Advertisement

Pentalenene synthase

Part of the Springer Handbook of Enzymes book series (HDBKENZYMES, volume S7)

Keywords

Bond Cleavage Reaction Type Active Site Residue Mechanistic Insight Partial Purification 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    Cane, D.E.: Cell-free studies of monoterpene and sesquiterpene biosynthesis. Biochem. Soc. Trans., 11, 510–515 (1983)PubMedGoogle Scholar
  2. [2]
    Cane, D.E.; Pargellis, C.: Partial purification and characterization of pentalenene synthase. Arch. Biochem. Biophys., 254, 421–429 (1987)CrossRefPubMedGoogle Scholar
  3. [3]
    Cane, D.E.; Oliver, J.S.; Harrison, P.H.M.; Abell, C.; Hubbard, B.R.; Kane, C.T.; Lattman, R.: The biosynthesis of pentalenene and pentalenolactosne. J. Am. Chem. Soc., 112, 4513–4524 (1990)CrossRefGoogle Scholar
  4. [4]
    Cane, D.E.; Abell, C.; Lattman, R.; Kane, C.T.; Hubbard, B.R.; Harrison, P.H.M.: Pentalenene biosynthesis and the enzymatic cyclisation of farnesyl pyrophosphate. Anti stereochemistry in a biological SE reaction. J. Am. Chem. Soc., 110, 4081–4082 (1988)CrossRefGoogle Scholar
  5. [5]
    Cane, D.E.; Sohng, J.K.; Lamberson, C.R.; Rudnicki, S.M.; Wu, Z.; Lloyd, M.D.; Oliver, J.S.; Hubbard, B.R.: Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319. Biochemistry, 33, 5846–5857 (1994)CrossRefPubMedGoogle Scholar
  6. [6]
    Cane, D.E.; Weiner, S.W.: Cyclization of farnesyl diphosphate to pentalenene. Orthogonal stereochemistry in an enzyme-catalyzed SE’ reaction. Can. J. Chem., 72, 118–127 (1994)Google Scholar
  7. [7]
    Lesburg, C.A.; Zhai, G.; Cane, D.E.; Christianson, D.W.: Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology. Science, 277, 1820–1824 (1997)CrossRefPubMedGoogle Scholar
  8. [8]
    Seemann, M.; Zhai, G.; Umezawa, K.; Cane, D.: Pentalenene synthase. Histidine-309 is not required for catalytic activity. J. Am. Chem. Soc., 121, 591–592 (1999)CrossRefGoogle Scholar
  9. [9]
    Seemann, M.; Zhai, G.; de Kraker, J.W.; Paschall, C.M.; Christianson, D.W.; Cane, D.E.: Pentalenene synthase. Analysis of active site residues by site-directed mutagenesis. J. Am. Chem. Soc., 124, 7681–7689 (2002)CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Personalised recommendations