Lung transplantation (LTx) is a successful treatment modality for carefully selected patients suffering from different forms of end-stage lung disease. The aim of this replacement therapy is not only to prolong survival but also to improve quality of life in patients at home or hospital bound that are often oxygen dependent with limited exercise capacity and activities of daily life. This ultimate therapy, just as transplantation for failure of any other solid organ, is limited by the shortage of suitable donors and acceptable grafts. In addition, LTx is hampered by early- and late-stage complications related to primary graft dysfunction, acute and chronic rejection (the so-called chronic lung allograft dysfunction), opportunistic infections, malignancies, and other side effects of lifelong immunosuppressive therapy. Further research to better understand the mechanisms behind these problems and to find new solutions to deal with limitations and obstacles of LTx is needed .
KeywordsLung transplantation Surgical techniques
Dirk Van Raemdonck was a senior clinical investigator supported by the Fund for Research-Flanders (G.3C04.99). We acknowledge the large contribution of all members of the Leuven Lung Transplant Group (www.longtransplantatie.be) to the success of our program.
Disclosures: Dirk Van Raemdonck was a consultant for Transmedics, Andover, MA, currently acting as principal co-investigator of the Expand Trial. He received research support from XVIVO Perfusion (XVIVO), Göteborg, Sweden, in the past.
Patient position on the operating table ready for bilateral thoracotomy (MP4 1623 kb)
Preparing the donor lung (MP4 8492 kb)
Bronchial anastomosis (MP4 14713 kb)
Pulmonary arterial anastomosis (MP4 13803 kb)
Left atrial anastomosis (MP4 14988 kb)
Reperfusion and ventilation of the donor lung (MP4 6882 kb)
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