L-Serine ammonia-lyase

Part of the Springer Handbook of Enzymes book series (HDBKENZYMES, volume S7)


Pyridoxal Phosphate Serine Racemase Threonine Dehydratase Racemization Reaction Serine Dehydratase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. [1]
    Porter, P.N.; Grishaver, M.S.; Jones, O.W.: Characterization of human cystathionine β-synthase. Evidence for the identity of human L-serine dehydratase and cystathionine β-synthase. Biochim. Biophys. Acta, 364, 128–139 (1974)PubMedGoogle Scholar
  2. [2]
    Farias, M.E.; Strasser de Saad, A.M.; Pesce de Ruiz Holgado, A.A.; Oliver, G.: Evidence for the presence of L-serine dehydratase in Lactobacillus murinus. J. Gen. Appl. Microbiol., 31, 563–567 (1985)CrossRefGoogle Scholar
  3. [3]
    Newman, E.B.; Kapoor, V.: In vitro studies on L-serine deaminase activity of Escherichia coli K12. Can. J. Biochem., 58, 1292–1297 (1980)PubMedGoogle Scholar
  4. [4]
    Yeung, Y.G.; Yeung, D.: Comparative studies on threonine and serine dehydratases in rat liver. Int. J. Biochem., 11, 161–164 (1980)CrossRefPubMedGoogle Scholar
  5. [5]
    Gannon, F.; Bridgeland, E.S.; Jones, K.M.: L-Serine dehydratase from Arthrobacter globiformis. Biochem. J., 161, 345–355 (1977)PubMedGoogle Scholar
  6. [6]
    Gannon, F.; Jones, K.M.: An activity stain for L-serine dehydratase in polyacrylamide gels. Anal. Biochem., 79, 594–596 (1977)CrossRefPubMedGoogle Scholar
  7. [7]
    Grillo, M.A.: Serine dehydratase in animal tissues. Acta Vitaminol. Enzymol., 27, 51–61 (1973)PubMedGoogle Scholar
  8. [8]
    Morikawa, Y.; Nakamura, N.; Kimura, K.: Purification and some properties of L-serine dehydratase of Corynebacterium sp.. Agric. Biol. Chem., 38, 531–537 (1974)Google Scholar
  9. [9]
    Isenberg, S.; Newman, E.B.: Studies on L-serine deaminase in Escherichia coli K-12. J. Bacteriol., 118, 53–58 (1974)PubMedGoogle Scholar
  10. [10]
    Simon, D.; Kroeger, H.: Interactions of L-serine dehydratase from rat liver with its coenzyme and substrates. Biochim. Biophys. Acta, 334, 208–217 (1974)Google Scholar
  11. [11]
    Simon, D.; Hoshino, J.; Kroeger, H.: L-Serine dehydratase from rat liver. Purification and some properties. Biochim. Biophys. Acta, 321, 361–368 (1973)PubMedGoogle Scholar
  12. [12]
    Hoshino, J.; Simon, D.; Kroeger, H.: Influence of monovalent cations on the activity of L-serine (L-threonine) dehydratase from rat liver. Eur. J. Biochem., 27, 388–394 (1972)CrossRefPubMedGoogle Scholar
  13. [13]
    Sagers, R.D.; Carter, J.E.: L-Serine dehydratase (Clostridium acidiurici). Methods Enzymol., 17B, 351–356 (1971)CrossRefGoogle Scholar
  14. [14]
    Pestana, A.; Sandoval, I.V.; Sols, A.: Inhibition by homocysteine of serine dehydratase and other pyridoxal 5′-phosphate enzymes of the rat through cofactor blockage. Arch. Biochem. Biophys., 146, 373–379 (1971)CrossRefPubMedGoogle Scholar
  15. [15]
    Kubota, K.; Yokozeki, K.; Ozaki, H.: Effect of l-serine dehydratase activity onL-serine production by Corynebacterium glycinophilum and an examination of the properties of the enzyme. J. Ferment. Bioeng., 67, 391–394 (1989)CrossRefGoogle Scholar
  16. [16]
    Farias, M.E.; Strasser de Saad, A.M.; Pesce de Ruiz Holgado, A.A.; Oliver, G.: Purification and properties of L-serine dehydratase from Lactobacillus fermentum ATCC 14931. Curr. Microbiol., 22, 205–211 (1991)CrossRefGoogle Scholar
  17. [17]
    Grabowski, R.; Hofmeister, A.E.M.; Buckel, W.: Bacterial L-serine dehydratases: a new family of enzymes containing iron-sulfur clusters. Trends Biochem. Sci., 18, 297–300 (1993)CrossRefPubMedGoogle Scholar
  18. [18]
    Zinecker, H.; Andreesen, J.R.; Pich, A.: Partial purification of an iron-dependent l-serine dehydratase from Clostridium sticklandii. J. Basic Microbiol., 38, 147–155 (1998)CrossRefPubMedGoogle Scholar
  19. [19]
    Hofmeister, A.E.M.; Grabowski, R.; Linder, D.; Buckel, W.: L-Serine and L-threonine dehydratase from Clostridium propionicum. Two enzymes with different prosthetic groups. Eur. J. Biochem., 215, 341–349 (1993)CrossRefPubMedGoogle Scholar
  20. [20]
    Hofmeister, A.E.M.; Albracht, S.P.J.; Buckel, W.: Iron-sulfur cluster-containing L-serine dehydratase from Peptostreptococcus asaccharolyticus: correlation of the cluster type with enzymatic activity. FEBS Lett., 351, 416–418 (1994)CrossRefPubMedGoogle Scholar
  21. [21]
    Grabowski, R.; Buckel, W.: Purification and properties of an iron-sulfur containing and pyridoxal-phosphate-independent L-serine dehydratase from Peptostreptococcus asaccharolyticus. Eur. J. Biochem., 199, 89–94 (1991)CrossRefPubMedGoogle Scholar
  22. [22]
    Su, H.; Moniakis, J.; Newman, E.B.: Use of gene fusion of the structural gene sdaA to purify L-serine deaminase 1 from Escherichia coli K-12. Eur. J. Biochem., 211, 521–527 (1993)CrossRefPubMedGoogle Scholar
  23. [23]
    Newman, E.B.; Walker, C.; Ziegler-Skylakis, K.: A possible mechanism for the in vitro activation of L-serine deaminase activity in Escherichia coli K12. Biochem. Cell Biol., 68, 723–728 (1990)CrossRefPubMedGoogle Scholar
  24. [24]
    Hopgood, M.F.; Ballard, F.J.: The relative stability of liver cytosol enzymes incubated in vitro. Biochem. J., 144, 371–376 (1974)PubMedGoogle Scholar
  25. [25]
    Ramos, F.; Wiame, J.M.: Occurrence of a catabolic L-serine (L-threonine) deaminase in Saccharomyces cerevisiae. Eur. J. Biochem., 123, 571–576 (1982)PubMedCrossRefGoogle Scholar
  26. [26]
    Suda, M.; Nakagawa, H.: L-Serine dehydratase (rat liver). Methods Enzymol., 17B, 346–351 (1971)CrossRefGoogle Scholar
  27. [27]
    Ogawa, H.; Takasugawa, F.; Wakaki, K.; Kishi, H.; Eskandarian, M.R.; Kobayashi, M.; Date, T.; Huh, N.H.; Pitot, H.C.: Rat liver serine dehydratase. J. Biol. Chem., 274, 12855–12869 (1999)CrossRefPubMedGoogle Scholar
  28. [28]
    Sun, L.; Li, X.; Dong, Y.; Yang, M.; Liu, Y.; Han, X.; Zhang, X.; Pang, H.; Rao, Z.: Crystallization and preliminary crystallographic analysis of human serine dehydratase. Acta Crystallogr. Sect. D, 59, 2297–2299 (2003)CrossRefGoogle Scholar
  29. [29]
    Yamada, T.; Komoto, J.; Takata, Y.; Ogawa, H.; Pitot, H.C.; Takusagawa, F.: Crystal structure of serine dehydratase from rat liver. Biochemistry, 42, 12854–12865 (2003)CrossRefPubMedGoogle Scholar
  30. [30]
    Imai, S.; Kanamoto, R.; Yagi, I.; Kotaru, M.; Saeki, T.; Iwami, K.: Response of the induction of rat liver serine dehydratase to changes in the dietary protein requirement. Biosci. Biotechnol. Biochem., 67, 383–387 (2003)CrossRefPubMedGoogle Scholar
  31. [31]
    Laroche, M.; Pukall, R.; Ulber, R.: Recovery and characterization of a L-serine dehydratase from the marine bacterium Paracoccus seriniphilus for the construction of bioanalytical systems. Chem.-Ing.-Tech., 75, 146–149 (2003)CrossRefGoogle Scholar
  32. [32]
    Velayudhan, J.; Jones, M.A.; Barrow, P.A.; Kelly, D.J.: L-serine catabolism via an oxygen-labile L-serine dehydratase is essential for colonization of the avian gut by Campylobacter jejuni. Infect. Immun., 72, 260–268 (2004)CrossRefPubMedGoogle Scholar
  33. [33]
    Ogawa, H.; Gomi, T.; Takusagawa, F.; Masuda, T.; Goto, T.; Kan, T.; Huh, N.-H.: Evidence for a dimeric structure of rat liver serine dehydratase. Int. J. Biochem. Cell Biol., 34, 533–543 (2002)CrossRefPubMedGoogle Scholar
  34. [34]
    Ogawa, H.; Takusagawa, F.; Wakaki, K.; Kishi, H.; Eskandarian, M.R.; Kobayashi, M.; Date, T.; Huh, N.-H.; Pitot, H.C.: Rat liver serine dehydratase. Bacterial expression and two folding domains as revealed by limited proteolysis. J. Biol. Chem., 274, 12855–12860 (1999)CrossRefPubMedGoogle Scholar
  35. [35]
    Xue, H.H.; Fujie, M.; Sakaguchi, T.; Oda, T.; Ogawa, H.; Kneer, N.M.; Lardy, H.A.; Ichiyama, A.: Flux of the L-serine metabolism in rat liver. The predominant contribution of serine dehydratase. J. Biol. Chem., 274, 16020–16027 (1999)CrossRefPubMedGoogle Scholar
  36. [36]
    Strisovsky, K.; Jiraskova, J.; Mikulova, A.; Rulisek, L.; Konvalinka, J.: Dual substrate and reaction specificity in mouse serine racemase: identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the β-eliminase activity. Biochemistry, 44, 13091–13100 (2005)CrossRefPubMedGoogle Scholar
  37. [37]
    Strisovsky, K.; Jiraskova, J.; Barinka, C.; Majer, P.; Rojas, C.; Slusher, B.S.; Konvalinka, J.: Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate. FEBS Lett., 535, 44–48 (2003)CrossRefPubMedGoogle Scholar
  38. [38]
    Foltyn, V.N.; Bendikov, I.; De Miranda, J.; Panizzutti, R.; Dumin, E.; Shleper, M.; Li, P.; Toney, M.D.; Kartvelishvily, E.; Wolosker, H.: Serine racemase modulates intracellular D-serine levels through an α,β-elimination activity. J. Biol. Chem., 280, 1754–1763 (2005)CrossRefPubMedGoogle Scholar
  39. [39]
    Neidle, A.; Dunlop, D.S.: Allosteric regulation of mouse brain serine racemase. Neurochem. Res., 27, 1719–1724 (2002)CrossRefPubMedGoogle Scholar
  40. [40]
    Nagayoshi, C.; Ishibashi, M.; Kita, Y.; Matsuoka, M.; Nishimoto, I.; Tokunaga, M.: Expression, refolding and characterization of human brain serine racemase in Escherichia coli with N-terminal His-tag. Protein Pept. Lett., 12, 487–490 (2005)CrossRefPubMedGoogle Scholar
  41. [41]
    Kanamoto, R.; Fujita, K.; Kumasaki, M.; Imai, S.; Kotaru, M.; Saeki, T.; Iwami, K.: Inverse correlation between the nitrogen balance and induction of rat liver serine dehydratase (SDH) by dietary protein. Biosci. Biotechnol. Biochem., 68, 888–893 (2004)CrossRefPubMedGoogle Scholar
  42. [42]
    Burman, J.D.; Harris, R.L.; Hauton, K.A.; Lawson, D.M.; Sawers, R.G.: The iron-sulfur cluster in the L-serine dehydratase TdcG from Escherichia coli is required for enzyme activity. FEBS Lett., 576, 442–444 (2004)CrossRefPubMedGoogle Scholar
  43. [43]
    Kashii, T.; Gomi, T.; Oya, T.; Ishii, Y.; Oda, H.; Maruyama, M.; Kobayashi, M.; Masuda, T.; Yamazaki, M.; Nagata, T.; Tsukada, K.; Nakajima, A.; Tatsu, K.; Mori, H.; Takusagawa, F.; Ogawa, H.; Pitot, H.C.: Some biochemical and histochemical properties of human liver serine dehydratase. Int. J. Biochem. Cell Biol., 37, 574–589 (2005)CrossRefPubMedGoogle Scholar
  44. [44]
    Cicchillo, R.M.; Baker, M.A.; Schnitzer, E.J.; Newman, E.B.; Krebs, C.; Booker, S.J.: Escherichia coli L-serine deaminase requires a [4Fe-4S] cluster in catalysis. J. Biol. Chem., 279, 32418–32425 (2004)CrossRefPubMedGoogle Scholar
  45. [45]
    Lopez-Flores, I.; Barroso, J.B.; Valderrama, R.; Esteban, F.J.; Martinez-Lara, E.; Luque, F.; Peinado, M.A.; Ogawa, H.; Lupianez, J.A.; Peragon, J.: Serine dehydratase expression decreases in rat livers injured by chronic thioacetamide ingestion. Mol. Cell. Biochem., 268, 33–43 (2005)CrossRefPubMedGoogle Scholar
  46. [46]
    Sun, L.; Bartlam, M.; Liu, Y.; Pang, H.; Rao, Z.: Crystal structure of the pyridoxal-5′-phosphate-dependent serine dehydratase from human liver. Protein Sci., 14, 791–798 (2005)CrossRefPubMedGoogle Scholar

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