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Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)

Part of the Springer Handbook of Enzymes book series (HDBKENZYMES, volume S7)

Keywords

Escherichia Coli Nicotinic Acid Catalytic Site Native Activity Intermediate Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Crouzet, J.; Cauchois, L.; Blanche, F.; Debussche, L.; Thibaut, D.; Rouyez, M.C.; Rigault, S.; Mayaux, J.F.; Cameron, B.: Nucleotide sequence of a Pseudomonas denitrificans 5.4-kilobase DNA fragment containing five cob genes and identification of structural genes encoding S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase and cobyrinic acid a,c-diamide synthase. J. Bacteriol., 172, 5968–5979 (1990)PubMedGoogle Scholar
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    Debussche, L.; Thibaut, D.; Cameron, B.; Crouzet, J.; and Blanche, F.: Purification and characterization of cobyrinic acid a,c-diamide synthase from Pseudomonas denitrificans. J. Bacteriol., 172, 6239–6244 (1990)PubMedGoogle Scholar
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    Blanche, F.; Couder, M.; Debussche, L.; Thibaut, D.; Cameron, B.; Cruzet, J.: Biosynthesis of vitamin B12: stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide is catalyzed by one enzyme in Pseudomonas denitrificans. J. Bacteriol., 173, 6046–6051 (1991)PubMedGoogle Scholar
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    Tsang, A.W.; Escalante-Semerena, J.C.: cobB function is required for catabolism of propionate in Salmonella typhimurium LT2: evidence for existence of a substitute function for CobB within the 1,2-propanediol utilization (pdu) operon. J. Bacteriol., 178, 7016–7019 (1996)PubMedGoogle Scholar
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    Tsang, A.W.; Escalante-Semerena, J.C.: CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2. J. Biol. Chem., 273, 31788–31794 (1998)CrossRefPubMedGoogle Scholar
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    Galperin, M.Y.; Grishin, N.V.: The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to dethiobiotin synthetase. Proteins, 41, 238–247 (2000)CrossRefPubMedGoogle Scholar
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    Fresquet, V.; Williams, L.; Raushel, F.M.: Mechanism of cobyrinic acid a,cdiamide synthetase from Salmonella typhimurium LT2. Biochemistry, 43, 10619–10627 (2004)CrossRefPubMedGoogle Scholar

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