Advertisement

Amorpha-4,11-diene synthase

Part of the Springer Handbook of Enzymes book series (HDBKENZYMES, volume S7)

Keywords

Antimalarial Drug Minor Product Cyclization Reaction Farnesyl Diphosphate Artemisia Annua 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    Mercke, P.; Bengtsson, M.; Bouwmeester, H.J.; Posthumus, M.A.; Brodelius, P.E.: Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L.. Arch. Biochem. Biophys., 381, 173–180 (2000)CrossRefPubMedGoogle Scholar
  2. [2]
    Chang, Y.-J.; Song, S.-H.; Park, S.-H.; Kim, S.-U.: Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis. Arch. Biochem. Biophys., 383, 178–184 (2000)CrossRefPubMedGoogle Scholar
  3. [3]
    Picaud, S.; Olofsson, L.; Brodelius, M.; Brodelius, P.E.: Expression, purification, and characterization of recombinant amorpha-4,11-diene synthase from Artemisia annua L. Arch. Biochem. Biophys., 436, 215–226 (2005)CrossRefPubMedGoogle Scholar
  4. [4]
    Picaud, S.; Mercke, P.; He, X.; Sterner, O.; Brodelius, M.; Cane, D.E.; Brodelius, P.E.: Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate. Arch. Biochem. Biophys., 448, 150–155 (2006)CrossRefPubMedGoogle Scholar
  5. [5]
    Kim, S.H.; Heo, K.; Chang, Y.J.; Park, S.H.; Rhee, S.K.; Kim, S.U.: Cyclization mechanism of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis. J. Nat. Prod., 69, 758–762 (2006)CrossRefPubMedGoogle Scholar
  6. [6]
    Martin, V.J.; Pitera, D.J.; Withers, S.T.; Newman, J.D.; Keasling, J.D.: Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat. Biotechnol., 21, 796–802 (2003)CrossRefPubMedGoogle Scholar
  7. [7]
    Bouwmeester, H.J.; Wallaart, T.E.; Janssen, M.H.A.; Van Loo, B.; Jansen, B.J.M.; Posthumus, M.A.; Schmidt, C.O.; De Kraker, J.-W.; Konig, W.A.; Franssen, M.C.R.: Amorpha-4,11-diene synthase catalyzes the first probable step in artemisinin biosynthesis. Phytochemistry, 52, 843–854 (1999)CrossRefPubMedGoogle Scholar
  8. [8]
    Wallaart, T.E.; Bouwmeester, H.J.; Hille, J.; Poppinga, L.; Maijers, N.C.A.: Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin. Planta, 212, 460–465 (2001)CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Personalised recommendations