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(Carboxyethyl)arginine β-lactam-synthase

Part of the Springer Handbook of Enzymes book series (HDBKENZYMES, volume S7)

Keywords

Biological Role Acid Biosynthesis Reaction Type Early Step Clavulanic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Bachmann, B.O.; Li, R.; Townsend, C.A.: β-Lactam synthetase: a new biosynthetic enzyme. Proc. Natl. Acad. Sci. USA, 95, 9082–9086 (1998)CrossRefPubMedGoogle Scholar
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    Bachmann, B.O.; Townsend, C.A.: Kinetic mechanism of the β-Lactam synthetase of Streptomyces clavuligerus. Biochemistry, 39, 11187–11193 (2000)CrossRefPubMedGoogle Scholar
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    Miller, M.T.; Bachmann, B.O.; Townsend, C.A.; Rosenzweig, A.C.: The catalytic cycle of β-lactam synthetase observed by X-ray crystallographic snapshots. Proc. Natl. Acad. Sci. USA, 99, 14752–14757 (2002)CrossRefPubMedGoogle Scholar
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    Miller, M.T.; Bachmann, B.O.; Townsend, C.A.; Rosenzweig, A.C.: Structure of β-lactam synthetase reveals how to synthesize antibiotics instead of asparagine. Nat. Struct. Biol., 8, 684–689 (2001)CrossRefPubMedGoogle Scholar
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    McNaughton, H.J.; Thirkettle, J.E.; Zhang, Z.; Schofield, C.J.; Jensen, S.E.; Barton, B.; Greaves, P.: β-Lactam synthetase: implications for β-lactamase evolution. Chem. Commun., 1998, 2325–2326 (1998)CrossRefGoogle Scholar
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    Townsend, C.A.: New reactions in clavulanic acid biosynthesis. Curr. Opin. Chem. Biol., 6, 583–589 (2002)CrossRefPubMedGoogle Scholar

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