Chondroitin B lyase

Part of the Springer Handbook of Enzymes book series (HDBKENZYMES, volume S7)


Ricinoleic Acid Dermatan Sulfate Elaidic Acid Vaccenic Acid Behenic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. [1]
    Gu, K.; Linhardt, R.L.; Laliberte, M.; Gu, K.; Zimmermann, J.: Purification, characterization and specificity of chondroitin lyases and glycuronidase from Flavobacterium heparinum. Biochem. J., 312, 569–577 (1995)PubMedGoogle Scholar
  2. [2]
    Li, Y.; Matte, A.; Su, H.; Cygler, M.: Crystallization and preliminary X-ray analysis of chondroitinase B from Flavobacterium heparinum. Acta Crystallogr. Sect. D, 55, 1055–1057 (1999)CrossRefGoogle Scholar
  3. [3]
    Tkalec, A.L.; Fink, D.; Blain, F.; Zhang-Sun, G.; Laliberte, M.; Bennett, D.C.; Gu, K.; Zimmermann, J.J.F.; Su, H.: Isolation and expression in Escherichia coli of cslA and cslB, genes coding for the chondroitin sulfate-degrading enzymes chondroitinase AC and chondroitinase B, respectively, from Flavobacterium heparinum. Appl. Environ. Microbiol., 66, 29–35 (2000)CrossRefPubMedGoogle Scholar
  4. [4]
    Pojasek, K.; Shriver, Z.; Kiley, P.; Venkataraman, G.; Sasisekharan, R.: Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum. Biochem. Biophys. Res. Commun., 286, 343–351 (2001)CrossRefPubMedGoogle Scholar
  5. [5]
    Ototani, N.; Yosizawa, Z.: Purification of chondroitinase B and chondroitinase C using glycosaminoglycan-bound AH-Sepharose 4B. Carbohydr. Res., 70, 295–306 (1979)CrossRefPubMedGoogle Scholar
  6. [6]
    Denholm, E.M.; Lin, Y.Q.; Silver, P.J.: Anti-tumor activities of chondroitinase AC and chondroitinase B: inhibition of angiogenesis, proliferation and invasion. Eur. J. Pharmacol., 416, 213–221 (2001)CrossRefPubMedGoogle Scholar
  7. [7]
    Pojasek, K.; Raman, R.; Kiley, P.; Venkataraman, G.; Sasisekharan, R.: Biochemical characterization of the chondroitinase B active site. J. Biol. Chem., 277, 31179–31186 (2002)CrossRefPubMedGoogle Scholar
  8. [8]
    Michel, G.; Pojasek, K.; Li, Y.; Sulea, T.; Linhardt, R.J.; Raman, R.; Prabhakar, V.; Sasisekharan, R.; Cygler, M.: The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calciumdependent catalytic machinery. J. Biol. Chem., 279, 32882–32896 (2004)CrossRefPubMedGoogle Scholar
  9. [9]
    Suzuki, K.; Terasaki, Y.; Uyeda, M.: Inhibition of hyaluronidases and chondroitinases by fatty acids. J. Enzyme Inhib. Med. Chem., 17, 183–186 (2002)CrossRefPubMedGoogle Scholar
  10. [10]
    Huang, W.; Matte, A.; Li, Y.; Kim, Y.S.; Linhardt, R.J.; Su, H.; Cygler, M.: Crystal structure of chondroitinase B from Flavobacterium heparinum and its complex with a disaccharide product at 1.7 A resolution. J. Mol. Biol., 294, 1257–1269 (1999)CrossRefPubMedGoogle Scholar

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