Advertisement

Abietadiene synthase

Part of the Springer Handbook of Enzymes book series (HDBKENZYMES, volume S7)

Keywords

Reaction Type Recombinant Enzyme Resin Acid Pinus Taeda Diffusive Transfer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    Ravn, M.M.; Coates, R.M.; Flory, J.E.; Peters, R.J.; Croteau, R.: Stereochemistry of the cyclization-rearrangement of (+)-copalyl diphosphate to (−)-abietadiene catalyzed by recombinant abietadiene synthase from Abies grandis. Org. Lett., 2, 573–576 (2000)CrossRefPubMedGoogle Scholar
  2. [2]
    Peters, R.J.; Flory, J.E.; Jetter, R.; Ravn, M.M.; Lee, H.J.; Coates, R.M.; Croteau, R.B.: Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the “pseudomature” recombinant enzyme. Biochemistry, 39, 15592–15602 (2000)CrossRefPubMedGoogle Scholar
  3. [3]
    Peters, R.J.; Ravn, M.M.; Coates, R.M.; Croteau, R.B.: Bifunctional abietadiene synthase: Free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites. J. Am. Chem. Soc., 123, 8974–8978 (2001)CrossRefPubMedGoogle Scholar
  4. [4]
    Peters, R.J.; Croteau, R.B.: Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate. Biochemistry, 41, 1836–1842 (2002)CrossRefPubMedGoogle Scholar
  5. [5]
    Peters, R.J.; Croteau, R.B.: Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement. Proc. Natl. Acad. Sci. USA, 99, 580–584 (2002)CrossRefPubMedGoogle Scholar
  6. [6]
    Ravn, M.M.; Peters, R.J.; Coates, R.M.; Croteau, R.: Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates. J. Am. Chem. Soc., 124, 6998–7006 (2002)CrossRefPubMedGoogle Scholar
  7. [7]
    Peters, R.J.; Carter, O.A.; Zhang, Y.; Matthews, B.W.; Croteau, R.B.: Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations. Biochemistry, 42, 2700–2707 (2003)CrossRefPubMedGoogle Scholar
  8. [8]
    Vogel, B.S.; Wildung, M.R.; Vogel, G.; Croteau, R.: Abietadiene synthase from grand fir (Abies grandis). cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase involved in resin acid biosynthesis. J. Biol. Chem., 271, 23262–23268 (1996)CrossRefPubMedGoogle Scholar
  9. [9]
    Ro, D.K.; Bohlmann, J.: Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): Functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1). Phytochemistry, 67, 1572–1578 (2006)CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Personalised recommendations