis: case report and literature review. Mayo Clin Proc 75:403–408PubMedCrossRefGoogle Scholar
  14. 302.
    Garcia RJ, Troya P, Edwards C (2006) Invasive aspergillosis with central nervous system dissemination in a presumably immunocompetent, non-neutropenic patient: case report and review. South Med J 99:607–610PubMedCrossRefGoogle Scholar
  15. 303.
    Glass HC, Wirrell E, Sarnat HB, et al. (2007) MRI findings in an immunocompromised boy with CNS fungal infection. Can J Neurol Sci 34:88–91PubMedGoogle Scholar
  16. 304.
    Gottfredsson M Perfect JR (2000) Fungal meningitis. Semin Neurol 20:307–322PubMedCrossRefGoogle Scholar
  17. 305.
    Girmenia C, Martino P (2003) New antifungal drugs and new clinical trials: interpreting results may be difficult. Curr Opin Oncol 15:283–288PubMedCrossRefGoogle Scholar
  18. 306.
    Herbrecht R, Denning DW, Paterson TF (2002) Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med 347:408–415PubMedCrossRefGoogle Scholar
  19. 307.
    Javadi A, Ataei B, Koleini N, Saboori M (2010) Central nervous system aspergillosis in an immunocompetent patient. Neurosciences (Riyadh) 15:193–195Google Scholar
  20. 308.
    Kowacs PA, Soares Silvado CE, Monteiro De Almeida S, et al. (2004) Infection of the CNS by Scedosporium apiospermum after near drowning. Report of a fatal case and analysis of its confounding factors. J Clin Pathol 57:205–207PubMedCrossRefGoogle Scholar
  21. 309.
    Labadie EL, Hamilton RH (1986) Survival improvement in coccidioidal meningitis by high-dose intrathecal amphotericin B. Arch Intern Med 146:2013–2018PubMedCrossRefGoogle Scholar
  22. 310.
    Lazo A, Wilner HJ, Metes JJ (1981) Craniofacial mucormycosis: computed tomographic and angiographic findings in two cases. Radiology 139:623–626PubMedGoogle Scholar
  23. 311.
    Lowe JT, Hudson WR (1975) Rhinocerebral phycomycosis and internal carotid artery thrombosis. Arch Otolaryngol 101:100–103PubMedCrossRefGoogle Scholar
  24. 312.
    Mathews M, Paré L, Hasso A (2007) Intraventricular cryptococcal cysts masquerading as racemose neurocysticercosis. Surg Neurol 67:647–649PubMedCrossRefGoogle Scholar
  25. 313.
    Mazumder SA, Cleveland KO (2010) Cryptococcal meningitis after neurosurgery. Am J Med Sci 339:582–583PubMedGoogle Scholar
  26. 314.
    Moen MD, Lyseng-Willliamson KA, Scott LJ (2009). Liposomal amphotericin B: a review of its use as empirical therapy in febrile neutropenia and in the treatment of invasive fungal infections. Drugs 69:361–392PubMedCrossRefGoogle Scholar
  27. 315.
    Munoz P, Valerio M, Palomo J, et al. (2010) Infectious and non-infectious neurologic complications in heart transplant recipients. Medicine (Baltimore) 89:166–175CrossRefGoogle Scholar
  28. 316.
    Mylonakis E, Paliou M, Sax PE, et al (2000) Central nervous system aspergillosis in patients with human iummunodefficiency virus infection. Medicine 79:269–280PubMedCrossRefGoogle Scholar
  29. 317.
    Nevado J, De Alarcon A, Hernandez A (2005) Caspofungin: a new therapeutic option for fungal endocarditis. Clin Microbiol Infect 11:248–252PubMedCrossRefGoogle Scholar
  30. 318.
    Perea JR, Diaz De Rada BS, Quetglas EG, et al. (2004) Oral versus intravneous therapy in the treatment of systemic mycosis. Clin Microbiol Infect 1:96–106CrossRefGoogle Scholar
  31. 319.
    Perlroth J, Choi B, Spellberg B (2007) Nosocomial fungal infections: epidemiology, diagnosis, and treatment. Med Mycol 45:321–346PubMedCrossRefGoogle Scholar
  32. 320.
    Pfausler, Kampfl A, Berek K, Maier H, Aichner F, Schmutzhard E (1995) Syndrome of the Anterior Spinal Artery as the Primary Manifestation of Aspergillosis. Infection 23:240–242PubMedCrossRefGoogle Scholar
  33. 321.
    Purkins L, Wood N, Ghahramani P, et al. (2003) Coadministration of voriconazole and phenytoin: pharmacokinetic interaction, safety, and toleration. Br J Clin Pharmacol 1:37–44CrossRefGoogle Scholar
  34. 322.
    Raman Sharma R (2010) Fungal infections of the nervous system: current perspective and controversies in management. Int J Surg 8:591–601PubMedCrossRefGoogle Scholar
  35. 323.
    Ramesha KN, Kate MP, Kesavadas C, et al. (2010) Fungal infections of the central nervous system in HIV-negative patients: experience from a tertiary referral center of South India. Ann Indian Acad Neurol 13:112–116PubMedCrossRefGoogle Scholar
  36. 324.
    Raparia K, Powell SZ, Cernoch P, Takei H (2010) Cerebral mycosis: 7-year retrospective series in a tertiary center. Neuropathology 30:218–223PubMedCrossRefGoogle Scholar
  37. 325.
    Revankar SG, Sutton DA, Rinaldi MG (2004) Primary central nervous system phaeohyphomycocis: a review of 101 cases Clin Infect Dis 38:206–216Google Scholar
  38. 326.
    Rubio MC, de Ocariz IR, Gil J, et al. (2005) Potential fungicidal effect of voriconazole against Candida spp. Int J Antimicrob Agents 25:264–267PubMedCrossRefGoogle Scholar
  39. 327.
    Ruchel R, et al. (1995) Cerebral Pseudallescheria mycosis after near-drowning. Mycoses 38:473–475PubMedCrossRefGoogle Scholar
  40. 328.
    Sakhuja V, Sud K, Kalra OP, et al. (2001) Central nervous system complications in renal transplant recipients in a tropical environment. J Neurol Sci 183:89–93PubMedCrossRefGoogle Scholar
  41. 329.
    Sasaki T, Mineta M, Kobayashi K, Ando M, Obata M (2010) Zygomycotic invasion of the central nervous system. Jpn J Radiol 28:376–80PubMedCrossRefGoogle Scholar
  42. 330.
    Schmutzhard E (2006) Fungal Infections. In: Noseworthy JH (ed) Neurological Therapeutics-Principles and Practice. Informa Healthcare, Abingdon, Oxon, pp 1085–1115Google Scholar
  43. 331.
    Scully EP, Baden LR, Katz JT (2008) Fungal brain infections. Curr Opin Neurol 21:347–352PubMedCrossRefGoogle Scholar
  44. 332.
    Senzolo M, Ferronato C, Burra P (2009) Neurologic complications after solid organ transplantation. Transpl Int 22:269–278PubMedCrossRefGoogle Scholar
  45. 333.
    Shamin MS, Enam SA, Ali R, Anwar S (2010) Craniocerebral aspergillosis: a review of advances in diagnosis and management. J Pak Med Assoc 60:573–579Google Scholar
  46. 334.
    Siegal JA, Cacayorinb ED, Nassif AS, et al. (2000) Cerebral mucormycosis: proton MR spectroscopy and MR imaging. Magn Reson Imaging 18:915–920PubMedCrossRefGoogle Scholar
  47. 335.
    Sun HY, Forrest G, Gupta KL, et al. (2010) Rhino-orbitalcerebral zygomycosis in solid organ transplant recipients. Transplantation 15:85–92CrossRefGoogle Scholar
  48. 336.
    Van Hal SJ, Clezy K (2005) Emergence of invasive cerebral aspergillosis in an HIV-positive patient on voriconazole therapy. HIV Med 6:45–46PubMedCrossRefGoogle Scholar
  49. 337.
    Varanasi NL, Baskaran I, Alangaden GJ, et al. (2004) Novel effect of voriconazole on conidiation of Aspergillus species. Int J Antimicrob Agens, 23:72–79CrossRefGoogle Scholar
  50. 338.
    Vos MJ, Debets-Ossenkopp YJ, Claessen FA, et al. (2000) Cerebellar and medullar histoplasmosis. Neurology 54:1441PubMedGoogle Scholar
  51. 339.
    Weng CT, Lee NY, Liu MF, et al. (2010) A retrospective study of catastrophic invasive fungal infections in patients with systemic lupus erythematosus from southern Taiwan. Lupus 19:1204–1209PubMedCrossRefGoogle Scholar
  52. 340.
    Wingard JR, Leather H (2004) A new era of antifungal therapy. Biol Blood Marrow Transplant 10:73–90PubMedCrossRefGoogle Scholar
  53. 341.
    Zivkovic (2007) Neuroimaging and neurologic complications after organ transplantation. J Neuroimaging 17:110–23PubMedCrossRefGoogle Scholar

Zu 32.10

  1. 342.
    Alhelm F, et al. (2006) Spondylitis/Spondylodiszitis. Radiologe 46:480–485CrossRefGoogle Scholar
  2. 343.
    Belzunegui J, et al. (1999) Vertebral osteomyelitis in northern Spain. Report of 62 cases. Clin Exp Rheumatol 177:447–452Google Scholar
  3. 344.
    Beronius M, Bergman B, Andersson R (2001) Vertebral osteomyelitis in Göteborg, Sweden: a retrospective study of patients during 1990–95. Scand J Infect Dis 33:527–532PubMedCrossRefGoogle Scholar
  4. 345.
    Chelsom J, Solberg CO (1998) Vertebral osteomyelitis at a Norwegian university hospital 1987–97: clinical features, laboratory findings and outcome. Scand J Infect Dis 30:147–151PubMedCrossRefGoogle Scholar
  5. 346.
    Cordonnier C, et al. (2003) Prospective study of patients presenting with acute partial transverse myelopathy. J Neurol 250:1447–1452PubMedCrossRefGoogle Scholar
  6. 347.
    Debette S, de Sèze J, Pruvo J-P, Zephir H, Pasquier F, Leys D, Vermersch P (2009) Long-term outcome of acute and subacute myelopathies. J Neurol 256:980–988PubMedCrossRefGoogle Scholar
  7. 348.
    De Seze J, et al. (2001) Acute Myelopathies. Clinical. Laboratory and outcome profiles in 79 patients. Brain 124:1509–1521PubMedCrossRefGoogle Scholar
  8. 349.
    Erickson BJ, Weinshenker BG (2010) Compressive myelopathy mimicking transverse myelitis. Neurologist 16:120–122PubMedCrossRefGoogle Scholar
  9. 350.
    Frohmann EM, Wingerchuk DM (2010) Clinical Practice. Transverse Myelitis. N Engl J Med 363:564–572CrossRefGoogle Scholar
  10. 351.
    Greenberg BM, et al. (2007) Idiopathic transverse myelitis. Corticosteroids, plasma exchange, or cyclophosphamid. Neurology 68:1614–1617PubMedCrossRefGoogle Scholar
  11. 352.
    Honnorat J, Antoine J-C (2007) Paraneoplastic neurological syndromes. Orphanet J Rare Dis 2:22PubMedCrossRefGoogle Scholar
  12. 353.
    Irani DN, Kerr DA (2000) 14-3-3 protein in the cerebrospinal fluid of patients with acute transverse myelitis. Lancet 355 (9207):901PubMedCrossRefGoogle Scholar
  13. 354.
    Jacob A, Weinshenker BG (2008) An Approach to the Diagnosis of Acute Tranverse Myelitis. Semin Neurol 28:105–120PubMedCrossRefGoogle Scholar
  14. 355.
    Kalita J, Misra UK, Mandal SK (1998) Prognostic predictors of acute transverse myelitis. Acta Neurol Scand 98:60–63PubMedCrossRefGoogle Scholar
  15. 356.
    Kalita J, Misra UK (2000) Neurophysiological studies in acute transverse myelitis. J Neurol 247:943–948PubMedCrossRefGoogle Scholar
  16. 357.
    Kalita J, Misra UK (2001) Is methyl prednisolone useful in acute transverse myelitis? Spinal Cord 39:471–476PubMedCrossRefGoogle Scholar
  17. 358.
    Krishnan C, et al. (2004) Transverse Myelitis: pathogenesis, diagnosis and treatment. Front Biosci. 9:1483–1499PubMedCrossRefGoogle Scholar
  18. 359.
    Lewis M, Howdle PD (2003) The neurology of liver failure. Q J Med 96:623–633CrossRefGoogle Scholar
  19. 360.
    Meyding-Lamadé U, et al. (2005) Akute spinale Entzündungen. Intensivmed 42:337–344Google Scholar
  20. 361.
    Rotbart HA (2000) Viral meningitis. Semin Neurol 20:277–292PubMedCrossRefGoogle Scholar
  21. 362.
    Schellinger PD, Schmutzhard E, Fiebach JB, Pfausler B, Maier H, Schwab S (2000) Poliomyelitic-like illness in central european encephalitis. Neurology 55:299–302PubMedGoogle Scholar
  22. 363.
    Schlossbauer T, Panteleon A, Becker-Gaab C (2006) Entzündliche Wirbelsäulenerkrankungen als Ursache für Rückenschmerzen. Radiologe 46:468–479PubMedCrossRefGoogle Scholar
  23. 364.
    Schmalstieg W, Weinshenker BG (2010) Approach to acute or subacute myelopathy. Neurology Clinical Practice 75 (Suppl 1): S2–S8Google Scholar
  24. 365.
    Sellner J, et al. (2010) EFNS Guidelines on diagnosis and management of neuromyelitis optica. Eur J Neurol 17:1019–1032PubMedCrossRefGoogle Scholar
  25. 366.
    Transverse Myelitis Consortium Working Group Neurology (2002) Proposed diagnostic citeria and nosology of acute tranverse myelitis. Neurology 59:499–505Google Scholar
  26. 367.
    Wingerchuk DM, et al. (2007) The spectrum of neuromyelitis optica. Lancet Neurol 6:805–815PubMedCrossRefGoogle Scholar
  27. 368.
    Wong SH, et al. (2008) Myelopathy but normal MRI: where next? Pract Neurol 8:90–102PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Stefan Schwab
    • 1
  • Peter Schellinger
    • 2
  • Christian Werner
    • 3
  • Andreas Unterberg
    • 4
  • Werner Hacke
    • 4
  1. 1.Neurologische KlinikFriedrich-Alexander- Universität Erlangen-NürnbergErlangen
  2. 2.BenediktuskrankenhausNeurologische Klinik und Geriatrie Johannes Wesling Klinikum MindenMinden
  3. 3.Klinik für AnästhesiologieKlinikum der Johannes Gutenberg-Universität MainzMainz
  4. 4.Neurochirurgische KlinikRuprecht-Karls-Universität HeidelbergHeidelberg

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